1. Infiltrating Microglia and Neuropathic Pain
Ji Zhang, Xiang Qun Shi, Stefania Echeverry, Jeffrey S. Mogil, Yves
De Koninck, and Serge Rivest
Microglia are everywhere these days. This week, it's neuropathic pain
and the spinal cord. Zhang et al. report that resident CNS microglia,
as well as those derived from hematogenous macrophages/
infiltrate the spinal cord, participate in neuropathic pain. The
authors tested mice after a partial ligation injury of the sciatic
nerve. The authors tracked the two microglia populations using
chimeric mice in which bone marrow stem cells expressing green
fluorescent protein were transplanted into irradiated mice. The
microglial signaling pathway involved chemokine monocyte
chemoattractant protein 1 (MCP-1; also called CCL2) and its receptor,
CCR2. MCP-1 is not normally present in the nervous system, but it is
induced by injury. The authors report that intrathecal injection of
MCP-1 activated microglia in the spinal cord, whereas a neutralizing
antibody prevented the injury-induced infiltration of bone marrow-
derived microglia. Microglia were not activated in mice lacking CCR2,
and these mice did not show mechanical allodynia.
Contact: Sara Harris
sharris@sfn.
202-962-4000
Society for Neuroscience
News tips from the Journal of Neuroscience
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StemCells subscribers may also be interested in these sites:
Children's Neurobiological Solutions
http://www.CNSfoundation.org/
Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123
The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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