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Adieu to nuclear recycling
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Nuclear energy: The hybrid returns
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Science education: Reading, writing and nanofabrication
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Commentary
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Too small to overlook
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Nanooptics: Photons pushed together
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Applied physics: A leak of information
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Materials science: Nanotubes sorted using DNA
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Evaluation of nanoparticle immunotoxicity
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A single-molecule optical transistor
J. Hwang et al.
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Giant tunnel electroresistance for non-destructive readout of
ferroelectric states
V. Garcia et al.
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DNA sequence motifs for structure-specific recognition and separation
of carbon nanotubes
Xiaomin Tu, Suresh Manohar, Anand Jagota & Ming Zheng
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An omnidirectional retroreflector based on the transmutation of
dielectric singularities
Yun Gui Ma, C. K. Ong, Tomas Tyc, Ulf Leonhardt
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Periodic rotation of magnetization in a non-centrosymmetric soft magnet
induced by an electric field
M. Saito, K. Ishikawa, S. Konno, K. Taniguchi, T. Arima
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Engineering light absorption in semiconductor nanowire devices
Linyou Cao et al.
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Three-dimensional nanopillar-array photovoltaics on low-cost and
flexible substrates
Zhiyong Fan et al.
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Organic electronics for precise delivery of neurotransmitters to
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Daniel T. Simon et al.
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Plasmonic analogue of electromagnetically induced transparency at the
Drude damping limit
Na Liu et al.
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Determination of protein structural flexibility by microsecond force
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Mingdong Dong, Sudhir Husale & Ozgur Sahin
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Partial sequencing of a single DNA molecule with a scanning tunnelling
microscope
Hiroyuki Tanaka & Tomoji Kawai
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Measurement of the quantum capacitance of graphene
Jilin Xia, Fang Chen, Jinghong Li & Nongjian Tao
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Measurement of single-molecule frictional dissipation in a prototypical
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H. Hedgeland et al.
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Voltage-programmable liquid optical interface
C. V. Brown, G. G. Wells, M. I. Newton, G. McHale
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Pressure-assisted tip-enhanced Raman imaging at a resolution of a few
nanometres
Taka-aki Yano et al.
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Articles
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Selective positioning of organic dyes in a mesoporous inorganic oxide
film
Kyungtae Lee, Se Woong Park, Min Jae Ko, Kyungkon Kim & Nam-Gyu Park
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Printed artificial cilia from liquid-crystal network actuators modularly
driven by light
Casper L. van Oosten, Cees W. M. Bastiaansen & Dirk J. Broer
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Self-assembled cationic peptide nanoparticles as an efficient
antimicrobial agent
Lihong Liu et al.
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----------------------
HAVE YOU SEEN ...?
----------------------
Nonconformity in ubiquitin compliance pp1825 - 1827
Inbal Ziv, Oded Kleifeld and Michael Glickman
doi:10.1038/emboj.2009.132
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A histone code for the DNA damage response in mammalian cells[quest] pp1828 - 1830
Armelle Corpet and Genevieve Almouzni
doi:10.1038/emboj.2009.180
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----------------------
ARTICLES
----------------------
A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism pp1831 - 1842
Yuxin Mao, Daniel M Balkin, Roberto Zoncu, Kai S Erdmann, Livia Tomasini,
Fenghua Hu, Moonsoo M Jin, Michael E Hodsdon and Pietro De Camilli
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Abstract: http://links.ealert.nature.com/ctt?kn=67&m=33545931&r=MTc2ODY3NTU2NQS2&b=2&j=NTI4MDUyMTkS1&mt=1&rt=0
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JNK signalling modulates intestinal homeostasis and tumourigenesis in mice pp1843 - 1854
Rocio Sancho, Abdolrahman S Nateri, Amaya Garcia de Vinuesa, Cristina Aguilera,
Emma Nye, Bradley Spencer-Dene and Axel Behrens
doi:10.1038/emboj.2009.153
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The fungal RNA-binding protein Rrm4 mediates long-distance transport of ubi1 and rho3 mRNAs pp1855 - 1866
Julian König, Sebastian Baumann, Janine Koepke, Thomas Pohlmann,
Kathi Zarnack and Michael Feldbrügge
doi:10.1038/emboj.2009.145
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S5a promotes protein degradation by blocking synthesis of nondegradable forked ubiquitin chains pp1867 - 1877
Hyoung Tae Kim, Kwang Pyo Kim, Tomoaki Uchiki, Steven P Gygi and Alfred L Goldberg
doi:10.1038/emboj.2009.115
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Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells pp1878 - 1889
Jorrit V Tjeertes, Kyle M Miller and Stephen P Jackson
doi:10.1038/emboj.2009.119
Abstract: http://links.ealert.nature.com/ctt?kn=89&m=33545931&r=MTc2ODY3NTU2NQS2&b=2&j=NTI4MDUyMTkS1&mt=1&rt=0
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The epidermal differentiation-associated Grainyhead gene Get1/Grhl3 also regulates urothelial differentiation pp1890 - 1903
Zhengquan Yu, Jaana Mannik, Amelia Soto, Kevin K Lin and Bogi Andersen
doi:10.1038/emboj.2009.142
Abstract: http://links.ealert.nature.com/ctt?kn=9&m=33545931&r=MTc2ODY3NTU2NQS2&b=2&j=NTI4MDUyMTkS1&mt=1&rt=0
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Rescue of key features of the p63-null epithelial phenotype by inactivation of Ink4a and Arf pp1904 - 1915
Xiaohua Su, Min Soon Cho, Young-Jin Gi, Bernard A Ayanga, Charles J Sherr and Elsa R Flores
doi:10.1038/emboj.2009.151
Abstract: http://links.ealert.nature.com/ctt?kn=29&m=33545931&r=MTc2ODY3NTU2NQS2&b=2&j=NTI4MDUyMTkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=11&m=33545931&r=MTc2ODY3NTU2NQS2&b=2&j=NTI4MDUyMTkS1&mt=1&rt=0

