May 2009 Volume 9 Number 5
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Nature Reviews Cancer
Focus on Migration and Metastasis
The resurgence of interest in the underlying processes of metastasis has led
to significant new insights and translational developments. The articles in
this Focus on Migration and metastasis discuss the new and re-emerging models
and pathways that have been redefined with regard to their role in metastasis
and metastasis suppression.
The Focus is freely available online at http://links.ealert.nature.com/ctt?kn=38&m=32500849&r=MTc2Njc4NzkyNgS2&b=2&j=NDc4NzI4NjkS1&mt=1&rt=0
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This month's Featured article:
Tumour necrosis factor and cancer
Frances Balkwill
p361 | doi:10.1038/nrc2628
http://links.ealert.nature.com/ctt?kn=61&m=32500849&r=MTc2Njc4NzkyNgS2&b=2&j=NDc4NzI4NjkS1&mt=1&rt=0
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From the editors
p313 | doi:10.1038/nrc2651
http://links.ealert.nature.com/ctt?kn=67&m=32500849&r=MTc2Njc4NzkyNgS2&b=2&j=NDc4NzI4NjkS1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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Therapy: Opposition: biphasic pharmacodynamics
p315 | doi:10.1038/nrc2655
http://links.ealert.nature.com/ctt?kn=81&m=32500849&r=MTc2Njc4NzkyNgS2&b=2&j=NDc4NzI4NjkS1&mt=1&rt=0
Apoptosis: Dodging death
p316 | doi:10.1038/nrc2642
http://links.ealert.nature.com/ctt?kn=86&m=32500849&r=MTc2Njc4NzkyNgS2&b=2&j=NDc4NzI4NjkS1&mt=1&rt=0
Cell cycle: Akt Skps through
p316 | doi:10.1038/nrc2649
http://links.ealert.nature.com/ctt?kn=49&m=32500849&r=MTc2Njc4NzkyNgS2&b=2&j=NDc4NzI4NjkS1&mt=1&rt=0
Therapeutics: Two for one
p316 | doi:10.1038/nrc2653
http://links.ealert.nature.com/ctt?kn=16&m=32500849&r=MTc2Njc4NzkyNgS2&b=2&j=NDc4NzI4NjkS1&mt=1&rt=0
IN BRIEF
Leukaemia | Angiogenesis | Therapy
p317 | doi:10.1038/nrc2652
http://links.ealert.nature.com/ctt?kn=77&m=32500849&r=MTc2Njc4NzkyNgS2&b=2&j=NDc4NzI4NjkS1&mt=1&rt=0
Autophagy: Breaking and exiting
p318 | doi:10.1038/nrc2650
http://links.ealert.nature.com/ctt?kn=57&m=32500849&r=MTc2Njc4NzkyNgS2&b=2&j=NDc4NzI4NjkS1&mt=1&rt=0
Immunotherapy: A hidden target
p318 | doi:10.1038/nrc2654
http://links.ealert.nature.com/ctt?kn=93&m=32500849&r=MTc2Njc4NzkyNgS2&b=2&j=NDc4NzI4NjkS1&mt=1&rt=0
Metabolism: Less is more is mutation dependent
p319 | doi:10.1038/nrc2643
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PROGRESS
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Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics
Mark S. Cragg, Claire Harris, Andreas Strasser and Clare L. Scott
p321 | doi:10.1038/nrc2615
Can combining oncogenic kinase inhibitors with direct activators of the apoptosis machinery, such as the BH3 mimetic ABT-737, produce durable clinical responses in patients with cancer?
Abstract: http://links.ealert.nature.com/ctt?kn=74&m=32500849&r=MTc2Njc4NzkyNgS2&b=2&j=NDc4NzI4NjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=12&m=32500849&r=MTc2Njc4NzkyNgS2&b=2&j=NDc4NzI4NjkS1&mt=1&rt=0
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REVIEWS
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DNA topoisomerase II and its growing repertoire of biological functions
John L. Nitiss
p327 | doi:10.1038/nrc2608
The importance of targeting toposimerase II (TOP2) for the treatment of cancer is not a new concept; however,
understanding of the biological functions of this enzyme has lagged behind the use of the drugs to target it. This Review discusses what we now know about the functions of TOP2.
Abstract: http://links.ealert.nature.com/ctt?kn=23&m=32500849&r=MTc2Njc4NzkyNgS2&b=2&j=NDc4NzI4NjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=64&m=32500849&r=MTc2Njc4NzkyNgS2&b=2&j=NDc4NzI4NjkS1&mt=1&rt=0
Targeting DNA topoisomerase II in cancer chemotherapy
John L. Nitiss
p338 | doi:10.1038/nrc2607
The ability to interfere with topoisomerase II (TOP2) and generate enzyme-mediated DNA damage is an effective strategy for cancer chemotherapy. Can recent studies lead to refined targeting of TOP2 and an improved anticancer strategy?
Abstract: http://links.ealert.nature.com/ctt?kn=88&m=32500849&r=MTc2Njc4NzkyNgS2&b=2&j=NDc4NzI4NjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=39&m=32500849&r=MTc2Njc4NzkyNgS2&b=2&j=NDc4NzI4NjkS1&mt=1&rt=0
Radiation-induced bystander signalling in cancer therapy
Kevin M. Prise and Joe M. O'Sullivan
p351 | doi:10.1038/nrc2603
It has become clear that cell-cell signalling - known as the bystander effect - has an important role in responses to ionizing radiation. What do we know about this effect and how might it affect the response to radiotherapy?
Abstract: http://links.ealert.nature.com/ctt?kn=6&m=32500849&r=MTc2Njc4NzkyNgS2&b=2&j=NDc4NzI4NjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=70&m=32500849&r=MTc2Njc4NzkyNgS2&b=2&j=NDc4NzI4NjkS1&mt=1&rt=0
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PERSPECTIVES
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TIMELINE
Tumour necrosis factor and cancer
Frances Balkwill
p361 | doi:10.1038/nrc2628
Tumour necrosis factor (TNF) was initially isolated as a factor that induced necrosis of cancer cells. However, it has become clear that TNF can also promote cancer. This Timeline examines the long history of TNF in cancer biology, asking whether it is a target, a therapeutic or both.
Abstract: http://links.ealert.nature.com/ctt?kn=61&m=32500849&r=MTc2Njc4NzkyNgS2&b=2&j=NDc4NzI4NjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=8&m=32500849&r=MTc2Njc4NzkyNgS2&b=2&j=NDc4NzI4NjkS1&mt=1&rt=0
OPINION
The ups and downs of p53: understanding protein dynamics in single cells
Eric Batchelor, Alexander Loewer and Galit Lahav
p371 | doi:10.1038/nrc2604
The complex web of regulation that surrounds the tumour suppressor p53 is well known, but few have considered the effect that this has on the dynamics of p53 itself. This forward-looking Perspective speculates on the insights that we might gain by examining the p53 dynamics in individual tumour cells.
Abstract: http://links.ealert.nature.com/ctt?kn=5&m=32500849&r=MTc2Njc4NzkyNgS2&b=2&j=NDc4NzI4NjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=46&m=32500849&r=MTc2Njc4NzkyNgS2&b=2&j=NDc4NzI4NjkS1&mt=1&rt=0
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