July 2009 Volume 10 Number 7
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This month's FEATURED article:
Proximal events in Wnt signal transduction
Stephane Angers and Randall T. Moon
p468 | doi:10.1038/nrm2717
http://links.ealert.nature.com/ctt?kn=16&m=33452821&r=MTc2NzYzNjQ2NgS2&b=2&j=NTE5MzI2NjkS1&mt=1&rt=0
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From the editors
p437 | doi:10.1038/nrm2725
http://links.ealert.nature.com/ctt?kn=88&m=33452821&r=MTc2NzYzNjQ2NgS2&b=2&j=NTE5MzI2NjkS1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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Cell signalling: An activating inhibitor?
p439 | doi:10.1038/nrm2724
http://links.ealert.nature.com/ctt?kn=69&m=33452821&r=MTc2NzYzNjQ2NgS2&b=2&j=NTE5MzI2NjkS1&mt=1&rt=0
IN THE NEWS
Seeing red
p440 | doi:10.1038/nrm2710
http://links.ealert.nature.com/ctt?kn=24&m=33452821&r=MTc2NzYzNjQ2NgS2&b=2&j=NTE5MzI2NjkS1&mt=1&rt=0
Gene expression: UV-induced coupling
p440 | doi:10.1038/nrm2715
http://links.ealert.nature.com/ctt?kn=95&m=33452821&r=MTc2NzYzNjQ2NgS2&b=2&j=NTE5MzI2NjkS1&mt=1&rt=0
Apoptosis: Death by ubiquitylation
p441 | doi:10.1038/nrm2714
http://links.ealert.nature.com/ctt?kn=56&m=33452821&r=MTc2NzYzNjQ2NgS2&b=2&j=NTE5MzI2NjkS1&mt=1&rt=0
IN BRIEF
Cytoskeleton | Cell division | DNA damage response
p441 | doi:10.1038/nrm2723
http://links.ealert.nature.com/ctt?kn=1&m=33452821&r=MTc2NzYzNjQ2NgS2&b=2&j=NTE5MzI2NjkS1&mt=1&rt=0
Membrane trafficking: Lipid sorting and clustering
p442 | doi:10.1038/nrm2711
http://links.ealert.nature.com/ctt?kn=19&m=33452821&r=MTc2NzYzNjQ2NgS2&b=2&j=NTE5MzI2NjkS1&mt=1&rt=0
Protein degradation: Assembly from the base
p442 | doi:10.1038/nrm2719
http://links.ealert.nature.com/ctt?kn=54&m=33452821&r=MTc2NzYzNjQ2NgS2&b=2&j=NTE5MzI2NjkS1&mt=1&rt=0
IN BRIEF
Membrane trafficking | Protein translocation | Development | Cell death
p442 | doi:10.1038/nrm2722
http://links.ealert.nature.com/ctt?kn=72&m=33452821&r=MTc2NzYzNjQ2NgS2&b=2&j=NTE5MzI2NjkS1&mt=1&rt=0
Cell signalling: A fertility network
p443 | doi:10.1038/nrm2721
http://links.ealert.nature.com/ctt?kn=80&m=33452821&r=MTc2NzYzNjQ2NgS2&b=2&j=NTE5MzI2NjkS1&mt=1&rt=0
JOURNAL CLUB
Building on the shoulders of giants
p444 | doi:10.1038/nrm2709
http://links.ealert.nature.com/ctt?kn=90&m=33452821&r=MTc2NzYzNjQ2NgS2&b=2&j=NTE5MzI2NjkS1&mt=1&rt=0
Gene expression: Complex interactions
p444 | doi:10.1038/nrm2716
http://links.ealert.nature.com/ctt?kn=5&m=33452821&r=MTc2NzYzNjQ2NgS2&b=2&j=NTE5MzI2NjkS1&mt=1&rt=0
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REVIEWS
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Collective cell migration in morphogenesis, regeneration and cancer
Peter Friedl and Darren Gilmour
p445 | doi:10.1038/nrm2720
The collective migration of cells as cohesive groups is prevalent
during embryogenesis, organ development, wound repair and tumour
invasion. The mechanisms that underlie different forms of collective
cell migration are not well understood, but some general principles
are emerging.