The Apaf-1[bull]procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer pp1916 - 1925
Srinivas Malladi, Madhavi Challa-Malladi, Howard O Fearnhead and Shawn B Bratton
doi:10.1038/emboj.2009.152
Abstract: http://links.ealert.nature.com/ctt?kn=1&m=33545931&r=MTc2ODY3NTU2NQS2&b=2&j=NTI4MDUyMTkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=36&m=33545931&r=MTc2ODY3NTU2NQS2&b=2&j=NTI4MDUyMTkS1&mt=1&rt=0

MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway pp1926 - 1939
Francesca Mancini, Giusy Di Conza, Marsha Pellegrino, Cinzia Rinaldo, Andrea Prodosmo,
Simona Giglio, Igea D'Agnano, Fulvio Florenzano, Lara Felicioni, Fiamma Buttitta,
Antonio Marchetti, Ada Sacchi, Alfredo Pontecorvi, Silvia Soddu and Fabiola Moretti
doi:10.1038/emboj.2009.154
Abstract: http://links.ealert.nature.com/ctt?kn=42&m=33545931&r=MTc2ODY3NTU2NQS2&b=2&j=NTI4MDUyMTkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=61&m=33545931&r=MTc2ODY3NTU2NQS2&b=2&j=NTI4MDUyMTkS1&mt=1&rt=0

Noc protein binds to specific DNA sequences to coordinate cell division with chromosome segregation pp1940 - 1952
Ling Juan Wu, Shu Ishikawa, Yoshikazu Kawai, Taku Oshima, Naotake Ogasawara and Jeff Errington
doi:10.1038/emboj.2009.144
Abstract: http://links.ealert.nature.com/ctt?kn=53&m=33545931&r=MTc2ODY3NTU2NQS2&b=2&j=NTI4MDUyMTkS1&mt=1&rt=0
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How the MccB bacterial ancestor of ubiquitin E1 initiates biosynthesis of the microcin C7 antibiotic pp1953 - 1964
Catherine A Regni, Rebecca F Roush, Darcie J Miller, Amanda Nourse,
Christopher T Walsh and Brenda A Schulman
doi:10.1038/emboj.2009.146
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Molecular recognition of histone lysine methylation by the Polycomb group repressor dSfmbt pp1965 - 1977
Clemens Grimm, Raquel Matos, Nga Ly-Hartig, Ulrich Steuerwald, Doris Lindner,
Vladimir Rybin, Jürg Müller and Christoph W Müller
doi:10.1038/emboj.2009.147
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Article: http://links.ealert.nature.com/ctt?kn=70&m=33545931&r=MTc2ODY3NTU2NQS2&b=2&j=NTI4MDUyMTkS1&mt=1&rt=0

3D architecture of DNA Pol [alpha] reveals the functional core of multi-subunit replicative polymerases pp1978 - 1987
Sebastian Klinge, Rafael Núñez-Ramírez, Oscar Llorca and Luca Pellegrini
doi:10.1038/emboj.2009.150
Abstract: http://links.ealert.nature.com/ctt?kn=64&m=33545931&r=MTc2ODY3NTU2NQS2&b=2&j=NTI4MDUyMTkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=68&m=33545931&r=MTc2ODY3NTU2NQS2&b=2&j=NTI4MDUyMTkS1&mt=1&rt=0

