June 2008 Volume 8 Number 6
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Nature Reviews Immunology
Focus on Mucosal Immunology
The field of mucosal immunology is undergoing a revival.
Nature Reviews Immunology is proud to present a special Focus issue
highlighting the recent advances in this field, including insights into
HIV infection, mucosal vaccines, immune regulation and its relationship
to inflammation, inflammatory bowel disease and the immunological
importance of epithelial cells.
Access the Focus free online for 6 months:
http://ealerts.nature.com/cgi-bin24/DM/y/ek2U0Xztnp0Hjd0BvbQ0EM
Produced in collaboration with FOCIS and supported by Beckman Coulter.
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This month's FEATURED article:
Setting the stage: host invasion by HIV
Florian Hladik and M. Juliana McElrath
p447 | doi:10.1038/nri2302
http://ealerts.nature.com/cgi-bin24/DM/y/ek2U0Xztnp0Hjd0BvbR0EN
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From the editors
p399 | doi:10.1038/nri2350
http://ealerts.nature.com/cgi-bin24/DM/y/ek2U0Xztnp0Hjd0BvbS0EO
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RESEARCH HIGHLIGHTS
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Lymphoid architecture: Restoration project
p400 | doi:10.1038/nri2344
http://ealerts.nature.com/cgi-bin24/DM/y/ek2U0Xztnp0Hjd0BvbT0EP
Innate immunity: Linking hypoxia and NF-[kappa]B
p401 | doi:10.1038/nri2341
http://ealerts.nature.com/cgi-bin24/DM/y/ek2U0Xztnp0Hjd0BvbU0EQ
IN BRIEF
Mucosal immunology | Immunogenetics | Mucosal immunology
p401 | doi:10.1038/nri2349
http://ealerts.nature.com/cgi-bin24/DM/y/ek2U0Xztnp0Hjd0BvbV0ER
Autoimmunity: Type I interferon target revealed
p402 | doi:10.1038/nri2339
http://ealerts.nature.com/cgi-bin24/DM/y/ek2U0Xztnp0Hjd0BvbW0ES
Mucosal vaccines: NKT cells help fight flu
p402 | doi:10.1038/nri2345
http://ealerts.nature.com/cgi-bin24/DM/y/ek2U0Xztnp0Hjd0BvbX0ET
Regulatory T cells: Lending a hand to protective immunity
p402 | doi:10.1038/nri2352
http://ealerts.nature.com/cgi-bin24/DM/y/ek2U0Xztnp0Hjd0BvbY0EU
IN BRIEF
Immune regulation | B-cell signalling | NKT cells
p403 | doi:10.1038/nri2354
http://ealerts.nature.com/cgi-bin24/DM/y/ek2U0Xztnp0Hjd0BvbZ0EV
T-cell signalling: ITAMs: quantity over quality
p404 | doi:10.1038/nri2351
http://ealerts.nature.com/cgi-bin24/DM/y/ek2U0Xztnp0Hjd0Bvba0Ec
Thymocyte development: Making a commitment
p404 | doi:10.1038/nri2353
http://ealerts.nature.com/cgi-bin24/DM/y/ek2U0Xztnp0Hjd0Bvbb0Ed
Cytokines: Keep your partner close
p405 | doi:10.1038/nri2348
http://ealerts.nature.com/cgi-bin24/DM/y/ek2U0Xztnp0Hjd0Bvbc0Ee
T-cell responses: DCs get KITted out
p406 | doi:10.1038/nri2346
http://ealerts.nature.com/cgi-bin24/DM/y/ek2U0Xztnp0Hjd0Bvbd0Ef
IN THE NEWS
Outmanoeuvering HIV
p406 | doi:10.1038/nri2347
http://ealerts.nature.com/cgi-bin24/DM/y/ek2U0Xztnp0Hjd0Bvbe0Eg
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FOREWORD
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Mucosal matters
Gerald T. Nepom
p409 | doi:10.1038/nri2342
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ek2U0Xztnp0Hjd0Bvbf0Eh
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ek2U0Xztnp0Hjd0Bvbg0Ei
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Focus on: Mucosal Immunology
http://ealerts.nature.com/cgi-bin24/DM/y/ek2U0Xztnp0Hjd0Bvbh0Ej
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REVIEWS
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Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut
David Artis
p411 | doi:10.1038/nri2316
It was thought that intestinal epithelial cells functioned solely as a barrier to the external environment, but as described here, these cells are now known to have an integral role in facilitating and controlling crosstalk between commensal bacteria and the immune system.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ek2U0Xztnp0Hjd0Bvbi0Ek
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ek2U0Xztnp0Hjd0Bvbj0El
The regulation of IgA class switching
Andrea Cerutti
p421 | doi:10.1038/nri2322
IgA is the most abundant antibody class and provides a first line of defence at mucosal surfaces. Class switching to IgA occurs through both T-cell-dependent and T-cell-independent pathways, and recent studies reveal a role for commensal bacteria in intestinal IgA responses.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ek2U0Xztnp0Hjd0Bvbk0Em
