April 2009 Volume 6 Number 4
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Introducing: Nature Reviews Cardiology
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RESEARCH HIGHLIGHTS
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Surgery: Insights into patients' outcomes after the Ross procedure
p263 | doi:10.1038/nrcardio.2009.15
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Stress-related behavior and CVD
p264 | doi:10.1038/nrcardio.2009.16
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Hypertension: Aliskerin outshines diuretic
p264 | doi:10.1038/nrcardio.2009.21
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Arrhythmias: Catheter ablation can prevent VT
p265 | doi:10.1038/nrcardio.2009.17
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Acute coronary syndromes: Prehospital ECG improves outcome in STEMI
p265 | doi:10.1038/nrcardio.2009.19
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PAD patients walk to better health
p265 | doi:10.1038/nrcardio.2009.20
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Hypertension: A new marker of irreversible PAH
p266 | doi:10.1038/nrcardio.2009.18
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Coronary artery disease: Measuring FFR improves success of PCI
p266 | doi:10.1038/nrcardio.2009.22
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NEWS AND VIEWS
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Interventional cardiology: Coronary angioplasty: do we need to EuroSCORE?
Scot Garg and Patrick W. Serruys
p267 | doi:10.1038/nrcardio.2009.27
An effective risk score for patients undergoing coronary angioplasty is
yet to be established. In this article we discuss the merits of using the
EuroSCORE risk model for assessing these patients, and propose a potential
modification to the system.
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Cardiomyopathies: The fatty hearts of patients with diabetes
Ildiko Lingvay, Philip Raskin and Lidia S. Szczepaniak
p268 | doi:10.1038/nrcardio.2009.30
Magnetic Resonance Spectroscopy is a novel research tool used to
noninvasively quantify myocardial triglyceride content. This method provides
the opportunity to study myocardial steatosis in patients with diabetes.
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Hypertension: Combination therapy for hypertension
Norman M. Kaplan
p270 | doi:10.1038/nrcardio.2009.31
Two or more drugs are needed to control blood pressure in the majority of
patients with hypertension. The most commonly used combinations include a
diuretic; however, results of two large, controlled trials show that better
cardiovascular protection is provided by a combination of a renin-angiotensin
inhibitor and a long-acting calcium-channel blocker than combinations that
include a diuretic.
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Antiplatelet therapy: The P2Y12 receptor: no active metabolite, no party
Carlo Patrono
p271 | doi:10.1038/nrcardio.2009.29
Poor responders to clopidogrel have low levels of circulating active
metabolite. However, in vitro experiments have shown that blood platelets
from poor responders are fully inhibited by the active metabolite of this
prodrug. Impaired platelet inhibition reflects inadequate plasma levels of
active metabolites, and not differences in platelet P2Y12 receptor function.
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REVIEWS
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Antiplatelet drug 'resistance'. Part 1: mechanisms and clinical measurements
Joseph M. Sweeny, Diana A. Gorog and Valentin Fuster
p273 | doi:10.1038/nrcardio.2009.10
In the first section of this two-part Review, Dr Sweeny and colleagues
explore the phenomenon of 'resistance' to antiplatelet drug therapy. They
discuss the various factors influencing the patient's response to these
drugs, and examine the link between laboratory-assessed nonresposiveness and
clinical outcome.
Abstract: http://links.ealert.nature.com/ctt?kn=19&m=32199957&r=MTc2NDI1MzEzNAS2&b=2&j=NDY4OTE1NDcS1&mt=1&rt=0
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Novel pharmacotherapies to abrogate postinfarction ventricular remodeling
Gerald W. Dorn II
p283 | doi:10.1038/nrcardio.2009.12
Ventricular remodeling occurs over the weeks and months after myocardial
infarction, and, therefore, provides a large temporal therapeutic window.
In this Review, Dr Dorn examines recent developments in pharmacological
treatment of ventricular remodeling in preclinical models of myocardial
infarction.
