June 2008 Volume 9 Number 6
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Breaking Down Memories
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T Cells Work Away from Home
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Original reference: Science 319, 198-202 (2008)
Protective medicine under the tongue
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This month's FEATURED article:
Spatial and temporal coordination of mitosis by Ran GTPase
Paul R. Clarke and Chuanmao Zhang
p464 | doi:10.1038/nrm2410
http://ealerts.nature.com/cgi-bin24/DM/y/ek4Q0Xztnp0Hjf0Bvjh0Er
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From the editors
p421 | doi:10.1038/nrm2425
http://ealerts.nature.com/cgi-bin24/DM/y/ek4Q0Xztnp0Hjf0Bvji0Es
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RESEARCH HIGHLIGHTS
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Cellular microbiology: Virus plays dead
p422 | doi:10.1038/nrm2420
http://ealerts.nature.com/cgi-bin24/DM/y/ek4Q0Xztnp0Hjf0Bvjs0E3
DNA repair: Working on different ends
p423 | doi:10.1038/nrm2411
http://ealerts.nature.com/cgi-bin24/DM/y/ek4Q0Xztnp0Hjf0Bvjk0Eu
Cell signalling: Dynamic redistribution
p423 | doi:10.1038/nrm2413
http://ealerts.nature.com/cgi-bin24/DM/y/ek4Q0Xztnp0Hjf0Bvjp0Ez
DNA replication: Follow the path
p424 | doi:10.1038/nrm2409
http://ealerts.nature.com/cgi-bin24/DM/y/ek4Q0Xztnp0Hjf0Bvjl0Ev
Cell signalling: A Rac1-JNK2-[beta]-catenin domino cascade
p424 | doi:10.1038/nrm2412
http://ealerts.nature.com/cgi-bin24/DM/y/ek4Q0Xztnp0Hjf0Bvjm0Ew
IN THE NEWS
'Skin deep' goes to a new depth
p424 | doi:10.1038/nrm2418
http://ealerts.nature.com/cgi-bin24/DM/y/ek4Q0Xztnp0Hjf0Bvjn0Ex
IN BRIEF
DNA replication | DNA repair | Nuclear envelope
p425 | doi:10.1038/nrm2423
http://ealerts.nature.com/cgi-bin24/DM/y/ek4Q0Xztnp0Hjf0Bvjo0Ey
Cell migration: The importance of being selective
p426 | doi:10.1038/nrm2422
http://ealerts.nature.com/cgi-bin24/DM/y/ek4Q0Xztnp0Hjf0Bvjq0E1
Small RNAs: Endo-siRNAs truly endogenous
p426 | doi:10.1038/nrm2424
http://ealerts.nature.com/cgi-bin24/DM/y/ek4Q0Xztnp0Hjf0Bvjr0E2
Gene expression: Pioneering research
p427 | doi:10.1038/nrm2416
http://ealerts.nature.com/cgi-bin24/DM/y/ek4Q0Xztnp0Hjf0Bvjj0Et
AN INTERVIEW WITH...
Joan Steitz
p428 | doi:10.1038/nrm2421
http://ealerts.nature.com/cgi-bin24/DM/y/ek4Q0Xztnp0Hjf0Bvjt0E4
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PROGRESS
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Membrane nanotubes: dynamic long-distance connections between animal cells
Daniel M. Davis and Stefanie Sowinski
p431 | doi:10.1038/nrm2399
Membrane nanotubes are thin extensions of the plasma membrane that connect cells transiently and might facilitate intercellular communication. Recent studies have revealed considerable heterogeneity in their structure, formation, mode of cargo transport and functional properties, depending on the cell types involved.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ek4Q0Xztnp0Hjf0Bvju0E5
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ek4Q0Xztnp0Hjf0Bvjv0E6
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REVIEWS
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Multiple roles for lipids in the Hedgehog signalling pathway
Suzanne Eaton
p437 | doi:10.1038/nrm2414
Sterols and sterol derivatives modulate the Hedgehog (Hh) pathway at multiple levels. Progress in understanding Hh signalling will depend on deepening our knowledge of the cell biology of sterol metabolism and trafficking.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ek4Q0Xztnp0Hjf0Bvjw0E7
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ek4Q0Xztnp0Hjf0Bvjx0E8
Filopodia: molecular architecture and cellular functions
Pieta K. Mattila and Pekka Lappalainen
p446 | doi:10.1038/nrm2406
Filopodia are thin, actin-rich, finger-like structures that are involved in numerous cellular processes, such as cell migration, wound healing, neurite outgrowth and embryonic development. But what are the mechanisms that regulate filopodia formation in distinct cell types?
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ek4Q0Xztnp0Hjf0Bvjy0EA
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ek4Q0Xztnp0Hjf0Bvjz0EB
Changing directions in the study of chemotaxis
Robert R. Kay, Paul Langridge, David Traynor and Oliver Hoeller
p455 | doi:10.1038/nrm2419
Chemotaxis enables immune cells to reach sites of infection, wounds to heal and the formation of embryonic patterns. Recent results have shed light on how cells orientate in chemotactic gradients, the forces that enable pseudopodia projection and the role of the endocytic cycle in movement.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ek4Q0Xztnp0Hjf0Bvj10Ew
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ek4Q0Xztnp0Hjf0Bvj20Ex
Spatial and temporal coordination of mitosis by Ran GTPase
Paul R. Clarke and Chuanmao Zhang
p464 | doi:10.1038/nrm2410
The small nuclear GTPase Ran controls the directionality of macromolecular transport between the nucleus and the cytoplasm. Ran also has important roles during mitosis and directs nuclear-envelope dynamics, assembly of the mitotic spindle and the timing of cell-cycle transitions.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ek4Q0Xztnp0Hjf0Bvjh0Er
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ek4Q0Xztnp0Hjf0Bvj30Ey
The septin family of GTPases: architecture and dynamics
Christine S. Weirich, Jan P. Erzberger and Yves Barral
p478 | doi:10.1038/nrm2407
How do septins, GTP-binding proteins, function in a wide range of cellular processes, such as cell division, cytoskeletal organization and membrane remodelling? Electron microscopy and crystallographic studies provide a glimpse into septin-complex assembly that could answer this question.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ek4Q0Xztnp0Hjf0Bvj40Ez
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ek4Q0Xztnp0Hjf0Bvj50E1
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PERSPECTIVE
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ESSAY
How to succeed in science: a concise guide for young biomedical scientists. Part II: making discoveries
Jonathan W. Yewdell
p491 | doi:10.1038/nrm2390
Making discoveries is the most important part of being a scientist, and also the most fun. This article provides practical advice to young scientists on choosing a research topic, on designing, performing and interpreting experiments and on maintaining their sanity in the process.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ek4Q0Xztnp0Hjf0Bvj60E2
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ek4Q0Xztnp0Hjf0Bvj70E3
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