January 2009 Volume 9 Number 1
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Genetics and Genomics of Infectious Diseases 2009
March 21-24, 2009
Ritz Carlton Millenia, Singapore
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=========================== ADVERTISEMENT ===========================
This month's FEATURED article:
Harnessing invariant NKT cells in vaccination strategies
Vincenzo Cerundolo, Jonathan D. Silk, S. Hajar Masri and Mariolina
Salio
p28 | doi:10.1038/nri2451
http://links.ealert.nature.com/ctt?kn=18&m=30766632&r=MTUwNzk4Njk3OAS2&b=2&j=NDQzNDIxODIS1&mt=1&rt=0
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From the editors
p1 | doi:10.1038/nri2486
http://links.ealert.nature.com/ctt?kn=29&m=30766632&r=MTUwNzk4Njk3OAS2&b=2&j=NDQzNDIxODIS1&mt=1&rt=0
----------------------
RESEARCH HIGHLIGHTS
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T-cell development: Thymocytes run the 'gauntlet'
p2 | doi:10.1038/nri2480
http://links.ealert.nature.com/ctt?kn=45&m=30766632&r=MTUwNzk4Njk3OAS2&b=2&j=NDQzNDIxODIS1&mt=1&rt=0
Immune tolerance: A T-cell-independent function for AIRE?
p3 | doi:10.1038/nri2475
http://links.ealert.nature.com/ctt?kn=31&m=30766632&r=MTUwNzk4Njk3OAS2&b=2&j=NDQzNDIxODIS1&mt=1&rt=0
IN BRIEF
Apoptosis | Tumour immunology | Immunotherapy
p3 | doi:10.1038/nri2485
http://links.ealert.nature.com/ctt?kn=67&m=30766632&r=MTUwNzk4Njk3OAS2&b=2&j=NDQzNDIxODIS1&mt=1&rt=0
Vaccines: Predicting immunity
p4 | doi:10.1038/nri2478
http://links.ealert.nature.com/ctt?kn=81&m=30766632&r=MTUwNzk4Njk3OAS2&b=2&j=NDQzNDIxODIS1&mt=1&rt=0
Immune regulation: Tightening responses by TIGIT
p5 | doi:10.1038/nri2482
http://links.ealert.nature.com/ctt?kn=55&m=30766632&r=MTUwNzk4Njk3OAS2&b=2&j=NDQzNDIxODIS1&mt=1&rt=0
IN THE NEWS
Hopeful beginnings
p5 | doi:10.1038/nri2483
http://links.ealert.nature.com/ctt?kn=86&m=30766632&r=MTUwNzk4Njk3OAS2&b=2&j=NDQzNDIxODIS1&mt=1&rt=0
Inflammation: Recruitment freeze
p6 | doi:10.1038/nri2472
http://links.ealert.nature.com/ctt?kn=69&m=30766632&r=MTUwNzk4Njk3OAS2&b=2&j=NDQzNDIxODIS1&mt=1&rt=0
Allergy: Allergic mimicry
p6 | doi:10.1038/nri2479
http://links.ealert.nature.com/ctt?kn=13&m=30766632&r=MTUwNzk4Njk3OAS2&b=2&j=NDQzNDIxODIS1&mt=1&rt=0
Dendritic cells: Assessing cross-presentation in vivo
p7 | doi:10.1038/nri2481
http://links.ealert.nature.com/ctt?kn=36&m=30766632&r=MTUwNzk4Njk3OAS2&b=2&j=NDQzNDIxODIS1&mt=1&rt=0
Immune responses: Rearranging the cytoskeleton
p8 | doi:10.1038/nri2477
http://links.ealert.nature.com/ctt?kn=87&m=30766632&r=MTUwNzk4Njk3OAS2&b=2&j=NDQzNDIxODIS1&mt=1&rt=0
IN BRIEF
Immune responses | Thymocyte development | Innate immunity
p8 | doi:10.1038/nri2484
http://links.ealert.nature.com/ctt?kn=19&m=30766632&r=MTUwNzk4Njk3OAS2&b=2&j=NDQzNDIxODIS1&mt=1&rt=0
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PROGRESS
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Newly discovered roles for basophils: a neglected minority gains new
respect
Hajime Karasuyama, Kaori Mukai, Yusuke Tsujimura and Kazushige Obata
p9 | doi:10.1038/nri2458
Basophils, often regarded as a lesser relative to the mast cell, are
now proving to have important, non-redundant roles in immune
responses. This Progress article updates us on the latest studies
that identify new roles for basophils in allergic reactions and
immune regulation.
