28 February 2008 Volume 451 Number 7182, p1029-1138
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Malaria
The malaria crisis is starting to yield to new tools and new strategies,
made possible by a substantial increase in resources over the past ten
years - from less than $100 million to almost $1 billion this year. Is it
enough to provide the killer blow? In Nature this week find a commentary by
Mark Grabowsky of the Global Fund on how these funds should best be spent,
alongside news features on the hunt for a malarial vaccine, and a case report
from Zambia. For all this and more, visit the Nature News malaria special, at:
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Booo0EL
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EDITORIALS
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A new Silver Age? p1029
The Spanish government has doubled research spending in four years.
The next government must create the legal structures to ensure that
this money is wisely spent.
doi:10.1038/4511029a
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Boop0EM
Lone Star vs creationism p1030
The battle against anti-scientific literalism continues.
Next stop Texas.
doi:10.1038/4511030a
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Booq0EN
Time to take control p1030
With money now flowing in, the fight against malaria must shift from
advocacy to getting results.
doi:10.1038/4511030b
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Boor0EO
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RESEARCH HIGHLIGHTS
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Research highlights p1032-1033
doi:10.1038/4511032a
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Boos0EP
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JOURNAL CLUB
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Journal club p1033
Eric J. Nestler
doi:10.1038/4511033a
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Boot0EQ
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NEWS
----------------------
Animal-rights activists invade Europe p1034-1035
Experts fear extremists may be travelling from Britain.
Geoff Brumfiel
doi:10.1038/4511034a
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Boou0ER
Acclaimed photo was faked p1034-1035
Chinese prizewinner merged two images.
Jane Qiu
doi:10.1038/4511034b
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Boov0ES
Revamp for NIH grants p1035
US funding body slims down application process.
Meredith Wadman
doi:10.1038/4511035a
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Boow0ET
The aftermath of independence p1036-1036
The formerly Serbian province of Kosovo unilaterally declared its
independence on 17 February. Some 10,000 Serbian students and academics
live in enclaves in the ethnically divided city of Kosovska Mitrovica
in the north of the new country dominated by Kosovar Albanians.
Endocrinologist Aleksandar Jovanovic, vice-rector for science and
international relations at the University of Mitrovica, discusses
recent events.
Quirin Schiermeier
doi:10.1038/4511036a
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Boox0EU
Neglected diseases get vaccine research boost p1037-1037
Drug company opens non-profit centre in Italy.
Alison Abbott
doi:10.1038/4511037a
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Booy0EV
Snapshot: 'Doomsday vault' opens p1037-1037
Michael Hopkin
doi:10.1038/4511037b
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Booz0EW
Sidelines p1037-1037
Scribbles on the margins of science.
doi:10.1038/4511037c
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Boo10EJ
Iran refuses to cooperate with atomic agency p1038-1038
IAEA report highlights unanswered questions.
Declan Butler
doi:10.1038/4511038a
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Boo20EK
First chapter of book of life goes live p1038-1039
Online encyclopedia launches first data.
Emma Marris
doi:10.1038/4511038b
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Boo30EL
Meat meter measures marbled muscles p1039
Scientists devise way to measure tastiness of meat.
David Cyranoski
doi:10.1038/4511039a
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Boo40EM
English grants under review p1039
Funding agency ditches peer review in favour of metrics.
Daniel Cressey
doi:10.1038/4511039b
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Boo50EN
Strict ordering slashes tarmac time p1040
Physicist identifies fastest way to board aircraft.
