June 2008 Volume 8 Number 6
Visit Nature Reviews Cancer online to browse the journal.
Now available at http://ealerts.nature.com/cgi-bin24/DM/y/ek4G0Xztnp0Hja0cZl0Ez
Please note that you need to be a subscriber to enjoy full text access to Nature Reviews Cancer online.
To purchase a subscription, please visit:
http://ealerts.nature.com/cgi-bin24/DM/y/ek4G0Xztnp0Hja0a5J0Em
Alternatively, to recommend a subscription to your library, please visit
http://ealerts.nature.com/cgi-bin24/DM/y/ek4G0Xztnp0Hja0sRD0ET
*********************************************************************
Nature Reviews Cancer Impact Factor: 31.583*
(*Journal Citation Reports, Thomson, 2006)
*********************************************************************
=====================================================================
IT'S NOW FREE TO POST YOUR VACANCY ON
naturejobs.com http://ealerts.nature.com/cgi-bin24/DM/y/ek4G0Xztnp0Hja0bZD0EK
It's the breakthrough you've been waiting for. Naturejobs.com — the scientific jobs board from Nature —
now lets you advertise your vacancy completely FREE OF CHARGE
Go to http://ealerts.nature.com/cgi-bin24/DM/y/ek4G0Xztnp0Hja0BGJp0ER or telephone:
Europe: +44 (0) 20 78434961
US: + 1 800 9897718
=====================================================================
=====================================================================
Cancer Research UK's research is innovative and ambitious and is helping
more and more people to survive cancer. We believe that the successful
recruitment and retention of staff is vital to our continuing success.
For information about our current vacancies visit
http://ealerts.nature.com/cgi-bin24/DM/y/ek4G0Xztnp0Hja0BvhW0EJ
=====================================================================
=====================================================================
Nature Reviews Stem Cell Collection
Free online access
Stem-cell research has a history of more than 20 years, and has made
some outstanding contributions to our understanding of haematopoiesis
and embryology. The Nature Reviews journals present a Stem Cell
Collection, which includes Research Highlights, Reviews and Perspectives
articles from Nature Reviews Cancer, Nature Reviews Immunology and
Nature Reviews Molecular Cell Biology.
All these articles will be available free online for six months at:
http://ealerts.nature.com/cgi-bin24/DM/y/ek4G0Xztnp0Hja0Bqfi0EU
=====================================================================
=====================================================================
This month's FEATURED article:
Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
Mark W. Dewhirst, Yiting Cao and Benjamin Moeller
p425 | doi:10.1038/nrc2397
http://ealerts.nature.com/cgi-bin24/DM/y/ek4G0Xztnp0Hja0BvhX0EK
=====================================================================
From the editors
p405 | doi:10.1038/nrc2417
http://ealerts.nature.com/cgi-bin24/DM/y/ek4G0Xztnp0Hja0BvhY0EL
----------------------
RESEARCH HIGHLIGHTS
----------------------
Leukaemia: A provoking end?
p407 | doi:10.1038/nrc2412
http://ealerts.nature.com/cgi-bin24/DM/y/ek4G0Xztnp0Hja0BvhZ0EM
Oncogenesis: A sideways move?
p408 | doi:10.1038/nrc2405
http://ealerts.nature.com/cgi-bin24/DM/y/ek4G0Xztnp0Hja0Bvha0ET
Imaging: Early detection for pancreatic cancer
p408 | doi:10.1038/nrc2407
http://ealerts.nature.com/cgi-bin24/DM/y/ek4G0Xztnp0Hja0Bvhb0EU
TRIAL WATCH
Prickly promise
p408 | doi:10.1038/nrc2416
http://ealerts.nature.com/cgi-bin24/DM/y/ek4G0Xztnp0Hja0Bvhc0EV
Metastasis: Trading in mitochondria
p409 | doi:10.1038/nrc2411
http://ealerts.nature.com/cgi-bin24/DM/y/ek4G0Xztnp0Hja0Bvhd0EW
Microenvironment: What do your surroundings mean?
Published online: 15 May 2008
p410 | doi:10.1038/nrc2409
http://ealerts.nature.com/cgi-bin24/DM/y/ek4G0Xztnp0Hja0Bvhe0EX
Metastasis: Which way to the lungs?
p410 | doi:10.1038/nrc2410
http://ealerts.nature.com/cgi-bin24/DM/y/ek4G0Xztnp0Hja0Bvhf0EY
IN THE NEWS
Ensuring a good collection
p410 | doi:10.1038/nrc2415
http://ealerts.nature.com/cgi-bin24/DM/y/ek4G0Xztnp0Hja0Bvhg0EZ
IN BRIEF
Metabolism | Angiogenesis | Non-coding RNAS
p411 | doi:10.1038/nrc2414
http://ealerts.nature.com/cgi-bin24/DM/y/ek4G0Xztnp0Hja0Bvhh0Ea
Therapy: Reversed protection
p412 | doi:10.1038/nrc2406
http://ealerts.nature.com/cgi-bin24/DM/y/ek4G0Xztnp0Hja0Bvhi0Eb
Cell polarity: APC throws the anchor
p412 | doi:10.1038/nrc2413
http://ealerts.nature.com/cgi-bin24/DM/y/ek4G0Xztnp0Hja0Bvhj0Ec
Cell signalling: Dynamic redistribution
p413 | doi:10.1038/nrc2408
http://ealerts.nature.com/cgi-bin24/DM/y/ek4G0Xztnp0Hja0Bvhk0Ed
=====================================================================
The Affymetrix Solution for Integrated Genomics
Register for the Integrated Genomics Seminar Series
and learn how you can achieve focused discovery and
faster validation in your cancer studies. Study copy
number, LOH, gene and exon expression and more with
a single sample and two arrays.