Abstract: http://links.ealert.nature.com/ctt?kn=62&m=30766632&r=MTUwNzk4Njk3OAS2&b=2&j=NDQzNDIxODIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=41&m=30766632&r=MTUwNzk4Njk3OAS2&b=2&j=NDQzNDIxODIS1&mt=1&rt=0
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REVIEWS
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The who, how and where of antigen presentation to B cells
Facundo D. Batista and Naomi E. Harwood
p15 | doi:10.1038/nri2454
How B cells see antigen has been an area of intense research for many
years. Here, recent advances in our understanding of the specific
sites, cells and molecules that are involved in the presentation of
antigen to B cells are discussed.
Abstract: http://links.ealert.nature.com/ctt?kn=49&m=30766632&r=MTUwNzk4Njk3OAS2&b=2&j=NDQzNDIxODIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=71&m=30766632&r=MTUwNzk4Njk3OAS2&b=2&j=NDQzNDIxODIS1&mt=1&rt=0
Harnessing invariant NKT cells in vaccination strategies
Vincenzo Cerundolo, Jonathan D. Silk, S. Hajar Masri and Mariolina
Salio
p28 | doi:10.1038/nri2451
Targeting invariant natural killer T (iNKT) cells could be a good way
to boost vaccine responses, according to recent studies reviewed here.
Structural and functional analyses of iNKT-cell ligands are helping
to direct approaches that harness the capacity of iNKT cells to
enhance immune responses.
Abstract: http://links.ealert.nature.com/ctt?kn=37&m=30766632&r=MTUwNzk4Njk3OAS2&b=2&j=NDQzNDIxODIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=23&m=30766632&r=MTUwNzk4Njk3OAS2&b=2&j=NDQzNDIxODIS1&mt=1&rt=0
SLAM receptors and SAP influence lymphocyte interactions, development
and function
Pamela L. Schwartzberg, Kristen L. Mueller, Hai Qi and
Jennifer L. Cannons
p39 | doi:10.1038/nri2456
This article discusses the recently identified role of SLAM-associated
protein (SAP) - which mediates signals from signalling lymphocytic
activation molecule (SLAM) receptors - in regulating interactions
between lymphocytes in the thymus and germinal centres, and suggests
that SAP and SLAM family members have roles in lymphocyte adhesion
that affect development and differentiation.
Abstract: http://links.ealert.nature.com/ctt?kn=50&m=30766632&r=MTUwNzk4Njk3OAS2&b=2&j=NDQzNDIxODIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=20&m=30766632&r=MTUwNzk4Njk3OAS2&b=2&j=NDQzNDIxODIS1&mt=1&rt=0
Scaffold proteins and immune-cell signalling
Andrey S. Shaw and Erin L. Filbert
p47 | doi:10.1038/nri2473
Scaffold proteins are known to have an important role in signal
transduction but their mechanisms of activation are still unclear. In
this Review, recent studies that have shed light on the function of
cytoplasmic scaffold proteins in immune-cell signalling are discussed.
Abstract: http://links.ealert.nature.com/ctt?kn=28&m=30766632&r=MTUwNzk4Njk3OAS2&b=2&j=NDQzNDIxODIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=75&m=30766632&r=MTUwNzk4Njk3OAS2&b=2&j=NDQzNDIxODIS1&mt=1&rt=0
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PERSPECTIVES
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SCIENCE AND SOCIETY
The ageing immune system: is it ever too old to become young again?
Kenneth Dorshkind, Encarnacion Montecino-Rodriguez and
Robert A. J. Signer
p57 | doi:10.1038/nri2471
As a result of advances in medicine, public-health policies and
socioeconomic development, we are living longer than ever before.
Here, the authors describe how ageing affects immune function and
discuss the potential of different therapies to slow or reverse this
process in the elderly population.
Abstract: http://links.ealert.nature.com/ctt?kn=22&m=30766632&r=MTUwNzk4Njk3OAS2&b=2&j=NDQzNDIxODIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=52&m=30766632&r=MTUwNzk4Njk3OAS2&b=2&j=NDQzNDIxODIS1&mt=1&rt=0
OPINION
Annexin A1 and glucocorticoids as effectors of the resolution of
inflammation
Mauro Perretti and Fulvio D'Acquisto
p62 | doi:10.1038/nri2470
In this Opinion article, the effector function of annexin A1 in the
anti-inflammatory action of glucocorticoids is discussed, and a model
to address the opposing effects of glucocorticoids on the expression
of annexin A1 by different immune cells is proposed.
Abstract: http://links.ealert.nature.com/ctt?kn=42&m=30766632&r=MTUwNzk4Njk3OAS2&b=2&j=NDQzNDIxODIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=24&m=30766632&r=MTUwNzk4Njk3OAS2&b=2&j=NDQzNDIxODIS1&mt=1&rt=0
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