Nature 05 March 2009 Volume 458 Number 7234 pp7-114

NATURE

5 March 2009 Volume 458 Number 7234, pp 7 - 114

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EDITORIALS
----------------------
What price health? p7
When it comes to health care, the balance between cost and
effectiveness is a difficult one to strike. The injection
of $1.1 billion into the US system therefore needs to produce
sustainable results.
doi:10.1038/458007a
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Down, but not out p8
NASA should work immediately to replace the lost Orbiting Carbon
Observatory.
doi:10.1038/458008a
http://links.ealert.nature.com/ctt?kn=171&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

Advice needed p8
The Obama administration should ensure that science informs the US
strategy on nuclear waste.
doi:10.1038/458008b
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RESEARCH HIGHLIGHTS
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Ecology: Shark sex line p10
doi:10.1038/458010a
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Astronomy: Galactic striptease p10
doi:10.1038/458010b
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Plant science: Pigment puzzle p10
doi:10.1038/458010c
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Zoology: Nightingale serenade p10
doi:10.1038/458010d
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Genetics: Hopping hope p10
doi:10.1038/458010e
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Neurosciences: Child abuse 'scars' DNA pp10-11
doi:10.1038/458010f
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Mechanics: Good vibrations p11
doi:10.1038/458011a
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Palaeoclimatology: Global cooling p11
doi:10.1038/458011b
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Microscopy: Pogo-stick pictures p11
doi:10.1038/458011c
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Metamaterials: Taming terahertz p11
doi:10.1038/458011d
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JOURNAL CLUB
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Journal club p11
Paolo Tammaro
doi:10.1038/458011e
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NEWS
----------------------
Something wiki this way comes p13
Stephen Friend and Eric Schadt reveal their vision for an
open-access platform in medical research.
Bryn Nelson
doi:10.1038/458013a
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Public universities left reeling by recession pp14-15
Slumping state revenues are putting US public universities under
pressure. Rex Dalton reports on how one institution is coping.
Rex Dalton
doi:10.1038/458014a
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Looking for worlds like this one p17
NASA's Kepler mission is the best shot yet at detecting an
Earth-sized planet elsewhere in the Galaxy.
Katharine Sanderson
doi:10.1038/458017a
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Budget numbers for US science looking up p18
Big boosts for climate and basic research in President Barack
Obama's proposed spending for next year.
Eric Hand and Meredith Wadman
doi:10.1038/458018a
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Virus-free pluripotency for human cells p19
Stem-cell advance could bring tailored treatments closer.
Erika Check Hayden and Monya Baker
doi:10.1038/458019a
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US climate-research shake-up recommended p20
doi:10.1038/458020a
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Italy plans nuclear plants in cooperation with France p20
doi:10.1038/458020b
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Korean egg-donor lawsuit thrown out of court p20
doi:10.1038/458020c
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Ranbaxy censured by FDA over falsified data p20
doi:10.1038/458020d
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Europe delays decision on GM crop approvals p20
doi:10.1038/458020e
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Obama has second go at choosing US health chief p20
doi:10.1038/458020f
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----------------------
COLUMN
----------------------
The climate to get things done p21
Despite huge obstacles, political forces in Washington may
finally get greenhouse-gas legislation moving, says
David Goldston.
doi:10.1038/458021a
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NEWS FEATURES
----------------------
Profile: Being Bob Langer pp22-24
Running one of the biggest academic labs in America gives Robert
Langer almost 100 people to help and advise; his BlackBerry gives
him the rest of the world. Helen Pearson joins the throng.
Helen Pearson
doi:10.1038/458022a
http://links.ealert.nature.com/ctt?kn=220&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

Neuroscience: Rethinking rehab pp25-27
Alcoholics Anonymous and its spin-off programmes have been helping
people with addictions for decades. Jim Schnabel talks to the
neuroscientists who are looking deeper into the approach.
Jim Schnabel
doi:10.1038/458025a
http://links.ealert.nature.com/ctt?kn=146&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

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CORRESPONDENCE
----------------------
OPINION
Caution urged in trial of stem cells to treat spinal-cord injury p29
Yves Barde
doi:10.1038/458029a
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Cuts to research funding could hurt health care too p29
Kamran Ahmed and Hutan Ashrafian
doi:10.1038/458029b
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Separate name for fungus's sexual stage may cause confusion p29
David L. Hawksworth
doi:10.1038/458029c
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----------------------
ESSAY
----------------------
OPINION
We cannot live by scepticism alone p30
Scientists have been too dogmatic about scientific truth and
sociologists have fostered too much scepticism -- social scientists
must now elect to put science back at the core of society,
says Harry Collins.
doi:10.1038/458030a
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BOOKS AND ARTS
----------------------
OPINION
Biologist in the Beltway p32
Nobel prizewinner Harold Varmus's autobiography reveals his skill and
passion for research and politics, and shows why he is one of Barack
Obama's top science advisers in Washington DC, explains Iain Mattaj.
Iain Mattaj reviews The Art and Politics of Science by Harold Varmus
doi:10.1038/458032a
http://links.ealert.nature.com/ctt?kn=147&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

Artistic responses to Darwinism p33
Alison Abbott reviews Darwin: Art and the Search for Origins by
doi:10.1038/458033a
http://links.ealert.nature.com/ctt?kn=82&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

The body as a commodity pp33-34
Andrew Webster reviews Biofutures: Owning Body Parts and Information
by Robert Mitchell, Helen J. Burgess and Phillip Thurtle
doi:10.1038/458033b
http://links.ealert.nature.com/ctt?kn=257&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

Primed for evolution p34
Eugenie Scott reviews Why Evolution is True by Jerry A. Coyne
doi:10.1038/458034a
http://links.ealert.nature.com/ctt?kn=175&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

Q&A: Poetry in the genes p35
Canadian poet Christian Bok plans to encode his verse into DNA that
will sit within the genome of a live bacterium. He tells Nature why
he wants to create an organism that will translate its own poetic
response.
Krista Zala
doi:10.1038/458035a
http://links.ealert.nature.com/ctt?kn=284&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

----------------------
NEWS AND VIEWS
----------------------
Structural biology: Inside the living cell pp37-38
Proteins work properly only if they have the correct three-dimensional
atomic structure. It is now possible to look at the structures and
dynamics of these biological macromolecules as they function inside
cells.
David S. Burz and Alexander Shekhtman
doi:10.1038/458037a
http://links.ealert.nature.com/ctt?kn=211&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

Condensed-matter physics: Carbon conductor corrupted pp38-39
Atomically thin sheets of graphite are metal-like conductors -- until
they react with hydrogen, when they become insulators. This curious
effect could be an excellent model for studying metal-insulator
transitions.
Michael S. Fuhrer and Shaffique Adam
doi:10.1038/458038a
http://links.ealert.nature.com/ctt?kn=274&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

Drug discovery: Not as fab as we thought pp39-40
Ever since penicillin was isolated from mould, it has been assumed
that naturally occurring antibiotics are good starting points for
drug-discovery programmes. The latest study shows that this isn't
always true.
Soumaya Zlitni and Eric D. Brown
doi:10.1038/458039a
http://links.ealert.nature.com/ctt?kn=250&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

Astrophysics: Capturing black-hole pairs pp40-41
The observed growth of galaxies suggests that the black holes thought
to lurk at their centres may find each other and merge. A large survey
of galaxies has finally netted two black holes in a tight pairing.
Jon M. Miller
doi:10.1038/458040a
http://links.ealert.nature.com/ctt?kn=85&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

Cancer: Blood vessels kept quiet pp41-42
Tumours must get their oxygen fix, otherwise invasive tumour growth
and spread can occur. One way of quelling oxygen-deprived tumours
might be through manipulating the oxygen sensor PHD2.
Andrew V. Benest and Hellmut G. Augustin
doi:10.1038/458041a
http://links.ealert.nature.com/ctt?kn=255&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

