May 2009 Volume 9 Number 5
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Free download alert from Nature Reviews Immunology
Poster on Antigen processing and presentation
Understanding the processes and mechanisms of antigen processing and
presentation provides us with crucial insights necessary for the
design of vaccines and therapeutic strategies to bolster T-cell
responses.
This Poster provides an updated overview of the intracellular
pathways and mechanisms by which antigens are captured, processed and
loaded onto MHC class I, class II and CD1d molecules for presentation
to T cells.
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This month's FEATURED article:
Immunogenic and tolerogenic cell death
Douglas R. Green, Thomas Ferguson, Laurence Zitvogel and Guido
Kroemer
p353 | doi:10.1038/nri2545
http://links.ealert.nature.com/ctt?kn=7&m=32497449&r=MTc2NzU2Mjg3MwS2&b=2&j=NDc4NjcyMjES1&mt=1&rt=0
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From the Editors
p301 | doi:10.1038/nri2558
http://links.ealert.nature.com/ctt?kn=25&m=32497449&r=MTc2NzU2Mjg3MwS2&b=2&j=NDc4NjcyMjES1&mt=1&rt=0
Editorial: Do the terms innate and adaptive immunity create
conceptual barriers?
Lewis L. Lanier and Joseph C. Sun
p302 | doi:10.1038/nri2547
http://links.ealert.nature.com/ctt?kn=22&m=32497449&r=MTc2NzU2Mjg3MwS2&b=2&j=NDc4NjcyMjES1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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T cell development: Open sesame! Thymic entry commands revealed
p305 | doi:10.1038/nri2561
http://links.ealert.nature.com/ctt?kn=97&m=32497449&r=MTc2NzU2Mjg3MwS2&b=2&j=NDc4NjcyMjES1&mt=1&rt=0
T cell activation: Fine-tuning the immunological synapse
p306 | doi:10.1038/nri2557
http://links.ealert.nature.com/ctt?kn=18&m=32497449&r=MTc2NzU2Mjg3MwS2&b=2&j=NDc4NjcyMjES1&mt=1&rt=0
Mucosal immunology: Setting up camp
p306 | doi:10.1038/nri2560
http://links.ealert.nature.com/ctt?kn=87&m=32497449&r=MTc2NzU2Mjg3MwS2&b=2&j=NDc4NjcyMjES1&mt=1&rt=0
Funding watch: Cash injection for US research
p306 | doi:10.1038/nri2562
http://links.ealert.nature.com/ctt?kn=30&m=32497449&r=MTc2NzU2Mjg3MwS2&b=2&j=NDc4NjcyMjES1&mt=1&rt=0
B cell development: Stepping up PAX5 expression
p307 | doi:10.1038/nri2555
http://links.ealert.nature.com/ctt?kn=43&m=32497449&r=MTc2NzU2Mjg3MwS2&b=2&j=NDc4NjcyMjES1&mt=1&rt=0
Innate immunity: Targeting the messenger
p308 | doi:10.1038/nri2552
http://links.ealert.nature.com/ctt?kn=21&m=32497449&r=MTc2NzU2Mjg3MwS2&b=2&j=NDc4NjcyMjES1&mt=1&rt=0
Transplantation: G-CSF therapy after BMT: getting the timing right
p308 | doi:10.1038/nri2559
http://links.ealert.nature.com/ctt?kn=80&m=32497449&r=MTc2NzU2Mjg3MwS2&b=2&j=NDc4NjcyMjES1&mt=1&rt=0
IN BRIEF
Allergy and asthma | T cells | Immune responses
p308 | doi:10.1038/nri2563
http://links.ealert.nature.com/ctt?kn=91&m=32497449&r=MTc2NzU2Mjg3MwS2&b=2&j=NDc4NjcyMjES1&mt=1&rt=0
IN BRIEF
Viral immunity | Antigen presentation | Allergy
p309 | doi:10.1038/nri2564
http://links.ealert.nature.com/ctt?kn=65&m=32497449&r=MTc2NzU2Mjg3MwS2&b=2&j=NDc4NjcyMjES1&mt=1&rt=0
Dendritic cells: Growing up in vivo
p310 | doi:10.1038/nri2551
http://links.ealert.nature.com/ctt?kn=73&m=32497449&r=MTc2NzU2Mjg3MwS2&b=2&j=NDc4NjcyMjES1&mt=1&rt=0
Natural killer T cells: A requirement for WASP
p310 | doi:10.1038/nri2553
http://links.ealert.nature.com/ctt?kn=79&m=32497449&r=MTc2NzU2Mjg3MwS2&b=2&j=NDc4NjcyMjES1&mt=1&rt=0
Regulatory T cells: Taking the right route
p311 | doi:10.1038/nri2556
http://links.ealert.nature.com/ctt?kn=44&m=32497449&r=MTc2NzU2Mjg3MwS2&b=2&j=NDc4NjcyMjES1&mt=1&rt=0
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REVIEWS
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The gut microbiota shapes intestinal immune responses during health
and disease
June L. Round and Sarkis K. Mazmanian
p313 | doi:10.1038/nri2515
Disturbances in the balance between 'good' and 'bad' bacteria that
reside in the gut could underlie the development of inflammatory
bowel diseases, according to the authors of this Review. They
describe how a 'normal' microbiota is required for proper functioning
of the immune system.
