November 2008 Volume 8 Number 11
Visit Nature Reviews Cancer online to browse the journal.
Now available at http://ealerts.nature.com/cgi-bin24/DM/y/eoPY0Xztnp0Hja0cZl0Ep
Please note that you need to be a subscriber to enjoy full text access
to Nature Reviews Cancer online. To purchase a subscription,
please visit: http://ealerts.nature.com/cgi-bin24/DM/y/eoPY0Xztnp0Hja0a5J0Ec
Alternatively, to recommend a subscription to your library, please visit
http://ealerts.nature.com/cgi-bin24/DM/y/eoPY0Xztnp0Hja0sRD0EJ
*********************************************************************
Nature Reviews Cancer Impact Factor: 29.19 *
(*Journal Citation Reports, Thomson, 2007)
*********************************************************************
=====================================================================
New! WideScreen Biomarker Assays
http://ealerts.nature.com/cgi-bin24/DM/y/eoPY0Xztnp0Hja0B8km0EW
Accelerate your drug discovery and preclinical studies by using
multiplex immunoassays developed by EMD and RBM.
To ensure gold standard quality data, and to maximize the knowledge
gained from precious, often limited samples, the panels are validated
using CLSI/NCCLS quality standards.
http://ealerts.nature.com/cgi-bin24/DM/y/eoPY0Xztnp0Hja0B8mO0E3
=====================================================================
=====================================================================
IT'S NOW FREE TO POST YOUR VACANCY ON
naturejobs.com http://ealerts.nature.com/cgi-bin24/DM/y/eoPY0Xztnp0Hja0bZD0EA
It's the breakthrough you've been waiting for. Naturejobs.com —
the scientific jobs board from Nature —
now lets you advertise your vacancy completely FREE OF CHARGE
Go to http://ealerts.nature.com/cgi-bin24/DM/y/eoPY0Xztnp0Hja0BGJp0EH or telephone:
Europe: +44 (0) 20 78434961
US: + 1 800 9897718
=====================================================================
=====================================================================
Cancer Research UK's research is innovative and ambitious and is helping
more and more people to survive cancer. We believe that the successful
recruitment and retention of staff is vital to our continuing success.
For information about our current vacancies visit
http://ealerts.nature.com/cgi-bin24/DM/y/eoPY0Xztnp0Hja0BvhW0E8
=====================================================================
=====================================================================
Nature Reviews Genetics and Nature Genetics
A Look at Next-Generation Sequencing Technologies
DNA sequencing is undergoing a revolution. Sanger
sequencing has reached its limits and is being
replaced by a new generation of technologies that
promise faster and cheaper delivery of sequencing
information. Nature Genetics and Nature Reviews
Genetics present a Poster and Podcast that explore
the conceptual basis of these next-generation
sequencing technologies, their myriad applications
and challenges for the future.
Access the FREE Poster and Podcast online!
http://ealerts.nature.com/cgi-bin24/DM/y/eoPY0Xztnp0Hja0B77i0EZ
Produced with support from:
Applied Biosystems
http://ealerts.nature.com/cgi-bin24/DM/y/eoPY0Xztnp0Hja0B77j0Ea
=====================================================================
=====================================================================
This month's FEATURED article:
The von Hippel–Lindau tumour suppressor protein: O2 sensing and cancer
William G. Kaelin Jr
p865 | doi:10.1038/nrc2502
http://ealerts.nature.com/cgi-bin24/DM/y/eoPY0Xztnp0Hja0B8ke0EO
=====================================================================
From the editors
p825 | doi:10.1038/nrc2535
http://ealerts.nature.com/cgi-bin24/DM/y/eoPY0Xztnp0Hja0B8kN0Ez
----------------------
RESEARCH HIGHLIGHTS
----------------------
Immunology: An unexpected complement
p827 | doi:10.1038/nrc2531
http://ealerts.nature.com/cgi-bin24/DM/y/eoPY0Xztnp0Hja0B8kO0E1
Angiogenesis: Multipotent tumour endothelial cells
p828 | doi:10.1038/nrc2526
http://ealerts.nature.com/cgi-bin24/DM/y/eoPY0Xztnp0Hja0B8kP0E2
Metastasis: A sweet sabre promotes cell invasion
p828 | doi:10.1038/nrc2532
http://ealerts.nature.com/cgi-bin24/DM/y/eoPY0Xztnp0Hja0B8kQ0E3
TRIAL WATCH
Inhibiting survivin | Prenatal environment and breast cancer risk
p828 | doi:10.1038/nrc2534
http://ealerts.nature.com/cgi-bin24/DM/y/eoPY0Xztnp0Hja0B8kR0E4
Tumorigenesis: Keeping a watchful eye
p829 | doi:10.1038/nrc2530
http://ealerts.nature.com/cgi-bin24/DM/y/eoPY0Xztnp0Hja0B8kS0E5
Radiotherapy: Worming your way to cell death
p830 | doi:10.1038/nrc2533
http://ealerts.nature.com/cgi-bin24/DM/y/eoPY0Xztnp0Hja0B8kT0E6
IN THE NEWS
Vitamin C: friend or foe?
