January 2008 Volume 8 Number 1
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Nature Reviews Cancer Impact Factor: 31.583*
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This alert is sponsored by Thermo scientific
Experience the sensitivity of Thermo Scientific Pierce Western blotting technology with the specificity of Thermo Scientific Dharmacon siRNA technology. Our siRNA/Ab & chemiluminescent detection modules are optimized for specific gene knockdown and accurate protein detection via Western blot.
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A Bone Marrow Transplantation special issue on Myeloma
Guest edited by Ray Powles, Kenneth Anderson, Jean Luc Harrousseau and Bhawna Sirohi, this special issue comes at a crucial time, following three new targeted therapies which have recently been approved for myeloma. It gives guidance on how the sequence of treatments and supportive therapy can be put together to optimize the patient's treatment pathway, to produce prolonged normal symptom-free survival. It is a model for other Cancers.
The journal received an unrestricted educational grant from the Parkside Oncology Clinic in London which contributed to the costs of producing this issue of Bone Marrow Transplantation.
http://ealerts.nature.com/cgi-bin24/DM/y/eiI30Xztnp0Hja0Bjws0En
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This month's FEATURED article:
The interplay between MYC and HIF in cancer
Chi V. Dang, Jung-whan Kim, Ping Gao and Jason Yustein
p51 | doi:10.1038/nrc2274
http://ealerts.nature.com/cgi-bin24/DM/y/eiI30Xztnp0Hja0Bjwt0Eo
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From the editors
p1 | doi:10.1038/nrc2312
http://ealerts.nature.com/cgi-bin24/DM/y/eiI30Xztnp0Hja0Bjwu0Ep
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RESEARCH HIGHLIGHTS
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Immunology: Stalemate
p3 | doi:10.1038/nrc2301
http://ealerts.nature.com/cgi-bin24/DM/y/eiI30Xztnp0Hja0Bjwv0Eq
Tumour suppressors: Crystal clear
p4 | doi:10.1038/nrc2302
http://ealerts.nature.com/cgi-bin24/DM/y/eiI30Xztnp0Hja0Bjww0Er
Therapeutics: Smac it to them!
p4 | doi:10.1038/nrc2305
http://ealerts.nature.com/cgi-bin24/DM/y/eiI30Xztnp0Hja0Bjwx0Es
Cell migration: Follow the leader!
p5 | doi:10.1038/nrc2298
http://ealerts.nature.com/cgi-bin24/DM/y/eiI30Xztnp0Hja0Bjwy0Et
Epigenetics: Silence of the nucleosomes
p6 | doi:10.1038/nrc2299
http://ealerts.nature.com/cgi-bin24/DM/y/eiI30Xztnp0Hja0Bjwz0Eu
Translation: Switching to cap-independence
p6 | doi:10.1038/nrc2303
http://ealerts.nature.com/cgi-bin24/DM/y/eiI30Xztnp0Hja0Bjw10Eh
IN THE NEWS
A vast incredulity?