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Protein modifications: beyond the usual suspects

http://links.ealert.nature.com/ctt?kn=25&m=33545931&r=MTc2ODY3NTU2NQS2&b=2&j=NTI4MDUyMTkS1&mt=1&rt=0

EMBO reports web focus

Get a sense of the molecular diversity that exists within cells!
This series of comprehensive and engaging reviews highlights the complexity
of post-translational protein modifications. Leading experts analyze atypical
ubiquitin-chain formation, ATGylation, polyglutamylation, neddylation, and Urmylation,
and update our knowledge on poly(ADP-ribosyl)ation and O-GlcNAcylation.
A complex but important topic to understand!

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Gene Therapy - Table of Contents alert Volume 16 Issue 7

GENE THERAPY

July 2009 Volume 16 Number 7, pp 827 - 941
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Advance Online Publication
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Articles for this journal are published online ahead of print
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----------------------
NEWS AND COMMENTARY
----------------------
Asymmetry in siRNA design
D Grimm
http://links.ealert.nature.com/ctt?kn=34&m=33545926&r=MTc2MTA1MzIyNwS2&b=2&j=NTI4MDUxNTgS1&mt=1&rt=0

----------------------
ORIGINAL ARTICLES
----------------------
Visualization of in vivo electroporation-mediated transgene expression
in experimental tumors by optical and magnetic resonance imaging
W Aung, S Hasegawa, M Koshikawa-Yano, T Obata, H Ikehira, T Furukawa,
I Aoki and T Saga
Abstract: http://links.ealert.nature.com/ctt?kn=83&m=33545926&r=MTc2MTA1MzIyNwS2&b=2&j=NTI4MDUxNTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=78&m=33545926&r=MTc2MTA1MzIyNwS2&b=2&j=NTI4MDUxNTgS1&mt=1&rt=0

Excision repair cross-complementing 1 expression protects against
ischemic injury following middle cerebral artery occlusion in the rat
brain
K-Y He, S-Z Yang, D-H Shen, L-M Zhang, S-D Lu and F-Y Sun
Abstract: http://links.ealert.nature.com/ctt?kn=87&m=33545926&r=MTc2MTA1MzIyNwS2&b=2&j=NTI4MDUxNTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=96&m=33545926&r=MTc2MTA1MzIyNwS2&b=2&j=NTI4MDUxNTgS1&mt=1&rt=0

VSV virotherapy improves chemotherapy by triggering apoptosis due to
proteasomal degradation of Mcl-1
P Schache, E Gurlevik, N Struver, N Woller, N Malek, L Zender, M Manns,
T Wirth, F Kuhnel and S Kubicka
Abstract: http://links.ealert.nature.com/ctt?kn=94&m=33545926&r=MTc2MTA1MzIyNwS2&b=2&j=NTI4MDUxNTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=86&m=33545926&r=MTc2MTA1MzIyNwS2&b=2&j=NTI4MDUxNTgS1&mt=1&rt=0

Effects of ciliary muscle plasmid electrotransfer of TNF-[alpha] soluble
receptor variants in experimental uveitis
E Touchard, C Bloquel, P Bigey, L Kowalczuc, L Jonet, B Thillaye-
Goldenberg, M-C Naud, D Scherman, Y de Kozak, D BenEzra and F Behar-Cohen
Abstract: http://links.ealert.nature.com/ctt?kn=98&m=33545926&r=MTc2MTA1MzIyNwS2&b=2&j=NTI4MDUxNTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=33&m=33545926&r=MTc2MTA1MzIyNwS2&b=2&j=NTI4MDUxNTgS1&mt=1&rt=0

Independent and high-level dual-gene expression in adult stem-progenitor
cells from a single lentiviral vector
J Tian and S T Andreadis
Abstract: http://links.ealert.nature.com/ctt?kn=29&m=33545926&r=MTc2MTA1MzIyNwS2&b=2&j=NTI4MDUxNTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=58&m=33545926&r=MTc2MTA1MzIyNwS2&b=2&j=NTI4MDUxNTgS1&mt=1&rt=0

