January 2008 Volume 8 Number 1
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Clinical Pharmacology & Therapeutics: Women's Health issue
Featuring:
Point-Counterpoint: insight on emergency contraception
State of the Art: advances in the treatment of breast cancer
Practice: emergency contraception update: a Canadian perspective
Visit http://ealerts.nature.com/cgi-bin24/DM/y/eiLL0Xztnp0Hjd0BBTU0EZ to view these articles from CPT's Women's Health issue.
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This month's FEATURED article:
Launching the T-cell-lineage developmental programme
Ellen V. Rothenberg, Jonathan E. Moore & Mary A. Yui
p9 | doi:10.1038/nri2232
http://ealerts.nature.com/cgi-bin24/DM/y/eiLL0Xztnp0Hjd0BkBY0E1
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From the editors
p1 | doi:10.1038/nri2248
http://ealerts.nature.com/cgi-bin24/DM/y/eiLL0Xztnp0Hjd0BkBZ0E2
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RESEARCH HIGHLIGHTS
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Cell migration: Immunosurveillance by recirculating HSPCs
p2 | doi:10.1038/nri2242
http://ealerts.nature.com/cgi-bin24/DM/y/eiLL0Xztnp0Hjd0BkBa0EA
Lymphocyte development: SLAM dunk for innate T cells
p3 | doi:10.1038/nri2243
http://ealerts.nature.com/cgi-bin24/DM/y/eiLL0Xztnp0Hjd0BkBb0EB
IN THE NEWS
Aggravating asthma
p3 | doi:10.1038/nri2247
http://ealerts.nature.com/cgi-bin24/DM/y/eiLL0Xztnp0Hjd0BkBc0EC
Inflammation: TIM3: dual role in immunity
p4 | doi:10.1038/nri2239
http://ealerts.nature.com/cgi-bin24/DM/y/eiLL0Xztnp0Hjd0BkBd0ED
Transplantation: Making space for HSCs
p4 | doi:10.1038/nri2241
http://ealerts.nature.com/cgi-bin24/DM/y/eiLL0Xztnp0Hjd0BkGN0Eu
HIV: The escape artist
p4 | doi:10.1038/nri2246
http://ealerts.nature.com/cgi-bin24/DM/y/eiLL0Xztnp0Hjd0BkBe0EE
IN BRIEF
Immune tolerance | Infectious disease | T-cell development
p5 | doi:10.1038/nri2250
http://ealerts.nature.com/cgi-bin24/DM/y/eiLL0Xztnp0Hjd0BkBf0EF
Antibody responses: IgA - peacemaker in the gut
p6 | doi:10.1038/nri2237
http://ealerts.nature.com/cgi-bin24/DM/y/eiLL0Xztnp0Hjd0BkBg0EG
Signalling: The ins and outs of Ca2+ signalling in mast cells
p6 | doi:10.1038/nri2245
http://ealerts.nature.com/cgi-bin24/DM/y/eiLL0Xztnp0Hjd0BkBh0EH
Tumour Immunology: Stalemate
p7 | doi:10.1038/nri2238
http://ealerts.nature.com/cgi-bin24/DM/y/eiLL0Xztnp0Hjd0BkBi0EI
Lung inflammation: Disarming neutrophils in cystic fibrosis
p8 | doi:10.1038/nri2244
http://ealerts.nature.com/cgi-bin24/DM/y/eiLL0Xztnp0Hjd0BkBj0EJ
IN BRIEF
Inflammation | Mucosal immunology | Autoimmunity
p8 | doi:10.1038/nri2249
http://ealerts.nature.com/cgi-bin24/DM/y/eiLL0Xztnp0Hjd0BkBk0EK
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REVIEWS
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Launching the T-cell-lineage developmental programme
Ellen V. Rothenberg, Jonathan E. Moore and Mary A. Yui
p9 | doi:10.1038/nri2232
In this article, Ellen Rothenberg and colleagues review the key transcription factors and other regulatory factors involved in the processes of specification and commitment to the T-cell lineage, and outline the outstanding questions in the field.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiLL0Xztnp0Hjd0BkBY0E1
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiLL0Xztnp0Hjd0BkBl0EL
Germinal centres: role in B-cell physiology and malignancy
Ulf Klein and Riccardo Dalla-Favera
p22 | doi:10.1038/nri2217
Germinal centres are the main source of memory B cells and plasma cells that produce high-affinity antibodies in the body. In this Review, Ulf Klein and Riccardo Dalla-Favera describe the relationship between the cellular and molecular dynamics of germinal centres and the pathogenesis of B-cell lymphomas.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiLL0Xztnp0Hjd0BkBm0EM
