June 2009 Volume 28 Number 25, pp 2365 - 2424
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Special Issue on Gene Therapy for Chronic Pain
Guest Editors: Joseph Glorioso and David Fink
Volume 16 Number 4
Chronic pain is a significant medical problem. Recent studies suggest that
employing gene transfer to release neuroactive peptides at targeted sites in
the pain pathway may be an effective means to reduce pain, while avoiding
off-target side effects that limit pharmacologic treatment. This issue surveys
results from preclinical animal studies using several different vector
technologies, and describes the first clinical trial of gene transfer for the
treatment of pain using an HSV-based vector that began enrolling patients in
December 2008.
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ORIGINAL ARTICLES
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The role of PAK-1 in activation of MAP kinase cascade and oncogenic transformation by Akt
P R Somanath, J Vijai, J V Kichina, T Byzova and E S Kandel
Abstract: http://links.ealert.nature.com/ctt?kn=20&m=33464230&r=MTc2ODI0Mjc1MwS2&b=2&j=NTIwODMxOTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=14&m=33464230&r=MTc2ODI0Mjc1MwS2&b=2&j=NTIwODMxOTQS1&mt=1&rt=0
HDAC3 represses the expression of NKG2D ligands ULBPs in epithelial tumour cells: potential implications for the immunosurveillance of cancer
A Lopez-Soto, A R Folgueras, E Seto and S Gonzalez
Abstract: http://links.ealert.nature.com/ctt?kn=43&m=33464230&r=MTc2ODI0Mjc1MwS2&b=2&j=NTIwODMxOTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=22&m=33464230&r=MTc2ODI0Mjc1MwS2&b=2&j=NTIwODMxOTQS1&mt=1&rt=0
Gene deletion of inositol hexakisphosphate kinase 2 predisposes to aerodigestive tract carcinoma
B H Morrison, R Haney, E Lamarre, J Drazba, G D Prestwich and D J Lindner
Abstract: http://links.ealert.nature.com/ctt?kn=12&m=33464230&r=MTc2ODI0Mjc1MwS2&b=2&j=NTIwODMxOTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=6&m=33464230&r=MTc2ODI0Mjc1MwS2&b=2&j=NTIwODMxOTQS1&mt=1&rt=0
Fbw7 promotes ubiquitin-dependent degradation of c-Myb: involvement of GSK3-mediated phosphorylation of Thr-572 in mouse c-Myb
K Kitagawa, Y Hiramatsu, C Uchida, T Isobe, T Hattori, T Oda, K Shibata, S Nakamura, A Kikuchi and M Kitagawa
Abstract: http://links.ealert.nature.com/ctt?kn=26&m=33464230&r=MTc2ODI0Mjc1MwS2&b=2&j=NTIwODMxOTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=42&m=33464230&r=MTc2ODI0Mjc1MwS2&b=2&j=NTIwODMxOTQS1&mt=1&rt=0
The transcriptional induction of PIK3CA in tumor cells is dependent on the oncoprotein Y-box binding protein-1
A Astanehe, M R Finkbeiner, P Hojabrpour, K To, A Fotovati, A Shadeo, A L Stratford, W L Lam, I M Berquin, V Duronio and S E Dunn
Abstract: http://links.ealert.nature.com/ctt?kn=36&m=33464230&r=MTc2ODI0Mjc1MwS2&b=2&j=NTIwODMxOTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=30&m=33464230&r=MTc2ODI0Mjc1MwS2&b=2&j=NTIwODMxOTQS1&mt=1&rt=0
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SHORT COMMUNICATION
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The mir-34 microRNA is required for the DNA damage response in vivo in C. elegans and in vitro in human breast cancer cells
M Kato, T Paranjape, R Ullrich, S Nallur, E Gillespie, K Keane, A Esquela-Kerscher, J B Weidhaas and F J Slack
Abstract: http://links.ealert.nature.com/ctt?kn=41&m=33464230&r=MTc2ODI0Mjc1MwS2&b=2&j=NTIwODMxOTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=45&m=33464230&r=MTc2ODI0Mjc1MwS2&b=2&j=NTIwODMxOTQS1&mt=1&rt=0
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