July 2009 Volume 9 Number 7
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Nature Reviews Immunology
Focus on Neuroimmunology
Understanding the crosstalk between the nervous and immune systems
and how it can be dysregulated provides us with crucial insights
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Nature Reviews Immunology presents a special Focus issue featuring
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Nature Reviews Microbiology
Poster on inhibition of the replicative cycle of hepatitis C virus
It is estimated that 170 million people are infected with the
hepatitis C virus (HCV). Because current drugs against HCV have poor
safety profiles and limited effectiveness, there is considerable
interest in identifying specific inhibitors of HCV replication.
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This month's FEATURED article:
New insights into the regulation of T cells by [gamma]c family
cytokines
Yrina Rochman, Rosanne Spolski and Warren J. Leonard
p480 | doi:10.1038/nri2580
http://links.ealert.nature.com/ctt?kn=19&m=33464224&r=MTc2NzU2Mjg3MwS2&b=2&j=NTIwODI5NzkS1&mt=1&rt=0
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From the editors
p457 | doi:10.1038/nri2596
http://links.ealert.nature.com/ctt?kn=53&m=33464224&r=MTc2NzU2Mjg3MwS2&b=2&j=NTIwODI5NzkS1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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T cell memory: Keeping energy levels up
p458 | doi:10.1038/nri2593
http://links.ealert.nature.com/ctt?kn=50&m=33464224&r=MTc2NzU2Mjg3MwS2&b=2&j=NTIwODI5NzkS1&mt=1&rt=0
HIV: Selective pressure
p459 | doi:10.1038/nri2595
http://links.ealert.nature.com/ctt?kn=3&m=33464224&r=MTc2NzU2Mjg3MwS2&b=2&j=NTIwODI5NzkS1&mt=1&rt=0
IN BRIEF
Autoimmunity | NKT cells | T cell responses
p459 | doi:10.1038/nri2600
http://links.ealert.nature.com/ctt?kn=67&m=33464224&r=MTc2NzU2Mjg3MwS2&b=2&j=NTIwODI5NzkS1&mt=1&rt=0
T cell memory: Live long with WNT
p460 | doi:10.1038/nri2594
http://links.ealert.nature.com/ctt?kn=39&m=33464224&r=MTc2NzU2Mjg3MwS2&b=2&j=NTIwODI5NzkS1&mt=1&rt=0
IN THE NEWS
Immunization in the spotlight
p460 | doi:10.1038/nri2598
http://links.ealert.nature.com/ctt?kn=71&m=33464224&r=MTc2NzU2Mjg3MwS2&b=2&j=NTIwODI5NzkS1&mt=1&rt=0
T cell differentiation: Inhibiting TH17 cells
p460 | doi:10.1038/nri2601
http://links.ealert.nature.com/ctt?kn=52&m=33464224&r=MTc2NzU2Mjg3MwS2&b=2&j=NTIwODI5NzkS1&mt=1&rt=0
IN BRIEF
Inflammation | Antigen presentation
p461 | doi:10.1038/nri2599
http://links.ealert.nature.com/ctt?kn=36&m=33464224&r=MTc2NzU2Mjg3MwS2&b=2&j=NTIwODI5NzkS1&mt=1&rt=0
Antigen presentation: Basophils do it too
p462 | doi:10.1038/nri2592
http://links.ealert.nature.com/ctt?kn=84&m=33464224&r=MTc2NzU2Mjg3MwS2&b=2&j=NTIwODI5NzkS1&mt=1&rt=0
T cell responses: A new starting point
p462 | doi:10.1038/nri2597
http://links.ealert.nature.com/ctt?kn=55&m=33464224&r=MTc2NzU2Mjg3MwS2&b=2&j=NTIwODI5NzkS1&mt=1&rt=0
Antiviral immunity: TRIMming the response
p463 | doi:10.1038/nri2589
http://links.ealert.nature.com/ctt?kn=66&m=33464224&r=MTc2NzU2Mjg3MwS2&b=2&j=NTIwODI5NzkS1&mt=1&rt=0
Evolution: A common solution to an age-old problem
p464 | doi:10.1038/nri2590
http://links.ealert.nature.com/ctt?kn=73&m=33464224&r=MTc2NzU2Mjg3MwS2&b=2&j=NTIwODI5NzkS1&mt=1&rt=0
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REVIEWS
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Signalling through C-type lectin receptors: shaping immune responses
Teunis B. H. Geijtenbeek and Sonja I. Gringhuis
p465 | doi:10.1038/nri2569
Here, Teunis Geijtenbeek and Sonja Gringhuis discuss the role of the
signalling pathways induced by C-type lectin receptors in determining
T helper cell lineage commitment and describe how these pathways can
be exploited for the development of new vaccination strategies.