Chemical physics: Melted in a flash pp42-43
The observation that atomic disorder emerges exceptionally fast
during laser-induced melting of crystalline bismuth prompts fresh
thinking about the nature of this phase transition.
A. Cavalleri
doi:10.1038/458042a
http://links.ealert.nature.com/ctt?kn=267&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

Immunology: Cause of death matters pp44-45
The process of programmed cell death can either induce anti-inflammatory
immune responses or actively promote inflammation. Whether the dying
cell is infected seems to govern which response is triggered.
Brigitta Stockinger
doi:10.1038/458044a
http://links.ealert.nature.com/ctt?kn=136&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

Planetary science: Volatility in Martian magmas p45
The geochemistry of the Martian surface has largely been determined
by the eruption of magmas to form basaltic rocks. A new line of
argument has chlorine as an influential agent in that process.
Harry Y. McSween
doi:10.1038/458045a
http://links.ealert.nature.com/ctt?kn=11&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

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ARTICLE
----------------------
Molecular basis of transport and regulation in the Na+/betaine
symporter BetP pp47-52
This paper presents the first X-ray structure of a member of the the
betaine/choline/carnitine transporter family. This Na+-coupled symporter
(BetP) has the same overall fold as other unrelated Na+-coupled transporters
and is captured in an intermediate conformation, whereby the substrate
(glycine betaine) is occluded from both sides of the membrane.
Susanne Ressl et al.
doi:10.1038/nature07819
Abstract: http://links.ealert.nature.com/ctt?kn=269&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
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LETTERS
----------------------
A candidate sub-parsec supermassive binary black hole system pp53-55
The role of mergers in producing galaxies, together with the finding
that most large galaxies harbour black holes in their nuclei, implies
that binary supermassive black hole systems should be common. This
study reports that the quasar SDSS J153636.22+044127.0 is a candidate
binary, and shows two broad-line emission systems, separated in
velocity by 3,500 km s-1.
Todd A. Boroson and Tod R. Lauer
doi:10.1038/nature07779
Abstract: http://links.ealert.nature.com/ctt?kn=290&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=204&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

Electronic acceleration of atomic motions and disordering in bismuth pp56-59
Electron diffraction is used to show that the melting of crystalline
bismuth after laser excitation occurs exceptionally fast, within half
the period of a lattice vibration. The extraordinary fast melting is
attributed to profound laser-induced changes in the potential energy
surface of the bismuth lattice: in the changed potential, the atoms
experience strong driving forces that launch them from their initial
equilibrium positions and towards the disorder typical of liquids.
German Sciaini et al.
doi:10.1038/nature07788
Abstract: http://links.ealert.nature.com/ctt?kn=148&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
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Temperature-induced A-B intersite charge transfer in an A-site-ordered
LaCu3Fe4O12 perovskite pp60-63
This paper identifies an oxide system where changes in valence state
occur as a result of charge being shuffled between different cations
in the host structure, rather than via doping, this charge transfer
being sensitive to temperature. As a result, the material can be
reversibly transformed from one possessing iron in an unusually high
Fe3.75+ state to one possessing rare Cu3+ ions. These changes are
reflected in the magnetic and electronic properties of the material and,
intriguingly, are accompanied by negative thermal expansion.
Y. W. Long et al.
doi:10.1038/nature07816
Abstract: http://links.ealert.nature.com/ctt?kn=67&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=209&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

Shallow fault-zone dilatancy recovery after the 2003 Bam earthquake
in Iran pp64-68
This study used interferometric analysis of synthetic aperture radar
images to measure postseismic surface deformation after the 2003 Bam,
Iran earthquake and shows reversal of coseismic dilatancy in the shallow
fault zone that causes subsidence of the surface. Such deformation
spread through a fault zone volume may explain the observed shallow slip
deficits for some strike-slip fault ruptures.
Eric J. Fielding, Paul R. Lundgren, Roland Burgmann and Gareth J. Funning
doi:10.1038/nature07817
Abstract: http://links.ealert.nature.com/ctt?kn=286&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
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Phytoplankton in the ocean use non-phosphorus lipids in response to
phosphorus scarcity pp69-72
Phytoplankton respond to phosphorous limitation with a decrease in
cellular phosphorous content. Using the populations in the oligotrophic
Saragossa Sea as an example, it is now shown that phytoplankton, but
not heterotrophic bacteria, substitute their membrane phospholipids
with lipid classes containing sulphur and nitrogen, which may provide
them with a competitive advantage in these environments.
Benjamin A. S. Van Mooy et al.
doi:10.1038/nature07659
Abstract: http://links.ealert.nature.com/ctt?kn=142&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
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Sleep and sensorimotor integration during early vocal learning in
a songbird pp73-77
In sleeping adult zebra finches, forebrain premotor neuron activity
is proposed to reflect daytime singing episodes. This study shows
that in juvenile songbirds yet to master their song, auditory exposure
to an adult 'tutor' song produced profound changes in the premotor
neuronal activity during the subsequent sleep session. These changes
in night time activity preceded and reflected tutor-song induced
changes in singing the next day.
Sylvan S. Shank and Daniel Margoliash
doi:10.1038/nature07615
Abstract: http://links.ealert.nature.com/ctt?kn=37&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=116&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

Innate immune recognition of infected apoptotic cells directs TH17
cell differentiation pp78-82
Apoptotic cell engulfment of infected cells is shown to be a prominent
signal for the induction of TH17 cell development.
Miriam Beer Torchinsky, Johan Garaude, Andrea P. Martin and
J. Magarian Blander
doi:10.1038/nature07781
Abstract: http://links.ealert.nature.com/ctt?kn=86&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=66&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

Type II fatty acid synthesis is not a suitable antibiotic target for
Gram-positive pathogens pp83-86
The type II fatty acid biosynthesis pathway has been suggested to be
a promising antimicrobial target. It is shown that major Gram-positive
pathogen groups may circumvent the action of these antimicrobials by
using host derived fatty acids instead, leaving these antibiotics
ineffective.
Sophie Brinster et al.
doi:10.1038/nature07772
Abstract: http://links.ealert.nature.com/ctt?kn=92&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=232&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

The rate of N-WASP exchange limits the extent of ARP2/3-complex-dependent
actin-based motility pp87-91
Use of live cell imaging of vaccinia virus-infected cells with
fluorescence bleaching shows that the turnover rate of N-WASP
(an activator of the ARP2/3 complex) is inversely proportional to the
rate of actin-based motility of the virus. Actin polymerization is also
required to promote N-WASP turnover on the virus. These observations
are consistent with a model in which the stability of N-WASP association
beneath the virus controls the overall rate of Arp2/3 complex-dependent
actin-based motility.
Ina Weisswange, Timothy P. Newsome, Sibylle Schleich and Michael Way
doi:10.1038/nature07773
Abstract: http://links.ealert.nature.com/ctt?kn=97&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=215&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

Casein kinase 1[agr] governs antigen-receptor-induced NF-[kgr]B
activation and human lymphoma cell survival pp92-96
The CBM complex has a key role in transducing signals from the antigen
receptors in T and B cells to the transcription factor NF-[kappa]B during
lymphocyte activation. Casein kinase 1[alpha] (CK1[alpha]) is shown to
regulate the CBM complex in two opposing ways, first promoting and then
subsequently terminating receptor-induced NF-[kappa]B activity and
lymphocyte activation.
Nicolas Bidere et al.
doi:10.1038/nature07613
Abstract: http://links.ealert.nature.com/ctt?kn=229&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=230&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

Transcriptome sequencing to detect gene fusions in cancer pp97-101
Using a combination of new generation long- and short-read sequencing
technologies, this study analyses cancer samples for gene fusion
transcripts. The approach uncovers transcripts arising from known gene
fusions in leukaemia and prostate cancer, as well as newly discovered
ones in prostate cancer.
Christopher A. Maher et al.
doi:10.1038/nature07638
Abstract: http://links.ealert.nature.com/ctt?kn=200&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=42&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