p830 | doi:10.1038/nrc2537
http://ealerts.nature.com/cgi-bin24/DM/y/eoPY0Xztnp0Hja0B8kU0E7
IN BRIEF
Tumorigenesis | Genomic instability | Cell cycle | Signalling
p831 | doi:10.1038/nrc2538
http://ealerts.nature.com/cgi-bin24/DM/y/eoPY0Xztnp0Hja0B8kV0E8
Metastasis: Preparing the soil
p832 | doi:10.1038/nrc2525
http://ealerts.nature.com/cgi-bin24/DM/y/eoPY0Xztnp0Hja0B8kW0EA
Tumorigenesis: It's a knockout!
p832 | doi:10.1038/nrc2527
http://ealerts.nature.com/cgi-bin24/DM/y/eoPY0Xztnp0Hja0B8kX0EB
Genetics: ALK takes the rap
p833 | doi:10.1038/nrc2529
http://ealerts.nature.com/cgi-bin24/DM/y/eoPY0Xztnp0Hja0B8kY0EC
----------------------
REVIEWS
----------------------
Derailed endocytosis: an emerging feature of cancer
Yaron Mosesson, Gordon B. Mills and Yosef Yarden
p835 | doi:10.1038/nrc2521
Oncogenic alteration of the endocytic machinery is a hallmark of cancer.
As reviewed here, these alterations can lead to changes in morphology,
polarity, motility, adhesion and growth factor-activated signalling
pathways.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoPY0Xztnp0Hja0B8kZ0ED
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoPY0Xztnp0Hja0B8ka0EK
Hypoxia signalling through mTOR and the unfolded protein response in cancer
Bradly G. Wouters and Marianne Koritzinsky
p851 | doi:10.1038/nrc2501
Responses to hypoxia are orchestrated not only through activation of the
hypoxia-inducible factor family of transcription factors (HIFs), but also
through HIF-independent signalling pathways. How are these pathways integrated?
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoPY0Xztnp0Hja0B8kb0EL
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoPY0Xztnp0Hja0B8kc0EM
The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer
William G. Kaelin Jr
p865 | doi:10.1038/nrc2502
Deregulation of hypoxia-inducible factor (HIF) is an established feature of
tumours that develop in patients with von Hippel-Lindau disease, caused by
inactivating germline mutations of the VHL tumour suppressor gene. However,
HIF-independent activities of VHL also seem to be important for the
pathogenesis of the disease.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoPY0Xztnp0Hja0B8kd0EN
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoPY0Xztnp0Hja0B8ke0EO
----------------------
PERSPECTIVES
----------------------
OPINION
Ageing, oxidative stress and cancer: paradigms in parallax
Christopher C. Benz and Christina Yau
p875 | doi:10.1038/nrc2522
Ageing is thought to be associated with increased oxidative stress and
increased cancer risk. However, recent evidence that breast cancers
arising in older women are not associated with oxidative stress questions
the link between age and increasing oxidative stress. Does ageing cause or
simply permit cancer development?
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoPY0Xztnp0Hja0B8kf0EP
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoPY0Xztnp0Hja0B8kg0EQ
OPINION
VEGF-A splicing: the key to anti-angiogenic therapeutics?
Steven J. Harper and David O. Bates
p880 | doi:10.1038/nrc2505
Recent data indicates an anti-angiogenic function for a new class of VEGF-A
isoforms. In this Opinion article, Steven Harper and David Bates discuss the
emerging role of these proteins in tumourigenesis and anti-angiogenic
therapeutic strategies.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoPY0Xztnp0Hja0B8kh0ER
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoPY0Xztnp0Hja0B8ki0ES
OPINION
Cytokines and their relationship to the symptoms and outcome of cancer
Bostjan Seruga, Haibo Zhang, Lori J. Bernstein and Ian F. Tannock
p887 | doi:10.1038/nrc2507
In patients with advanced cancer, pro-inflammatory cytokines are associated with
anorexia and cachexia, pain, fatigue, depression, toxicity of treatment and
resistance to treatment. What is our current understanding of the pathways that
mediate these effects and how can we prevent them?
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoPY0Xztnp0Hja0B8kj0ET
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoPY0Xztnp0Hja0B8kk0EU
=====================================================================
Natureevents Directory 2009
Want to inform a potential one million scientists about your
scientific events, courses and conferences?
Natureevents Directory 2009 is now in its 10th year.
Click here to find out how to be included.
http://ealerts.nature.com/cgi-bin24/DM/y/eoPY0Xztnp0Hja0B6rM0E4
=====================================================================
You have been sent this Table of Contents Alert because you have opted in to
receive it. You can change or discontinue your e-mail alerts at any time,
by modifying your preferences on your nature.com account at:
http://ealerts.nature.com/cgi-bin24/DM/y/eoPY0Xztnp0Hja0Zzu0EN
(You will need to log in to be recognised as a nature.com registrant).
For further technical assistance, please contact our registration department:
registration@nature.com
For print subscription enquiries, please contact our subscription department:
subscriptions@nature.com
For other enquiries, please contact our customer feedback department:
feedback@nature.com
Nature Publishing Group | 75 Varick Street, 9th Floor | New York |
NY 10013-1917 | USA
Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne -
San Diego - San Francisco - Washington - New York - Boston
(c) Copyright 2008 Nature Publishing Group
=====================================================================