p6 | doi:10.1038/nrc2308
http://ealerts.nature.com/cgi-bin24/DM/y/eiI30Xztnp0Hja0Bjw20Ei
IN BRIEF
Targeted therapeutics | Targeted therapeutics | Metabolism | Metastasis
p7 | doi:10.1038/nrc2307
http://ealerts.nature.com/cgi-bin24/DM/y/eiI30Xztnp0Hja0Bjw30Ej
Tumour suppressors: Keeping Trim
p8 | doi:10.1038/nrc2300
http://ealerts.nature.com/cgi-bin24/DM/y/eiI30Xztnp0Hja0Bjw40Ek
Therapeutics: Attacked from all sides
p8 | doi:10.1038/nrc2304
http://ealerts.nature.com/cgi-bin24/DM/y/eiI30Xztnp0Hja0Bjw50El
Tumorigenesis: Keeping a good thing down
p8 | doi:10.1038/nrc2306
http://ealerts.nature.com/cgi-bin24/DM/y/eiI30Xztnp0Hja0Bjw60Em
IN BRIEF
Angiogenesis | Nanotechnology | MicroRNA
p9 | doi:10.1038/nrc2309
http://ealerts.nature.com/cgi-bin24/DM/y/eiI30Xztnp0Hja0Bjw70En
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REVIEWS
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The anaplastic lymphoma kinase in the pathogenesis of cancer
Roberto Chiarle, Claudia Voena, Chiara Ambrogio, Roberto Piva and Giorgio Inghirami
p11 | doi:10.1038/nrc2291
The receptor tyrosine kinase anaplastic lymphoma kinase (ALK) was first identified as part of a chromosomal translocation associated with some anaplastic large cell lymphomas (ALCLs). Now data are emerging that indicate that ALK might be a valid therapeutic target in ALCL and that it could also be involved in other cancers.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiI30Xztnp0Hja0Bjw80Eo
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiI30Xztnp0Hja0BjxA0Ey
Thiopurines in current medical practice: molecular mechanisms and contributions to therapy-related cancer
Peter Karran and Natalie Attard
p24 | doi:10.1038/nrc2292
Thiopurines are effective anti-inflammatory, anticancer and immunosuppresive drugs. However, azathioprine is also a carcinogen. So, how do thiopurines exert their therapeutic and carcinogenic effects?
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiI30Xztnp0Hja0BjxB0Ez
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiI30Xztnp0Hja0BjxC0E1
The properties of high-dimensional data spaces: implications for exploring gene and protein expression data
Robert Clarke, Habtom W. Ressom, Antai Wang, Jianhua Xuan, Minetta C. Liu, Edmund A. Gehan and Yue Wang
p37 | doi:10.1038/nrc2294
High-dimensional genomic and proteomic data are now commonplace in cancer research. This Review aims to help biologists understand the properties of high-dimensional data spaces and how these affect our ability to derive meaningful information from the data.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiI30Xztnp0Hja0BjxD0E2
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiI30Xztnp0Hja0BjxE0E3
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PERSPECTIVES
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OPINION
The interplay between MYC and HIF in cancer
Chi V. Dang, Jung-whan Kim, Ping Gao and Jason Yustein
p51 | doi:10.1038/nrc2274
This Perspective considers the differences between the hypoxia-inducible factor (HIF)-MYC transcriptional network that operates under normal homeostatic conditions and the network that operates in a tumorigenic milieu.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiI30Xztnp0Hja0BjxF0E4
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiI30Xztnp0Hja0Bjwt0Eo
OPINION
A microenvironmental model of carcinogenesis
Robert A. Gatenby and Robert J. Gillies
p56 | doi:10.1038/nrc2255
The authors propose a model of carcinogenesis that identifies microenvironmental barriers that have to be overcome before cancer can become invasive. These adaptations lead to the hallmarks of the malignant phenotype.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiI30Xztnp0Hja0BjxG0E5
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiI30Xztnp0Hja0BjxH0E6
OPINION
Survivin, cancer networks and pathway-directed drug discovery
Dario C. Altieri
p61 | doi:10.1038/nrc2293
In the past 10 years, much has been learned about the biology of the inhibitor of apoptosis protein survivin and its expression and roles in cancer. Does survivin function as a nodal protein in cancer networks, and does this make it a promising therapeutic target?
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiI30Xztnp0Hja0BjxI0E7
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiI30Xztnp0Hja0BjxJ0E8
Erratum: Innovations in image-guided radiotherapy
Dirk Verellen, Mark De Ridder, Nadine Linthout, Koen Tournel, Guy Soete and Guy Storme
p71 | doi:10.1038/nrc2310
http://ealerts.nature.com/cgi-bin24/DM/y/eiI30Xztnp0Hja0BjxK0EA
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CORRESPONDENCE
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Correspondence: Peripheral neurotoxicity of platinum-based chemotherapy
Guido Cavaletti
doi:10.1038/nrc2167-c1
http://ealerts.nature.com/cgi-bin24/DM/y/eiI30Xztnp0Hja0BjxL0EB
Correspondence: The author's response
Lloyd Kelland
doi:10.1038/nrc2167-c2
http://ealerts.nature.com/cgi-bin24/DM/y/eiI30Xztnp0Hja0BjxM0EC
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