Protein structure determination in living cells by in-cell NMR
spectroscopy pp102-105
This paper determines the first 3D protein structure calculated
exclusively on the basis of information obtained in living cells.
The model protein used in this 'proof of principle' study is the
putative heavy metal-binding protein TTHA1718 from Thermus thermophilus,
and it is proposed that the approach could be used to generate accurate
high-resolution structures of many other proteins in living environments.
Daisuke Sakakibara et al.
doi:10.1038/nature07814
Abstract: http://links.ealert.nature.com/ctt?kn=227&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=206&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

High-resolution multi-dimensional NMR spectroscopy of proteins in
human cells pp106-109
In-cell NMR is a relatively new technique that can be used to
examine the conformations of proteins in living cells at the atomic
level. This method has been successfully used in bacteria and Xenopus
laevis oocytes, but wider application of the technique to living
eukaryote cells has been limited by the inefficient delivery of
isotope-labeled proteins into eukaryote somatic cells. This study
shows that it is possible to deliver suitably labelled proteins into
the cytosol of human cells through the pyrenebutyrate-mediated action
of cell-penetrating peptides that have been linked covalently to the
proteins of interest.
Kohsuke Inomata et al.
doi:10.1038/nature07839
Abstract: http://links.ealert.nature.com/ctt?kn=161&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=16&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

----------------------
ADDENDUM
----------------------
Reconciling complexity with stability in naturally assembling food webs p110
Anje-Margriet Neutel et al.
doi:10.1038/nature07825
http://links.ealert.nature.com/ctt?kn=173&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

----------------------
NATUREJOBS
----------------------
Prospects
Levelling the playing field p111
There are concrete ways to address the obstacles that face women and
people from minority groups in science.
Karen Kaplan
doi:10.1038/nj7234-111a
http://links.ealert.nature.com/ctt?kn=242&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

Career View
Mary Pearl, dean and administrative vice-president, Stony Brook
University, Southampton, New York p112
Conservation scientist brings zeal to innovative new curriculum.
Karen Kaplan
doi:10.1038/nj7234-112a
http://links.ealert.nature.com/ctt?kn=48&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

Precourt takes up energy challenge p112
New energy institute at Stanford aims to help meet future energy
demands.
Virginia Gewin
doi:10.1038/nj7234-112b
http://links.ealert.nature.com/ctt?kn=98&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

Cyclical science p112
Not your father's recession
Bryan Venters
doi:10.1038/nj7234-112c
http://links.ealert.nature.com/ctt?kn=194&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

----------------------
FUTURES
----------------------
A smooth hero p114
Dancing machine.
Julian Tang
doi:10.1038/458114a
http://links.ealert.nature.com/ctt?kn=5&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

----------------------
Advance Online Publication
----------------------
04 March 2009
Germline-encoded amino acids in the [agr][bgr] T-cell receptor
control thymic selection
James P. Scott-Browne et al.
doi:10.1038/nature07812
Abstract: http://links.ealert.nature.com/ctt?kn=275&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=53&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

AMPK regulates energy expenditure by modulating NAD+ metabolism
and SIRT1 activity
Carles Canto et al.
doi:10.1038/nature07813
Abstract: http://links.ealert.nature.com/ctt?kn=174&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=145&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

Natural variation in a neural globin tunes oxygen sensing in
wild Caenorhabditis elegans
Annelie Persson et al.
doi:10.1038/nature07820
Abstract: http://links.ealert.nature.com/ctt?kn=109&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=178&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

Glycerol monolaurate prevents mucosal SIV transmission
Qingsheng Li et al.
doi:10.1038/nature07831
Abstract: http://links.ealert.nature.com/ctt?kn=27&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=56&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

01 March 2009
Nicotine binding to brain receptors requires a strong
cation-[pgr] interaction
Xinan Xiu et al.
doi:10.1038/nature07768
Abstract: http://links.ealert.nature.com/ctt?kn=198&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=199&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

Toxin B is essential for virulence of Clostridium difficile
Dena Lyras et al.
doi:10.1038/nature07822
Abstract: http://links.ealert.nature.com/ctt?kn=277&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=28&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

The structural basis of lipopolysaccharide recognition by the
TLR4-MD-2 complex
Beom Seok Park et al.
doi:10.1038/nature07830
Abstract: http://links.ealert.nature.com/ctt?kn=113&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=265&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

A mutation in Ihh that causes digit abnormalities alters its
signalling capacity and range
Bo Gao et al.
doi:10.1038/nature07862
Abstract: http://links.ealert.nature.com/ctt?kn=233&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=104&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

piggyBac transposition reprograms fibroblasts to induced pluripotent
stem cells
Knut Woltjen et al.
doi:10.1038/nature07863
Abstract: http://links.ealert.nature.com/ctt?kn=144&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=87&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

Virus-free induction of pluripotency and subsequent excision of
reprogramming factors
Keisuke Kaji et al.
doi:10.1038/nature07864
Abstract: http://links.ealert.nature.com/ctt?kn=110&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=126&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0

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Nature Structural & Molecular Biology Contents: March 2009 Volume #16 pp 229- 344

NATURE STRUCTURAL & MOLECULAR BIOLOGY

March 2009 Volume 16 Number 3, pp 229 - 344

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----------------------
EDITORIAL
----------------------
Stimulating science p229
The economic benefits of biomedical research are recognized by
governments around the world, but investment in science should
go beyond profitability.
doi:10.1038/nsmb0309-229
http://links.ealert.nature.com/ctt?kn=9&m=31809103&r=MTc2OTcxOTY5MQS2&b=2&j=NDYyNzI0MjIS1&mt=1&rt=0

----------------------
OBITUARY
----------------------
Frederic M Richards 1925-2009 pp230 - 232
Wendell A Lim
doi:10.1038/nsmb0309-230
http://links.ealert.nature.com/ctt?kn=108&m=31809103&r=MTc2OTcxOTY5MQS2&b=2&j=NDYyNzI0MjIS1&mt=1&rt=0

----------------------
NEWS AND VIEWS
----------------------
Universal epitopes of influenza virus hemagglutinins? pp233 - 234
The influenza virus has proved an elusive target in the development
of broadly protective vaccines. A new study identifies an antibody
with broad neutralizing activity against influenza viruses of
different subtypes. The antibody recognizes a highly conserved
region on the viral hemagglutinin that may be targeted to prevent
infection.
Taia T Wang and Peter Palese
doi:10.1038/nsmb.1574
http://links.ealert.nature.com/ctt?kn=99&m=31809103&r=MTc2OTcxOTY5MQS2&b=2&j=NDYyNzI0MjIS1&mt=1&rt=0

Visualizing the twists and turns of a molecular chaperone
pp235 - 236
Intermediate conformations of the Hsp90 ATPase cycle have been
identified in solution by fluorescence resonance energy transfer,
and the impact of nucleotides and of modulatory cochaperones has
been visualized in real time.
Len Neckers, Shinji Tsutsumi and Mehdi Mollapour
doi:10.1038/nsmb0309-235
http://links.ealert.nature.com/ctt?kn=52&m=31809103&r=MTc2OTcxOTY5MQS2&b=2&j=NDYyNzI0MjIS1&mt=1&rt=0

----------------------
RESEARCH HIGHLIGHTS
----------------------
Research highlights p237
doi:10.1038/nsmb0309-237
http://links.ealert.nature.com/ctt?kn=34&m=31809103&r=MTc2OTcxOTY5MQS2&b=2&j=NDYyNzI0MjIS1&mt=1&rt=0

----------------------
ARTICLES
----------------------
Phosphorylation-mediated unfolding of a KH domain regulates KSRP
localization via 14-3-3 binding pp238 - 246
KSRP is involved in mRNA instability, a role that is repressed upon
AKT kinase-mediated phosphorylation, which promotes 14-3-3
interaction. This modification site is now shown to be exposed upon
AKT phosphorylation through unfolding of the KH1 domain of KSRP, an
event that allows 14-3-3 interaction, which in turn affects nuclear
cytoplasmic partitioning.
Irene Diaz-Moreno et al.
doi:10.1038/nsmb.1558
Abstract: http://links.ealert.nature.com/ctt?kn=39&m=31809103&r=MTc2OTcxOTY5MQS2&b=2&j=NDYyNzI0MjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=91&m=31809103&r=MTc2OTcxOTY5MQS2&b=2&j=NDYyNzI0MjIS1&mt=1&rt=0

