January 2008 Volume 9 Number 1
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This month's FEATURED article:
The BCL-2 protein family: opposing activities that mediate cell death
Richard J. Youle & Andreas Strasser
p47 | doi:10.1038/nrm2308
http://ealerts.nature.com/cgi-bin24/DM/y/eiK50Xztnp0Hjf0Bj7J0ED
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From the editors
p1 | doi:10.1038/nrm2315
http://ealerts.nature.com/cgi-bin24/DM/y/eiK50Xztnp0Hjf0Bj7K0EE
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RESEARCH HIGHLIGHTS
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Endocytosis: A new way to hijack the cell
p2 | doi:10.1038/nrm2318
http://ealerts.nature.com/cgi-bin24/DM/y/eiK50Xztnp0Hjf0Bj7L0EF
Proteomics: Solving a 3D jigsaw puzzle
p3 | doi:10.1038/nrm2316
http://ealerts.nature.com/cgi-bin24/DM/y/eiK50Xztnp0Hjf0Bj7M0EG
Molecular motors: Power in numbers
p4 | doi:10.1038/nrm2322
http://ealerts.nature.com/cgi-bin24/DM/y/eiK50Xztnp0Hjf0Bj7N0EH
DNA replication: Wakey wakey!
p4 | doi:10.1038/nrm2325
http://ealerts.nature.com/cgi-bin24/DM/y/eiK50Xztnp0Hjf0Bj7O0EI
STRUCTURE WATCH
'Fight or flight' receptor revealed
p4 | doi:10.1038/nrm2326
http://ealerts.nature.com/cgi-bin24/DM/y/eiK50Xztnp0Hjf0Bj7P0EJ
IN THE NEWS
Cloned monkeys yield stem cells
p5 | doi:10.1038/nrm2311
http://ealerts.nature.com/cgi-bin24/DM/y/eiK50Xztnp0Hjf0Bj7Q0EK
Stem cells: Ringing the changes
p6 | doi:10.1038/nrm2314
http://ealerts.nature.com/cgi-bin24/DM/y/eiK50Xztnp0Hjf0Bj7R0EL
DNA damage: Conducting repair
p6 | doi:10.1038/nrm2323
http://ealerts.nature.com/cgi-bin24/DM/y/eiK50Xztnp0Hjf0Bj7S0EM
IN BRIEF
Stem cells | Circadian rhythms | Transcription | Small RNAs
p7 | doi:10.1038/nrm2324
http://ealerts.nature.com/cgi-bin24/DM/y/eiK50Xztnp0Hjf0Bj7T0EN
AN INTERVIEW WITH...
Sydney Brenner
p8 | doi:10.1038/nrm2320
http://ealerts.nature.com/cgi-bin24/DM/y/eiK50Xztnp0Hjf0Bj7U0EO
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REVIEWS
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Article series: Stem cells http://ealerts.nature.com/cgi-bin24/DM/y/eiK50Xztnp0Hjf0BaYe0E4
No place like home: anatomy and function of the stem cell niche
D. Leanne Jones and Amy J. Wagers
p11 | doi:10.1038/nrm2319
The balance between stem cell self-renewal and differentiation is ultimately controlled by the integration of intrinsic factors with extrinsic cues supplied by the surrounding microenvironment, known as the stem cell niche. How much do we know about this intriguing microenvironment?
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiK50Xztnp0Hjf0Bj7V0EP
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiK50Xztnp0Hjf0Bj7W0EQ
Argonaute proteins: key players in RNA silencing
Gyorgy Hutvagner and Martin J. Simard
p22 | doi:10.1038/nrm2321
The family of Argonaute proteins has important roles in RNA-mediated gene silencing. Argonaute proteins form complexes with small non-coding RNAs such as small interfering RNAs and microRNAs, control protein synthesis and mRNA stability, and participate in the production of a new class of small RNAs, Piwi-interacting RNAs.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiK50Xztnp0Hjf0Bj7X0ER
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiK50Xztnp0Hjf0Bj7Y0ES
Molecular architecture of the kinetochore-microtubule interface
Iain M. Cheeseman and Arshad Desai
p33 | doi:10.1038/nrm2310
Kinetochores are large proteinaceous structures that link centromeric DNA to spindle microtubules. More than 80 kinetochore proteins have been identified so far, and recent analyses are revealing how these proteins function to direct kinetochore specification and assembly, bind to microtubules and regulate chromosome segregation.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiK50Xztnp0Hjf0Bj7Z0ET
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiK50Xztnp0Hjf0Bj7a0Ea
The BCL-2 protein family: opposing activities that mediate cell death
Richard J. Youle and Andreas Strasser
p47 | doi:10.1038/nrm2308
BCL-2 family proteins have either pro- or anti-apoptotic activities that are crucial for the regulation of apoptosis, tumorigenesis and cellular responses to anti-cancer therapy. Recent advances suggest that interactions between BCL-2 family proteins affect their localization and conformation and regulate their bioactivity.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiK50Xztnp0Hjf0Bj7J0ED
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiK50Xztnp0Hjf0Bj7b0Eb
Heterotrimeric G protein activation by G-protein-coupled receptors
William M. Oldham and Heidi E. Hamm
p60 | doi:10.1038/nrm2299
Extracellular signals can be transduced across the plasma membrane by activating G-protein-coupled receptors. The conformational changes induced in the receptor on ligand binding and how this causes the activation of the associated G protein are beginning to be understood.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiK50Xztnp0Hjf0Bj7c0Ec
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiK50Xztnp0Hjf0Bj7d0Ed
Regulation of iron acquisition and storage: consequences for iron-linked disorders
Ivana De Domenico, Diane McVey Ward and Jerry Kaplan
p72 | doi:10.1038/nrm2295
Mammalian iron homeostasis is achieved through iron acquisition and storage. Intestinal iron absorption and macrophage-mediated recycling of iron from red blood cells are highly regulated. The discovery of iron transporters and insight into their regulation has provided important information about iron-related disorders.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiK50Xztnp0Hjf0Bj7e0Ee
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiK50Xztnp0Hjf0Bj7f0Ef
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PERSPECTIVE
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Article series: Stem cells http://ealerts.nature.com/cgi-bin24/DM/y/eiK50Xztnp0Hjf0BaYe0E4
OPINION
Epidermal homeostasis: do committed progenitors work while stem cells sleep?
Philip Jones and Benjamin D. Simons
p82 | doi:10.1038/nrm2292
Studies of epidermis in vivo have revealed that a committed progenitor cell population can maintain normal adult tissue in the long term without support from a stem-cell population. Here, the stem-cell theories that explain epidermal homeostasis are challenged.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiK50Xztnp0Hjf0Bj7g0Eg
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiK50Xztnp0Hjf0Bj7h0Eh
Corrigendum: When cilia go bad: cilia defects and ciliopathies
Manfred Fliegauf, Thomas Benzing and Heymut Omran
p88 | doi:10.1038/nrm2317
http://ealerts.nature.com/cgi-bin24/DM/y/eiK50Xztnp0Hjf0Bj7i0Ei
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Gene Therapy Stem Cells special issue - January 2008
http://ealerts.nature.com/cgi-bin24/DM/y/eiK50Xztnp0Hjf0C3x0EA
Stem Cell research is booming and much progress has been made within the last few years. This special issue focuses on the fundamental, underappreciated aspects of current stem cell research that have not yet been emphasized within the field. Reviews cover current research with the translational potential for stem cell drug development.
Don't miss out, access this special issue today!
http://ealerts.nature.com/cgi-bin24/DM/y/eiK50Xztnp0Hjf0C3x0EA
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