Philip Ball
doi:10.1038/4511040a
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Boo60EO
UCLA wins restraining order against activists p1041-1041
doi:10.1038/4511041a
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Boo70EP
Indonesia relents over bird-flu sample release p1041-1041
doi:10.1038/4511041b
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Boo80EQ
Biosafety lapses cost Texas A&M $1 million p1041
doi:10.1038/4511041c
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0BopA0Ea
US missile destroys toxic tank on spy satellite p1041-1041
doi:10.1038/4511041d
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0BopB0Eb
Florida adopts teaching of evolution in its schools p1041-1041
doi:10.1038/4511041e
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0BopC0Ec
Grey wolf no longer in danger, says US government p1041-1041
doi:10.1038/4511041f
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0BopD0Ed
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NEWS FEATURES
----------------------
Malaria: The end of the beginning p1042-1046
After decades of work, a pioneering malaria vaccine may soon reach
the final phase of clinical trials. In the first of two features
on efforts against malaria, Brendan Maher reports on a vaccine that
is far from perfect — but which may provide new direction and save
thousands of lives.
doi:10.1038/4511042a
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0BopE0Ee
Malaria: The big push p1047-1049
Zambia, with help from partners around the world, is stepping up
its battle against malaria. Michael Hopkin reports from the rural
front line.
doi:10.1038/4511047a
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0BopF0Ef
----------------------
CORRESPONDENCE
----------------------
Political debate: science will be the loser p1050
Daniel Sarewitz
doi:10.1038/4511050a
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0BopG0Eg
Political debate: it is a risk, but one that's worth taking p1050
Neal Lane
doi:10.1038/4511050b
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0BopH0Eh
Government subsidized by academia on conservation p1050
Philip Wheeler
doi:10.1038/4511050c
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0BopI0Ei
Celebrations for Darwin downplay Wallace's role p1050
George W. Beccaloni and Vincent S. Smith
doi:10.1038/4511050d
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0BopJ0Ej
----------------------
COMMENTARY
----------------------
The billion-dollar malaria moment p1051-1052
For years the global malaria effort has been asking for more resources.
Now the field needs to figure out a systematic strategy for spending
the money effectively, says Mark Grabowsky.
Mark Grabowsky
doi:10.1038/4511051a
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0BopK0Ek
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BOOKS AND ARTS
----------------------
Pest friends in the Cretaceous p1053
Fossils preserved in amber hint at surprising links between dinosaurs and
their insect contemporaries.
Karen Chin reviews What Bugged the Dinosaurs? Insects, Disease, and Death
in the Cretaceous by George Poinar and Roberta Poinar
doi:10.1038/4511053a
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0BopL0El
Exhibition: Shots of Silicon Valley p1054
Fred Turner reviews Gabriele Basilico: From San Francisco to Silicon Valley
doi:10.1038/4511054a
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0BopM0Em
Fly image wins photo prize p1054
Joanne Baker reviews the winning image in the photographic competition that
forms part of celebrations marking the 200th anniversary of the Royal
Netherlands Academy of Arts and Sciences
doi:10.1038/4511054b
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0BopN0En
Biopiracy started with a bounce p1055
Michael Gollin reviews The Thief at the End of the World: Rubber, Power, and
the Seeds of Empire by Joe Jackson
doi:10.1038/4511055a
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0BopO0Eo
A feverish imagination p1056
Martin Kemp reviews the poems, plays and novels that punctuated the life
of Ronald Ross
doi:10.1038/4511056a
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0BopP0Ep
Hidden treasures: Eise Eisinga Planetarium p1057
The world's oldest functioning planetarium was built by an eighteenth-century
wool-comber in the Netherlands. Alison Abbot reports, in the second of her
monthly series on small museums
Alison Abbot
doi:10.1038/4511057a
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0BopQ0Eq
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ESSAY
----------------------
When authorship met authenticity p1058-1059
As counterfeit drugs abound, Adrian Johns recalls how medical patenting was
created in the seventeenth century to secure trust across growing international
trade networks by quashing fakes.
Adrian Johns
doi:10.1038/4511058a
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0BopR0Er
----------------------
NEWS AND VIEWS
----------------------
Palaeoclimate: The rhythm of the rains p1061-1063
Deposits in a Chinese cave tell the story of the region's climate stretching
back more than 200,000 years, well past the last interglacial warm period - an
invaluable resource for understanding the Asian monsoon.