The mRNA export protein DBP5 binds RNA and the cytoplasmic
nucleoporin NUP214 in a mutually exclusive manner
pp247 - 254
The DEAD-box protein DBP5 is involved in yeast mRNA export, though
the mechanism by which it helps to remodel and release transcripts
on the cytoplasmic face of the nuclear pore complex has been
unclear. The structures of DBP5 in complex with the mRNA and AMPPNP,
as well as with the nucleoporin NUP214, indicate that the transcript
and nucleoporin compete for the same binding site, suggesting a
model for the sequence of events occurring at the last step of export.
Holger von Moeller, Claire Basquin and Elena Conti
doi:10.1038/nsmb.1561
Abstract: http://links.ealert.nature.com/ctt?kn=46&m=31809103&r=MTc2OTcxOTY5MQS2&b=2&j=NDYyNzI0MjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=57&m=31809103&r=MTc2OTcxOTY5MQS2&b=2&j=NDYyNzI0MjIS1&mt=1&rt=0

A complex gene regulatory mechanism that operates at the nexus of
multiple RNA processing decisions pp255 - 264
Meiosis is a highly conserved and tightly regulated process in which
one round of DNA synthesis is followed by two rounds of division. By
studying the expression of crs1 pre-mRNA, a meiotic cyclin in fission
yeast, Wise and co-workers found that increased RNA accumulation
during meiosis is not due to an increase in transcription but rather
is a result of RNA processing and turnover. Moreover, they found
that polyadenylation of crs1 is linked to splicing, a coupling
previously thought to occur only in mammals. They suggest that this
highly integrated crs1 regulatory system may allow a rapid response
to adverse conditions.
David S McPheeters et al.
doi:10.1038/nsmb.1556
Abstract: http://links.ealert.nature.com/ctt?kn=58&m=31809103&r=MTc2OTcxOTY5MQS2&b=2&j=NDYyNzI0MjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=92&m=31809103&r=MTc2OTcxOTY5MQS2&b=2&j=NDYyNzI0MjIS1&mt=1&rt=0

Structural and functional bases for broad-spectrum neutralization of
avian and human influenza A viruses pp265 - 273
A group of neutralizing monoclonal antibodies (mAbs) targeting the
influenza A hemagglutinin has been selected and characterized.
Remarkably, these mAbs were able to neutralize a broad array of
group 1 strains and could protect mice from infection when given
prophylactically or therapeutically. The crystal structure of one
such mAb in complex with hemagglutinin provides insight into its
mechanism of neutralization and broad specificity.
Jianhua Sui et al.
doi:10.1038/nsmb.1566
Abstract: http://links.ealert.nature.com/ctt?kn=81&m=31809103&r=MTc2OTcxOTY5MQS2&b=2&j=NDYyNzI0MjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=4&m=31809103&r=MTc2OTcxOTY5MQS2&b=2&j=NDYyNzI0MjIS1&mt=1&rt=0

Transient ribosomal attenuation coordinates protein synthesis and
co-translational folding pp274 - 280
Rare codons along transcripts have been proposed to influence the
local rate of translation and the folding of nascent polypeptide
chains. Now this idea is demonstrated for a bacterial protein:
rare-codon clusters are shown to affect translation rates, and
this was important for efficient protein folding in vitro and in vivo.
Gong Zhang, Magdalena Hubalewska and Zoya Ignatova
doi:10.1038/nsmb.1554
Abstract: http://links.ealert.nature.com/ctt?kn=54&m=31809103&r=MTc2OTcxOTY5MQS2&b=2&j=NDYyNzI0MjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=109&m=31809103&r=MTc2OTcxOTY5MQS2&b=2&j=NDYyNzI0MjIS1&mt=1&rt=0

The large conformational changes of Hsp90 are only weakly coupled to
ATP hydrolysis pp281 - 286
The Hsp90 chaperone is responsible for the stabilization of a large
variety of regulatory proteins. Single-molecule FRET was used to
examine the conformational dynamics of Hsp90 in its different
nucleotide-bound states. The findings suggest that, in the absence
of substrate and cochaperone proteins, Hsp90's conformational
changes are not strongly coupled to ATP hydrolysis.
Moritz Mickler et al.
doi:10.1038/nsmb.1557
Abstract: http://links.ealert.nature.com/ctt?kn=44&m=31809103&r=MTc2OTcxOTY5MQS2&b=2&j=NDYyNzI0MjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=84&m=31809103&r=MTc2OTcxOTY5MQS2&b=2&j=NDYyNzI0MjIS1&mt=1&rt=0

Dissection of the ATP-induced conformational cycle of the molecular
chaperone Hsp90 pp287 - 293
The Hsp90 chaperone is responsible for the stabilization of a large
variety of regulatory proteins. By labeling the subunits in the
Hsp90 homodimer with different dyes and in different positions,
the kinetics of Hsp90 conformational changes along the ATPase
cycle was characterized, revealing different intermediate states
and the different roles of cochaperones.
Martin Hessling, Klaus Richter and Johannes Buchner
doi:10.1038/nsmb.1565
Abstract: http://links.ealert.nature.com/ctt?kn=45&m=31809103&r=MTc2OTcxOTY5MQS2&b=2&j=NDYyNzI0MjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=47&m=31809103&r=MTc2OTcxOTY5MQS2&b=2&j=NDYyNzI0MjIS1&mt=1&rt=0

A Mek1-Mek2 heterodimer determines the strength and duration of the
Erk signal pp294 - 303
Mek1 and Mek2 are kinases that phosphorylate Erk, participating in
the signal transduction pathway controlling cellular growth and
adhesion. Though closely related, there are clear functional
differences, with Mek1 being subject to negative-feedback regulation
via phosphorylation by Erk. Now Mek1 and Mek2 are shown to form a
heterodimer in vivo, in which Mek2 activity is also controlled by
Erk phosphorylation of Mek1.
Federica Catalanotti et al.
doi:10.1038/nsmb.1564
Abstract: http://links.ealert.nature.com/ctt?kn=62&m=31809103&r=MTc2OTcxOTY5MQS2&b=2&j=NDYyNzI0MjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=97&m=31809103&r=MTc2OTcxOTY5MQS2&b=2&j=NDYyNzI0MjIS1&mt=1&rt=0

PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling
histone and DNA methylation in gene silencing pp304 - 311
Mammalian gene silencing is associated with both histone and DNA
methylation. The PRMT5 arginine histone methyltransferase is now
found to affect DNA methylation at the gamma-globin locus in mice.
This is mediated by an effect on recruitment of the DNA
methyltransferase DNMT3A, but through interaction with the product
of PRMT5 activity. This suggests that DNMT3A reads the histone
methylation, coupling it to nearby DNA methylation.
Quan Zhao et al.
doi:10.1038/nsmb.1568
Abstract: http://links.ealert.nature.com/ctt?kn=51&m=31809103&r=MTc2OTcxOTY5MQS2&b=2&j=NDYyNzI0MjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=27&m=31809103&r=MTc2OTcxOTY5MQS2&b=2&j=NDYyNzI0MjIS1&mt=1&rt=0

Structural basis for G9a-like protein lysine methyltransferase
inhibition by BIX-01294 pp312 - 317
The G9a-like lysine methyltransferases can be inhibited by the small
molecule BIX-01294, recently identified through a chemical screen and
shown to be capable of replacing Oct3/4. The structure of GLP in
complex with BIX-01294 indicates an overlap with the known position
of histone peptide binding, and further work indicates that the drug
inhibits methylation of DNMT1, indicating that it is enzyme specific
but non specific with regard to substrate.
Yanqi Chang et al.
doi:10.1038/nsmb.1560
Abstract: http://links.ealert.nature.com/ctt?kn=67&m=31809103&r=MTc2OTcxOTY5MQS2&b=2&j=NDYyNzI0MjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=56&m=31809103&r=MTc2OTcxOTY5MQS2&b=2&j=NDYyNzI0MjIS1&mt=1&rt=0