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ek2U0Xztnp0Hjd0Bvbl0En
Dendritic cells in intestinal immune regulation
Janine L. Coombes and Fiona Powrie
p435 | doi:10.1038/nri2335
A delicate balance between tolerance to commensal bacteria and immunity to pathogens occurs in the intestine. Intestinal dendritic cells have a central role in maintaining this balance and, as described here, some of the molecular pathways involved have recently been resolved.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ek2U0Xztnp0Hjd0Bvbm0Eo
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ek2U0Xztnp0Hjd0Bvbn0Ep
Setting the stage: host invasion by HIV
Florian Hladik and M. Juliana McElrath
p447 | doi:10.1038/nri2302
Infection by HIV requires the virus to breach the mucosal barrier to gain access to the immune cells that it infects. But what are the immediate events that follow HIV exposure at genital mucosal sites and what are the key cells that facilitate HIV invasion?
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ek2U0Xztnp0Hjd0BvbR0EN
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ek2U0Xztnp0Hjd0Bvbo0Eq
The genetics and immunopathogenesis of inflammatory bowel disease
Judy H. Cho
p458 | doi:10.1038/nri2340
Great progress has been made recently in the identification of genes or genetic loci that are associated with inflammatory bowel diseases. This knowledge is now providing insight into the pathogenesis of these diseases, highlighting roles for genes involved in bacterial sensing and cytokine signalling.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ek2U0Xztnp0Hjd0Bvbp0Er
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ek2U0Xztnp0Hjd0Bvbq0Es
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REVIEWS
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Inhibitory B7-family molecules in the tumour microenvironment
Weiping Zou and Lieping Chen
p467 | doi:10.1038/nri2326
This Review describes how the expression of inhibitory members of the B7 family, particularly B7-H1 and B7-H4, by cancer cells, stromal cells and haematopoietic cells in the tumour microenvironment is regulated and acts to inhibit T-cell immunity, as well as the therapeutic implications.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ek2U0Xztnp0Hjd0Bvbr0Et
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ek2U0Xztnp0Hjd0Bvbs0Eu
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PERSPECTIVE
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OPINION
Immunomodulatory mast cells: negative, as well as positive, regulators of immunity
Stephen J. Galli, Michele Grimbaldeston and Mindy Tsai
p478 | doi:10.1038/nri2327
In this Opinion article, Stephen Galli and colleagues discuss the recent evidence that mast cells can have negative, as well as positive, immunomodulatory functions, and suggest that mast cells might have distinct roles at different phases of an immune response.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ek2U0Xztnp0Hjd0Bvbt0Ev
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ek2U0Xztnp0Hjd0Bvbu0Ew
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CORRESPONDENCE
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Correspondence: B-cell-derived interleukin-10 in autoimmune disease: regulating the regulators
Aja Rieger and Amit Bar-Or
Published online: 23 June 2008
p486 | doi:10.1038/nri2315-c1
http://ealerts.nature.com/cgi-bin24/DM/y/ek2U0Xztnp0Hjd0Bvbw0Ey
Corrigendum: T-cell quality in memory and protection: implications for vaccine design
Robert A. Seder, Patricia A. Darrah and Mario Roederer
p486 | doi:10.1038/nri2355
http://ealerts.nature.com/cgi-bin24/DM/y/ek2U0Xztnp0Hjd0Bvbv0Ex
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NATURE IMMUNOLOGY
FOCUS ON NATURAL KILLER CELLS
Natural killer cells influence immune responses to tumors, infections
and pregnancy. Nature Immunology presents a series of specially
commissioned articles that focus on natural killer cells and their
far-reaching effects on diverse cell types and biological responses.
The web focus, free for six months, also includes highlights of recent
research findings, an annotated list of classic articles and links to
selected NPG papers pertinent to this field.
For more information visit:
http://ealerts.nature.com/cgi-bin24/DM/y/ek2U0Xztnp0Hjd0BssN0EX
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