Signaling Gateway - 20 March 2009
http://links.ealert.nature.com/ctt?kn=32&m=32088729&r=MTc2ODc4NDI0MAS2&b=2&j=NDY2NzMzMzMS1&mt=1&rt=0
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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CELL CYCLE REGULATION: AKT SKPS THROUGH THE CELL CYCLE
Akt-mediated phosphorylation of Skp2 promotes E3 ubiquitin ligase
complex formation and stimulates p27 ubiquitylation and degradation.
Original research paper: Nature Cell Biology advance online
publication, 8 March 2009
http://links.ealert.nature.com/ctt?kn=27&m=32088729&r=MTc2ODc4NDI0MAS2&b=2&j=NDY2NzMzMzMS1&mt=1&rt=0
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Molecule Pages
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Protein N-myristoyltransferase 2
http://links.ealert.nature.com/ctt?kn=4&m=32088729&r=MTc2ODc4NDI0MAS2&b=2&j=NDY2NzMzMzMS1&mt=1&rt=0
Myristoylation is a co-translational lipid modification of proteins
in which a myristoyl group (a 14-carbon fatty acid) is covalently
attached to the amino terminus of eukaryotic and viral proteins.
This lipidic modification of proteins is catalyzed by the enzyme
N-myristoyltransferase (NMT). NMT2 is overexpressed in human
colorectal cancer compared with normal tissues, with maximal
expression in polyps. Human NMT2 has been shown to interact with
p53, caspase-3 and Bcl2.
Search the molecule pages
http://links.ealert.nature.com/ctt?kn=25&m=32088729&r=MTc2ODc4NDI0MAS2&b=2&j=NDY2NzMzMzMS1&mt=1&rt=0
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Selected Updates
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INFLAMMATION: TAKING AIM IN THE CYTOPLASM
AIM2 (absent in melanoma 2) senses cytoplasmic DNA and associates
with the inflammasome, which leads to caspase 1 activation and the
generation of the mature cytokines that induce innate immune
responses.
Original research paper: Nature advance online publication,
21 January 2009 (doi: 10.1038/nature07710)
http://links.ealert.nature.com/ctt?kn=33&m=32088729&r=MTc2ODc4NDI0MAS2&b=2&j=NDY2NzMzMzMS1&mt=1&rt=0
DEVELOPMENT: DECIPHERING THE WINGLESS GRADIENT
In Drosophila, the Wingless (Wg) morphogen activates two
nonautonomous inhibitory pathways that modulate the reaction of
surrounding cells to the Wg signal, thereby enhancing their ability
to recognize their position within the Wg gradient.
Original research paper: Cell 136, 296-307 (2009)
http://links.ealert.nature.com/ctt?kn=24&m=32088729&r=MTc2ODc4NDI0MAS2&b=2&j=NDY2NzMzMzMS1&mt=1&rt=0
VIROLOGY: E7 TAKES THE FOOT OFF THE BRAKE
Two reports show that the human papillomavirus (HPV) E7 protein can
affect the process of mitosis through multiple mechanisms, shedding
light on how HPV transforms epithelial cells and causes cervical
cancer.