The mechanism of folding of Im7 reveals competition between functional
and kinetic evolutionary constraints pp318 - 324
Im7 is a small Escherichia coli colicin binding protein that uses a
remarkably complex folding pathway. Analysis of the Im7 folding
landscape reveals details of the earliest transition state in its
folding pathway and indicates that the formation of non-native
contacts that result in intermediate folding states is necessary
to maintain elements essential to the protein's function.
Claire T Friel et al.
doi:10.1038/nsmb.1562
Abstract: http://links.ealert.nature.com/ctt?kn=24&m=31809103&r=MTc2OTcxOTY5MQS2&b=2&j=NDYyNzI0MjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=43&m=31809103&r=MTc2OTcxOTY5MQS2&b=2&j=NDYyNzI0MjIS1&mt=1&rt=0

Helix sliding in the stalk coiled coil of dynein couples ATPase and
microtubule binding pp325 - 333
The ATPase and the microtubule binding domains of dynein are
separated by a long stalk coiled coil, which has to communicate and
coordinate the activities of these domains along the mechanochemical
cycle. Now this communication is shown to occur via sliding of the
alpha-helices of the coiled coil.
Takahide Kon et al.
doi:10.1038/nsmb.1555
Abstract: http://links.ealert.nature.com/ctt?kn=96&m=31809103&r=MTc2OTcxOTY5MQS2&b=2&j=NDYyNzI0MjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=14&m=31809103&r=MTc2OTcxOTY5MQS2&b=2&j=NDYyNzI0MjIS1&mt=1&rt=0

Cyanobacterial photosystem II at 2.9-A resolution and the role of
quinones, lipids, channels and chloride pp334 - 342
Photosystem II (PSII) catalyzes the first light-dependent step in
photosynthesis. An improved structural model of a cyanobacterial
PSII provides complete assignment of all subunits in the complex
and reveals possible channels used for the transport of protons,
oxygen and water to the thylakoid lumen.
Albert Guskov et al.
doi:10.1038/nsmb.1559
Abstract: http://links.ealert.nature.com/ctt?kn=11&m=31809103&r=MTc2OTcxOTY5MQS2&b=2&j=NDYyNzI0MjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=23&m=31809103&r=MTc2OTcxOTY5MQS2&b=2&j=NDYyNzI0MjIS1&mt=1&rt=0

----------------------
BRIEF COMMUNICATION
----------------------
Cocrystal structure of a class I preQ1 riboswitch reveals a
pseudoknot recognizing an essential hypermodified nucleobase
pp343 - 344
Riboswitches are RNA domains that alter gene expression in response
to ligand binding. The structure of the Bacillus subtilis preQ1
ribsoswitch, which recognizes the conserved modified nucleobase
preQ1, in complex with its ligand indicates how an RNA of only 34
nucleotides recognizes its ligand.
Daniel J Klein, Thomas E Edwards and Adrian R Ferre-D'Amare
doi:10.1038/nsmb.1563
Abstract: http://links.ealert.nature.com/ctt?kn=7&m=31809103&r=MTc2OTcxOTY5MQS2&b=2&j=NDYyNzI0MjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=77&m=31809103&r=MTc2OTcxOTY5MQS2&b=2&j=NDYyNzI0MjIS1&mt=1&rt=0

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Genes and Immunity - Table of Contents alert Volume 10 Issue 2

GENES AND IMMUNITY

March 2009 Volume 10 Number 2, pp 101 - 199
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A Focus and Poster on CD4+ T-cell diversity

This Focus issue, produced with support from Schering-Plough, covers
the latest research on how the differentiation of TH-cell subsets and
regulatory T cells is controlled.

The Focus content is freely available for 6 months at
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function and plasticity of CD4+ T cells.

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Advance Online Publication
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----------------------
REVIEW
----------------------
Rheumatoid arthritis: a view of the current genetic landscape
M J H Coenen and P K Gregersen
Abstract: http://links.ealert.nature.com/ctt?kn=7&m=31808029&r=MTc2MTE2NTAwMwS2&b=2&j=NDYyNjg5MDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=33&m=31808029&r=MTc2MTE2NTAwMwS2&b=2&j=NDYyNjg5MDES1&mt=1&rt=0

----------------------
ORIGINAL ARTICLES
----------------------
Integrated analysis of genetic and proteomic data identifies biomarkers
associated with adverse events following smallpox vaccination
D M Reif, A A Motsinger-Reif, B A McKinney, M T Rock, J E Crowe and J H Moore
Abstract: http://links.ealert.nature.com/ctt?kn=63&m=31808029&r=MTc2MTE2NTAwMwS2&b=2&j=NDYyNjg5MDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=45&m=31808029&r=MTc2MTE2NTAwMwS2&b=2&j=NDYyNjg5MDES1&mt=1&rt=0

A coding polymorphism in NALP1 confers risk for autoimmune Addison's
disease and type 1 diabetes
N F Magitta, A S Boe Wolff, S Johansson, B Skinningsrud, B A Lie,
K-M Myhr, D E Undlien, G Joner, P R Njolstad, T K Kvien, O Forre,
P M Knappskog and E S Husebye
Abstract: http://links.ealert.nature.com/ctt?kn=28&m=31808029&r=MTc2MTE2NTAwMwS2&b=2&j=NDYyNjg5MDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=65&m=31808029&r=MTc2MTE2NTAwMwS2&b=2&j=NDYyNjg5MDES1&mt=1&rt=0

Human interferon-[lambda]3 is a potent member of the type III interferon
family
C Dellgren, H H Gad, O J Hamming, J Melchjorsen and R Hartmann
Abstract: http://links.ealert.nature.com/ctt?kn=75&m=31808029&r=MTc2MTE2NTAwMwS2&b=2&j=NDYyNjg5MDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=35&m=31808029&r=MTc2MTE2NTAwMwS2&b=2&j=NDYyNjg5MDES1&mt=1&rt=0

Expression analysis and functional activity of interleukin-7 splice
variants
N K Vudattu, I Magalhaes, H Hoehn, D Pan and M J Maeurer
Abstract: http://links.ealert.nature.com/ctt?kn=81&m=31808029&r=MTc2MTE2NTAwMwS2&b=2&j=NDYyNjg5MDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=88&m=31808029&r=MTc2MTE2NTAwMwS2&b=2&j=NDYyNjg5MDES1&mt=1&rt=0

Genetic variants of the HLA-A, HLA-B and AIF1 loci show independent
associations with type 1 diabetes in Norwegian families
M C Eike, M Olsson, D E Undlien, K Dahl-Jorgensen, G Joner, K S Ronningen,
E Thorsby and B A Lie
Abstract: http://links.ealert.nature.com/ctt?kn=53&m=31808029&r=MTc2MTE2NTAwMwS2&b=2&j=NDYyNjg5MDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=72&m=31808029&r=MTc2MTE2NTAwMwS2&b=2&j=NDYyNjg5MDES1&mt=1&rt=0

The shared CTLA4-ICOS risk locus in celiac disease, IgA deficiency and
common variable immunodeficiency
K Haimila, E Einarsdottir, A de Kauwe, L L E Koskinen, Q Pan-Hammarstrom,
T Kaartinen, K Kurppa, F Ziberna, T Not, S Vatta, A Ventura, I R Korponay-Szabo,
R Adany, Z Pocsai, G Szeles, E Dukes, K Kaukinen, M Maki, S Koskinen, J Partanen,
L Hammarstrom and P Saavalainen
Abstract: http://links.ealert.nature.com/ctt?kn=89&m=31808029&r=MTc2MTE2NTAwMwS2&b=2&j=NDYyNjg5MDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=36&m=31808029&r=MTc2MTE2NTAwMwS2&b=2&j=NDYyNjg5MDES1&mt=1&rt=0