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiLL0Xztnp0Hjd0BkBn0EN
Fc[gamma] receptors as regulators of immune responses
Falk Nimmerjahn and Jeffrey V. Ravetch
p34 | doi:10.1038/nri2206
The function of the various subclasses of IgG molecules is mediated by the family of Fc receptors for IgG (Fc[gamma]Rs). This Review outlines how Fc[gamma]Rs regulate immune responses and the relevance of this information to developing new therapies for treating human diseases.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiLL0Xztnp0Hjd0BkBo0EO
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiLL0Xztnp0Hjd0BkBp0EP
Complement driven by conformational changes
Piet Gros, Fin J. Milder and Bert J. C. Janssen
p48 | doi:10.1038/nri2231
The recent resolution of the long-awaited structures of the central components of the complement system - C3 and factor B - has finally revealed the molecular details of complement activation. With this, clues to how complement activation is regulated and evaded by pathogens are also emerging.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiLL0Xztnp0Hjd0BkBq0EQ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiLL0Xztnp0Hjd0BkBr0ER
Immunological aspects of cancer chemotherapy
Laurence Zitvogel, Lionel Apetoh, Francois Ghiringhelli and Guido Kroemer
p59 | doi:10.1038/nri2216
Here, the authors describe how the antitumour effects of many conventional cancer treatments involve the immune system, by promoting immunogenic tumour-cell death or by direct stimulation of immune cells. Taking advantage of this 'bystander effect' may help in the fight against cancer.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiLL0Xztnp0Hjd0BkBs0ES
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiLL0Xztnp0Hjd0BkBt0ET
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PERSPECTIVES
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OPINION
Creating immune privilege: active local suppression that benefits friends, but protects foes
Andrew L. Mellor and David H. Munn
p74 | doi:10.1038/nri2233
How do antigenic tumour cells and chronic pathogens exploit natural regulatory mechanisms to become non-immunogenic? Andrew Mellor and David Munn propose that such immune unresponsiveness is an indirect consequence of the need to control the potentially lethal consequences of unrestrained immunity to innocuous substances.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiLL0Xztnp0Hjd0BkBu0EU
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiLL0Xztnp0Hjd0BkBv0EV
OPINION
How microorganisms tip the balance between interleukin-12 family members
Stanislas Goriely, Markus F. Neurath and Michel Goldman
p81 | doi:10.1038/nri2225
Distinct members of the interleukin-12 (IL-12) cytokine family can differentially regulate T-cell-mediated inflammation. In this Opinion article, the authors propose that microbial products and endogenous mediators can control the balance between these cytokines, thereby directly regulating the inflammatory response.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiLL0Xztnp0Hjd0BkBw0EW
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiLL0Xztnp0Hjd0BkBx0EX
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CORRESPONDENCE
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Correspondence: Efficacy of regulatory T-cell immunotherapy: are inflammatory cytokines key determinants?
Jagadeesh Bayry, Sébastien Lacroix-Desmazes, Suryasarathi Dasgupta, Michel D. Kazatchkine & Srini V. Kaveri
doi:10.1038/nri2138-c1
http://ealerts.nature.com/cgi-bin24/DM/y/eiLL0Xztnp0Hjd0BkBy0EY
Correspondence: In vivo neutralization of inflammatory cytokines might not be necessary for regulatory T-cell immunotherapy
Manuela Battaglia and Maria-Grazia Roncarolo
doi:10.1038/nri2138-c2
http://ealerts.nature.com/cgi-bin24/DM/y/eiLL0Xztnp0Hjd0BkBz0EZ
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