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World Stem Cell Summit 2010

Wednesday, December 30, 2009

Kidney International - Table of Contents alert Volume 77 Issue 2

KIDNEY INTERNATIONAL

January 2010 Volume 77 Number 2, pp 79 - 168


International Society of Nephrology
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Your contribution is essential:
Renew your ISN membership now!
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----------------------
IN THIS ISSUE
----------------------
In this Issue
http://links.ealert.nature.com/ctt?kn=45&m=34520843&r=MTc2MzAwNDQzNwS2&b=2&j=NjMzMTE2NTgS1&mt=1&rt=0

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JOURNAL CLUB
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Journal Club
http://links.ealert.nature.com/ctt?kn=51&m=34520843&r=MTc2MzAwNDQzNwS2&b=2&j=NjMzMTE2NTgS1&mt=1&rt=0

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COMMENTARIES
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Comorbidity and confounding in end-stage renal disease
Stephen L Seliger
Abstract: http://links.ealert.nature.com/ctt?kn=53&m=34520843&r=MTc2MzAwNDQzNwS2&b=2&j=NjMzMTE2NTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=54&m=34520843&r=MTc2MzAwNDQzNwS2&b=2&j=NjMzMTE2NTgS1&mt=1&rt=0

Hydrogen: another gas with therapeutic potential
James F George and Anupam Agarwal
Abstract: http://links.ealert.nature.com/ctt?kn=56&m=34520843&r=MTc2MzAwNDQzNwS2&b=2&j=NjMzMTE2NTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=47&m=34520843&r=MTc2MzAwNDQzNwS2&b=2&j=NjMzMTE2NTgS1&mt=1&rt=0

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MINI REVIEWS
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Linking an insect enzyme to hypertension: angiotensin II-epoxide hydrolase interactions
Ding Ai, John Y-J Shyy and Yi Zhu
Abstract: http://links.ealert.nature.com/ctt?kn=48&m=34520843&r=MTc2MzAwNDQzNwS2&b=2&j=NjMzMTE2NTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=49&m=34520843&r=MTc2MzAwNDQzNwS2&b=2&j=NjMzMTE2NTgS1&mt=1&rt=0

Parathyroid hormone measurement in CKD
Jean-Claude P Souberbielle, Hubert Roth and Denis P Fouque
Abstract: http://links.ealert.nature.com/ctt?kn=15&m=34520843&r=MTc2MzAwNDQzNwS2&b=2&j=NjMzMTE2NTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=14&m=34520843&r=MTc2MzAwNDQzNwS2&b=2&j=NjMzMTE2NTgS1&mt=1&rt=0

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ORIGINAL ARTICLES
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Oral hydrogen water prevents chronic allograft nephropathy in rats
Jon S Cardinal, Jianghua Zhan, Yinna Wang, Ryujiro Sugimoto, Allan Tsung, Kenneth R McCurry, Timothy R Billiar and Atsunori Nakao
Abstract: http://links.ealert.nature.com/ctt?kn=13&m=34520843&r=MTc2MzAwNDQzNwS2&b=2&j=NjMzMTE2NTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=12&m=34520843&r=MTc2MzAwNDQzNwS2&b=2&j=NjMzMTE2NTgS1&mt=1&rt=0

Inhibition of calcineurin phosphatase promotes exocytosis of renin from juxtaglomerular cells
Kirsten Madsen, Ulla G Friis, Jennifer L Gooch, Pernille B Hansen, Lisbeth Holmgaard, Ole Skott and Boye L Jensen
Abstract: http://links.ealert.nature.com/ctt?kn=11&m=34520843&r=MTc2MzAwNDQzNwS2&b=2&j=NjMzMTE2NTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=9&m=34520843&r=MTc2MzAwNDQzNwS2&b=2&j=NjMzMTE2NTgS1&mt=1&rt=0

Phosphoinositol 3-kinase-[gamma] mediates antineutrophil cytoplasmic autoantibody-induced glomerulonephritis
Adrian Schreiber, Susanne Rolle, Ludmilla Peripelittchenko, Joerg Rademann, Wolfgang Schneider, Friedrich C Luft and Ralph Kettritz
Abstract: http://links.ealert.nature.com/ctt?kn=74&m=34520843&r=MTc2MzAwNDQzNwS2&b=2&j=NjMzMTE2NTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=73&m=34520843&r=MTc2MzAwNDQzNwS2&b=2&j=NjMzMTE2NTgS1&mt=1&rt=0

