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World Stem Cell Summit 2010

Monday, December 31, 2007

[StemCells] question

I am trying to take my autistic son for stem cell therapy, I am
confused between china and costarica, could anybody help please

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StemCells subscribers may also be interested in these sites:

Children's Neurobiological Solutions
http://www.CNSfoundation.org/

Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123

The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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[StemCells] Fat SCS for Corneal Stroma Regeneration

Adipose-Derived Stem Cells are a Source for Cell Therapy of The
Corneal Stroma
F. Arnalich-Montiel 1, S. Pastor 2, A. Blazquez-Martinez 1, J.
Fernandez-Delgado 3, M. Nistal 4, J. L. Alio 2, M. P. De Miguel 1*
1 Cell Engineering Laboratory, La Paz University Hospital, Madrid,
Spain
2 Vissum Ophtalmological Institute of Alicante, and Miguel Hernandez
University, Alicante, Spain
3 Plastic and Reconstructive Surgery Department, La Paz University
Hospital, Madrid, Spain
4 Pathology Department, La Paz University Hospital, Madrid, Spain

* To whom correspondence should be addressed. E-mail:
maria.demiguel@uam.es.

Abstract

Most corneal diseases affect corneal stroma, and include immune or
infectious diseases, ecstatic disorders, traumatic scars and corneal
dystrophies. Cell-based therapy is a promising therapeutic approach
to overcome the current disadvantages of corneal transplantation. We
aimed to search for a cell source to repopulate and regenerate
corneal stroma.

We investigated the ability of human processed lipoaspirate-derived
(PLA) cells to regenerate corneal stroma in experimental animals. In
a first set of experiments, we tested the biosafety and
immunogenicity of human PLA stem cells transplanted into the corneal
stroma of rabbits. No immune response was elicited even though we
used immunecompetent animals. PLA cells survived up to 10 weeks post-
transplant, maintained their shape and remained intermingled between
the stroma without disrupting its histological pattern.
Interestingly, transparency was preserved even 10 weeks after the
transplant, when PLA cells formed a discontinuous layer in the
stroma. In a second set of experiments, regeneration of the corneal
stroma by PLA cells was assessed, creating a niche by partial
ablation of the stroma. After 12 weeks, human cells were disposed
following a multilayered pattern, and differentiated into functional
keratocytes, as assessed by the expression of aldehyde-3-
dehydrogenase and cornea-specific proteoglycan keratocan.

Based on our results, we believe that adipose-derived adult stem
cells can be a cell source for stromal regeneration and repopulation
in diseased corneas. The low health impact of the surgical procedure
performed to obtain the PLA cells provides this cell source with an
additional beneficial feature for their possible future autologous
use in human patients.

Key Words. Cornea, cell therapy, adipose-derived stem cells,
Mesenchymal stem cells, transplant, keratocan, stem cells
transplantation, keratocyte

http://stemcells.alphamedpress.org/cgi/content/abstract/2007-0653v1

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¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯
StemCells subscribers may also be interested in these sites:

Children's Neurobiological Solutions
http://www.CNSfoundation.org/

Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123

The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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[StemCells] Institute of Regenerative Medicine Closed in Scandal

BEWARE of Off-Shore Clinics)

Stem cell clinic closed
Published on: 11/26/07.
by Sanka Price

BARBADOS IS NO LONGER in the controversial stem cell treatment
business.

The Institute of Regenerative Medicine (IRM) which was named in a
critical British Broadcasting Corporation (BBC) television report
last December as one of the clinics using stem cells from aborted
foetuses and dismembered babies, closed in May. Its closure brings to
an end four contentious years of operation here.

The clinic, which was located at Hempstead, Two Mile Hill, St
Michael, was forced to close its doors because business slowed after
the BBC investigation was aired, said Professor Yuliy Baltaytis, the
IRM's scientific director.

"The brutal attack of the BBC and the British papers ruined our
business," said Baltaytis, who spoke to the SUNDAY SUN from New York.

The BBC documentary aired last December 12 and was re-screened on BBC
World News on December 13, claimed that stem cells in the city of
Kharkiv, Ukraine in eastern Europe were not only procured from
aborted foetuses in the first trimester, but that healthy living
babies may have been delivered through induced labour at two weeks'
gestation, killed, their bodies dismembered and their internal organs
and brains removed for the harvest of stem cells.

