Signaling Gateway - 21 December 2007
http://ealerts.nature.com/cgi-bin24/DM/y/eiLP0Xztnp0H2W0M40Ec
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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TLR SIGNALING: PROMPTLY PROMOTING PATHOGEN PHAGOCYTOSIS
Simulation of the Toll-like receptor (TLR) in human macrophages
promotes phagocytosis of extracellular organisms by stimulating
signaling pathways traditionally associated with autophagy.
Original research paper: Nature 450, 1253-1257 (2007)
http://ealerts.nature.com/cgi-bin24/DM/y/eiLP0Xztnp0H2W0vP0El
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Selected Updates
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CYTOKINES: TNF RISES TO THE OCCASION
The tumor-necrosis factor (TNF) receptors TNFR1 and TNFR2 may be
essential for the detection and response to spontaneous malignancies,
raising concerns about the use of TNF antagonists in patients with
cancer or autoimmune disease.
Original research paper: J. Clin. Invest. 117, 3833-3845 (2007)
http://ealerts.nature.com/cgi-bin24/DM/y/eiLP0Xztnp0H2W0BkCt0EP
ANGIOGENESIS: ANOTHER TARGET
Tumor cell growth is blocked by the inhibition of placental growth
factor (PGF), a vascular endothelial growth factor (VEGF) homologue
that selectively binds to VEGF receptor 1, suggesting that PGF could
be a potential target for the development of novel anti-cancer
therapies.
Original research paper: Cell 131, 463-475 (2007)
http://ealerts.nature.com/cgi-bin24/DM/y/eiLP0Xztnp0H2W0BkCu0EQ
TUMOUR SUPPRESSORS: WIP'PING UP A STORM
Additional complexity is added to the known feedback loop between p53
and the ubiquitin ligase MDM2 by the observation that wild-type
p53-induced phosphatase 1 (WIP1) binds to and dephosphorylates MDM2,
which indirectly reduces p53 expression.
Original research paper: Cancer Cell 12, 342-354 (2007)
http://ealerts.nature.com/cgi-bin24/DM/y/eiLP0Xztnp0H2W0BkCv0ER
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/eiLP0Xztnp0H2W0vO0Ek
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Research Library
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Cdc48/p97 PROMOTES REFORMATION OF THE NUCLEUS BY EXTRACTING THE
KINASE AURORA B FROM CHROMATIN
Nature 450, 1258-1262 (2007)
http://ealerts.nature.com/cgi-bin24/DM/y/eiLP0Xztnp0H2W0BkCw0ES
CD4+CD25+Foxp3+ REGULATORY T CELLS INDUCE CYTOKINE
DEPRIVATION–MEDIATED APOPTOSIS OF EFFECTOR CD4+ T CELLS
Nature Immunology 8, 1353-1362 (2007)
http://ealerts.nature.com/cgi-bin24/DM/y/eiLP0Xztnp0H2W0BkCx0ET
IDENTIFICATION OF HEME AS THE LIGAND FOR THE ORPHAN NUCLEAR
RECEPTORS REV-ERBalpha AND REV-ERBbeta
Nature Structural & Molecular Biology 14, 1207-1213 (2007)
http://ealerts.nature.com/cgi-bin24/DM/y/eiLP0Xztnp0H2W0BkCy0EU
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Signaling News
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NATURE COLLECTION: CANCER GENOMICS
http://ealerts.nature.com/cgi-bin24/DM/y/eiLP0Xztnp0H2W0BiON0Ev
Cancer is driven by multiple genetic and epigenetic changes. In
recent years, advanced high-throughput technologies have allowed
researchers to survey many cancer genomes, providing an overview of
the landscape of somatic mutations and copy-number alterations in
human cancers. In this special collection, we are pleased to present
FREE access to a selection of papers published in Nature that yield
insight into the genetic basis of human cancers.
More News
http://ealerts.nature.com/cgi-bin24/DM/y/eiLP0Xztnp0H2W0Crw0ET
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Gateway Updates
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NCI-NATURE PATHWAY INTERACTION DATABASE - DECEMBER UPDATE
http://ealerts.nature.com/cgi-bin24/DM/y/eiLP0Xztnp0H2W0BGyx0El
The Pathway Interaction Database is a free, high quality resource of
signaling pathways in human cells for biologists and
bioinformaticians to explore, visualize and mine signaling events.
This month's update features
the TGF-beta receptor signaling pathway
http://ealerts.nature.com/cgi-bin24/DM/y/eiLP0Xztnp0H2W0BjEX0Ew
and the alpha6beta1 and alpha6beta4 integrin signaling pathways
http://ealerts.nature.com/cgi-bin24/DM/y/eiLP0Xztnp0H2W0BjEY0Ex
and a new Bioinformatics primer on the Reactome knowledgebase
http://ealerts.nature.com/cgi-bin24/DM/y/eiLP0Xztnp0H2W0BjEW0Ev
Sign up to receive the monthly update alert for the
NCI-Nature Pathway Interaction Database.
http://ealerts.nature.com/cgi-bin24/DM/y/eiLP0Xztnp0H2W0BJYy0EJ
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Signaling Job of the Week
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Professorship Positions
Employer: University of Massachusetts
Location: Boston, Massachusetts, USA
http://ealerts.nature.com/cgi-bin24/DM/y/eiLP0Xztnp0H2W0BkCz0EV
The Department of Biology at the University of Massachusetts, Boston,
seeks applicants for a tenure-track Assistant Professor or tenured
Associate or Full Professor. The successful applicant is expected to
establish an externally funded research program in cell signaling.
Applications will be particularly welcome from candidates who use
creative experimental approaches that combine genetics,
bioinformatics and molecular and cellular biology.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/eiLP0Xztnp0H2W0Ba6W0EX
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http://ealerts.nature.com/cgi-bin24/DM/y/eiLP0Xztnp0H2W0dIO0Ef
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