Cyclic nucleotide signaling in polycystic kidney disease
Xiaofang Wang, Christopher J Ward, Peter C Harris and Vicente E Torres
Abstract: http://links.ealert.nature.com/ctt?kn=77&m=34520843&r=MTc2MzAwNDQzNwS2&b=2&j=NjMzMTE2NTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=76&m=34520843&r=MTc2MzAwNDQzNwS2&b=2&j=NjMzMTE2NTgS1&mt=1&rt=0

An improved comorbidity index for outcome analyses among dialysis patients
Jiannong Liu, Zhi Huang, David T Gilbertson, Robert N Foley and Allan J Collins
Abstract: http://links.ealert.nature.com/ctt?kn=64&m=34520843&r=MTc2MzAwNDQzNwS2&b=2&j=NjMzMTE2NTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=65&m=34520843&r=MTc2MzAwNDQzNwS2&b=2&j=NjMzMTE2NTgS1&mt=1&rt=0

Mycophenolate mofetil and intravenous cyclophosphamide are similar as induction therapy for class V lupus nephritis
Jai Radhakrishnan, Dimitrios-Anestis Moutzouris, Ellen M Ginzler, Neil Solomons, Ilias I Siempos and Gerald B Appel
Abstract: http://links.ealert.nature.com/ctt?kn=66&m=34520843&r=MTc2MzAwNDQzNwS2&b=2&j=NjMzMTE2NTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=67&m=34520843&r=MTc2MzAwNDQzNwS2&b=2&j=NjMzMTE2NTgS1&mt=1&rt=0

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THE RENAL CONSULT
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Non-hepatitis virus associated mixed essential cryoglobulinemia
Nicholas M P Annear, H Terence Cook, Mark Atkins, Charles D Pusey and Alan D Salama
Abstract: http://links.ealert.nature.com/ctt?kn=68&m=34520843&r=MTc2MzAwNDQzNwS2&b=2&j=NjMzMTE2NTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=69&m=34520843&r=MTc2MzAwNDQzNwS2&b=2&j=NjMzMTE2NTgS1&mt=1&rt=0

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LETTERS TO THE EDITOR
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Regarding `Calcium channel blocker-induced chylous ascites in peritoneal dialysis'
Renee Graice and Joanne M Bargman
http://links.ealert.nature.com/ctt?kn=99&m=34520843&r=MTc2MzAwNDQzNwS2&b=2&j=NjMzMTE2NTgS1&mt=1&rt=0

Response to: "Regarding `Calcium channel blocker-induced chylous ascites in peritoneal dialysis'"
Wei-Liang Chen and Yu-Tzu Tsao
http://links.ealert.nature.com/ctt?kn=96&m=34520843&r=MTc2MzAwNDQzNwS2&b=2&j=NjMzMTE2NTgS1&mt=1&rt=0

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NEPHROLOGY IMAGE
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Intrathoracic kidney with right Bochdalek's hernia
Shiu-Dong Chung, Kuo-Hsin Chen, Ming-Kuen Lai, Hsiao-Chun Chang, Chao-Yuan Huang and Hong-Jeng Yu
http://links.ealert.nature.com/ctt?kn=92&m=34520843&r=MTc2MzAwNDQzNwS2&b=2&j=NjMzMTE2NTgS1&mt=1&rt=0

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MAKE YOUR DIAGNOSIS
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The Case | Best not shaken or stirred! Chronic lymphocytic leukemia and hyperkalemia
Rebecca M Smalley, Shelly Cook and Micah R Chan
http://links.ealert.nature.com/ctt?kn=90&m=34520843&r=MTc2MzAwNDQzNwS2&b=2&j=NjMzMTE2NTgS1&mt=1&rt=0


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Tuesday, December 29, 2009

Nature Methods Contents: January 2010 Volume 7 pp 1 - 85

NATURE METHODS

January 2010 Volume 7 Number 1, pp 1 - 85

Visit Nature Methods online to browse the journal.