Video footage of exhumed bodies detailing this barbaric practice was
lodged with the Council of Europe. The Council of Europe had already
investigated the maternity clinic in Kharkiv at the centre of the
allegations in August 2006 and expressed its extreme concern
about "the disappearance of new-born babies in the country and
allegations of trafficking of babies for adoption and of foetuses for
scientific purposes".

The Institute of Cryobiology in Kharkiv, that supplied the IRM with
stem cells, refused to be interviewed for the BBC documentary.

Baltaytis, a Ukrainian, reiterated his condemnation of the British
reports saying: "The European Commissioner said that no crime was
being committed in Ukraine. They said the BBC report and Daily Mail
reports were not true."

The professor, who established the first stem cell clinic here in
2002 - a rejuvenation clinic called "Vita Nova" at Villa Nova, St
John, which was rebranded the IRM in 2004 - said he no longer worked
for the company, and was trying to set up his own business, possibly
in Europe.

Baltaytis said he would like to return here, though he couldn't say
how soon he would. "I like to work in Barbados. I have some patients
over there."

As to the allegations that IRM skipped the country owing their former
landlord $8,000 rent; their employees', salaries; and other companies
money for services provided, Baltaytis stoutly denied this.

"We paid everybody. The only one we may owe is the telephone
company," he insisted.

"I personally delivered cash to [the landlord] from our chairman, Mr
Irme Pakh. ... We paid staff not only money but told them they could
take the furniture," he added.

A staff member however disagreed with Baltaytis. The person told the
SUN an affidavit was signed by the professor agreeing to pay the
National Insurance Scheme (NIS) the deductions taken from their
salaries over the last two years. That apart companies were calling
about monies owed.

"It is just a complete mess," the former employee said.

Quizzed on the NIS payments for staff, Baltaytis said he was "not a
financial officer of the company, so I have limited knowledge. I was
scientific director".

Both Cable & Wireless and the National Insurance Scheme declined to
divulge information about monies owed by the IRM; but the former
confirmed the service had been disconnected.

http://www.nationnews.com/story/315095110731643.php

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¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯
StemCells subscribers may also be interested in these sites:

Children's Neurobiological Solutions
http://www.CNSfoundation.org/

Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123

The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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[StemCells] Children's Hosp. (Boston) - Interactive Library

Interactive Library Offers a Look at Cancer, Neurons, Stem Cells

Web-based Flash interactives, developed by the Research department at
Children's Hospital Boston, present complex ideas in a user-friendly
format.

Boston, MA (PRWEB) November 15, 2007 -- Express your inner scientist,
explore the interactive library at the Children's Hospital Boston
Research Web site. Recently launched on the site: How Cancer Grows
and Spreads and The Neuron. Also available are features that let
users manipulate stem cells and control cell structure.

How Cancer Grows and Spreads
This animated Flash feature illustrates the growth, progression and
metastasis of carcinomas. In this presentation, cancer researchers
Bruce Zetter, PhD, and Marsha Moses, PhD, identify fourteen possible
stages of a carcinoma and show the possible paths the disease can
take as it moves from one stage to another. Using the
presentation's "roadmap," users are able to choose their own routes
as they travel from one possible cancer stage to the next. At each
stop along the way, they learn details about that stage through
descriptions and animated illustrations, and they can learn about
current treatments and the latest research advances.

The Neuron
The Neuron gives users the opportunity to experiment with a virtual
neuron to see what conditions are needed to make it fire and also
with a circuit of interconnected neurons to see how neurons work
together to process information. In addition, the feature provides
step-through animations that illustrate how electrical currents move
down the neuron along the axon (action potential) and how neurons
pass their signals along (synaptic transmission).