Abstract: http://links.ealert.nature.com/ctt?kn=63&m=32497449&r=MTc2NzU2Mjg3MwS2&b=2&j=NDc4NjcyMjES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=33&m=32497449&r=MTc2NzU2Mjg3MwS2&b=2&j=NDc4NjcyMjES1&mt=1&rt=0
Immunoregulatory functions of mTOR inhibition
Angus W. Thomson, Heth R. Turnquist and Giorgio Raimondi
p324 | doi:10.1038/nri2546
Angus Thomson and colleagues describe the consequences of mammalian
target of rapamycin (mTOR) inhibition by rapamycin on dendritic
cells, effector T cells and regulatory T cells. These effects make
mTOR inhibition a promising immunosuppressive, but
tolerance-promoting, therapeutic strategy.
Abstract: http://links.ealert.nature.com/ctt?kn=37&m=32497449&r=MTc2NzU2Mjg3MwS2&b=2&j=NDc4NjcyMjES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=98&m=32497449&r=MTc2NzU2Mjg3MwS2&b=2&j=NDc4NjcyMjES1&mt=1&rt=0
Turning 'sweet' on immunity: galectin-glycan interactions in immune
tolerance and inflammation
Gabriel A. Rabinovich and Marta A. Toscano
p338 | doi:10.1038/nri2536
This Review discusses the importance of galectin-glycan interactions
in regulating T cell survival, activation, cytokine production and
regulatory functions, as well as shaping the B cell compartment.
Targeting these interactions could have important therapeutic
implications for inflammation, autoimmunity and cancer.
Abstract: http://links.ealert.nature.com/ctt?kn=92&m=32497449&r=MTc2NzU2Mjg3MwS2&b=2&j=NDc4NjcyMjES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=3&m=32497449&r=MTc2NzU2Mjg3MwS2&b=2&j=NDc4NjcyMjES1&mt=1&rt=0
Immunogenic and tolerogenic cell death
Douglas R. Green, Thomas Ferguson, Laurence Zitvogel and Guido
Kroemer
p353 | doi:10.1038/nri2545
How should the immune system respond to a dying cell? Should it
ignore it (to allow normal tissue turnover), tolerate it (to prevent
autoimmunity) or respond to it (to clear pathogens or tumours)? This
Review describes our current understanding of the mechanisms involved
in this decision.
Abstract: http://links.ealert.nature.com/ctt?kn=7&m=32497449&r=MTc2NzU2Mjg3MwS2&b=2&j=NDc4NjcyMjES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=76&m=32497449&r=MTc2NzU2Mjg3MwS2&b=2&j=NDc4NjcyMjES1&mt=1&rt=0
Intravascular immunity: the host-pathogen encounter in blood vessels
Michael J. Hickey and Paul Kubes
p364 | doi:10.1038/nri2532
A dynamic face-off occurring in the vasculature between invading
bacterial pathogens and the host immune system is crucial for
limiting the spread of pathogens throughout the body. Recent studies
visualizing these intravascular events reveal the immune mechanisms
that are involved in this process and how bacteria can overcome them.
Abstract: http://links.ealert.nature.com/ctt?kn=78&m=32497449&r=MTc2NzU2Mjg3MwS2&b=2&j=NDc4NjcyMjES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=88&m=32497449&r=MTc2NzU2Mjg3MwS2&b=2&j=NDc4NjcyMjES1&mt=1&rt=0
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PERSPECTIVES
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SCIENCE AND SOCIETY
How cigarette smoke skews immune responses to promote infection, lung
disease and cancer
Martin R. Stampfli and Gary P. Anderson
p377 | doi:10.1038/nri2530
The devastating impact of smoking on health is well known. Here the
authors warn of the complex and multiple adverse effects of cigarette
smoke on the immune system, which increase susceptibility to
respiratory infections, lung pathologies and cancer.
Abstract: http://links.ealert.nature.com/ctt?kn=48&m=32497449&r=MTc2NzU2Mjg3MwS2&b=2&j=NDc4NjcyMjES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=56&m=32497449&r=MTc2NzU2Mjg3MwS2&b=2&j=NDc4NjcyMjES1&mt=1&rt=0
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