Dramatically reduced surface expression of NK cell receptor KIR2DS3 is
attributed to multiple residues throughout the molecule
C J VandenBussche, T J Mulrooney, W R Frazier, S Dakshanamurthy and C K Hurley
Abstract: http://links.ealert.nature.com/ctt?kn=40&m=31808029&r=MTc2MTE2NTAwMwS2&b=2&j=NDYyNjg5MDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=87&m=31808029&r=MTc2MTE2NTAwMwS2&b=2&j=NDYyNjg5MDES1&mt=1&rt=0

Genetic, epidemiological and biological analysis of interleukin-10 promoter
single-nucleotide polymorphisms suggests a definitive role for -819C/T in
leprosy susceptibility
A C Pereira, V N Brito-de-Souza, C C Cardoso, I M F Dias-Baptista, F P C Parelli,
J Venturini, F R Villani-Moreno, A G Pacheco and M O Moraes
Abstract: http://links.ealert.nature.com/ctt?kn=37&m=31808029&r=MTc2MTE2NTAwMwS2&b=2&j=NDYyNjg5MDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=44&m=31808029&r=MTc2MTE2NTAwMwS2&b=2&j=NDYyNjg5MDES1&mt=1&rt=0

A TLR2 polymorphism is associated with type 1 diabetes and allergic asthma
M Bjornvold, M C Munthe-Kaas, T Egeland, G Joner, K Dahl-Jorgensen, P R Njolstad,
H E Akselsen, K Gervin, K C L Carlsen, K H Carlsen and D E Undlien
Abstract: http://links.ealert.nature.com/ctt?kn=90&m=31808029&r=MTc2MTE2NTAwMwS2&b=2&j=NDYyNjg5MDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=64&m=31808029&r=MTc2MTE2NTAwMwS2&b=2&j=NDYyNjg5MDES1&mt=1&rt=0

----------------------
SHORT COMMUNICATIONS
----------------------
Analysis of 17 autoimmune disease-associated variants in type 1 diabetes
identifies 6q23/TNFAIP3 as a susceptibility locus
E Y M G Fung, D J Smyth, J M M Howson, J D Cooper, N M Walker, H Stevens,
L S Wicker and J A Todd
Abstract: http://links.ealert.nature.com/ctt?kn=78&m=31808029&r=MTc2MTE2NTAwMwS2&b=2&j=NDYyNjg5MDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=52&m=31808029&r=MTc2MTE2NTAwMwS2&b=2&j=NDYyNjg5MDES1&mt=1&rt=0

Differential expression of SMAD3 transcripts is not regulated by cis-acting
genetic elements but has a gender specificity
L Busque, C Belisle, S Provost, M Giroux and C Perreault
Abstract: http://links.ealert.nature.com/ctt?kn=22&m=31808029&r=MTc2MTE2NTAwMwS2&b=2&j=NDYyNjg5MDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=31&m=31808029&r=MTc2MTE2NTAwMwS2&b=2&j=NDYyNjg5MDES1&mt=1&rt=0

----------------------
LETTERS TO THE EDITOR
----------------------
Confirmation of differential binding of Interferon Regulatory Factor-1 (IRF-1)
to the functional and HIV disease-influencing -2578 A/G polymorphism in CCL2
S Mummidi, G B Bonello and S K Ahuja
http://links.ealert.nature.com/ctt?kn=46&m=31808029&r=MTc2MTE2NTAwMwS2&b=2&j=NDYyNjg5MDES1&mt=1&rt=0

Reply to Mummidi et al.
E K Wright, S H Page, S A Barber and J E Clements
http://links.ealert.nature.com/ctt?kn=15&m=31808029&r=MTc2MTE2NTAwMwS2&b=2&j=NDYyNjg5MDES1&mt=1&rt=0

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In April 2009 Nature Clinical Practice Rheumatology will become
Nature Reviews Rheumatology, with a new look and additional content.

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British Journal of Cancer - Table of Contents alert Volume 100 Issue n5

BRITISH JOURNAL OF CANCER

Volume 100 Number 5
Published online 3 March 2009 (671 - 864)

---------------------------------------------------------------------
British Journal of Cancer publishes high quality original papers
and reviews that make a significant contribution to increasing
understanding of the causes of cancer and to improving the treatment
and survival of patients.

Visit the journal online at
http://links.ealert.nature.com/ctt?kn=87&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0
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British Journal of Cancer has an impact factor 4.635*

*2007 Journal Citation Report (Thomson Reuters, 2008)

----------------------
REVIEW
----------------------
CYP17 blockade by abiraterone: further evidence for frequent
continued hormone-dependence in castration-resistant prostate cancer
J E Ang, D Olmos and J S de Bono
Abstract: http://links.ealert.nature.com/ctt?kn=102&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=45&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0

----------------------
CLINICAL STUDIES
----------------------
The expression of RUNX3 in colorectal cancer is associated with
disease stage and patient outcome
R Soong, N Shah, B K Peh, P Y Chong, S S Ng, N Zeps, D Joseph,
M Salto-Tellez, B Iacopetta and Y Ito
Abstract: http://links.ealert.nature.com/ctt?kn=82&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=32&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0

Poor survival outcomes in HER2-positive breast cancer patients with
low-grade, node-negative tumours
S M Tovey, S Brown, J C Doughty, E A Mallon, T G Cooke and J Edwards
Abstract: http://links.ealert.nature.com/ctt?kn=98&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=80&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0

Management of cardiac health in trastuzumab-treated patients with
breast cancer: updated United Kingdom National Cancer Research
Institute recommendations for monitoring
A L Jones, M Barlow, P J Barrett-Lee, P A Canney, I M Gilmour,
S D Robb, C J Plummer, A M Wardley and M W Verrill
Abstract: http://links.ealert.nature.com/ctt?kn=61&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=106&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0

The impact of 18-fluorodeoxyglucose positron emission tomography
on the staging, management and outcome of anal cancer
E de Winton, A G Heriot, M Ng, R J Hicks, A Hogg, A Milner,
T Leong, M Fay, J MacKay, E Drummond and S Y Ngan
Abstract: http://links.ealert.nature.com/ctt?kn=44&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=14&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0

Comparison of tumour-based (Petersen Index) and inflammation-based
(Glasgow Prognostic Score) scoring systems in patients
undergoing curative resection for colon cancer
C S D Roxburgh, J E M Crozier, F Maxwell, A K Foulis, J Brown,
R F McKee, J H Anderson, P G Horgan and D C McMillan
Abstract: http://links.ealert.nature.com/ctt?kn=2&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=72&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0

Extended weekly dose-dense paclitaxel//carboplatin is feasible and
active in heavily pre-treated platinum-resistant recurrent ovarian
cancer
R Sharma, J Graham, H Mitchell, A Brooks, S Blagden and H Gabra
Abstract: http://links.ealert.nature.com/ctt?kn=19&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=157&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0

----------------------
TRANSLATIONAL THERAPEUTICS
----------------------
Dietary supplementation with a specific combination of high protein,
leucine, and fish oil improves muscle function and daily activity
in tumour-bearing cachectic mice
K van Norren, D Kegler, J M Argiles, Y Luiking, M Gorselink, A Laviano,
K Arts, J Faber, H Jansen, E M van der Beek and A van Helvoort
Abstract: http://links.ealert.nature.com/ctt?kn=141&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=46&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0

Protoporphyrin IX enhancement by 5-aminolaevulinic acid peptide
derivatives and the effect of RNA silencing on intracellular metabolism
L Bourre, F Giuntini, I M Eggleston, M Wilson and A J MacRobert
Abstract: http://links.ealert.nature.com/ctt?kn=130&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=100&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0

Biomarker analysis in stage III-IV (M0) gastric cancer patients who
received curative surgery followed by adjuvant 5-fluorouracil and
cisplatin chemotherapy: epidermal growth factor receptor (EGFR)
associated with favourable survival
J-S Kim, M-A Kim, T M Kim, S-H Lee, D-W Kim, S-A Im, T-Y Kim, W H Kim,
H-K Yang, D S Heo, Y-J Bang, K-U Lee, K-J Choe and N K Kim
Abstract: http://links.ealert.nature.com/ctt?kn=41&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=115&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0