Additional Interactive Features

Virtual Stem Cell Laboratory
The Virtual Stem Cell Laboratory is home to a computer-
generated "living" culture of embryonic stem cells. When the Flash-
based feature is launched, the cells quickly begin to reproduce
through the process of mitosis (cell division). Users can then add
different "coaxing" factors -- proteins, for example -- to
differentiate the cells into increasingly specialized cell types.
From the initial colony of embryonic stem cells, virtual scientists
can create 16 cell types ranging from red blood cells to motor
neurons. The cells are even programmed to behave like their real
counterparts. As the lab produces new cell types, the user learns
what scientists know about the cells, including any known or
potential therapeutic applications.

Make a Micrograph
Creating a micrograph -- a photo taken through a microscope -- is not
simply a matter of attaching a camera to a microscope and releasing
the shutter. Rather, it's a multistep process that
involves "staining" with antibodies, illuminating with various
wavelengths of light, and adding and combining colors. This
interactive feature details the process.

Tensegrity in a Cell
For more than three decades, Children's researcher Donald Ingber, MD,
PhD, has explored and verified the notion that living cells are
tensegrity structures -- structures that stabilize themselves by
balancing tension and compression. With this interactive feature,
users can control a cell's internal structural elements to discover
what tensegrity is all about and why it's important to cell function.

Ingber's Egg Analogy
In his lectures, Dr. Ingber often uses simple analogies to explain
how tissues form and how diseases develop. In this Flash
presentation, he uses eggs in a carton to illustrate how cells in
tissues behave during wound healing and tumor formation.

Introduction to Proteomics
Proteomics -- the study of protein complexity in cells, tissues and
organisms -- is the hot new science that picks up where the Human
Genome Project left off. With this animated, user-controlled
interactive feature, find out how researchers sequence and identify
proteins. You can also take a virtual tour of Children's new
Proteomics Center and read about how researchers are using proteomics
to better understand the human body and improve medical care.

http://www.childrenshospital.org/research/interactives

Children's Hospital Boston is home to the world's largest research
enterprise based at a pediatric medical center, where its discoveries
have benefited both children and adults since 1869. More than 500
scientists, including eight members of the National Academy of
Sciences, 11 members of the Institute of Medicine and 12 members of
the Howard Hughes Medical Institute comprise Children's research
community. Founded as a 20-bed hospital for children, Children's
Hospital Boston today is a 377-bed comprehensive center for pediatric
and adolescent health care grounded in the values of excellence in
patient care and sensitivity to the complex needs and diversity of
children and families. Children's also is the primary pediatric
teaching affiliate of Harvard Medical School. For more information
about the hospital and its research visit:
http://www.childrenshospital.org/newsroom

# # #

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¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯
StemCells subscribers may also be interested in these sites:

Children's Neurobiological Solutions
http://www.CNSfoundation.org/

Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123

The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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[StemCellInformation] # 402 Friday, December 28, 2007 - WHEELCHAIR WARRIOR CHALLENGES PRESIDENTIAL CON

# 402 Friday, December 28, 2007 - WHEELCHAIR WARRIOR CHALLENGES PRESIDENTIAL CONTENDER

 

First, the dynamite.

 

"We at Wired Science think that people suffering from these 73 conditions would love to know where they can receive these cord blood and adult stem-cell treatments.  So to (Presidential contender Fred) Thompson, we issue a challenge: Provide a list of locations where Americans can receive these treatments." Steven Edwards. 

 

--(Wired Science Issues Stem-Cell Challenge to Fred Thompson, by Steven Edwards, November 26, 2007)

 

A little background: wheelchair warrior Steven Edwards of South Carolina is a friend of research from way back. Computer-savvy from the git-go, he helped spread the message about the Roman Reed Spinal Cord Injury Research Act of 1999. I think he was about 19 years old at the time, which was a shock to me, that he could navigate the electronic world so effortlessly.

 

After Roman's law was signed, I lost track of him for a while. We went different ways, only occasionally bumping into each other at events like Unite2Fight Paralysis (where I received a second surprise: that he has red hair bright enough to start fires with).

 

He became a writer for WIRED, the famous internet organization, and routinely produces quality work. Sometimes we agreed, sometimes we disagreed.

 

His long term goals include lobbying for increased NIH funding, anybody got any tips, pointers, or contacts for him?

 

But nothing prepared me for what came next.

