Signaling Gateway - 24 October 2008
http://ealerts.nature.com/cgi-bin24/DM/y/eoPe0Xztnp0H2W0M40E8
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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http://ealerts.nature.com/cgi-bin24/DM/y/eoPe0Xztnp0H2W0B78e0Ec
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In Signaling Update this week:
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Featured Article
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GLIOBLASTOMA: AN ATLAS OF SIGNALING PATHWAYS
The Cancer Genome Atlas Research Network has generated a
comprehensive data set of proteins and signaling pathways that are
deregulated in glioblastoma, which can be used to explore the
molecular mechanisms of tumorigenesis and inform the development of
targeted therapies.
Original research paper: Nature 455, 1061-1068 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eoPe0Xztnp0H2W0vP0EI
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Molecule Pages
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The Molecule Pages - A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
Ksr1
http://ealerts.nature.com/cgi-bin24/DM/y/eoPe0Xztnp0H2W0B8mD0Ex
KSR1 is a member of the Kinase Suppressor of Ras (KSR) family of
proteins, which function as scaffolds for the ERK cascade. Members of
the KSR family interact with the core kinase components of the ERK
cascade - Raf, MEK and ERK - and provide spatial and temporal
regulation of Ras-dependent ERK cascade signaling. The KSR1 scaffold
complex also contains numerous other signaling proteins that can
impact ERK cascade activation, as well as the duration and amplitude
of ERK cascade signaling.
Also published this week:
Dok2
http://ealerts.nature.com/cgi-bin24/DM/y/eoPe0Xztnp0H2W0B8mE0Ey
Dyrk1a:
http://ealerts.nature.com/cgi-bin24/DM/y/eoPe0Xztnp0H2W0B8mF0Ez
Search the molecule pages
http://ealerts.nature.com/cgi-bin24/DM/y/eoPe0Xztnp0H2W0BUuz0EU
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Selected Updates
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INNATE IMMUNITY: STING: ADDING TO THE ANTIVIRAL ARSENAL
STING (stimulator of interferon (IFN) genes) is an ER adaptor protein
that mediates host responses to pathogen-derived nucleic acids.
Original research paper: Nature 455, 674-678 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eoPe0Xztnp0H2W0B8mG0E1
TUMORIGENESIS: TAKING THE MYC
Expression of a dominant-negative MYC mutant known as Omomyc reduces
lung tumor volume in mice without causing obvious side effects,
suggesting that MYC inhibition might be an effective anticancer
strategy.
Original research paper: Nature 455, 679-683 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eoPe0Xztnp0H2W0B8mH0E2
AUTOIMMUNE DISEASE: BLOCKING THE DRIVERS
The protein kinase C (PKC) inhibitor AEB071 has potential as a novel
treatment for psoriasis and other human diseases that are associated
with aberrant T-cell activation.
Original research paper: J. Clin. Invest. 118, 3151-3159 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eoPe0Xztnp0H2W0B8mI0E3
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/eoPe0Xztnp0H2W0vO0EH
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Research Library
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SOMATIC MUTATIONS AFFECT KEY PATHWAYS IN LUNG ADENOCARCINOMA
Nature 455, 1069-1075 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eoPe0Xztnp0H2W0B8mJ0E4
JADE-1 INHIBITS WNT SIGNALLING BY UBIQUITYLATING [beta]-CATENIN AND
MEDIATES WNT PATHWAY INHIBITION BY pVHL
Nature Cell Biology 10, 1208-1216 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eoPe0Xztnp0H2W0B8mK0E5
KRAS REGULATORY ELEMENTS AND EXON 4A DETERMINE MUTATION SPECIFICITY
IN LUNG CANCER
Nature Genetics 40, 1240-1244 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eoPe0Xztnp0H2W0B8mL0E6
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Signaling News
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WEB FOCUS ON METABOLIC SYNDROME
http://ealerts.nature.com/cgi-bin24/DM/y/eoPe0Xztnp0H2W0B7MF0ES
This free collection of Nature Publishing Group articles highlights
the various medical conditions that make up what is commonly referred
to as Metabolic Syndrome. The syndrome, which affects nearly
50 million Americans, is a cluster of conditions that occur together
and increase the risk for heart disease, stroke and diabetes.
This web focus provides valuable insight into this emerging medical
and public health epidemic.
More News
http://ealerts.nature.com/cgi-bin24/DM/y/eoPe0Xztnp0H2W0Crw0Ey
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Gateway Updates
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PSI-NATURE STRUCTURAL GENOMICS KNOWLEDGEBASE — OCTOBER UPDATE
http://ealerts.nature.com/cgi-bin24/DM/y/eoPe0Xztnp0H2W0B5yq0Er
The Structural Genomics Knowledgebase is a free portal to research
data and other resources from the Protein Structure Initiative for
structural biologists to keep informed of the latest developments in
their field. This month's update features the following articles:
Antiviral evasion
http://ealerts.nature.com/cgi-bin24/DM/y/eoPe0Xztnp0H2W0B7Xd0E8
A new metal-binding domain
http://ealerts.nature.com/cgi-bin24/DM/y/eoPe0Xztnp0H2W0B7Xe0EA
The bacteriophage lambda cII protein
http://ealerts.nature.com/cgi-bin24/DM/y/eoPe0Xztnp0H2W0B8mM0E7
Sign up to receive monthly updates from the PSI-Nature Structural
Genomics Knowledgebase.
http://ealerts.nature.com/cgi-bin24/DM/y/eoPe0Xztnp0H2W0B5ys0Et
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Signaling Job of the Week
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Program Director and Assistant Professor
Employer: University of Florida
Location: Gainesville, Florida
http://ealerts.nature.com/cgi-bin24/DM/y/eoPe0Xztnp0H2W0B8mN0E8
The Department of Urology at the University of Florida College of
Medicine is seeking a Program Director and Assistant Professor.
The ideal candidate will have an established record of scientific
accomplishment in cell signaling and cancer biology and should be
prepared to work with a research team to develop innovative clinical
trials for the treatment of genitourinary cancers.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/eoPe0Xztnp0H2W0BnjC0En
To advertise a job in this spot, please contact Naturejobs.
http://ealerts.nature.com/cgi-bin24/DM/y/eoPe0Xztnp0H2W0vqs0Ek
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http://ealerts.nature.com/cgi-bin24/DM/y/eoPe0Xztnp0H2W0dIO0EC
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