July 2009 Volume 6 Number 7
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RESEARCH HIGHLIGHTS
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Interventional cardiology: Drug-eluting stents are superior to bare-metal
stents in elderly patients
p439 | doi:10.1038/nrcardio.2009.82
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Heart Failure: HF potentially preventable in the elderly
p440 | doi:10.1038/nrcardio.2009.90
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Hypertension: ECG strain predicts cardiovascular risk
p440 | doi:10.1038/nrcardio.2009.91
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Intramyocardial injections are safe
p441 | doi:10.1038/nrcardio.2009.87
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Interventional cardiology: Guidance for carotid stenting
p442 | doi:10.1038/nrcardio.2009.84
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Blood pressure predicts AF in women
p442 | doi:10.1038/nrcardio.2009.86
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Cardiomyopathies: Syncope is a risk factor for death in HCM
p443 | doi:10.1038/nrcardio.2009.83
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Atrial fibrillation: Physician specialty and ICD implant outcome
p443 | doi:10.1038/nrcardio.2009.85
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Drug therapy does not match guidelines
p443 | doi:10.1038/nrcardio.2009.92
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Infection: Infections related to outpatient health care cause native
endocarditis
p444 | doi:10.1038/nrcardio.2009.100
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Acute coronary syndromes: Early versus late intervention in NSTEMI
p444 | doi:10.1038/nrcardio.2009.101
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Echo versus ECG for suspected CAD
p445 | doi:10.1038/nrcardio.2009.93
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Interventional cardiology: New polymer-free dual-drug-eluting stent
p446 | doi:10.1038/nrcardio.2009.88
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Genetics: Identification of genes associated with stroke risk
p446 | doi:10.1038/nrcardio.2009.89
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NEWS AND VIEWS
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Heart failure: Support for exercise training in CHF
Andrew J. S. Coats
p447 | doi:10.1038/nrcardio.2009.96
The results of HF-ACTION-the largest ever intervention trial of a
nonpharmacological treatment for chronic heart failure-have been reported.
The investigators randomly allocated participants to either a structured
exercise program or to usual care. Although the primary end point was not
reached at the prespecified significance level, the background evidence
and data from previous trials and other prespecified analyses compel me
to conclude that exercise training should be recommended for patients
with stable chronic heart failure.
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Stroke: Atrial fibrillation, stroke prevention therapy and aging
J. David Spence
p448 | doi:10.1038/nrcardio.2009.98
Stroke risk in patients with nonvalvular atrial fibrillation increases
markedly with age. Although anticoagulation is more effective than
antiplatelet therapy in atrial fibrillation, it tends to be underutilized
in the elderly. A study by van Walraven et al. examines the influence of
age on stroke prevention therapy in atrial fibrillation.
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Cardiomyopathies: New test for arrhythmogenic right ventricular
cardiomyopathy
J. Peter van Tintelen and Richard N. W. Hauer
p450 | doi:10.1038/nrcardio.2009.97
Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is
challenging to diagnose because of nonspecific findings, particularly
in the early phases of the disease. Clinical diagnosis is made on the
basis of several criteria, but these lack sensitivity. Asimaki et al.
suggest that immunohistochemical analysis of myocardial desmosomal
proteins is a highly sensitive and specific diagnostic test for ARVD/C.
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Diabetes: Does screening for inducible ischemia improve outcomes?
Prediman K. Shah
p452 | doi:10.1038/nrcardio.2009.95
The DIAD trial investigators have demonstrated that screening for inducible
myocardial ischemia did not improve overall clinical outcome in a
contemporary cohort of patients with asymptomatic type 2 diabetes, most
of whom were receiving excellent medical management and few of whom
underwent revascularization. Future studies should be designed to evaluate
the clinical value and cost effectiveness of unconditional treatment
versus screening using techniques to detect atherosclerotic and ischemic
burden, coupled with therapeutic interventions, risk-factor management,
and selective use of revascularization in high-risk patients.
