April 2009 Volume 10 Number 4
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This month's FEATURED article:
Polo-like kinases: conservation and divergence in their functions
and regulation
Vincent Archambault and David M. Glover
p265 | doi:10.1038/nrm2653
http://links.ealert.nature.com/ctt?kn=34&m=32139462&r=MTc2NzYzNjQ2NgS2&b=2&j=NDY3NjU2MjYS1&mt=1&rt=0
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From the editors
p235 | doi:10.1038/nrm2667
http://links.ealert.nature.com/ctt?kn=3&m=32139462&r=MTc2NzYzNjQ2NgS2&b=2&j=NDY3NjU2MjYS1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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Cell migration: Cells go A-B-C
p237 | doi:10.1038/nrm2658
http://links.ealert.nature.com/ctt?kn=60&m=32139462&r=MTc2NzYzNjQ2NgS2&b=2&j=NDY3NjU2MjYS1&mt=1&rt=0
Calcium: InsP3 hosts a receptor get-together
p238 | doi:10.1038/nrm2660
http://links.ealert.nature.com/ctt?kn=42&m=32139462&r=MTc2NzYzNjQ2NgS2&b=2&j=NDY3NjU2MjYS1&mt=1&rt=0
Plant cell biology: When autumn falls
p238 | doi:10.1038/nrm2662
http://links.ealert.nature.com/ctt?kn=53&m=32139462&r=MTc2NzYzNjQ2NgS2&b=2&j=NDY3NjU2MjYS1&mt=1&rt=0
TECHNOLOGY WATCH
Without a trace | Origin of blood
p238 | doi:10.1038/nrm2664
http://links.ealert.nature.com/ctt?kn=30&m=32139462&r=MTc2NzYzNjQ2NgS2&b=2&j=NDY3NjU2MjYS1&mt=1&rt=0
DNA repair: Persistent breaks
p239 | doi:10.1038/nrm2659
http://links.ealert.nature.com/ctt?kn=87&m=32139462&r=MTc2NzYzNjQ2NgS2&b=2&j=NDY3NjU2MjYS1&mt=1&rt=0
Cell cycle: Push me, pull you
p240 | doi:10.1038/nrm2655
http://links.ealert.nature.com/ctt?kn=71&m=32139462&r=MTc2NzYzNjQ2NgS2&b=2&j=NDY3NjU2MjYS1&mt=1&rt=0
Cytoskeleton: N-WASP turnover: the sting in the actin tail
p240 | doi:10.1038/nrm2661
http://links.ealert.nature.com/ctt?kn=32&m=32139462&r=MTc2NzYzNjQ2NgS2&b=2&j=NDY3NjU2MjYS1&mt=1&rt=0
IN BRIEF
DNA damage response | Prions | Mechanotransduction
p241 | doi:10.1038/nrm2665
http://links.ealert.nature.com/ctt?kn=64&m=32139462&r=MTc2NzYzNjQ2NgS2&b=2&j=NDY3NjU2MjYS1&mt=1&rt=0
Mechanisms of disease: Prions hijack the nanotube
p242 | doi:10.1038/nrm2656
http://links.ealert.nature.com/ctt?kn=54&m=32139462&r=MTc2NzYzNjQ2NgS2&b=2&j=NDY3NjU2MjYS1&mt=1&rt=0
JOURNAL CLUB
The curious case of the ageing cells
p242 | doi:10.1038/nrm2666
http://links.ealert.nature.com/ctt?kn=91&m=32139462&r=MTc2NzYzNjQ2NgS2&b=2&j=NDY3NjU2MjYS1&mt=1&rt=0
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REVIEWS
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The emerging role of nuclear architecture in DNA repair and genome
maintenance
Tom Misteli and Evi Soutoglou
p243 | doi:10.1038/nrm2651
DNA repair occurs in the context of nuclear architecture. Assembly of
the repair machinery on damaged chromatin and the ensuing signalling
events require tight spatial and temporal coordination. Higher-order
chromatin structure, chromatin dynamics and non-random global genome
organization also influence genome maintenance.