 

Remember the famous list of 73 adult stem cell "treatments"? Invented by Family Research Council employee Dr. David Prentice, this list has been used as ammunition by every Religious Right congressman and Senator who ever wanted to attack embryonic stem cell research. (To understand the huge impact of the Prentice list, the Congressional debate on the Stem Cell Research Enhancement Act is instructive: the list is mentioned, I believe, by every opponent of the research.)

 

That is a problem, because the list is bogus.

 

It is what I call a "lawyer's lie", where the facts themselves may not be inaccurate, but the planned impact is utterly false.

 

A lawyer could probably find ways to talk about the list with a straight face, because technically a treatment is undoubtedly available for every disease on earth,  you could give aspirin for cancer and call it a treatment.

 

But the implication?  

 

To imply there is no need for embryonic stem cells because adult stem cells are all we need, when one hundred million Americans suffer chronic disease and disabilities?   

 

Among the conditions which the Prentice list claims as having an adult stem cell treatment is spinal cord injury paralysis: which affects my son.

 

Now, if there is a cure for paralysis, I am reasonably certain I would know about it. There isn't one; that is why we fight, so the research can go forward.

 

As far as the alleged "treatments", I have heard all the babble about OEG's, (Olfactory Ensheathing Glia) etc., and don't buy it, because I have talked to several people who have actually had the operation. None are doing well enough for me to recommend a similar procedure for my son. That is my standard; would I want my son to have the treatment?

 

One person says he can now feel skin sensation on his elbow, feel the shirt sliding on when he is being dressed in the morning. But he is still paralyzed.

 

I would not send my worst enemy to have his or her spine opened up for the insertion of cells from deep inside their nose, (where OEG's come from) not only because I see no real evidence that it helps, but also because things can get worse. Imagine being paralyzed, and then having a treatment-- which resulted in continual pain for the rest of your life, paralysis AND pain?

 

I have no problem with adult stem cells (or OEG's: there is disagreement if adult stem cells are even present in the OEG's); science only goes forward when freedom of research is allowed.

 

I support full stem cell research, adult, embryonic, nuclear transfer, and the new reprogramming methods, but none at the exclusion of the others.

 

I won't accept a substitute for an entire field of science, and that, unfortunately, is what the opposition to ESCR suggest.

 

For them, it is adult stem cells and nothing else.

 

So when Republican presidential contender Fred Thompson made the following statement, (about the iPS experiments) I just shook my head in frustration.

 

"In yet another breakthrough for adult cell research, scientists have made normal human skin cells take on the relevant properties of embryonic stem cells. That is in addition to 73 breakthroughs for adult and cord blood research, just one more indication that our current policy in relying only on adult cells is working." (emphasis added).

 

Politely, but publicly, Steven Edwards stepped up to the plate.

 

 First he inquired if the 73 breakthroughs mentioned by candidate Thompson did in fact refer to the Prentice List. When told that it was, he wrote the following:

 

"We at Wired Science think that people suffering from these 73 conditions would love to know where they can receive these cord blood and adult stem-cell treatments.  So to (Presidential contender Fred) Thompson, we issue a challenge: Provide a list of locations where Americans can receive these treatments." (emphasis added, dr)

 

Brilliant. If there are all these treatments available, where can we get them?

 

At first, there was no response. But Steve kept after them, and finally the campaign spokesman responded, with what I consider pure fast-talk and evasion.

 

The following is taken from the web.

 

 (Wired Science has no connections to me or my opinions; I just liked what I found and am printing it below; if that bothers them, I will retract it.)

 

"Fred Thompson's Campaign Responds to Stem-Cell Challenge

By Steven Edwards November 28, 2007 | 3:13:46 PMCategories: 2008 Presidential Election, Stem Cell Research  

Fred Thompson's campaign responded to our challenge to provide a list of locations where Americans could receive cord blood or adult stem-cell treatments for the 73 conditions he referenced last week.

In case you're just joining us, in response to the breakthrough last week in which scientists converted skin cells into stem cells, Fred Thompson praised adult stem cell research and cited what I believe is an inaccurate and politicized list of 73 adult stem cell treatments that conservative pundit David Prentice has compiled on his web site.