Abstract: http://links.ealert.nature.com/ctt?kn=5&m=32199957&r=MTc2NDI1MzEzNAS2&b=2&j=NDY4OTE1NDcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=81&m=32199957&r=MTc2NDI1MzEzNAS2&b=2&j=NDY4OTE1NDcS1&mt=1&rt=0
Mechanisms by which exercise training benefits patients with heart failure
Ettore Crimi, Louis J. Ignarro, Francesco Cacciatore and Claudio Napoli
p292 | doi:10.1038/nrcardio.2009.8
Current treatment guidelines recommend exercise training in patients with
heart failure classified as NYHA functional class II and III. This Review
focuses on current knowledge of mechanisms by which progressive and moderate
exercise training can have sustained beneficial effects on these patients.
Abstract: http://links.ealert.nature.com/ctt?kn=62&m=32199957&r=MTc2NDI1MzEzNAS2&b=2&j=NDY4OTE1NDcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=34&m=32199957&r=MTc2NDI1MzEzNAS2&b=2&j=NDY4OTE1NDcS1&mt=1&rt=0
Cardiovascular implications of proteinuria: an indicator of chronic kidney
disease
Varun Agrawal, Victor Marinescu, Mohit Agarwal and Peter A. McCullough
p301 | doi:10.1038/nrcardio.2009.11
Proteinuria often precedes any detectable decline in renal filtration
function and is a strong and independent predictor of increased risk for
all-cause and cardiovascular mortality. In this Review, Dr Agrawal and
colleagues examine potential pathophysiologic mechanisms to explain
simultaneous renal and cardiac disease, as well as therapeutic strategies
for amelioration of proteinuria.
Abstract: http://links.ealert.nature.com/ctt?kn=47&m=32199957&r=MTc2NDI1MzEzNAS2&b=2&j=NDY4OTE1NDcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=11&m=32199957&r=MTc2NDI1MzEzNAS2&b=2&j=NDY4OTE1NDcS1&mt=1&rt=0
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CASE STUDY
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Provokable left ventricular outflow tract obstruction in a patient without
hypertrophy
Ferdinando Pasquale, Maria Teresa Tome-Esteban, Riccardo Morgagni and
Perry Elliott
p313 | doi:10.1038/nrcardio.2009.7
Dr Pasquale and colleagues demonstrate that dynamic left ventricular
outflow tract obstruction was the cause of exertional chest pain and
dyspnea in a patient with no evidence of hypertrophic cardiomyopathy or
ischemic heart disease.
Abstract: http://links.ealert.nature.com/ctt?kn=10&m=32199957&r=MTc2NDI1MzEzNAS2&b=2&j=NDY4OTE1NDcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=84&m=32199957&r=MTc2NDI1MzEzNAS2&b=2&j=NDY4OTE1NDcS1&mt=1&rt=0
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PERSPECTIVES
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OPINION
Developmental origins of hypertrophic cardiomyopathy phenotypes: a unifying
hypothesis
Iacopo Olivotto, Franco Cecchi, Corrado Poggesi and Magdi H. Yacoub
p317 | doi:10.1038/nrcardio.2009.9
In this fascinating Perspective article, the authors propose a novel
hypothesis for the developmental origin of the variable phenotypes seen
in hypertrophic cardiomyopathy (HCM). They suggest that cross-talk between
healthy epicardium-derived cells and abnormally contracting cardiomyocytes
could account for the extramyocardial manifestations of HCM, by a putative
mechanism of mechanotransduction leading to abnormal gene expression and
cell differentiation.
Abstract: http://links.ealert.nature.com/ctt?kn=56&m=32199957&r=MTc2NDI1MzEzNAS2&b=2&j=NDY4OTE1NDcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=42&m=32199957&r=MTc2NDI1MzEzNAS2&b=2&j=NDY4OTE1NDcS1&mt=1&rt=0
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