Now available at http://links.ealert.nature.com/ctt?kn=165&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0

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=====================================================================

----------------------
SPECIAL FEATURE
----------------------
Method of the Year 2009
Nature Methods' Method of the Year 2009 goes to induced pluripotency
for its potential for biological discovery. This series of
articles-and the related video-showcase how induced pluripotency
is coming into its own in 2009 as a tool for discovery in both basic
and disease biology and explore the incredible impact this area
promises to have in biological research. The Methods to Watch
feature provides a glimpse of future Methods of the Year and the
Reader's Choice shows methods nominated by readers and editors,
and the votes that they received.
http://links.ealert.nature.com/ctt?kn=169&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0

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EDITORIAL
----------------------
Special feature: Method of the Year
Method of the Year 2009 p1
doi:10.1038/nmeth.f.294
The ability to return mature body cells to a pluripotent state has
wide-ranging potential as a tool for discovery in both disease and
basic biology.
http://links.ealert.nature.com/ctt?kn=111&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0

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THIS MONTH
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The author file p3
doi:10.1038/nmeth0110-03
Supercharged SRM: synthetic peptides bring high-throughput
assays to targeted proteomics.
http://links.ealert.nature.com/ctt?kn=113&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0

----------------------
CORRESPONDENCE
----------------------
A red-shifted Renilla luciferase for transient reporter-gene
expression pp5 - 6
Andreas Markus Loening, Anca Dragulescu-Andrasi and Sanjiv
Sam Gambhir
doi:10.1038/nmeth0110-05
http://links.ealert.nature.com/ctt?kn=110&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0

Restricted ethnic diversity in human embryonic stem cell
lines pp6 - 7
Louise C Laurent et al.
doi:10.1038/nmeth0110-06
http://links.ealert.nature.com/ctt?kn=66&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0

----------------------
RESEARCH HIGHLIGHTS
----------------------
The mobile microscope p9
Daniel Evanko
doi:10.1038/nmeth0110-09
A miniature head-mounted two-photon microscope small enough
for a rat to carry allows researchers to visualize neuronal signaling
while the animal freely interacts with its environment.
http://links.ealert.nature.com/ctt?kn=68&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0

Bring on the promoters pp10 - 11
Nicole Rusk
doi:10.1038/nmeth0110-10a
High-throughput saturation mutagenesis determines the contribution
of each base in a core promoter to overall promoter strength.
http://links.ealert.nature.com/ctt?kn=71&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0

The importance of being negative pp10 - 11
Allison Doerr
doi:10.1038/nmeth0110-10b
The Negatome is a database of non-interacting protein pairs that can
be used for training protein-protein interaction prediction
algorithms.
http://links.ealert.nature.com/ctt?kn=73&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0

News in brief p11
doi:10.1038/nmeth0110-11
http://links.ealert.nature.com/ctt?kn=75&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0

Caught in action p12
Michael Eisenstein
doi:10.1038/nmeth0110-12
Screening reveals a chemical activator that triggers apoptosis by
locking inactive but dynamic proenzymes into a more active state,
suggesting a promising strategy for targeting proteases.
http://links.ealert.nature.com/ctt?kn=77&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0

A family tree in a tumor p14
Monya Baker
doi:10.1038/nmeth0110-14
A new technique finds genomic subpopulations to indicate cancer
progression.
http://links.ealert.nature.com/ctt?kn=58&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0

----------------------
NEWS FEATURE
----------------------
Special feature: Method of the Year
iPS cells: potent stuff pp17 - 19
Monya Baker
doi:10.1038/nmeth.f.281
Now that the generation of induced pluripotent stem cells is becoming
routine, researchers can get on to the more exciting prospect of
using the cells to make discoveries in disease and basic biology.
Monya Baker reports.
http://links.ealert.nature.com/ctt?kn=61&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0

----------------------
PRIMER
----------------------
Special feature: Method of the Year
Primer: induced pluripotency pp20 - 21
Natalie de Souza
doi:10.1038/nmeth.f.293
A brief overview of methods for reprogramming to induced pluripotency
and of the properties of induced pluripotent stem cells.
http://links.ealert.nature.com/ctt?kn=62&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0

----------------------
COMMENTARIES
----------------------
Special feature: Method of the Year
The mysteries of induced pluripotency: where will they
lead? pp22 - 24
Andras Nagy and Kristina Nagy
doi:10.1038/nmeth.f.292
The discovery that it is possible to render somatic cells pluripotent
by the exogenous expression of a set of transcription factors
provides an experimental model for studying the molecular nature
of cellular identity.
http://links.ealert.nature.com/ctt?kn=63&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0