Abstract: http://links.ealert.nature.com/ctt?kn=75&m=32139462&r=MTc2NzYzNjQ2NgS2&b=2&j=NDY3NjU2MjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=69&m=32139462&r=MTc2NzYzNjQ2NgS2&b=2&j=NDY3NjU2MjYS1&mt=1&rt=0
Delivering proteins for export from the cytosol
Benedict C. S. Cross, Irmgard Sinning, Joen Luirink and Stephen High
p255 | doi:10.1038/nrm2657
Many proteins must be integrated into or transported across a membrane
to reach their site of function. Whereas ATP-dependent factors bind to
completed polypeptides and chaperone them until membrane translocation
is initiated, a GTP-dependent co-translational pathway couples ongoing
protein synthesis to membrane transport.
Abstract: http://links.ealert.nature.com/ctt?kn=55&m=32139462&r=MTc2NzYzNjQ2NgS2&b=2&j=NDY3NjU2MjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=39&m=32139462&r=MTc2NzYzNjQ2NgS2&b=2&j=NDY3NjU2MjYS1&mt=1&rt=0
Polo-like kinases: conservation and divergence in their functions
and regulation
Vincent Archambault and David M. Glover
p265 | doi:10.1038/nrm2653
Polo-like kinases (Plks) are key regulators of cell division that
are conserved from yeasts to humans. The functions and regulation
of Plks in the cell cycle and in development are being explored
in various organisms.
Abstract: http://links.ealert.nature.com/ctt?kn=11&m=32139462&r=MTc2NzYzNjQ2NgS2&b=2&j=NDY3NjU2MjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=34&m=32139462&r=MTc2NzYzNjQ2NgS2&b=2&j=NDY3NjU2MjYS1&mt=1&rt=0
[beta]-Catenin hits chromatin: regulation of Wnt target gene activation
Christian Mosimann, George Hausmann and Konrad Basler
p276 | doi:10.1038/nrm2654
The canonical Wnt pathway controls metazoan development and tissue
homeostasis, and its disregulation in humans results in cancer.
Transcription of Wnt target genes is regulated by nuclear [beta]-catenin.
How does [beta]-catenin interact with chromatin to regulate Wnt target
gene transcription?
Abstract: http://links.ealert.nature.com/ctt?kn=22&m=32139462&r=MTc2NzYzNjQ2NgS2&b=2&j=NDY3NjU2MjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=8&m=32139462&r=MTc2NzYzNjQ2NgS2&b=2&j=NDY3NjU2MjYS1&mt=1&rt=0
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CORRESPONDENCE
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Correspondence: China's policies on stem cell research: an opportunity
for international collaborations
Xi Jin, Lin Zheng, Ruo-heng Zheng and You-ming Li
p286 | doi:10.1038/nrm2528-c1
http://links.ealert.nature.com/ctt?kn=65&m=32139462&r=MTc2NzYzNjQ2NgS2&b=2&j=NDY3NjU2MjYS1&mt=1&rt=0
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PERSPECTIVES
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OPINION
New roles for endosomes: from vesicular carriers to multi-purpose
platforms
Gwyn W. Gould and Jennifer Lippincott-Schwartz
p287 | doi:10.1038/nrm2652
Endosomes have important roles in processes, including cytokinesis,
polarization and migration, in which their function might be distinct
from those classically associated with endosomes. We speculate that
endosomes function as multifunctional platforms on which unique sets
of molecular machines are assembled to suit different cellular roles.
Abstract: http://links.ealert.nature.com/ctt?kn=70&m=32139462&r=MTc2NzYzNjQ2NgS2&b=2&j=NDY3NjU2MjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=50&m=32139462&r=MTc2NzYzNjQ2NgS2&b=2&j=NDY3NjU2MjYS1&mt=1&rt=0
OPINION
The initial steps of myofibril assembly: integrins pave the way
John C. Sparrow and Frieder Schock
p293 | doi:10.1038/nrm2634
Myofibril assembly results in an array of identical sarcomeres in
striated muscle. Recent studies have begun to unravel the mechanisms
that set sarcomere spacing and the assembly of initial sarcomere arrays,
and point to integrin-dependent adhesion as the starting point for
myofibrillogenesis.
Abstract: http://links.ealert.nature.com/ctt?kn=84&m=32139462&r=MTc2NzYzNjQ2NgS2&b=2&j=NDY3NjU2MjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=81&m=32139462&r=MTc2NzYzNjQ2NgS2&b=2&j=NDY3NjU2MjYS1&mt=1&rt=0
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