January 2009 Volume 10 Number 1
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Nature Reviews Molecular Cell Biology
Focus on Mechanotransduction
Cellular responses to mechanical forces drive morphogenesis, regulate normal physiology and contribute to pathogenesis of many diseases. This special Focus reflects our current understanding of mechanotransduction in processes such as cell adhesion, vascular physiology, development and neurosensing.
The Focus content is FREE during the month of January. To access the Focus articles, visit:
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This month's FEATURED article:
Neurosensory mechanotransduction
Martin Chalfie
p44 | doi:10.1038/nrm2595
http://links.ealert.nature.com/ctt?kn=31&m=30766657&r=MTQ3NDE5NTc5NQS2&b=2&j=NDQzNDI1NDcS1&mt=1&rt=0
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From the editors
p1 | doi:10.1038/nrm2613
http://links.ealert.nature.com/ctt?kn=34&m=30766657&r=MTQ3NDE5NTc5NQS2&b=2&j=NDQzNDI1NDcS1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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Mechanotransduction: Under tension
p3 | doi:10.1038/nrm2606
http://links.ealert.nature.com/ctt?kn=33&m=30766657&r=MTQ3NDE5NTc5NQS2&b=2&j=NDQzNDI1NDcS1&mt=1&rt=0
Protein degradation: Fits like a glove
p4 | doi:10.1038/nrm2601
http://links.ealert.nature.com/ctt?kn=42&m=30766657&r=MTQ3NDE5NTc5NQS2&b=2&j=NDQzNDI1NDcS1&mt=1&rt=0
Protein folding: TRiC revealed
p4 | doi:10.1038/nrm2607
http://links.ealert.nature.com/ctt?kn=65&m=30766657&r=MTQ3NDE5NTc5NQS2&b=2&j=NDQzNDI1NDcS1&mt=1&rt=0
Cell death: DIAP1 puts ubiquitin on drICE
p4 | doi:10.1038/nrm2614
http://links.ealert.nature.com/ctt?kn=86&m=30766657&r=MTQ3NDE5NTc5NQS2&b=2&j=NDQzNDI1NDcS1&mt=1&rt=0
IN BRIEF
Cell death | Organelle dynamics | Protein folding
p5 | doi:10.1038/nrm2615
http://links.ealert.nature.com/ctt?kn=5&m=30766657&r=MTQ3NDE5NTc5NQS2&b=2&j=NDQzNDI1NDcS1&mt=1&rt=0
Mechanotransduction: Bent out of shape
p6 | doi:10.1038/nrm2605
http://links.ealert.nature.com/ctt?kn=43&m=30766657&r=MTQ3NDE5NTc5NQS2&b=2&j=NDQzNDI1NDcS1&mt=1&rt=0
TECHNOLOGY WATCH
Super-resolution imaging | MaxQuant for proteomics
p6 | doi:10.1038/nrm2610
http://links.ealert.nature.com/ctt?kn=74&m=30766657&r=MTQ3NDE5NTc5NQS2&b=2&j=NDQzNDI1NDcS1&mt=1&rt=0
Cell cycle: Destruct and arrest
p6 | doi:10.1038/nrm2612
http://links.ealert.nature.com/ctt?kn=76&m=30766657&r=MTQ3NDE5NTc5NQS2&b=2&j=NDQzNDI1NDcS1&mt=1&rt=0
WEB WATCH
Human protein factory
p7 | doi:10.1038/nrm2611
http://links.ealert.nature.com/ctt?kn=55&m=30766657&r=MTQ3NDE5NTc5NQS2&b=2&j=NDQzNDI1NDcS1&mt=1&rt=0
Nuclear transport: Cell-cycle-regulated mRNA traffic
p8 | doi:10.1038/nrm2599
http://links.ealert.nature.com/ctt?kn=11&m=30766657&r=MTQ3NDE5NTc5NQS2&b=2&j=NDQzNDI1NDcS1&mt=1&rt=0
JOURNAL CLUB
Chromosomes work better when they are tense
p8 | doi:10.1038/nrm2602
http://links.ealert.nature.com/ctt?kn=3&m=30766657&r=MTQ3NDE5NTc5NQS2&b=2&j=NDQzNDI1NDcS1&mt=1&rt=0
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Focus on: Mechanotransduction
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REVIEWS
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Environmental sensing through focal adhesions
Benjamin Geiger, Joachim P. Spatz and Alexander D. Bershadsky
p21 | doi:10.1038/nrm2593
Cells respond to a wide range of signals from the surrounding
extracellular matrix. Research into the complex interplay between cell
adhesion and the cytoskeleton, combined with advanced surface
nanoengineering technologies, can shed light on the mechanisms by
which cells sense the neighbouring nanoenvironment.