Special feature: Method of the Year
Induced pluripotent stem cell technology for the study of human
disease pp25 - 27
Gabsang Lee and Lorenz Studer
doi:10.1038/nmeth.f.283
iPS cell technology makes patient- and disease-specific human
cells widely available. While technical challenges still remain,
the use of these tools will greatly expand our understanding
of human disease.
http://links.ealert.nature.com/ctt?kn=83&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0

Special feature: Method of the Year
Stem cell research policy and iPS cells pp28 - 33
Timothy Caulfield et al.
doi:10.1038/nmeth.f.282
The field of induced pluripotent stem cells (iPSCs) will be subject
to a wide range of laws and research ethics policies, many of
which exist as a result of the controversies associated with research
on human embryonic stem cells. Understanding this potentially
complex regulatory environment will help iPSC research move
forward and will inform future policy.
http://links.ealert.nature.com/ctt?kn=81&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0

----------------------
METHODS TO WATCH
----------------------
Special feature: Method of the Year
Targeted proteomics p34
Allison Doerr
doi:10.1038/nmeth.f.284
Technology for sensitively and reproducibly detecting targeted
proteins by mass spectrometry picks up speed.
http://links.ealert.nature.com/ctt?kn=82&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0

Special feature: Method of the Year
Optical imaging of the native brain p34
Daniel Evanko
doi:10.1038/nmeth.f.285
Methodological developments are opening the functioning brain to
cellular-level investigation using light.
http://links.ealert.nature.com/ctt?kn=87&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0

Special feature: Method of the Year
Mapping genomes in 3D p35
Nicole Rusk
doi:10.1038/nmeth.f.286
Refinements in methods to uncover the higher-order structure of
the genome will allow functional insight into genomic architecture
at high resolution.
http://links.ealert.nature.com/ctt?kn=88&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0

Special feature: Method of the Year
Single-cell methods p35
Natalie de Souza
doi:10.1038/nmeth.f.287
The ability to study single cells will permit a better understanding
of cellular heterogeneity.
http://links.ealert.nature.com/ctt?kn=84&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0

Special feature: Method of the Year
Label-free microscopy p36
Daniel Evanko
doi:10.1038/nmeth.f.288
New methods to coax signals from unlabeled biological molecules
may finally fulfill the promise of practical label-free microscopy
with molecular specificity.
http://links.ealert.nature.com/ctt?kn=85&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0

Special feature: Method of the Year
High-throughput phenotyping p36
Natalie de Souza
doi:10.1038/nmeth.f.289
Automated methods to score phenotypes in model organisms continue
to develop and will permit previously inaccessible areas of biology
to be probed.
http://links.ealert.nature.com/ctt?kn=79&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0

Special feature: Method of the Year
Synthetic life p37
Allison Doerr
doi:10.1038/nmeth.f.290
Will new methods and an emerging understanding of the minimal
requirements for cellular life be sufficient to construct a synthetic
organism?
http://links.ealert.nature.com/ctt?kn=80&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0

Special feature: Method of the Year
A direct view of the fifth base p37
Nicole Rusk
doi:10.1038/nmeth.f.291
Will some single molecule sequencing strategies be able to deliver
on the promise of direct methyl cytosine sequencing?
http://links.ealert.nature.com/ctt?kn=78&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0

----------------------
NEWS AND VIEWS
----------------------
Reduce, reuse, reprogram pp39 - 40
Thomas P Zwaka
doi:10.1038/nmeth0110-39
Mouse lines with inducible reprogramming factors expressed from
a single genomic locus will allow reprogramming studies in multiple
cell types and defined genetic backgrounds.
http://links.ealert.nature.com/ctt?kn=205&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0

Sorting cardiomyocytes: a simple solution after all? pp40 - 42
Christine Mummery
doi:10.1038/nmeth0110-40
Cardiomyocytes can be sorted to high purity upon staining them with
a dye that labels mitochondria. This permits the preparation of pure
populations of cardiomyocytes differentiated from stem cells.
http://links.ealert.nature.com/ctt?kn=181&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0