Jonathan Overpeck and Julia Cole
doi:10.1038/4511061a
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0BopS0Es
50 & 100 Years Ago p1062
doi:10.1038/4511062a
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0BopT0Et
Biotechnology: A hold on plant meiosis p1063-1064
The process of meiosis involves genetic shuffling that dilutes the desirable
traits of sexually reproducing crops. Identification of a mutation in which
shuffling does not occur is a step forward for plant breeders.
Peter J. van Dijk
doi:10.1038/4511063a
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0BopU0Eu
History of science: Quinine steps back in time p1065-1066
Chemists have long memories. The claim, dating back to 1918, that a crucial
step in a synthesis of quinine had been carried out has been validated
experimentally, closing a chapter in this fascinating story.
Philip Ball
doi:10.1038/4511065a
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0BopV0Ev
Cancer: Crossing over to drug resistance p1066-1067
Certain cancers stem from mutations that prevent a cell from repairing its
damaged DNA efficiently. But antitumour chemotherapy that exploits that repair
defect can in turn be nullified by counter-mutation.
David M. Livingston and Daniel P. Silver
doi:10.1038/4511066a
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0BopW0Ew
Environmental economics: To the rich man the spoils p1067-1068
Global economic growth during the past century has lifted many into lives
of unprecedented luxury. The cost has been the degradation of vital
ecosystems - a cost borne disproportionately by the world's poor.
R. Kerry Turner and Brendan Fisher
doi:10.1038/4511067a
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0BopX0Ex
----------------------
BRIEF COMMUNICATIONS ARISING
----------------------
Do animal personalities emerge? pE8-E9
Francois Massol and Pierre-Andre Crochet
doi:10.1038/nature06743
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0BopY0Ey
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0BopZ0Ez
Wolf et al. reply pE9-E10
Max Wolf, G. Sander van Doorn, Olof Leimar and Franz J. Weissing
doi:10.1038/nature06744
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Bopa0E7
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Bopb0E8
----------------------
REVIEW
----------------------
Autophagy fights disease through cellular self-digestion p1069-1075
Noboru Mizushima, Beth Levine, Ana Maria Cuervo and Daniel J. Klionsky
doi:10.1038/nature06639
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Bopc0EA
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Bopd0EB
----------------------
ARTICLES
----------------------
Proteomic analysis of active multiple sclerosis lesions reveals therapeutic
targets p1076-p1082
Proteomic analysis of samples from multiple sclerosis lesions from different stages of
the disease indicates that loss of adequate control of coagulation and anti inflammatory
pathways might contribute to the disease process. Therapeutic administration of activated
protein C or the thrombin inhibitor hirudin are shown to inhibit progression of disease in
a mouse model of multiple
sclerosis.
May H. Han et al.
doi:10.1038/nature06559
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Bope0EC
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Bopf0ED
----------------------
LETTERS
----------------------
A minimum column density of 1g cm-2 for massive star formation p1082-1084
Massive stars are very rare, because efficient radiative cooling keeps most star forming
gas clouds close to isothermal as they collapse, and this favours fragmentation into stars
of one molar mass or lower. This paper shows that only clouds with column densities of at
least 1 g cm 2 can avoid fragmentation and form massive stars.
Mark R. Krumholz and Christopher F. McKee
doi:10.1038/nature06620
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Bopg0EE
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Boph0EF
Designing metallic glass matrix composites with high toughness and tensile
ductility p1085-1089
Bulk metallic glasses (BMGs) are a new class of engineering materials, but lack tensile
ductility and fail in an apparently brittle manner. To overcome such brittle failure in
tension, BMG-matrix composites have been introduced. These materials demonstrate high
ductility and their fracture toughness and energies for crack propagation make BMG composites
among the toughest known materials.