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Atrial Fibrillation: Predicting the efficacy of pulmonary vein isolation
with CMR
Mario J. Garcia
p453 | doi:10.1038/nrcardio.2009.99
Pulmonary vein antrum isolation is an accepted alternative to antiarrhythmic
therapy for restoring normal sinus rhythm in patients with atrial
fibrillation. The procedure has a high initial success rate, but many
patients subsequently experience recurrence of the arrhythmia. Cardiac
magnetic resonance might offer a means of identifying patients who are
more likely to experience successful long-term results from pulmonary
vein antrum isolation.
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REVIEWS
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Update on strategies to increase HDL quantity and function
Danielle Duffy and Daniel J. Rader
Published online: 02 June 2009
p455 | doi:10.1038/nrcardio.2009.94
Low levels of HDL-cholesterol are associated with an increased risk of
coronary heart disease. Rader and Duffy discuss new strategies that are
currently in development to improve HDL levels and/or function.
Abstract: http://links.ealert.nature.com/ctt?kn=46&m=33466217&r=MTc2NDI1MzEzNAS2&b=2&j=NTIwOTI2NDIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=63&m=33466217&r=MTc2NDI1MzEzNAS2&b=2&j=NTIwOTI2NDIS1&mt=1&rt=0
Biomarkers of AAA progression. Part 1: extracellular matrix degeneration
Femke A. M. V. I. Hellenthal, Willem A. Buurman, Will K. W. H. Wodzig and
Geert Willem H. Schurink
Published online: 26 May 2009
p464 | doi:10.1038/nrcardio.2009.80
In the first part of their Review on circulating biomarkers of abdominal
aortic aneurysm, Hellenthal et al. focus on the constituents and active
enzymes of the extracellular matrix and their possible roles in the
development and progression of this disease.
Abstract: http://links.ealert.nature.com/ctt?kn=132&m=33466217&r=MTc2NDI1MzEzNAS2&b=2&j=NTIwOTI2NDIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=127&m=33466217&r=MTc2NDI1MzEzNAS2&b=2&j=NTIwOTI2NDIS1&mt=1&rt=0
Molecular imaging of cardiovascular disease with contrast-enhanced
ultrasonography
Jonathan R. Lindner
Published online: 09 June 2009
p475 | doi:10.1038/nrcardio.2009.77
In the second article of our Molecular Imaging series, Dr. Lindner focuses
on molecular imaging of cardiovascular diseases using contrast-enhanced
ultrasound. The basics of targeted ultrasound contrast agents, the progress
that has been made in imaging key events in cardiovascular medicine, and
other potential clinical applications of targeted microbubbles are discussed.
Abstract: http://links.ealert.nature.com/ctt?kn=32&m=33466217&r=MTc2NDI1MzEzNAS2&b=2&j=NTIwOTI2NDIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=117&m=33466217&r=MTc2NDI1MzEzNAS2&b=2&j=NTIwOTI2NDIS1&mt=1&rt=0
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CASE STUDY
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Mechanical bridge to recovery in pheochromocytoma myocarditis
Stephen Westaby, Ashwin Shahir, Gregory Sadler, Fidelma Flynn and
Oliver Ormerod
p482 | doi:10.1038/nrcardio.2009.58
Professor Stephen Westaby and colleagues describe the case of a patient
who presented with cardiogenic shock that swiftly deteriorated to severe
heart failure. CT revealed a large adrenal tumor that was subsequently
indentified as pheochromocytoma. After the tumor was removed, the patient
underwent left ventricular assist device implantation as a bridge to left
ventricular recovery.
Abstract: http://links.ealert.nature.com/ctt?kn=8&m=33466217&r=MTc2NDI1MzEzNAS2&b=2&j=NTIwOTI2NDIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=31&m=33466217&r=MTc2NDI1MzEzNAS2&b=2&j=NTIwOTI2NDIS1&mt=1&rt=0
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PERSPECTIVES
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OPINION
Preventing CVD in resource-poor areas: perspectives from the 'real-world'
Simon Stewart and Karen Sliwa
p489 | doi:10.1038/nrcardio.2009.79
Abstract: http://links.ealert.nature.com/ctt?kn=104&m=33466217&r=MTc2NDI1MzEzNAS2&b=2&j=NTIwOTI2NDIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=95&m=33466217&r=MTc2NDI1MzEzNAS2&b=2&j=NTIwOTI2NDIS1&mt=1&rt=0
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