----------------------
BRIEF COMMUNICATIONS
----------------------
High-throughput generation of selected reaction-monitoring assays
for proteins and proteomes pp43 - 46
Paola Picotti et al.
doi:10.1038/nmeth.1408
Selected reaction monitoring (SRM) is a powerful mass spectrometry
technology to reliably detect selected protein targets, even those at
very low abundance, but requires tedious assay development for
each protein of interest. High-throughput SRM assay development
is now possible by using crude synthetic peptide libraries without
purification to represent each protein target.
Abstract: http://links.ealert.nature.com/ctt?kn=180&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=185&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0

Chromatin profiling by directly sequencing small quantities of
immunoprecipitated DNA pp47 - 49
Alon Goren et al.
doi:10.1038/nmeth.1404
Single-molecule sequencing of poly(A)-tailed chromatin
immunoprecipitated DNA proves equal in sensitivity and accuracy
to amplification-based sequencing technologies and allows analysis
of samples sizes as small as 50 pg.
Abstract: http://links.ealert.nature.com/ctt?kn=184&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=187&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0

Floxin, a resource for genetically engineering mouse
ESCs pp50 - 52
Veena Singla et al.
doi:10.1038/nmeth.1406
An efficient system for the reversion and modification of mouse
gene trap alleles is presented. It is applicable to available
collections of gene trap embryonic stem cell lines.
Abstract: http://links.ealert.nature.com/ctt?kn=186&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=189&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0

A reprogrammable mouse strain from gene-targeted embryonic stem
cells pp53 - 55
Matthias Stadtfeld, Nimet Maherali, Marti Borkent and Konrad
Hochedlinger
doi:10.1038/nmeth.1409
A mouse strain in which cellular reprogramming factors are expressed
from a defined genomic locus is presented. It will enable studies of
reprogramming in multiple cell types as well as facilitate
comparisons between induced pluripotent stem cells and embryonic
stem cells. Also in this issue, a paper by Carey et al. presents
related tools.
Abstract: http://links.ealert.nature.com/ctt?kn=188&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=176&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0

Single-gene transgenic mouse strains for reprogramming adult somatic
cells pp56 - 59
Bryce W Carey et al.
doi:10.1038/nmeth.1410
Mouse strains in which three or four cellular reprogramming factors
are expressed from a defined genomic locus are presented. They will
enable studies of reprogramming in multiple cell types as well as
facilitate comparisons between induced pluripotent stem cells and
embryonic stem cells. Also in this issue, a paper from Stadtfeld
et al. presents related tools.
Abstract: http://links.ealert.nature.com/ctt?kn=57&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=59&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0

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----------------------
ARTICLES
----------------------
Nongenetic method for purifying stem cell-derived
cardiomyocytes pp61 - 66
Fumiyuki Hattori et al.
doi:10.1038/nmeth.1403
Staining with a mitochondrial dye permits high-purity isolation of
cardiomyocytes from embryonic and induced pluripotent stem cells
of several species, without genetic modification.
Abstract: http://links.ealert.nature.com/ctt?kn=74&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=76&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0

Engineering a polarity-sensitive biosensor for time-lapse imaging of
apoptotic processes and degeneration pp67 - 73
Yujin E Kim, Jeannie Chen, Jonah R Chan and Ralf Langen
doi:10.1038/nmeth.1405
A polarity-sensitive annexin-based biosensor called pSIVA becomes
strongly fluorescent only after reversibly binding to the plasma
membrane. pSIVA allows live-cell imaging of the apoptotic process
in degenerating neurons in vitro and in vivo.
Abstract: http://links.ealert.nature.com/ctt?kn=69&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=72&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0

Integrated analysis of receptor activation and downstream signaling
with EXTassays pp74 - 80
Anna Botvinnik, Sven P Wichert, Tobias M Fischer and Moritz J Rossner
doi:10.1038/nmeth.1407
By combining a protein complementation assay with a transcriptional
reporter assay based on short expressed oligonucleotide tags (EXTs),
the authors monitor tyrosine kinase receptor dimerization in
conjunction with effector recruitment and downstream signaling.
Abstract: http://links.ealert.nature.com/ctt?kn=65&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0
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----------------------
TECHNOLOGY FEATURE
----------------------
IPSCs: One cell to rule them all? pp81 - 85
Michael Eisenstein
doi:10.1038/nmeth0110-81
Rapid progress with induced pluripotent stem cells is bringing
scientists closer to understanding their strengths and weaknesses
as embryonic stem cell stand-ins.
http://links.ealert.nature.com/ctt?kn=64&m=34519504&r=MTc2NjExMzUwMAS2&b=2&j=NjMyNzg0OTMS1&mt=1&rt=0