Apollon gene silencing induces apoptosis in breast cancer cells
through p53 stabilisation and caspase-3 activation
A Lopergolo, M Pennati, P Gandellini, N I Orlotti, P Poma, M G Daidone,
M Folini and N Zaffaroni
Abstract: http://links.ealert.nature.com/ctt?kn=101&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=26&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0

Treatment regimen determines whether an HIF-1 inhibitor enhances or
inhibits the effect of radiation therapy
H Harada, S Itasaka, Y Zhu, L Zeng, X Xie, A Morinibu, K Shinomiya and
M Hiraoka
Abstract: http://links.ealert.nature.com/ctt?kn=97&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=138&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0

Combined inhibition of DNA methylation and histone acetylation enhances
gene re-expression and drug sensitivity in vivo
N Steele, P Finn, R Brown and J A Plumb
Abstract: http://links.ealert.nature.com/ctt?kn=110&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=123&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0

----------------------
MOLECULAR DIAGNOSTICS
----------------------
Overexpression of E2F-5 correlates with a pathological basal phenotype
and a worse clinical outcome
S Umemura, M Shirane, S Takekoshi, T Kusakabe, J Itoh, N Egashira,
Y Tokuda, K Mori and Y R Osamura
Abstract: http://links.ealert.nature.com/ctt?kn=143&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=147&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0

HIF-1[alpha] determines the metastatic potential of gastric cancer cells
N Rohwer, S Lobitz, K Daskalow, T Jons, M Vieth, P M Schlag, W Kemmner,
B Wiedenmann, T Cramer and M Hocker
Abstract: http://links.ealert.nature.com/ctt?kn=150&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=77&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0

Relation between outcomes and localisation of p-mTOR expression in
gastric cancer
T Murayama, M Inokuchi, Y Takagi, H Yamada, K Kojima, J Kumagai,
T Kawano and K Sugihara
Abstract: http://links.ealert.nature.com/ctt?kn=40&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=55&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0

Taurine: a potential marker of apoptosis in gliomas
K S Opstad, B A Bell, J R Griffiths and F A Howe
Abstract: http://links.ealert.nature.com/ctt?kn=85&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=12&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0

----------------------
EPIDEMIOLOGY
----------------------
Does type 2 diabetes influence the risk of oesophageal adenocarcinoma?
R E Neale, J D Doecke, N Pandeya, S Sadhegi, A C Green, P M Webb and D C Whiteman
Abstract: http://links.ealert.nature.com/ctt?kn=74&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=58&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0

Trends in the incidence of primary liver cancer in Central Uganda,
1960-1980 and 1991-2005
P Ocama, S Nambooze, C K Opio, M S Shiels, H R Wabinga and G D Kirk
Abstract: http://links.ealert.nature.com/ctt?kn=16&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=28&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0

Birth characteristics and risk of colorectal cancer: a study among
Swedish twins
S Cnattingius, F Lundberg and A Iliadou
Abstract: http://links.ealert.nature.com/ctt?kn=42&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=81&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0

Is the biology of breast cancer changing? A study of hormone receptor
status 1984-1986 and 1996-1997
S B F Brown, E A Mallon, J Edwards, F M Campbell, L M McGlynn,
B Elsberger and T G Cooke
Abstract: http://links.ealert.nature.com/ctt?kn=104&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=30&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0

Radiation to supraclavicular and internal mammary lymph nodes in breast
cancer increases the risk of stroke
G Nilsson, L Holmberg, H Garmo, A Terent and C Blomqvist
Abstract: http://links.ealert.nature.com/ctt?kn=146&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=59&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0

Breast cancer risk in elderly women with systemic autoimmune rheumatic
diseases: a population-based case-control study
S M Gadalla, S Amr, P Langenberg, M Baumgarten, W F Davidson,
C Schairer, E A Engels, R M Pfeiffer and J J Goedert
Abstract: http://links.ealert.nature.com/ctt?kn=124&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=155&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0

Risks of myeloid malignancies in patients with autoimmune conditions
L A Anderson, R M Pfeiffer, O Landgren, S Gadalla, S I Berndt
and E A Engels
Abstract: http://links.ealert.nature.com/ctt?kn=18&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=108&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0

Cancer risk in hospitalised asthma patients
J Ji, X Shu, X Li, K Sundquist, J Sundquist and K Hemminki
Abstract: http://links.ealert.nature.com/ctt?kn=39&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=136&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0

Urinary tract infections and reduced risk of bladder cancer in
Los Angeles
X Jiang, J E Castelao, S Groshen, V K Cortessis, D Shibata,
D V Conti, J-M Yuan, M C Pike and M Gago-Dominguez
Abstract: http://links.ealert.nature.com/ctt?kn=145&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=23&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0

Pattern of cancer risk in persons with AIDS in Italy in the HAART era
L Dal Maso, J Polesel, D Serraino, M Lise, P Piselli, F Falcini, A Russo,
T Intrieri, M Vercelli, P Zambon, G Tagliabue, R Zanetti, M Federico,
R M Limina, L Mangone, V De Lisi, F Stracci, S Ferretti, S Piffer,
M Budroni, A Donato, A Giacomin, F Bellu, M Fusco, A Madeddu,
S Vitarelli, R Tessandori, R Tumino, B Suligoi and S Franceschi
Abstract: http://links.ealert.nature.com/ctt?kn=134&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=34&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0

Tobacco chewing and female oral cavity cancer risk in Karunagappally
cohort, India
P A Jayalekshmi, P Gangadharan, S Akiba, R R K Nair, M Tsuji
and B Rajan
Abstract: http://links.ealert.nature.com/ctt?kn=91&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=86&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0

Unchanged incidence and increased survival in children with
neuroblastoma in Denmark 1981-2000: a population-based study
H Schroeder, J Wacher, H Larsson, S Rosthoej, C Rechnitzer, B L Pedersen
and N L T Carlsen
Abstract: http://links.ealert.nature.com/ctt?kn=156&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=38&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0

Cancer survival discrepancies in developed and developing countries:
comparisons between the Philippines and the United States
M T Redaniel, A Laudico, M R Mirasol-Lumague, A Gondos, D Pulte,
C Mapua and H Brenner
Abstract: http://links.ealert.nature.com/ctt?kn=5&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=3&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0

----------------------
LETTER TO THE EDITOR
----------------------
Infections in early life and risk of childhood ALL
M Greaves and P A Buffler
http://links.ealert.nature.com/ctt?kn=57&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0

----------------------
BOOK REVIEW
----------------------
Apoptosis, senescence and cancer (cancer drug discovery and development)
A Young
http://links.ealert.nature.com/ctt?kn=129&m=31807394&r=MTc2MDAwMTgxNgS2&b=2&j=NDYyNjczMDMS1&mt=1&rt=0

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EMBO Reports - Table of Contents alert Volume 10 Issue 3, pp 193-292

EMBO REPORTS TABLE OF CONTENTS

March 2009 Volume 10 Number 3, pp 193-292
(c) Copyright 2009 by the European Molecular Biology Organization
Now available at http://links.ealert.nature.com/ctt?kn=17&m=31804185&r=MTc2MDI0MTQ4MQS2&b=2&j=NDYyNDU3ODYS1&mt=1&rt=0

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*********************************************************************

Contents: Volume 10, Number 3 (March 2009)

---------------------
EDITORIAL
---------------------

On our watch.
Frank Gannon
http://links.ealert.nature.com/ctt?kn=58&m=31804185&r=MTc2MDI0MTQ4MQS2&b=2&j=NDYyNDU3ODYS1&mt=1&rt=0