QuickMap: a public tool for large-scale gene therapy vector insertion site
mapping and analysis
J-U Appelt, F A Giordano, M Ecker, I Roeder, N Grund, A Hotz-Wagenblatt,
G Opelz, W J Zeller, H Allgayer, S Fruehauf and S Laufs
Abstract: http://links.ealert.nature.com/ctt?kn=60&m=33545926&r=MTc2MTA1MzIyNwS2&b=2&j=NTI4MDUxNTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=57&m=33545926&r=MTc2MTA1MzIyNwS2&b=2&j=NTI4MDUxNTgS1&mt=1&rt=0

(Strept)avidin-displaying lentiviruses as versatile tools for targeting
and dual imaging of gene delivery
M U Kaikkonen, H P Lesch, J Pikkarainen, J K Raty, T Vuorio, T Huhtala,
M Taavitsainen, T Laitinen, P Tuunanen, O Grohn, A Narvanen, K J Airenne
and S Yla-Herttuala
Abstract: http://links.ealert.nature.com/ctt?kn=90&m=33545926&r=MTc2MTA1MzIyNwS2&b=2&j=NTI4MDUxNTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=106&m=33545926&r=MTc2MTA1MzIyNwS2&b=2&j=NTI4MDUxNTgS1&mt=1&rt=0

Herpes simplex virus delivery to orthotopic rectal carcinoma results in
an efficient and selective antitumor effect
D Kolodkin-Gal, Y Edden, Z Hartshtark, L Ilan, A Khalaileh, A J Pikarsky,
E Pikarsky, S D Rabkin, A Panet and G Zamir
Abstract: http://links.ealert.nature.com/ctt?kn=3&m=33545926&r=MTc2MTA1MzIyNwS2&b=2&j=NTI4MDUxNTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=19&m=33545926&r=MTc2MTA1MzIyNwS2&b=2&j=NTI4MDUxNTgS1&mt=1&rt=0

Intravitreal delivery of AAV8 retinoschisin results in cell type-specific
gene expression and retinal rescue in the Rs1-KO mouse
T K Park, Z Wu, S Kjellstrom, Y Zeng, R A Bush, P A Sieving and P Colosi
Abstract: http://links.ealert.nature.com/ctt?kn=84&m=33545926&r=MTc2MTA1MzIyNwS2&b=2&j=NTI4MDUxNTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=81&m=33545926&r=MTc2MTA1MzIyNwS2&b=2&j=NTI4MDUxNTgS1&mt=1&rt=0

----------------------
SHORT COMMUNICATIONS
----------------------
Long-term AAV vector gene and protein expression in mouse brain from a
small pan-cellular promoter is similar to neural cell promoters
T Husain, M A Passini, M K Parente, N W Fraser and J H Wolfe
Abstract: http://links.ealert.nature.com/ctt?kn=18&m=33545926&r=MTc2MTA1MzIyNwS2&b=2&j=NTI4MDUxNTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=77&m=33545926&r=MTc2MTA1MzIyNwS2&b=2&j=NTI4MDUxNTgS1&mt=1&rt=0

Efficient lentiviral gene transfer into corneal stroma cells using a
femtosecond laser
A-P Bemelmans, Y Arsenijevic and F Majo
Abstract: http://links.ealert.nature.com/ctt?kn=69&m=33545926&r=MTc2MTA1MzIyNwS2&b=2&j=NTI4MDUxNTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=8&m=33545926&r=MTc2MTA1MzIyNwS2&b=2&j=NTI4MDUxNTgS1&mt=1&rt=0

----------------------
LETTER TO THE EDITOR
----------------------
'Recirculating cardiac delivery' method of gene delivery should be
called 'non-recirculating' method
C R Bridges
http://links.ealert.nature.com/ctt?kn=23&m=33545926&r=MTc2MTA1MzIyNwS2&b=2&j=NTI4MDUxNTgS1&mt=1&rt=0

----------------------
CORRIGENDUM
----------------------
Intravitreal delivery of AAV8 retinoschisin results in cell type-
specific gene expression and retinal rescue in the Rs1-KO mouse
T K Park, Z Wu, S Kjellstrom, Y Zeng, R A Bush, P A Sieving and P Colosi
http://links.ealert.nature.com/ctt?kn=17&m=33545926&r=MTc2MTA1MzIyNwS2&b=2&j=NTI4MDUxNTgS1&mt=1&rt=0

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Nature Reviews Goes Clinical!

In April 2009, Nature Clinical Practice Rheumatology was completely
redesigned and became Nature ReviewsRheumatology, bringing all the
qualities of thetop-ranked* life science review series to the
clinical sciences.

For more information visit:
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*2008 Journal Citation Report (Thomson Reuters, 2009)
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