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Laboratory Investigation - Table of Contents alert Volume 90 Issue 1

LABORATORY INVESTIGATION

January 2010 Volume 90 Number 1, pp 2 - 139

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EDITORIALS
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What editors want in an abstract
Catherine M Ketcham, Robert W Hardy, Brian Rubin and Gene P Siegal
http://links.ealert.nature.com/ctt?kn=55&m=34519494&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjMyNzgzMDgS1&mt=1&rt=0

Attacking the source: anti-PDX-1 responses in type 1 diabetes
Yaima Luzardo and Clayton Elwood Mathews
Abstract: http://links.ealert.nature.com/ctt?kn=56&m=34519494&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjMyNzgzMDgS1&mt=1&rt=0
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----------------------
RESEARCH ARTICLES
----------------------
FTY720, a sphingosine 1-phosphate receptor modulator, inhibits
CD1d-restricted NKT cells by suppressing cytokine production but not migration
Su Jin Hwang, Ji Hyung Kim, Hye Young Kim, Sanghee Kim and Doo Hyun Chung
Abstract: http://links.ealert.nature.com/ctt?kn=58&m=34519494&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjMyNzgzMDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=50&m=34519494&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjMyNzgzMDgS1&mt=1&rt=0

Rho/ROCK and MEK/ERK activation by transforming growth factor-[alpha]
induces articular cartilage degradation
C Thomas G Appleton, Shirine E Usmani, John S Mort and Frank Beier
Abstract: http://links.ealert.nature.com/ctt?kn=53&m=34519494&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjMyNzgzMDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=35&m=34519494&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjMyNzgzMDgS1&mt=1&rt=0

Pancreatic duodenal homeobox 1 protein is a novel [beta]-cell-specific
autoantigen for type I diabetes
Shi-Wu Li, Vijay Koya, Yi Li, William Donelan, Peng Lin, Westley H Reeves
and Li-Jun Yang
Abstract: http://links.ealert.nature.com/ctt?kn=39&m=34519494&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjMyNzgzMDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=40&m=34519494&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjMyNzgzMDgS1&mt=1&rt=0

Erythropoietin-induced upregulation of endothelial nitric oxide synthase
but not vascular endothelial growth factor prevents musculocutaneous
tissue from ischemic damage
Farid Rezaeian, Reto Wettstein, Jean-Francois Egger, Freya Sandmann,
Martin Rucker, Mickael Tobalem, Brigitte Vollmar, Michael D Menger
and Yves Harder
Abstract: http://links.ealert.nature.com/ctt?kn=37&m=34519494&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjMyNzgzMDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=38&m=34519494&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjMyNzgzMDgS1&mt=1&rt=0

Acyclic retinoid inhibits angiogenesis by suppressing the MAPK pathway
Yusuke Komi, Yukihisa Sogabe, Naoto Ishibashi, Yasufumi Sato,
Hisataka Moriwaki, Kentaro Shimokado and Soichi Kojima
Abstract: http://links.ealert.nature.com/ctt?kn=43&m=34519494&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjMyNzgzMDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=44&m=34519494&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjMyNzgzMDgS1&mt=1&rt=0

Isolation of targeting nanobodies against co-opted tumor vasculature
Ilse Roodink, Maarten Franssen, Malou Zuidscherwoude, Kiek Verrijp,
Tom van der Donk, Jos Raats and William PJ Leenders
Abstract: http://links.ealert.nature.com/ctt?kn=41&m=34519494&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjMyNzgzMDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=42&m=34519494&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjMyNzgzMDgS1&mt=1&rt=0

Effects of sulfur dioxide on hypoxic pulmonary vascular structural remodeling
Yan Sun, Yue Tian, Mainali Prabha, Die Liu, Stella Chen, Rongyuan Zhang,
Xueqin Liu, Chaoshu Tang, Xiuying Tang, Hongfang Jin and Junbao Du
Abstract: http://links.ealert.nature.com/ctt?kn=45&m=34519494&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjMyNzgzMDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=11&m=34519494&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjMyNzgzMDgS1&mt=1&rt=0

