Signaling Gateway - 24 April 2009
http://links.ealert.nature.com/ctt?kn=54&m=32495449&r=MTc2ODc4NDI0MAS2&b=2&j=NDc4NjM5NjgS1&mt=1&rt=0
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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DOPAMINE PATHWAY: ETS MAKE A NEURON
The ETS family of transcription factors bind to a conserved
cis-regulatory element in dopamine responsive genes to promote
neuronal differentiation.
Original research paper: Nature 458, 885-889 (2009)
http://links.ealert.nature.com/ctt?kn=18&m=32495449&r=MTc2ODc4NDI0MAS2&b=2&j=NDc4NjM5NjgS1&mt=1&rt=0
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Molecule Pages
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Rab11
http://links.ealert.nature.com/ctt?kn=56&m=32495449&r=MTc2ODc4NDI0MAS2&b=2&j=NDc4NjM5NjgS1&mt=1&rt=0
Rab11b belongs to the Rab GTPase family of proteins that constitutes
the largest group within the Ras-like small monomeric GTPase
superfamily. Although the function and subcellular localization of
Rab11b has not yet been extensively investigated, recent studies
have shown that Rab11b regulates the targeting of recycling endosomes
to the cleavage furrow during mitosis - a step that is required for
the successful completion of cytokinesis.
Also published this week: Rab11-FIP3
http://links.ealert.nature.com/ctt?kn=37&m=32495449&r=MTc2ODc4NDI0MAS2&b=2&j=NDc4NjM5NjgS1&mt=1&rt=0
Search the molecule pages
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Selected Updates
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IMMUNE REGULATION: DAMPENING INFLAMMATION
The CD24–SiglecG pathway selectively represses the NF-kappaB-driven
inflammatory response to danger-associated molecular patterns (DAMPs)
but not pathogen-associated molecular patterns (PAMPs), suggesting
that this pathway might be a general mechanism to distinguish between
tissue injury and infection.
Original research paper: Science 323, 1722-1725 (2009)
http://links.ealert.nature.com/ctt?kn=4&m=32495449&r=MTc2ODc4NDI0MAS2&b=2&j=NDc4NjM5NjgS1&mt=1&rt=0
METASTASIS: OXIDIZING ABNORMALITIES
The oxygen-sensitive prolyl hydroxylase Phd2 regulates endothelial
cell morphology, which consequently modifies the aggressiveness of
tumors.
Original research paper: Cell 136, 839–851 (2009)
http://links.ealert.nature.com/ctt?kn=39&m=32495449&r=MTc2ODc4NDI0MAS2&b=2&j=NDc4NjM5NjgS1&mt=1&rt=0
RESISTANCE: AGGRAVATING THE AGGRESSOR
Increased Akt activity in glioblastoma multiforme appears to be
associated with the acquisition of stem cell-like properties and
therapeutic resistance.
Original research paper: Cell Stem Cell 4, 226-235 (2009)
http://links.ealert.nature.com/ctt?kn=52&m=32495449&r=MTc2ODc4NDI0MAS2&b=2&j=NDc4NjM5NjgS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=16&m=32495449&r=MTc2ODc4NDI0MAS2&b=2&j=NDc4NjM5NjgS1&mt=1&rt=0
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Research Library
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DIRECTIONAL DELTA AND NOTCH TRAFFICKING IN SARA ENDOSOMES DURING
ASYMMETRIC CELL DIVISION
Nature 458, 1051-1055 (2009)
http://links.ealert.nature.com/ctt?kn=26&m=32495449&r=MTc2ODc4NDI0MAS2&b=2&j=NDc4NjM5NjgS1&mt=1&rt=0
MODULARITY OF MAP KINASES ALLOWS DEFORMATION OF THEIR SIGNALLING
PATHWAYS
Nature Cell Biology 11, 484-491 (2009)
http://links.ealert.nature.com/ctt?kn=25&m=32495449&r=MTc2ODc4NDI0MAS2&b=2&j=NDc4NjM5NjgS1&mt=1&rt=0
SPECIFIC RECRUITMENT OF PROTEIN KINASE A TO THE IMMUNOGLOBULIN
LOCUS REGULATES CLASS-SWITCH RECOMBINATION
Nature Immunology 10, 420-426 (2009)
http://links.ealert.nature.com/ctt?kn=7&m=32495449&r=MTc2ODc4NDI0MAS2&b=2&j=NDc4NjM5NjgS1&mt=1&rt=0
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Signaling News
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GENETIC PROFILING USED TO TAILOR CANCER THERAPY
http://links.ealert.nature.com/ctt?kn=23&m=32495449&r=MTc2ODc4NDI0MAS2&b=2&j=NDc4NjM5NjgS1&mt=1&rt=0
Molecular profiling has enabled physicians to treat drug-resistant
tumors with custom therapies that specifically target oncogenic
proteins or pathways. According to the results from a pilot study
presented at the American Association for Cancer Research (AACR)
annual meeting, this form of tailored therapy improved
progression-free survival in over a quarter of cancer patients.
More news
http://links.ealert.nature.com/ctt?kn=27&m=32495449&r=MTc2ODc4NDI0MAS2&b=2&j=NDc4NjM5NjgS1&mt=1&rt=0
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Gateway Updates
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RNAi GATEWAY
http://links.ealert.nature.com/ctt?kn=5&m=32495449&r=MTc2ODc4NDI0MAS2&b=2&j=NDc4NjM5NjgS1&mt=1&rt=0
From humble beginnings as an obscure phenomenon in plants, RNA
interference (RNAi) has evolved into an area of significant impact
in numerous fields. The RNAi Gateway provides a convenient portal
into Nature Publishing Group publications relevant to every aspect
of RNAi.
The gateway features a library of relevant reviews and articles
organized by date, subject or organism.
http://links.ealert.nature.com/ctt?kn=21&m=32495449&r=MTc2ODc4NDI0MAS2&b=2&j=NDc4NjM5NjgS1&mt=1&rt=0
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Job of the Week
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Senior Faculty Position in Cancer Research
Employer: Case Western Reserve University
Location: Cleveland, Ohio, USA
http://links.ealert.nature.com/ctt?kn=28&m=32495449&r=MTc2ODc4NDI0MAS2&b=2&j=NDc4NjM5NjgS1&mt=1&rt=0
The Case Comprehensive Cancer Center invites applications for tenured
faculty positions at the level of Associate and Full Professor.
Candidates should have an outstanding record of achievements in
studying the molecular mechanisms underlying cancer biology.
The successful applicant will receive a primary faculty appointment
in the Department of Molecular Biology & Microbiology.
More Jobs:
http://links.ealert.nature.com/ctt?kn=14&m=32495449&r=MTc2ODc4NDI0MAS2&b=2&j=NDc4NjM5NjgS1&mt=1&rt=0
To advertise a job in this spot, please contact Naturejobs.
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