July 2009 Volume 9 Number 7
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Access 20 FREE ARTICLES at SciBX Cover Story Archive
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This month's Featured article:
Novel anticancer targets: revisiting ERBB2 and discovering ERBB3
Jose Baselga and Sandra M. Swain
p463 | doi:10.1038/nrc2656
http://links.ealert.nature.com/ctt?kn=60&m=33459506&r=MTc2Njc4NzkyNgS2&b=2&j=NTIwMTg2OTkS1&mt=1&rt=0
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From the editors
p453 | doi:10.1038/nrc2692
http://links.ealert.nature.com/ctt?kn=67&m=33459506&r=MTc2Njc4NzkyNgS2&b=2&j=NTIwMTg2OTkS1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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Signalling: Hedgehog doesn't...
p455 | doi:10.1038/nrc2688
http://links.ealert.nature.com/ctt?kn=80&m=33459506&r=MTc2Njc4NzkyNgS2&b=2&j=NTIwMTg2OTkS1&mt=1&rt=0
Senescence: Playing games with epigenetics
p456 | doi:10.1038/nrc2685
http://links.ealert.nature.com/ctt?kn=86&m=33459506&r=MTc2Njc4NzkyNgS2&b=2&j=NTIwMTg2OTkS1&mt=1&rt=0
Angiogenesis: How Down's syndrome protects
p456 | doi:10.1038/nrc2687
http://links.ealert.nature.com/ctt?kn=49&m=33459506&r=MTc2Njc4NzkyNgS2&b=2&j=NTIwMTg2OTkS1&mt=1&rt=0
Therapeutics: Dependent on KRAS
p457 | doi:10.1038/nrc2689
http://links.ealert.nature.com/ctt?kn=15&m=33459506&r=MTc2Njc4NzkyNgS2&b=2&j=NTIwMTg2OTkS1&mt=1&rt=0
Breast cancer: Prioritizing targets
p458 | doi:10.1038/nrc2684
http://links.ealert.nature.com/ctt?kn=61&m=33459506&r=MTc2Njc4NzkyNgS2&b=2&j=NTIwMTg2OTkS1&mt=1&rt=0
Drug resistance: Getting through
p458 | doi:10.1038/nrc2686
http://links.ealert.nature.com/ctt?kn=41&m=33459506&r=MTc2Njc4NzkyNgS2&b=2&j=NTIwMTg2OTkS1&mt=1&rt=0
IN THE NEWS
Canine first
p458 | doi:10.1038/nrc2691
http://links.ealert.nature.com/ctt?kn=57&m=33459506&r=MTc2Njc4NzkyNgS2&b=2&j=NTIwMTg2OTkS1&mt=1&rt=0
IN BRIEF
Metastasis | Tumorigenesis | Non-coding RNA | Tumour initiation
p459 | doi:10.1038/nrc2690
http://links.ealert.nature.com/ctt?kn=88&m=33459506&r=MTc2Njc4NzkyNgS2&b=2&j=NTIwMTg2OTkS1&mt=1&rt=0
Breast cancer: Metastasis on the brain
p460 | doi:10.1038/nrc2678
http://links.ealert.nature.com/ctt?kn=11&m=33459506&r=MTc2Njc4NzkyNgS2&b=2&j=NTIwMTg2OTkS1&mt=1&rt=0
Breast cancer: A DEAR 1
p460 | doi:10.1038/nrc2680
http://links.ealert.nature.com/ctt?kn=89&m=33459506&r=MTc2Njc4NzkyNgS2&b=2&j=NTIwMTg2OTkS1&mt=1&rt=0
Epigenetics: Misreading the code
p461 | doi:10.1038/nrc2679
http://links.ealert.nature.com/ctt?kn=79&m=33459506&r=MTc2Njc4NzkyNgS2&b=2&j=NTIwMTg2OTkS1&mt=1&rt=0
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REVIEWS
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Article series: Therapeutic resistance
http://links.ealert.nature.com/ctt?kn=19&m=33459506&r=MTc2Njc4NzkyNgS2&b=2&j=NTIwMTg2OTkS1&mt=1&rt=0
Novel anticancer targets: revisiting ERBB2 and discovering ERBB3
Jose Baselga and Sandra M. Swain
p463 | doi:10.1038/nrc2656
Targeting the Erbb family of receptor tyrosine kinases, specifically ERBB1
(EGFR) and ERBB2, has led to successful cancer therapies. However, many
patients will progress on these therapies. As we learn more about this
pivotal receptor family, can we devise better methods of targeting it?