Nephron-deficient Fvb mice develop rapidly progressive renal failure
and heavy albuminuria involving excess glomerular GLUT1 and VEGF
Youli Wang, Kathleen O Heilig, Andrew W Minto, Shenglin Chen,
Minghui Xiang, David A Dean, Richard C Geiger, Anthony Chang,
Dimitrina D Pravtcheva, Martin Schlimme, Dilip K Deb, Ying Wang
and Charles W Heilig
Abstract: http://links.ealert.nature.com/ctt?kn=12&m=34519494&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjMyNzgzMDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=13&m=34519494&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjMyNzgzMDgS1&mt=1&rt=0

Intrarenal expression of microRNAs in patients with IgA nephropathy
Gang Wang, Bonnie C-H Kwan, Fernand M-M Lai, Paul C-L Choi,
Kai-Ming Chow, Philip K-T Li and Cheuk-Chun Szeto
Abstract: http://links.ealert.nature.com/ctt?kn=14&m=34519494&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjMyNzgzMDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=16&m=34519494&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjMyNzgzMDgS1&mt=1&rt=0

Curcumin limits the fibrogenic evolution of experimental steatohepatitis
Francesco Vizzutti, Angela Provenzano, Sara Galastri, Stefano Milani,
Wanda Delogu, Erica Novo, Alessandra Caligiuri, Elena Zamara,
Umberto Arena, Giacomo Laffi, Maurizio Parola, Massimo Pinzani and Fabio Marra
Abstract: http://links.ealert.nature.com/ctt?kn=17&m=34519494&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjMyNzgzMDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=19&m=34519494&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjMyNzgzMDgS1&mt=1&rt=0

Inhibition of nitric oxide synthesis during induced cholestasis ameliorates
hepatocellular injury by facilitating S-nitrosothiol homeostasis
Laura M Lopez-Sanchez, Fernando J Corrales, Montserrat Barcos, Isabel Espejo,
Juan R Munoz-Castaneda and Antonio Rodriguez-Ariza
Abstract: http://links.ealert.nature.com/ctt?kn=20&m=34519494&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjMyNzgzMDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=21&m=34519494&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjMyNzgzMDgS1&mt=1&rt=0

Plasma concentrations of inflammatory cytokines rise rapidly during ECMO-related
SIRS due to the release of preformed stores in the intestine
R Britt McILwain, Joseph G Timpa, Ashish R Kurundkar, David W Holt, David R Kelly,
Yolanda E Hartman, Mary Lauren Neel, Rajendra K Karnatak, Robert L Schelonka,
G M Anantharamaiah, Cheryl R Killingsworth and Akhil Maheshwari
Abstract: http://links.ealert.nature.com/ctt?kn=22&m=34519494&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjMyNzgzMDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=68&m=34519494&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjMyNzgzMDgS1&mt=1&rt=0

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Development and application of desorption electrospray mass spectrometry (DESI-MS) for the analysis of biomolecules on archaeological artefacts.

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New Ruthenium Complexes for Carbon-Carbon Triple Bond Cleavage – Towards Atom Efficient Wittig-type Chemistry

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Investigating Air Pollution in London

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Macromolecular residues in archaeological grave soils: reservoirs of past burial practices

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Development of high resolution mass spectrometry to study the formation of organic aerosols in the atmosphere

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Friday, December 25, 2009

ScienceDirect Alert: Cell, Vol. 139, Iss. 7, 2009


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Volume 139, Issue 7,  Pages 1199-1376 (24 December 2009)


  Leading Edge
 1. In This Issue
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 2. H1N1: A Mexican Perspective
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Laura Vargas-Parada
 
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Christophe Lavelle, Pierre Recouvreux, Hua Wong, Aurélien Bancaud, Jean-Louis Viovy, Ariel Prunell, Jean-Marc Victor
 
 7. Response: Right-Handed Half-Nucleosomes at Centromeres
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Takehito Furuyama, Steven Henikoff
 
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 9. Integrins and Mutant p53 on the Road to Metastasis
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Galina Selivanova, Johanna Ivaska
 
 10. FANCD2 Hurdles the DNA Interstrand Crosslink
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George-Lucian Moldovan, Alan D. D'Andrea
 
 11. Itching for Insight
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Michael Bandell, Ardem Patapoutian
 
 12. Tumor Self-Seeding: Bidirectional Flow of Tumor Cells
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Cheuk T. Leung, Joan S. Brugge
 
