Bone Marrow and Back Injury
Patients Experienced Increased Mobility After Autologous Bone Marrow
Stem Cell Treatment; Preliminary Results Involving 25 Patients
Presented at International Society for Cellular Therapy's Annual
Meeting in Sydney
PrimeCell™ Therapeutics LLC today announced that it provided research
support and pre-clinical studies for a clinical trial to assess the
safety, feasibility and efficacy of implanting autologous bone marrow
stem cells into spinal cord injury (SCI) patients.
Dr. Luis Geffner presented a preliminary report at the 13th Annual
Meeting of the International Society for Cellular Therapy, held here
June 24-27. From May 2006 to January 2007, 25 patients with SCI were
treated at Luis Vernaza Hospital in Guayaquil, Ecuador. They were
treated with autologous bone marrow stem cells – meaning the cells
were extracted from the patients' own bone marrow.
Fifteen patients (60 percent) could stand up, ten patients (40
percent) could walk on the parallels with braces, seven (28 percent)
could walk without braces, and four (16 percent) could walk with
crutches. Patients demonstrated improvements in sensitivity,
motility, bladder sensation, even controlling sphincters, erection
and ejaculation. No adverse event was observed.
"These preliminary results, while encouraging, must be interpreted
cautiously and prudently, and we must continue work examining the
benefits of surgically implanted autologous bone marrow stem cells to
patients with spinal cord injuries," said Geffner, director of the
stem cell program at the Junta de Beneficencia de Guayaquil. He
emphasized that this work was done with the help and support of the
Junta de Beneficencia, Benemerita Sociedad de Lucha Contra el Cancer
(SOLCA), and with the research support and pre-clinical studies
performed by stem cell biologist and senior author Francisco Silva
and his team at PrimeCell Therapeutics, based in Irvine, Calif.
The study included in vitro (laboratory tests), pre-clinical (animal)
and clinical (human) data.
"There is evidence demonstrating significant improvement in the
quality of life of patients receiving the treatment, including spinal
cord regeneration and additional clinical improvements following
these stem cell transplants,
and development for PrimeCell Therapeutics. "More research is needed,
of course, but this is very encouraging. Our ultimate goal, as
always, is not just research – but research that will lead to timely
viable therapies."
http://www.emaxheal
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StemCells subscribers may also be interested in these sites:
Children's Neurobiological Solutions
http://www.CNSfoundation.org/
Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123
The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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