Original research paper: J.Virol. 83, 2756-2764 (2009)
http://links.ealert.nature.com/ctt?kn=28&m=32088729&r=MTc2ODc4NDI0MAS2&b=2&j=NDY2NzMzMzMS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=16&m=32088729&r=MTc2ODc4NDI0MAS2&b=2&j=NDY2NzMzMzMS1&mt=1&rt=0
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Research Library
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OCT1 LOSS OF FUNCTION INDUCES A COORDINATE METABOLIC SHIFT THAT
OPPOSES TUMORIGENICITY
Nature Cell Biology 11, 320-327 (2009)
http://links.ealert.nature.com/ctt?kn=15&m=32088729&r=MTc2ODc4NDI0MAS2&b=2&j=NDY2NzMzMzMS1&mt=1&rt=0
THE GENE ENCODING EARLY GROWTH RESPONSE 2, A TARGET OF THE
TRANSCRIPTION FACTOR NFAT, IS REQUIRED FOR THE DEVELOPMENT AND
MATURATION OF NATURAL KILLER T CELLS
Nature Immunology 10, 306-313 (2009)
http://links.ealert.nature.com/ctt?kn=29&m=32088729&r=MTc2ODc4NDI0MAS2&b=2&j=NDY2NzMzMzMS1&mt=1&rt=0
A CONDITIONAL TRANSPOSON-BASED INSERTIONAL MUTAGENESIS SCREEN FOR
GENES ASSOCIATED WITH MOUSE HEPATOCELLULAR CARCINOMA
Nature Biotechnology 27, 264-274 (2009)
http://links.ealert.nature.com/ctt?kn=2&m=32088729&r=MTc2ODc4NDI0MAS2&b=2&j=NDY2NzMzMzMS1&mt=1&rt=0
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Signaling News
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CELL DEATH AND DIFFERENTIATION: SPECIAL ISSUE ON CELL DEATH MECHANISMS
http://links.ealert.nature.com/ctt?kn=17&m=32088729&r=MTc2ODc4NDI0MAS2&b=2&j=NDY2NzMzMzMS1&mt=1&rt=0
Although cell death occurs in ways ranging from necrosis and
excitotoxicity to autophagy and apoptosis, it follows several common
and evolutionarily conserved mechanisms. This collection of FREE
reviews summarizes our knowledge of the basic mechanisms of cell
death in the context of these different pathological processes.
http://links.ealert.nature.com/ctt?kn=17&m=32088729&r=MTc2ODc4NDI0MAS2&b=2&j=NDY2NzMzMzMS1&mt=1&rt=0
More news
http://links.ealert.nature.com/ctt?kn=23&m=32088729&r=MTc2ODc4NDI0MAS2&b=2&j=NDY2NzMzMzMS1&mt=1&rt=0
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Gateway Updates
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NATURE REPORTS STEM CELLS - MARCH UPDATE
http://links.ealert.nature.com/ctt?kn=11&m=32088729&r=MTc2ODc4NDI0MAS2&b=2&j=NDY2NzMzMzMS1&mt=1&rt=0
Nature Reports Stem Cells aims to enlighten and promote communication
in stem cell research by delivering stem cell science and news to
your desktop.
This month's articles include:
A news feature on the origins of hematopoietic stem cells (HSCs):
http://links.ealert.nature.com/ctt?kn=20&m=32088729&r=MTc2ODc4NDI0MAS2&b=2&j=NDY2NzMzMzMS1&mt=1&rt=0
A highlight on how chemotherapeutics used to target gliomas may
actually increase the cancer stem cell population
http://links.ealert.nature.com/ctt?kn=21&m=32088729&r=MTc2ODc4NDI0MAS2&b=2&j=NDY2NzMzMzMS1&mt=1&rt=0
Sign up to receive the monthly newsletter from
Nature Reports Stem Cells.
http://links.ealert.nature.com/ctt?kn=30&m=32088729&r=MTc2ODc4NDI0MAS2&b=2&j=NDY2NzMzMzMS1&mt=1&rt=0
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Job of the Week
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Computational Postdoctoral position
Employer: Institute for Cancer Research, the Norwegian Radium Hospital
Location: Oslo, Norway
http://links.ealert.nature.com/ctt?kn=9&m=32088729&r=MTc2ODc4NDI0MAS2&b=2&j=NDY2NzMzMzMS1&mt=1&rt=0
A postdoctoral position is available in the Institute for Cancer
Research at the Norwegian Radium Hospital to study the mechanisms of
autophagic degradation of ubiquitin-positive protein aggregates.
These processes will be studied using various biochemical and
molecular techniques in mammalian cells and in Drosophila
melanogaster.
More Jobs:
http://links.ealert.nature.com/ctt?kn=10&m=32088729&r=MTc2ODc4NDI0MAS2&b=2&j=NDY2NzMzMzMS1&mt=1&rt=0
To advertise a job in this spot, please contact Naturejobs.
http://links.ealert.nature.com/ctt?kn=22&m=32088729&r=MTc2ODc4NDI0MAS2&b=2&j=NDY2NzMzMzMS1&mt=1&rt=0
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