Abstract: http://links.ealert.nature.com/ctt?kn=20&m=30766657&r=MTQ3NDE5NTc5NQS2&b=2&j=NDQzNDI1NDcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=35&m=30766657&r=MTQ3NDE5NTc5NQS2&b=2&j=NDQzNDI1NDcS1&mt=1&rt=0
Mechanotransduction in development: a growing role for contractility
Michele A. Wozniak and Christopher S. Chen
p34 | doi:10.1038/nrm2592
Mechanical forces regulate basic cellular processes, such as proliferation,
differentiation and tissue organization during embryogenesis. What are the
mechanisms that underlie force-induced mechanotransduction during development?
And what is the role of actomyosin-mediated contractile forces in the
regulation of cell and tissue structure and function?
Abstract: http://links.ealert.nature.com/ctt?kn=45&m=30766657&r=MTQ3NDE5NTc5NQS2&b=2&j=NDQzNDI1NDcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=62&m=30766657&r=MTQ3NDE5NTc5NQS2&b=2&j=NDQzNDI1NDcS1&mt=1&rt=0
Neurosensory mechanotransduction
Martin Chalfie
p44 | doi:10.1038/nrm2595
Neurons that sense touch, sound and acceleration respond rapidly to specific
mechanical signals. But what are the proteins that transduce these signals?
Current studies are directed towards characterizing channel proteins as
candidate transduction molecules and determining how they are mechanically gated.
Abstract: http://links.ealert.nature.com/ctt?kn=52&m=30766657&r=MTQ3NDE5NTc5NQS2&b=2&j=NDQzNDI1NDcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=66&m=30766657&r=MTQ3NDE5NTc5NQS2&b=2&j=NDQzNDI1NDcS1&mt=1&rt=0
Mechanotransduction in vascular physiology and atherogenesis
Cornelia Hahn and Martin A. Schwartz
p53 | doi:10.1038/nrm2596
Blood flow is crucial for vascular morphogenesis and physiology. Endothelial
cells respond to blood flow by transducing mechanical forces into biochemical
signals that regulate cellular responses. Chronic exposure to disturbed flow
causes the constant activation of these cellular responses, which cause
vessel dysfunction and disease.
Abstract: http://links.ealert.nature.com/ctt?kn=4&m=30766657&r=MTQ3NDE5NTc5NQS2&b=2&j=NDQzNDI1NDcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=75&m=30766657&r=MTQ3NDE5NTc5NQS2&b=2&j=NDQzNDI1NDcS1&mt=1&rt=0
Mechanotransduction gone awry
Diana E. Jaalouk and Jan Lammerding
p63 | doi:10.1038/nrm2597
Cells sense their physical surroundings by translating mechanical forces
and deformations into biochemical signals. Defects in mechanotransduction
are implicated in the development of many diseases, ranging from muscular
dystrophies, cardiomyopathies and loss of hearing to cancer progression
and metastasis.
Abstract: http://links.ealert.nature.com/ctt?kn=46&m=30766657&r=MTQ3NDE5NTc5NQS2&b=2&j=NDQzNDI1NDcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=39&m=30766657&r=MTQ3NDE5NTc5NQS2&b=2&j=NDQzNDI1NDcS1&mt=1&rt=0
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Focus on: Mechanotransduction
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PERSPECTIVE
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OPINION
Mechanotransduction at a distance: mechanically coupling the extracellular
matrix with the nucleus
Ning Wang, Jessica D. Tytell and Donald E. Ingber
p75 | doi:10.1038/nrm2594
Mechanical forces that are exerted on surface-adhesion receptors can be
channelled along cytoskeletal filaments and concentrated at distant sites
in the cytoplasm and nucleus. How do these forces act at a distance to
induce mechanochemical conversion in the nucleus, and what effects can
they have on the cell?
Abstract: http://links.ealert.nature.com/ctt?kn=1&m=30766657&r=MTQ3NDE5NTc5NQS2&b=2&j=NDQzNDI1NDcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=17&m=30766657&r=MTQ3NDE5NTc5NQS2&b=2&j=NDQzNDI1NDcS1&mt=1&rt=0
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REVIEW
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The 3Ms of central spindle assembly: microtubules, motors and MAPs
Michael Glotzer
p9 | doi:10.1038/nrm2609
During anaphase, the mitotic spindle reorganizes in preparation for cytokinesis.
Kinesin motor proteins and microtubule-associated proteins (MAPs) bundle
the interpolar microtubule plus ends and generate the central spindle,
which regulates cleavage furrow initiation and the completion of cytokinesis.
Abstract: http://links.ealert.nature.com/ctt?kn=37&m=30766657&r=MTQ3NDE5NTc5NQS2&b=2&j=NDQzNDI1NDcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=84&m=30766657&r=MTQ3NDE5NTc5NQS2&b=2&j=NDQzNDI1NDcS1&mt=1&rt=0
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