Douglas C. Hofmann et al.
doi:10.1038/nature06598
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Bopi0EG
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Bopj0EH
Millennial- and orbital-scale changes in the East Asian monsoon over the past 224,000 years
p1090-1093
An oxygen isotope record from Sanbao Cave that completes the Chinese cave based record of
monsoon history over the past two glacial interglacial cycles has been produced. The completed
record confirms the proposal that tropical/subtropical monsoons respond dominantly and directly
to changes in Northern Hemisphere summer insolation on orbital timescales and indicates that the
duration and pacing of so called Chinese interstadials (millennial scale strong monsoon events)
are affected by ice sheet size.
Yongjin Wang et al.
doi:10.1038/nature06692
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Bopk0EI
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Bopl0EJ
Arc-parallel flow in the mantle wedge beneath Costa Rica and Nicaragua p1094-p1098
Isotope geochemistry and seismic velocity anisotropy provide strong evidence for trench parallel
flow in the mantle wedge beneath Costa Rica and Nicaragua. This finding contradicts classical
models, which predict trench normal flow due to the overlying wedge mantle being dragged
downwards by the subducting plate.
Kaj Hoernle et al.
doi:10.1038/nature06550
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Bopm0EK
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Bopn0EL
Scaling laws of marine predator search behaviour p1098-1102
Lévy flights are random walks characterized by many short steps and rare long steps. An analysis
of over one million movement displacements of individual animals carrying electronic tags shows
that diverse marine predators exhibit Lévy walk-like behaviour. Simulations suggest that predators
adopting Lévy type foraging maximize encounter rates in natural like prey fields.
David W. Sims et al.
doi:10.1038/nature06518
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Bopo0EM
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Bopp0EN
Selection overrides gene flow to break down maladaptive mimicry p1103-1106
Using indirect DNA-based methods, this paper provides evidence suggesting that mimics migrate from
sympatry, where mimicry is favoured, to allopatry, where it is disfavoured. Genetic evidence shows
that harmless king snake mimics of deadly coral snakes occur where coral snakes are absent because
of the dispersal of male king snakes from regions where coral snakes are present, to adjacent areas,
where coral snakes are absent. But selection overrides this gene flow leading to the rapid breakdown
of mimicry where coral snakes are absent and the expression of mimetic phenotypes is disadvantageous.
George R. Harper Jr and David W. Pfennig
doi:10.1038/nature06532
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Bopq0EO
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Bopr0EP
Facultative cheater mutants reveal the genetic complexity of cooperation in social amoebae
p1107-p1111
The evolution of cooperation, which is central in the transition by organisms from unicellular to
multicellular states, is studied. Mutant cells that cheat can confound this evolution, and here
Dictyostelium discoideum is examined on a genome wide scale, revealing more than 100 mutations
that allow cheating particularly in certain circumstances.
Lorenzo A. Santorelli et al.
doi:10.1038/nature06558
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Bops0EQ
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Bopt0ER
Resistance to therapy caused by intragenic deletion in BRCA2 p1111-p1116
One of two papers that show that internal deletions within certain BRCA2 mutant alleles can
restore the opening reading frame and its function in homologous recombination, which is
responsible for resistance to poly (ADP ribose) polymerase (PARP) inhibitors or cisplatin.
Such secondary mutations were found in several cisplain resistant ovarian cancer patients.
Stacey L. Edwards et al.
doi:10.1038/nature06548
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Bopu0ES
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Bopv0ET
Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers p1116-p1121
One of two papers that show that internal deletions within certain BRCA2 mutant alleles can
restore the opening reading frame and its function in homologous recombination, which is
responsible for resistance to poly (ADP ribose) polymerase (PARP) inhibitors or cisplatin.
Such secondary mutations were found in several cisplain resistant ovarian cancer patients.
