Signaling Gateway - 27 March 2009
http://links.ealert.nature.com/ctt?kn=33&m=32210333&r=MTc2ODc4NDI0MAS2&b=2&j=NDY5MTExNTIS1&mt=1&rt=0
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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MEK KINASES: DIMERS DIM MAPK SIGNALING
Mek1-Mek2 heterodimer formation is essential for Erk-mediated
attenuation of the Raf-Mek-Erk signaling cascade.
Original research paper: Nature Structural & Molecular Biology 16,
294-303 (2009)
http://links.ealert.nature.com/ctt?kn=27&m=32210333&r=MTc2ODc4NDI0MAS2&b=2&j=NDY5MTExNTIS1&mt=1&rt=0
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Molecule Pages
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VILIP-1
http://links.ealert.nature.com/ctt?kn=3&m=32210333&r=MTc2ODc4NDI0MAS2&b=2&j=NDY5MTExNTIS1&mt=1&rt=0
Visinin-like protein 1 (VILIP-1) belongs to a highly homologous
subfamily of neuronal Ca2+ sensor (NCS) proteins. VILIP-1 is
expressed predominantly in the brain, but lower levels of expression
are found in peripheral organs and in several cancer types, where
the protein exhibits a suppressive function for tumor invasion.
Interestingly, VILIP-1 expression is downregulated in several
neurodegenerative diseases, such as Alzheimer's disease, stroke,
spinal cord injury and amyotrophic lateral sclerosis (ALS).
Also published this week: Rab11a
http://links.ealert.nature.com/ctt?kn=25&m=32210333&r=MTc2ODc4NDI0MAS2&b=2&j=NDY5MTExNTIS1&mt=1&rt=0
Search the molecule pages
http://links.ealert.nature.com/ctt?kn=34&m=32210333&r=MTc2ODc4NDI0MAS2&b=2&j=NDY5MTExNTIS1&mt=1&rt=0
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Selected Updates
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MECHANOTRANSDUCTION: SWITCH AND STRETCH
Two papers provide new insights into the mechanism underlying the
mechanoresponsive activation of alpha5beta1 integrin, as well as the
basis for the interaction between the force-bearing cytoskeleton
protein talin and its binding partner vinculin.
Original research paper: Science 323, 638–641 (2009)
http://links.ealert.nature.com/ctt?kn=24&m=32210333&r=MTc2ODc4NDI0MAS2&b=2&j=NDY5MTExNTIS1&mt=1&rt=0
GENETICS: NETWORKING ON THE FLY
Analysis of gene networks in Drosophila can be an effective method
for identifying new genes that are deregulated in human disease.
Original research paper: Science 323, 1218-1222 (2009)
http://links.ealert.nature.com/ctt?kn=29&m=32210333&r=MTc2ODc4NDI0MAS2&b=2&j=NDY5MTExNTIS1&mt=1&rt=0
OBESITY: REVERSING LEPTIN RESISTANCE
Decreasing endoplasmic reticulum (ER) stress may sensitize the body
to the key metabolic regulator leptin, revealing a potential
therapeutic strategy for obesity.