Abstract: http://links.ealert.nature.com/ctt?kn=60&m=33459506&r=MTc2Njc4NzkyNgS2&b=2&j=NTIwMTg2OTkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=53&m=33459506&r=MTc2Njc4NzkyNgS2&b=2&j=NTIwMTg2OTkS1&mt=1&rt=0
Chemoprevention of lung carcinogenesis in addicted smokers and ex-smokers
Stephen S. Hecht, Fekadu Kassie and Dorothy K. Hatsukami
p476 | doi:10.1038/nrc2674
Chemoprevention of lung carcinogenesis is one potential approach to control
the epidemic of lung cancer caused by cigarette smoking. How should we go
about this and is using mixtures of chemopreventive agents a useful path to pursue?
Abstract: http://links.ealert.nature.com/ctt?kn=64&m=33459506&r=MTc2Njc4NzkyNgS2&b=2&j=NTIwMTg2OTkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=21&m=33459506&r=MTc2Njc4NzkyNgS2&b=2&j=NTIwMTg2OTkS1&mt=1&rt=0
Genetic prognostic and predictive markers in colorectal cancer
Axel Walther, Elaine Johnstone, Charles Swanton, Rachel Midgley, Ian Tomlinson
and David Kerr
p489 | doi:10.1038/nrc2645
New technologies have led to an explosive increase in the number of biomarkers
thought to be associated with prognosis and treatment outcome in colorectal
cancer. How effective are the biomarkers already in the public domain?
Abstract: http://links.ealert.nature.com/ctt?kn=28&m=33459506&r=MTc2Njc4NzkyNgS2&b=2&j=NTIwMTg2OTkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=43&m=33459506&r=MTc2Njc4NzkyNgS2&b=2&j=NTIwMTg2OTkS1&mt=1&rt=0
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PERSPECTIVES
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TIMELINE
Apoptosis and cancer: the genesis of a research field
Thomas G. Cotter
p501 | doi:10.1038/nrc2663
Ever since its discovery, apoptosis has been inextricably linked with cancer.
This Timeline article seeks to provide insights into the key discoveries
in the field and therapeutic applications based on apoptotic strategies.
Abstract: http://links.ealert.nature.com/ctt?kn=23&m=33459506&r=MTc2Njc4NzkyNgS2&b=2&j=NTIwMTg2OTkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=46&m=33459506&r=MTc2Njc4NzkyNgS2&b=2&j=NTIwMTg2OTkS1&mt=1&rt=0
TIMELINE
Cancer prevention research - then and now
Ann M. Bode and Zigang Dong
p508 | doi:10.1038/nrc2646
Cancer prevention is a global priority, but history indicates that the
journey towards achieving this goal is fraught with difficulties. What can
we learn from the past that is applicable to the reality of successful
cancer prevention?
Abstract: http://links.ealert.nature.com/ctt?kn=82&m=33459506&r=MTc2Njc4NzkyNgS2&b=2&j=NTIwMTg2OTkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=72&m=33459506&r=MTc2Njc4NzkyNgS2&b=2&j=NTIwMTg2OTkS1&mt=1&rt=0
SCIENCE AND SOCIETY
Wildlife cancer: a conservation perspective
Denise McAloose and Alisa L. Newton
p517 | doi:10.1038/nrc2665
Cancer in wildlife seems to be more prevalent than previously thought and
could have considerable effects on the populations of some species. This
Perspective discusses the conservation issues raised by cancer in wildlife.
Abstract: http://links.ealert.nature.com/ctt?kn=4&m=33459506&r=MTc2Njc4NzkyNgS2&b=2&j=NTIwMTg2OTkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=7&m=33459506&r=MTc2Njc4NzkyNgS2&b=2&j=NTIwMTg2OTkS1&mt=1&rt=0
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A new type of small interfering RNA in fungus
http://links.ealert.nature.com/ctt?kn=91&m=33459506&r=MTc2Njc4NzkyNgS2&b=2&j=NTIwMTg2OTkS1&mt=1&rt=0
Lui and colleagues have discovered a new type of endogenous small RNAs
in the filamentous fungus Neurospora crassa. As they interact with the
Argonaute protein QDE-2, the authors named these RNAs qiRNA. QiRNAs may
have a role in the response to spontaneous DNA damage.
RNAi gateway is sponsored by Alnylam Pharmaceuticals and Roche
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