---------------------
SCIENCE AND SOCIETY
---------------------

VIEWPOINTS

Natural products and drug discovery. Can thousands of years of ancient medical knowledge lead us to new and powerful drug combinations in the fight against cancer and dementia?.
Hong-Fang Ji, Xue-Juan Li & Hong-Yu Zhang
http://links.ealert.nature.com/ctt?kn=48&m=31804185&r=MTc2MDI0MTQ4MQS2&b=2&j=NDYyNDU3ODYS1&mt=1&rt=0

The role of social scientists in synthetic biology. Science & Society Series on Convergence Research.
Jane Calvert & Paul Martin
http://links.ealert.nature.com/ctt?kn=19&m=31804185&r=MTc2MDI0MTQ4MQS2&b=2&j=NDYyNDU3ODYS1&mt=1&rt=0

Sensitization: reciprocity and reflection in scientific practice. Science & Society Series on Convergence Research.
Bart Penders, Rein Vos & Klasien Horstman
http://links.ealert.nature.com/ctt?kn=67&m=31804185&r=MTc2MDI0MTQ4MQS2&b=2&j=NDYyNDU3ODYS1&mt=1&rt=0

ANALYSES

The crash reaches the universities. The global financial crisis threatens private and public university funding in the USA and Europe.
Howard Wolinsky
http://links.ealert.nature.com/ctt?kn=30&m=31804185&r=MTc2MDI0MTQ4MQS2&b=2&j=NDYyNDU3ODYS1&mt=1&rt=0

Extended phenotype redux. How far can the reach of genes extend in manipulating the environment of an organism?.
Philip Hunter
http://links.ealert.nature.com/ctt?kn=42&m=31804185&r=MTc2MDI0MTQ4MQS2&b=2&j=NDYyNDU3ODYS1&mt=1&rt=0

Free, at last! The progress of new disease eradication campaigns for Guinea worm disease and polio, and the prospect of tackling other diseases.
Andrea Rinaldi
http://links.ealert.nature.com/ctt?kn=46&m=31804185&r=MTc2MDI0MTQ4MQS2&b=2&j=NDYyNDU3ODYS1&mt=1&rt=0

---------------------
REVIEWS
---------------------

MEETING REPORT

Genomic imprinting in Singapore. Workshop on Genomic Imprinting.
Benjamin Loppin & Rebecca Oakey
http://links.ealert.nature.com/ctt?kn=22&m=31804185&r=MTc2MDI0MTQ4MQS2&b=2&j=NDYyNDU3ODYS1&mt=1&rt=0

LITERATURE REPORT

SASP reflects senescence.
Andrew R J Young & Masashi Narita
http://links.ealert.nature.com/ctt?kn=70&m=31804185&r=MTc2MDI0MTQ4MQS2&b=2&j=NDYyNDU3ODYS1&mt=1&rt=0

CONCEPT

Nucleolar targeting: the hub of the matter.
Edward Emmott & Julian A Hiscox
http://links.ealert.nature.com/ctt?kn=8&m=31804185&r=MTc2MDI0MTQ4MQS2&b=2&j=NDYyNDU3ODYS1&mt=1&rt=0
http://links.ealert.nature.com/ctt?kn=62&m=31804185&r=MTc2MDI0MTQ4MQS2&b=2&j=NDYyNDU3ODYS1&mt=1&rt=0

REVIEW

Control of histone methylation and genome stability by PTIP.
Ivan M Munoz & John Rouse
http://links.ealert.nature.com/ctt?kn=26&m=31804185&r=MTc2MDI0MTQ4MQS2&b=2&j=NDYyNDU3ODYS1&mt=1&rt=0
http://links.ealert.nature.com/ctt?kn=32&m=31804185&r=MTc2MDI0MTQ4MQS2&b=2&j=NDYyNDU3ODYS1&mt=1&rt=0

---------------------
SCIENTIFIC REPORTS
---------------------

Crystal structure of CbpF, a bifunctional choline-binding protein and autolysis regulator from Streptococcus pneumoniae.
Rafael Molina, Ana González, Meike Stelter, Inmaculada Pérez-Dorado, Richard Kahn, María Morales, Susana Campuzano, Nuria E Campillo, Shahriar Mobashery, José L García, Pedro García & Juan A Hermoso
http://links.ealert.nature.com/ctt?kn=20&m=31804185&r=MTc2MDI0MTQ4MQS2&b=2&j=NDYyNDU3ODYS1&mt=1&rt=0
http://links.ealert.nature.com/ctt?kn=56&m=31804185&r=MTc2MDI0MTQ4MQS2&b=2&j=NDYyNDU3ODYS1&mt=1&rt=0

RNA pol II subunit RPB7 is required for RNA pol I-mediated transcription in Trypanosoma brucei.
Xenia Penate, Diana López-Farfán, David Landeira, Amy Wentland, Isabel Vidal & Miguel Navarro
http://links.ealert.nature.com/ctt?kn=71&m=31804185&r=MTc2MDI0MTQ4MQS2&b=2&j=NDYyNDU3ODYS1&mt=1&rt=0
http://links.ealert.nature.com/ctt?kn=55&m=31804185&r=MTc2MDI0MTQ4MQS2&b=2&j=NDYyNDU3ODYS1&mt=1&rt=0

The NS3 protein of rice hoja blanca virus complements the RNAi suppressor function of HIV-1 Tat.
Esther Schnettler, Walter de Vries, Hans Hemmes, Joost Haasnoot, Richard Kormelink, Rob Goldbach & Ben Berkhout
http://links.ealert.nature.com/ctt?kn=47&m=31804185&r=MTc2MDI0MTQ4MQS2&b=2&j=NDYyNDU3ODYS1&mt=1&rt=0
http://links.ealert.nature.com/ctt?kn=1&m=31804185&r=MTc2MDI0MTQ4MQS2&b=2&j=NDYyNDU3ODYS1&mt=1&rt=0

Triggering the formation of tasiRNAs in Arabidopsis thaliana: the role of microRNA miR173.
Felipe F Felippes & Detlef Weigel
http://links.ealert.nature.com/ctt?kn=64&m=31804185&r=MTc2MDI0MTQ4MQS2&b=2&j=NDYyNDU3ODYS1&mt=1&rt=0
http://links.ealert.nature.com/ctt?kn=54&m=31804185&r=MTc2MDI0MTQ4MQS2&b=2&j=NDYyNDU3ODYS1&mt=1&rt=0

The M-type receptor PLA2R regulates senescence through the p53 pathway.
Arnaud Augert, Christine Payré, Yvan de Launoit, Jesus Gil, Gérard Lambeau & David Bernard
http://links.ealert.nature.com/ctt?kn=63&m=31804185&r=MTc2MDI0MTQ4MQS2&b=2&j=NDYyNDU3ODYS1&mt=1&rt=0
http://links.ealert.nature.com/ctt?kn=72&m=31804185&r=MTc2MDI0MTQ4MQS2&b=2&j=NDYyNDU3ODYS1&mt=1&rt=0

Regulation of human myoblast differentiation by PEBP4.
Reynaldo Garcia, Joan Grindlay, Oliver Rath, Frances Fee & Walter Kolch
http://links.ealert.nature.com/ctt?kn=11&m=31804185&r=MTc2MDI0MTQ4MQS2&b=2&j=NDYyNDU3ODYS1&mt=1&rt=0
http://links.ealert.nature.com/ctt?kn=50&m=31804185&r=MTc2MDI0MTQ4MQS2&b=2&j=NDYyNDU3ODYS1&mt=1&rt=0

DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy.
Einat Zalckvar, Hanna Berissi, Liat Mizrachy, Yulia Idelchuk, Itay Koren, Miriam Eisenstein, Helena Sabanay, Ronit Pinkas-Kramarski & Adi Kimchi
http://links.ealert.nature.com/ctt?kn=21&m=31804185&r=MTc2MDI0MTQ4MQS2&b=2&j=NDYyNDU3ODYS1&mt=1&rt=0
http://links.ealert.nature.com/ctt?kn=23&m=31804185&r=MTc2MDI0MTQ4MQS2&b=2&j=NDYyNDU3ODYS1&mt=1&rt=0

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