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 13. Metabolism, Cell Surface Organization, and Disease
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James W. Dennis, Ivan R. Nabi, Michael Demetriou
 
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 14. The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus
Pages 1243-1254
Abraham L. Brass, I-Chueh Huang, Yair Benita, Sinu P. John, Manoj N. Krishnan, Eric M. Feeley, Bethany J. Ryan, Jessica L. Weyer, Louise van der Weyden, Erol Fikrig, David J. Adams, Ramnik J. Xavier, Michael Farzan, Stephen J. Elledge
 
 15. A Physical and Regulatory Map of Host-Influenza Interactions Reveals Pathways in H1N1 Infection
Pages 1255-1267
Sagi D. Shapira, Irit Gat-Viks, Bennett O.V. Shum, Amelie Dricot, Marciela M. de Grace, Liguo Wu, Piyush B. Gupta, Tong Hao, Serena J. Silver, David E. Root, David E. Hill, Aviv Regev, Nir Hacohen
 
 16. A Wolbachia Symbiont in Aedes aegypti Limits Infection with Dengue, Chikungunya, and Plasmodium
Pages 1268-1278
Luciano A. Moreira, Iñaki Iturbe-Ormaetxe, Jason A. Jeffery, Guangjin Lu, Alyssa T. Pyke, Lauren M. Hedges, Bruno C. Rocha, Sonja Hall-Mendelin, Andrew Day, Markus Riegler, Leon E. Hugo, Karyn N. Johnson, Brian H. Kay, Elizabeth A. McGraw, Andrew F. van den Hurk, Peter A. Ryan, Scott L. O'Neill
 
 17. Structural Insight into Translesion Synthesis by DNA Pol II
Pages 1279-1289
Feng Wang, Wei Yang
 
 18. Jarid2/Jumonji Coordinates Control of PRC2 Enzymatic Activity and Target Gene Occupancy in Pluripotent Cells
Pages 1290-1302
Jamy C. Peng, Anton Valouev, Tomek Swigut, Junmei Zhang, Yingming Zhao, Arend Sidow, Joanna Wysocka
 
 19. Jumonji Modulates Polycomb Activity and Self-Renewal versus Differentiation of Stem Cells
Pages 1303-1314
Xiaohua Shen, Woojin Kim, Yuko Fujiwara, Matthew D. Simon, Yingchun Liu, Matthew R. Mysliwiec, Guo-Cheng Yuan, Youngsook Lee, Stuart H. Orkin
 
 20. Tumor Self-Seeding by Circulating Cancer Cells
Pages 1315-1326
Mi-Young Kim, Thordur Oskarsson, Swarnali Acharyya, Don X. Nguyen, Xiang H.-F. Zhang, Larry Norton, Joan Massagué
 
 21. Mutant p53 Drives Invasion by Promoting Integrin Recycling
Pages 1327-1341
Patricia A.J. Muller, Patrick T. Caswell, Brendan Doyle, Marcin P. Iwanicki, Ee H. Tan, Saadia Karim, Natalia Lukashchuk, David A. Gillespie, Robert L. Ludwig, Pauline Gosselin, Anne Cromer, Joan S. Brugge, Owen J. Sansom, Jim C. Norman, Karen H. Vousden
 
 22. Structure of a Bacterial Dynamin-like Protein Lipid Tube Provides a Mechanism For Assembly and Membrane Curving
Pages 1342-1352
Harry H. Low, Carsten Sachse, Linda A. Amos, Jan Löwe
 
 23. Sensory Neuron-Specific GPCR Mrgprs Are Itch Receptors Mediating Chloroquine-Induced Pruritus
Pages 1353-1365
Qin Liu, Zongxiang Tang, Lenka Surdenikova, Seungil Kim, Kush N. Patel, Andrew Kim, Fei Ru, Yun Guan, Hao-Jui Weng, Yixun Geng, Bradley J. Undem, Marian Kollarik, Zhou-Feng Chen, David J. Anderson, Xinzhong Dong
 
  Theory
 24. Growth Rate-Dependent Global Effects on Gene Expression in Bacteria
Pages 1366-1375
Stefan Klumpp, Zhongge Zhang, Terence Hwa
 


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Electrostatic focusing of unlabelled DNA into nanoscale pores using
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