Wataru Sakai et al.
doi:10.1038/nature06633
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Bopw0EU
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Bopx0EV
Gamete formation without meiosis in Arabidopsis p1121-p1125
Certain plant species produce seeds that are genetically identical by a process called apomixis.
The first step is the formation of genetically identical female gametes (apomeiosis). This paper
shows that in Arabidopsis, a single gene can generate functional apomeiotic gametes.
Maruthachalam Ravi, Mohan P. A. Marimuthu and Imran Siddiqi
doi:10.1038/nature06557
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Bopy0EW
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Bopz0EX
Regulation of progenitor cell proliferation and granulocyte function by microRNA-223
p1125-p11230
A microRNA (miR 233) that controls the production of granulocytes, and thus the inflammatory
response has been identified. MiR 233 was known to be myeloid specific. A loss of function
allele in mice was produced, and it was shown that the granulocytic compartment was expanded
due to an increase in the number of granulocytic progenitors. This leads to inflammatory lung
pathologies in the mice.
Jonathan B. Johnnidis et al.
doi:10.1038/nature06607
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Bop10EK
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Bop20EL
Backbone structure of the infectious epsi 15 virus capsid revealed by electron
cryomicroscopy p1130-1134
Single particle electron microscopy is a powerful structure tool that is used to resolve
the solution conformations of large biological assemblies. In this paper it is used to
provide the first 4.5-A near atomic resolution of an infectious bacteriophage.
Wen Jiang et al.
doi:10.1038/nature06665
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Bop30EM
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Bop40EN
----------------------
NATURE JOBS
----------------------
Prospect
Prospects p1135
Is science really undergoing globalization?
Gene Russo
doi:10.1038/nj7182-1135a
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Bop50EO
Career View
Felipe Pereira, distinguished professor, School of Energy Resources and
Department of Mathematics, University of Wyoming, Laramie p1136
Energy demand brings Brazilian mathematician to Wyoming.
Virginia Gewin
doi:10.1038/nj7182-1136a
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Bop60EP
Neuroscience in the developing world p1136
Neuroscience training in Argentina, by any means necessary.
Paul Smaglik
doi:10.1038/nj7182-1136b
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Bop70EQ
Role models p1136
My peers are my mentors.
Amanda Goh
doi:10.1038/nj7182-1136c
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0Bop80ER
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FUTURES
----------------------
Meeting with Max p1138
It's all about control.
John Gilbey
doi:10.1038/4511138a
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0BoqA0Eb
------------------------------
ADVANCE ONLINE PUBLICATION
------------------------------
27 February 2008
Letters
SLAC1 is required for plant guard cell S-type anion channel function in
stomatal signalling
Triin Vahisalu et al.
doi:10.1038/nature06608
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0BoqB0Ec
Dendritic cell PAR1–S1P3 signalling couples coagulation and inflammation
Frank Niessen et al.
doi:10.1038/nature06663
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0BoqC0Ed
CO2 regulator SLAC1 and its homologues are essential for anion homeostasis
in plant cells
Juntaro Negi et al.
doi:10.1038/nature06720
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0BoqD0Ee
UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes
You-Me Kim, Melanie M. Brinkmann, Marie-Eve Paquet and Hidde L. Ploegh
doi:10.1038/nature06726
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0BoqE0Ef
The Drosophila pheromone cVA activates a sexually dimorphic neural circuit
Sandeep Robert Datta et al.
doi:10.1038/nature06808
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0BoqF0Eg
24 February 2008
Letters
Preserving cell shape under environmental stress
Boaz Cook, Robert W. Hardy, William B. McConnaughey and Charles S. Zuker
doi:10.1038/nature06603
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0BoqG0Eh
Identification of a serotonin/glutamate receptor complex implicated in
psychosis
Javier González-Maeso et al.
doi:10.1038/nature06612
http://ealerts.nature.com/cgi-bin24/DM/y/ejQ40Xztnp0HjB0BoqH0Ei
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