http://ealerts.nature.com/cgi-bin24/DM/y/ek4G0Xztnp0Hja0Bvhl0Ee
=====================================================================
----------------------
REVIEWS
----------------------
Colonic crypt organization and tumorigenesis
Adam Humphries and Nicholas A. Wright
p415 | doi:10.1038/nrc2392
Recent advances in our understanding of intestinal crypt biology, including how mutations in stem cells become fixed and expand within the epithelium, has led to new theories on the origins of colonic adenomas and cancers.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ek4G0Xztnp0Hja0Bvhm0Ef
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ek4G0Xztnp0Hja0Bvhn0Eg
Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
Mark W. Dewhirst, Yiting Cao and Benjamin Moeller
p425 | doi:10.1038/nrc2397
Hypoxia and free radicals, such as reactive oxygen and nitrogen species, alter the activity of the transcription factor HIF1, which can regulate tumour cell survival and angiogenesis. Intratumoural heterogeneity of these factors significantly affects HIF1 and consequently the response to cytotoxic therapy.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ek4G0Xztnp0Hja0Bvho0Eh
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ek4G0Xztnp0Hja0BvhX0EK
Deregulated proteolysis by the F-box proteins SKP2 and [beta]-TrCP: tipping the scales of cancer
David Frescas and Michele Pagano
p438 | doi:10.1038/nrc2396
Cell cycle progression is regulated by phosphorylation and protein degradation, which is mediated by ubiquitin ligases. This Review explores the relevance of two ubiquitin ligase specificity factors (F-box proteins) that are emerging as important players in tumour development.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ek4G0Xztnp0Hja0Bvhp0Ei
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ek4G0Xztnp0Hja0Bvhq0Ej
Telomere dysfunction and tumour suppression: the senescence connection
Yibin Deng, Suzanne S. Chan and Sandy Chang
p450 | doi:10.1038/nrc2393
Using recent evidence from mouse models, this Review discusses whether p53-dependent senescence induced by dysfunctional telomeres is as potent as apoptosis in suppressing tumorigenesis in vivo.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ek4G0Xztnp0Hja0Bvhr0Ek
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ek4G0Xztnp0Hja0Bvhs0El
----------------------
PERSPECTIVES
----------------------
INNOVATION
The Mouse Tumor Biology database
Debra M. Krupke, Dale A. Begley, John P. Sundberg, Carol J. Bult and Janan T. Eppig
p459 | doi:10.1038/nrc2390
The Mouse Tumor Biology database seeks to facilitate the researcher's access to the ever increasing amount of data now being published using mouse models of cancer. Why is this database important and how does it relate to similar databases within the cancer research community?
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ek4G0Xztnp0Hja0Bvht0Em
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ek4G0Xztnp0Hja0Bvhu0En
SCIENCE AND SOCIETY
Heavy ion carcinogenesis and human space exploration
Marco Durante and Francis A. Cucinotta
p465 | doi:10.1038/nrc2391
The next generation of space missions will involve much longer exposures of astronauts to space radiation. Predicting what this means for cancer risk is a crucial but difficult task.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ek4G0Xztnp0Hja0Bvhv0Eo
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ek4G0Xztnp0Hja0Bvhw0Ep
TIMELINE
Paul Ehrlich's magic bullet concept: 100 years of progress
Klaus Strebhardt and Axel Ullrich
Published online: 12 May 2008
p473 | doi:10.1038/nrc2394
One hundred years ago, Paul Ehrlich received the Nobel Prize for Physiology or Medicine. His idea of creating 'magic bullets' for use in the fight against human diseases has inspired generations of scientists to devise powerful molecular cancer therapeutics.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ek4G0Xztnp0Hja0Bvhx0Eq
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ek4G0Xztnp0Hja0Bvhy0Er
=====================================================================
Cell Death & Differentiation presents 'Biology of hypoxia-inducible factors'
at http://ealerts.nature.com/cgi-bin24/DM/y/ek4G0Xztnp0Hja0BviU0EI
as the third special issue of 2008.
'Biology of hypoxia-inducible factors'features 10 review articles focusing on the regulators and biological consequences of HIF activation. To read the full selection of reviews from 'Biology of Hypoxia-inducible factors',
please visit the Special Issues online at:
http://ealerts.nature.com/cgi-bin24/DM/y/ek4G0Xztnp0Hja0BviV0EJ
=====================================================================
You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at:
http://ealerts.nature.com/cgi-bin24/DM/y/ek4G0Xztnp0Hja0Zzu0EX
(You will need to log in to be recognised as a nature.com registrant).
For further technical assistance, please contact our registration department:
registration@nature.com
For print subscription enquiries, please contact our subscription department:
subscriptions@nature.com
For other enquiries, please contact our customer feedback department:
feedback@nature.com
Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA
Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne -
San Diego - San Francisco - Washington - New York - Boston
(c) Copyright 2008 Nature Publishing Group
=====================================================================