Abstract: http://links.ealert.nature.com/ctt?kn=68&m=33452821&r=MTc2NzYzNjQ2NgS2&b=2&j=NTE5MzI2NjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=74&m=33452821&r=MTc2NzYzNjQ2NgS2&b=2&j=NTE5MzI2NjkS1&mt=1&rt=0
Dynamics and diversity in autophagy mechanisms: lessons from yeast
Hitoshi Nakatogawa, Kuninori Suzuki, Yoshiaki Kamada and Yoshinori Ohsumi
p458 | doi:10.1038/nrm2708
Studies of autophagy in yeast have identified a family of autophagy-related
(Atg) proteins, which are required for membrane formation in autophagy.
The dynamic assembly of Atg proteins into the pre-autophagosomal structure
dictates the localization and activity of the autophagic machinery.
Abstract: http://links.ealert.nature.com/ctt?kn=18&m=33452821&r=MTc2NzYzNjQ2NgS2&b=2&j=NTE5MzI2NjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=47&m=33452821&r=MTc2NzYzNjQ2NgS2&b=2&j=NTE5MzI2NjkS1&mt=1&rt=0
Proximal events in Wnt signal transduction
Stephane Angers and Randall T. Moon
p468 | doi:10.1038/nrm2717
The cytoplasmic and nuclear steps of the Wnt signalling pathway are
fairly well understood. New insights into how secreted Wnt ligands
stimulate receptor-mediated signalling have shown an unexpected diversity
of Wnt receptors and further complexity in cellular responses.
Abstract: http://links.ealert.nature.com/ctt?kn=94&m=33452821&r=MTc2NzYzNjQ2NgS2&b=2&j=NTE5MzI2NjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=78&m=33452821&r=MTc2NzYzNjQ2NgS2&b=2&j=NTE5MzI2NjkS1&mt=1&rt=0
Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis
Andrew J. Holland and Don W. Cleveland
p478 | doi:10.1038/nrm2718
The mitotic checkpoint is a cell cycle control mechanism that guards
against chromosome missegregation and the subsequent production of
aneuploid daughter cells. Although aneuploidy is a common characteristic
of tumours, it can suppress tumorigenesis in certain genetic contexts
and cell types.
Abstract: http://links.ealert.nature.com/ctt?kn=53&m=33452821&r=MTc2NzYzNjQ2NgS2&b=2&j=NTE5MzI2NjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=83&m=33452821&r=MTc2NzYzNjQ2NgS2&b=2&j=NTE5MzI2NjkS1&mt=1&rt=0
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PERSPECTIVES
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OPINION
Clearing the way for mitosis: is cohesin a target?
Mitsuhiro Yanagida
p489 | doi:10.1038/nrm2712
In interphase, chromosomes are associated with proteins and RNAs that
participate in many metabolic processes. During mitosis, these components
might inhibit chromosome segregation or reduce its fidelity. The author
proposes the existence of a molecular mechanism that eliminates unwanted
components from mitotic chromosomes.
Abstract: http://links.ealert.nature.com/ctt?kn=48&m=33452821&r=MTc2NzYzNjQ2NgS2&b=2&j=NTE5MzI2NjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=79&m=33452821&r=MTc2NzYzNjQ2NgS2&b=2&j=NTE5MzI2NjkS1&mt=1&rt=0
SCIENCE AND SOCIETY
Bio-art: the ethics behind the aesthetics
Frances Stracey
p496 | doi:10.1038/nrm2699
Bio-art - the crossover of art and biology - comes in many forms,
including genetic portraits, transgenic animals and semi-living entities.
But why do artists and scientists come together to collaborate on such
projects, and what are the ethical implications of turning life into art?
Abstract: http://links.ealert.nature.com/ctt?kn=42&m=33452821&r=MTc2NzYzNjQ2NgS2&b=2&j=NTE5MzI2NjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=13&m=33452821&r=MTc2NzYzNjQ2NgS2&b=2&j=NTE5MzI2NjkS1&mt=1&rt=0
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October 8-10, 2009
La Jolla, California, USA
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Early Bird Deadline: September 8, 2009
Abstract Submission: Deadline: August 21, 2009
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