In his most recent response, David Ng, a spokesman for Thompson seems to be backpedaling. He said the presidential candidate had characterized the list as "research," not treatments, which is true. But I had followed up with Ng last week to clarify whether Thompson was actually referring to Prentice's list of "treatments." Ng said yes. So, it seems clear that Thompson was saying there are 73 adult stem cell treatments, and I wanted to know where people could get them. Ng continued to dodge the question. His full response is after the jump. 

Sen. Thompson's statement praises another scientific breakthrough last week where adult skin cells were manipulated to take on the properties of embryonic stem cells. It referenced additional scientific breakthroughs in adult stem cell and cord blood research. There are 73 scientific breakthroughs (we never said cures) for non-embryonic stem cell research, and none for embryo destructive research.

THE BOTTOM LINE IS THIS:  We should use our limited research dollars in a manner that is most promising.

But in reference to your challenge, nowhere does the statement address the issue of where people suffering from these diseases can be treated. The statement only references the research that is occurring. The senator was not trying to refer patients to specific treatment centers but instead to refer reporters to the studies.

I reminded Ng that he had already confirmed that Thompson was referring to Prentice's list of "treatments," and that asking where people could get them seemed to be the logical follow-up. (Am I wrong?)

Steven Edwards: The challenge was issued because of repeated references to the 73 treatments over the years by multiple parties. The statements were a reference to Prentice's treatments for 73 conditions, as you indicated.

If the treatments exist, they will be available somewhere in some form, so I am just asking for a list of where Americans can receive these  treatments. It seems to be a logical follow-up question to the  statements made by Senator Thompson, and one that I know many people suffering from the 73 conditions have. (I personally have no movement  below my shoulders and use a ventilator to breath for me at night due to a 1996 spinal cord injury, suffered at the age of 16.)

I understand his statement does not address where people can receive these treatments, but that's the purpose of the challenge. If the treatments exist, where can we get them? If they don't exist, perpetuating the myth that they do is unkind at best.

Darrel Ng: The statement speaks about research. You ask about treatments. I don't think it's fair to make that jump. Research always precedes treatment. (That would be akin to the campaign issuing a statement about the success a certain type of alternative vehicle fuel research and encouraging future research in that area, and you asking where can people go and purchase these new cars.)

I hope that helps clarify our point of view.

It didn't.

Our final exchange went a little something like this:

Steven Edwards: The source for Senator Thompson's "73 breakthroughs" statement was the list of 73 cord blood and adult stem cell treatments at www.stemcellresearch.org, but your response below says the statement was about research instead of treatments.

Does this mean Senator Thompson does not believe that the 73 treatments listed at www.stemcellresearch.org exist?

Darrel Ng: You're missing the whole point of this. The point is that the Senator supports the use of limited science dollars in the way that looks to bring the greatest return.

I'm not sure why you're bringing us into the debate over the list. If you have issues with the list, that's something I'm sure you can and will discuss on your blog. What we said in reference to the research.

Steven Edwards: It's about accountability.

Senator Thompson praised the iPS work and referenced the list to back his opinion that cord blood and adult stem cell research are the most promising avenue to invest in going forward. His opinion may be imposed on Americans who hold other views if he wins the election, so it's important to ensure that his opinion can be backed by facts.

If the facts support his opinion, so be it. If the facts don't, hopefully Senator Thompson will realize that and modify his position to one that is more in line with the facts.

By that, I don't mean he should start supporting research he opposes on moral grounds, but perhaps suggest policies that would enable more people to access the treatments on the list. If the treatments do not yet exist in a form that is available to Americans, acknowledge the fact and suggest policies to help speed their development so that Americans can benefit.

Using your earlier analogy on alternative vehicle fuels, if your supporting documents suggest that the fuels are already available for purchase and use, you shouldn't be surprised if someone asks where they can be obtained.

Is simple accountability too much to ask from a presidential candidate?

Editor's note: this post has been edited.

 

Don Reed
www.stemcellbattles.com
 

 

Don C. Reed is co-chair (with Karen Miner) of Californians for Cures, and writes for their web blog, www.stemcellbattles.com. Reed was citizen-sponsor for California's Roman Reed Spinal Cord Injury Research Act of 1999, named after his paralyzed son; he worked as a grassroots advocate for California's Senator Deborah Ortiz's three stem cell regulatory laws, served as an executive board member for Proposition 71, the California Stem Cells for Research and Cures Act, and is director of policy outreach for Americans for Cures. The retired schoolteacher is the author of five books and thirty magazine articles, and has received the National Press Award.