Abstract: http://links.ealert.nature.com/ctt?kn=75&m=33464224&r=MTc2NzU2Mjg3MwS2&b=2&j=NTIwODI5NzkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=8&m=33464224&r=MTc2NzU2Mjg3MwS2&b=2&j=NTIwODI5NzkS1&mt=1&rt=0
New insights into the regulation of T cells by [gamma]c family
cytokines
Yrina Rochman, Rosanne Spolski and Warren J. Leonard
p480 | doi:10.1038/nri2580
In this Review, the authors discuss the central roles of the common
cytokine receptor [gamma]-chain ([gamma]c) family of cytokines, as
well as the related cytokine TSLP, in the homeostasis, proliferation
and differentiation of various T cell subsets and describe how these
cytokines could be exploited for therapeutic purposes.
Abstract: http://links.ealert.nature.com/ctt?kn=19&m=33464224&r=MTc2NzU2Mjg3MwS2&b=2&j=NTIwODI5NzkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=82&m=33464224&r=MTc2NzU2Mjg3MwS2&b=2&j=NTIwODI5NzkS1&mt=1&rt=0
Cracking the BAFF code
Fabienne Mackay and Pascal Schneider
p491 | doi:10.1038/nri2572
Studies showing how BAFF and its closely related homologue APRIL
activate their receptors and transmit growth and survival signals to
B cells have shed new light on the association between BAFF and
autoimmunity. This knowledge has prompted several clinical trials
testing BAFF and APRIL antagonists for the treatment of autoimmune
diseases and lymphomas.
Abstract: http://links.ealert.nature.com/ctt?kn=21&m=33464224&r=MTc2NzU2Mjg3MwS2&b=2&j=NTIwODI5NzkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=68&m=33464224&r=MTc2NzU2Mjg3MwS2&b=2&j=NTIwODI5NzkS1&mt=1&rt=0
MHC class I antigen presentation: learning from viral evasion
strategies
Ted H. Hansen and Marlene Bouvier
p503 | doi:10.1038/nri2575
To limit detection by host T cells, viruses have evolved numerous
mechanisms to inhibit viral antigens being processed and presented by
MHC class I molecules. As described here, studying these viral immune
evasion strategies is proving useful for understanding MHC class I
presentation and other cellular pathways.
Abstract: http://links.ealert.nature.com/ctt?kn=9&m=33464224&r=MTc2NzU2Mjg3MwS2&b=2&j=NTIwODI5NzkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=91&m=33464224&r=MTc2NzU2Mjg3MwS2&b=2&j=NTIwODI5NzkS1&mt=1&rt=0
CD95, BIM and T cell homeostasis
Philippe Bouillet and Lorraine A. O'Reilly
p514 | doi:10.1038/nri2570
Cell death has a vital role in maintaining homeostasis in the T cell
pool. However, the specific roles of BIM and CD95 in the contraction
phase of T cell responses has been controversial. Recent studies show
that BIM and CD95 have complementary roles in this process.
Abstract: http://links.ealert.nature.com/ctt?kn=15&m=33464224&r=MTc2NzU2Mjg3MwS2&b=2&j=NTIwODI5NzkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=7&m=33464224&r=MTc2NzU2Mjg3MwS2&b=2&j=NTIwODI5NzkS1&mt=1&rt=0
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PERSPECTIVES
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SCIENCE AND SOCIETY
Towards the identification of biomarkers of transplantation tolerance
Laurence A. Turka and Robert I. Lechler
p521 | doi:10.1038/nri2568
The identification of biomarkers of transplantation tolerance holds
promise to improve the care of transplant recipients and advance our
understanding of alloreactive immune responses. What progress has
been made towards reaching this goal and what challenges remain?
Abstract: http://links.ealert.nature.com/ctt?kn=57&m=33464224&r=MTc2NzU2Mjg3MwS2&b=2&j=NTIwODI5NzkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=1&m=33464224&r=MTc2NzU2Mjg3MwS2&b=2&j=NTIwODI5NzkS1&mt=1&rt=0
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