Original research paper: Cell Metab. 9, 35–51 (2009)
http://links.ealert.nature.com/ctt?kn=15&m=32210333&r=MTc2ODc4NDI0MAS2&b=2&j=NDY5MTExNTIS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=11&m=32210333&r=MTc2ODc4NDI0MAS2&b=2&j=NDY5MTExNTIS1&mt=1&rt=0
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Research Library
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INTERCELLULAR TRANSFER TO SIGNALLING ENDOSOMES REGULATES AN EX VIVO
BONE MARROW NICHE
Nature Cell Biology 11, 303–311 (2009)
http://links.ealert.nature.com/ctt?kn=30&m=32210333&r=MTc2ODc4NDI0MAS2&b=2&j=NDY5MTExNTIS1&mt=1&rt=0
INFLUENCE OF CRACC, A SLAM FAMILY RECEPTOR COUPLED TO THE ADAPTOR
EAT-2, ON NATURAL KILLER CELL FUNCTION
Nature Immunology 10, 297–305 (2009)
http://links.ealert.nature.com/ctt?kn=21&m=32210333&r=MTc2ODc4NDI0MAS2&b=2&j=NDY5MTExNTIS1&mt=1&rt=0
NEUROPROTECTIVE EFFECTS OF BRAIN-DERIVED NEUROTROPHIC FACTOR IN
RODENT AND PRIMATE MODELS OF ALZHEIMER'S DISEASE
Nature Medicine 15, 331–337 (2009)
http://links.ealert.nature.com/ctt?kn=35&m=32210333&r=MTc2ODc4NDI0MAS2&b=2&j=NDY5MTExNTIS1&mt=1&rt=0
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Signaling News
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PROMISCUOUS ANTIBODY TARGETS CANCER
http://links.ealert.nature.com/ctt?kn=12&m=32210333&r=MTc2ODc4NDI0MAS2&b=2&j=NDY5MTExNTIS1&mt=1&rt=0
A report in Science describes an engineered antibody that can
interact simultaneously with vascular endothelial growth factor
(VEGF) and human epidermal growth factor receptor 2 (HER2).
The antibody blocked HER2- and VEGF-mediated cellular proliferation
and slowed tumor progression in mice, suggesting that it could be a
novel means to achieve dual-targeting therapy in cancer.
More news
http://links.ealert.nature.com/ctt?kn=10&m=32210333&r=MTc2ODc4NDI0MAS2&b=2&j=NDY5MTExNTIS1&mt=1&rt=0
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Gateway Updates
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THE FUNCTIONAL GLYCOMICS GATEWAY - MARCH UPDATE
http://links.ealert.nature.com/ctt?kn=20&m=32210333&r=MTc2ODc4NDI0MAS2&b=2&j=NDY5MTExNTIS1&mt=1&rt=0
The Functional Glycomics Gateway is a comprehensive FREE online
resource to keep you abreast of the latest findings in the field.
This month's update features:
Targeted protein transport: Show your sugar pass
http://links.ealert.nature.com/ctt?kn=18&m=32210333&r=MTc2ODc4NDI0MAS2&b=2&j=NDY5MTExNTIS1&mt=1&rt=0
Lung metastasis: Novel carbohydrate receptors open the door
http://links.ealert.nature.com/ctt?kn=31&m=32210333&r=MTc2ODc4NDI0MAS2&b=2&j=NDY5MTExNTIS1&mt=1&rt=0
Sign up to receive the monthly table of contents e-alert for the
Functional Glycomics Update.
http://links.ealert.nature.com/ctt?kn=28&m=32210333&r=MTc2ODc4NDI0MAS2&b=2&j=NDY5MTExNTIS1&mt=1&rt=0
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Job of the Week
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Postdoctoral fellow
Employer: Jersey Medical School
Location: Newark, New Jersey, USA
http://links.ealert.nature.com/ctt?kn=8&m=32210333&r=MTc2ODc4NDI0MAS2&b=2&j=NDY5MTExNTIS1&mt=1&rt=0
A postdoctoral position is available in the newly opened Cancer
Center at the New Jersey Medical School to investigate how genetic
alterations in oncogenic and tumor suppressor signaling pathways
impact normal development and cancer. The successful applicant will
use tissue culture systems and mouse models to delineate various
signaling networks in the hematopoietic system, and prostate and
mammary glands.
More Jobs:
http://links.ealert.nature.com/ctt?kn=9&m=32210333&r=MTc2ODc4NDI0MAS2&b=2&j=NDY5MTExNTIS1&mt=1&rt=0
To advertise a job in this spot, please contact Naturejobs.
http://links.ealert.nature.com/ctt?kn=22&m=32210333&r=MTc2ODc4NDI0MAS2&b=2&j=NDY5MTExNTIS1&mt=1&rt=0
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