 

 

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Newsletter: 5 Stem Cell Patents Issued Last Week

View this newletter online to get all the info!

5 Stem Cell Patents Issued Last Week



Dear manoj kumar valluru,

Last week 5 patents of relevance to the area of stem cells were issued.

1. # 7,311,905 (Patent Spotlight), covers a population of adult stem cells that have characteristics of embryonic stem cells.

2. # 7,312,077 provides a hepatic cell line that makes insulin.

3. # 7,311,904 covers tissue matrices seeded with placentally derived embryonic-like cells.

4. # 7,312,078 covers chelating agents for expansion of hematopoietic stem cells.

5. # 7,313,442 teaches implantation of electrodes into specific brain areas for treatment of mood disorders.


In The News

Autologous G-CSF mobilized CD34 for angina

Friday December 28th, 2007 @ 22:54:26 EST

Chicago, IL -

The use of stem cells for myocardial repair was originally proposed after mouse studies demonstrated what appeared to be human bone marrow derived stem cells differentiating into myocardium. Subsequently, these experiments were translated into clinical studies, which utilized autologous bone marrow cells as sources of stem cells. Statistically significant increases in some efficacy parameters were seen in a double blind study study as well as another major randomized trial

Patients eager to attain stem cell therapy without waiting for clinical trials have been treated at ex-US venues with reports of positive results.

In a recent study (Losordo et al. Intramyocardial transplantation of autologous CD34+ stem cells for intractable angina: a phase I/IIa double-blind, randomized controlled trial. Circulation. 2007 Jun 26;115:3165-72) 24 patients with angina that were not eligible for revascularization were selected, of which 18 were randomized to receive escalating doses of autologous stem cell therapy and 4 placebo control. The stem cell therapy consisted of G-CSF mobilized Isolex-isolated CD34 cells. The cells were administered using electromechanical mapping of the myocardium using a NOGA system. Of the 18 patients in the treated group, subgroups of 4 patients received 5 × 10, 1 × 10, and 5 × 10 cells per kilogram. Cells were administered in a total volume of 2 ml, divided into 10 intramyocardial, transendocardial injections into areas identified as viable but ischemic. No dose dependent efficacy or adverse effects were observed. Although the study was not powered for efficacy determination, trends towards lower angina frequency, decreased nitroglycerine usage, increased exercise time, and decreased Canadian Cardiovascular Society class were observed in the patients receiving CD34 cells compared to placebo controls. The lead author, Dr Douglas W. Losordo from Feinberg Cardiovascular Research Institute and Program in Cardiovascular Regenerative Medicine, Division of Cardiovascular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine and Northwestern Memorial Hospital, Chicago, Ill is planning to expand the study to a multi-center 150 patient trial.

Ask a question OR leave your comments.

Read more StemCellPatents.com News


This Week's Patent Spotlight

Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells

Patent Number: 7,311,905

Stem cell populations are known from the cord blood as well as the placental matrix In the current patent a stem cell population from the placenta is covered that possesses markers of adult stem cells as well as embryonic stem cells.

For example, the first claim covers "A composition comprising human stem or progenitor cells and isolated human placental stem cells that are SH2.sup.+, SH3.sup.+, SH4.sup.+ and OCT-4.sup.+, wherein said placental stem cells are obtained from a placenta that has been drained of cord blood and flushed to remove residual blood".

The presence of embryonic stem cell markers such as OCT4 has previously been described in other non-embryonic sources of stem cells such as in the stem cells derived from the amniotic fluid

This patent is interesting since it has two clinical prophetic examples for the use of the cell population covered. The first involves treatment of ALS and the second involves treatment of atherosclerosis.

Although people may argue that there are issues surrounding the clinical use of allogeneic cell populations, since the cells appear to be mesenchymal, this may not be a significant problem given that mesenchymal stem cells appear to be capable of acting as universal donors

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