5 March 2009 Volume 458 Number 7234, pp 7 - 114
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EDITORIALS
----------------------
What price health? p7
When it comes to health care, the balance between cost and
effectiveness is a difficult one to strike. The injection
of $1.1 billion into the US system therefore needs to produce
sustainable results.
doi:10.1038/458007a
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Down, but not out p8
NASA should work immediately to replace the lost Orbiting Carbon
Observatory.
doi:10.1038/458008a
http://links.ealert.nature.com/ctt?kn=171&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Advice needed p8
The Obama administration should ensure that science informs the US
strategy on nuclear waste.
doi:10.1038/458008b
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RESEARCH HIGHLIGHTS
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Ecology: Shark sex line p10
doi:10.1038/458010a
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Astronomy: Galactic striptease p10
doi:10.1038/458010b
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Plant science: Pigment puzzle p10
doi:10.1038/458010c
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Zoology: Nightingale serenade p10
doi:10.1038/458010d
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Genetics: Hopping hope p10
doi:10.1038/458010e
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Neurosciences: Child abuse 'scars' DNA pp10-11
doi:10.1038/458010f
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Mechanics: Good vibrations p11
doi:10.1038/458011a
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Palaeoclimatology: Global cooling p11
doi:10.1038/458011b
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Microscopy: Pogo-stick pictures p11
doi:10.1038/458011c
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Metamaterials: Taming terahertz p11
doi:10.1038/458011d
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JOURNAL CLUB
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Journal club p11
Paolo Tammaro
doi:10.1038/458011e
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NEWS
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Something wiki this way comes p13
Stephen Friend and Eric Schadt reveal their vision for an
open-access platform in medical research.
Bryn Nelson
doi:10.1038/458013a
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Public universities left reeling by recession pp14-15
Slumping state revenues are putting US public universities under
pressure. Rex Dalton reports on how one institution is coping.
Rex Dalton
doi:10.1038/458014a
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Looking for worlds like this one p17
NASA's Kepler mission is the best shot yet at detecting an
Earth-sized planet elsewhere in the Galaxy.
Katharine Sanderson
doi:10.1038/458017a
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Budget numbers for US science looking up p18
Big boosts for climate and basic research in President Barack
Obama's proposed spending for next year.
Eric Hand and Meredith Wadman
doi:10.1038/458018a
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Virus-free pluripotency for human cells p19
Stem-cell advance could bring tailored treatments closer.
Erika Check Hayden and Monya Baker
doi:10.1038/458019a
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US climate-research shake-up recommended p20
doi:10.1038/458020a
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Italy plans nuclear plants in cooperation with France p20
doi:10.1038/458020b
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Korean egg-donor lawsuit thrown out of court p20
doi:10.1038/458020c
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Ranbaxy censured by FDA over falsified data p20
doi:10.1038/458020d
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Europe delays decision on GM crop approvals p20
doi:10.1038/458020e
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Obama has second go at choosing US health chief p20
doi:10.1038/458020f
http://links.ealert.nature.com/ctt?kn=51&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
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COLUMN
----------------------
The climate to get things done p21
Despite huge obstacles, political forces in Washington may
finally get greenhouse-gas legislation moving, says
David Goldston.
doi:10.1038/458021a
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NEWS FEATURES
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Profile: Being Bob Langer pp22-24
Running one of the biggest academic labs in America gives Robert
Langer almost 100 people to help and advise; his BlackBerry gives
him the rest of the world. Helen Pearson joins the throng.
Helen Pearson
doi:10.1038/458022a
http://links.ealert.nature.com/ctt?kn=220&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Neuroscience: Rethinking rehab pp25-27
Alcoholics Anonymous and its spin-off programmes have been helping
people with addictions for decades. Jim Schnabel talks to the
neuroscientists who are looking deeper into the approach.
Jim Schnabel
doi:10.1038/458025a
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CORRESPONDENCE
----------------------
OPINION
Caution urged in trial of stem cells to treat spinal-cord injury p29
Yves Barde
doi:10.1038/458029a
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Cuts to research funding could hurt health care too p29
Kamran Ahmed and Hutan Ashrafian
doi:10.1038/458029b
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Separate name for fungus's sexual stage may cause confusion p29
David L. Hawksworth
doi:10.1038/458029c
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ESSAY
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OPINION
We cannot live by scepticism alone p30
Scientists have been too dogmatic about scientific truth and
sociologists have fostered too much scepticism -- social scientists
must now elect to put science back at the core of society,
says Harry Collins.
doi:10.1038/458030a
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BOOKS AND ARTS
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OPINION
Biologist in the Beltway p32
Nobel prizewinner Harold Varmus's autobiography reveals his skill and
passion for research and politics, and shows why he is one of Barack
Obama's top science advisers in Washington DC, explains Iain Mattaj.
Iain Mattaj reviews The Art and Politics of Science by Harold Varmus
doi:10.1038/458032a
http://links.ealert.nature.com/ctt?kn=147&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Artistic responses to Darwinism p33
Alison Abbott reviews Darwin: Art and the Search for Origins by
doi:10.1038/458033a
http://links.ealert.nature.com/ctt?kn=82&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
The body as a commodity pp33-34
Andrew Webster reviews Biofutures: Owning Body Parts and Information
by Robert Mitchell, Helen J. Burgess and Phillip Thurtle
doi:10.1038/458033b
http://links.ealert.nature.com/ctt?kn=257&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Primed for evolution p34
Eugenie Scott reviews Why Evolution is True by Jerry A. Coyne
doi:10.1038/458034a
http://links.ealert.nature.com/ctt?kn=175&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Q&A: Poetry in the genes p35
Canadian poet Christian Bok plans to encode his verse into DNA that
will sit within the genome of a live bacterium. He tells Nature why
he wants to create an organism that will translate its own poetic
response.
Krista Zala
doi:10.1038/458035a
http://links.ealert.nature.com/ctt?kn=284&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
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NEWS AND VIEWS
----------------------
Structural biology: Inside the living cell pp37-38
Proteins work properly only if they have the correct three-dimensional
atomic structure. It is now possible to look at the structures and
dynamics of these biological macromolecules as they function inside
cells.
David S. Burz and Alexander Shekhtman
doi:10.1038/458037a
http://links.ealert.nature.com/ctt?kn=211&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Condensed-matter physics: Carbon conductor corrupted pp38-39
Atomically thin sheets of graphite are metal-like conductors -- until
they react with hydrogen, when they become insulators. This curious
effect could be an excellent model for studying metal-insulator
transitions.
Michael S. Fuhrer and Shaffique Adam
doi:10.1038/458038a
http://links.ealert.nature.com/ctt?kn=274&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Drug discovery: Not as fab as we thought pp39-40
Ever since penicillin was isolated from mould, it has been assumed
that naturally occurring antibiotics are good starting points for
drug-discovery programmes. The latest study shows that this isn't
always true.
Soumaya Zlitni and Eric D. Brown
doi:10.1038/458039a
http://links.ealert.nature.com/ctt?kn=250&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Astrophysics: Capturing black-hole pairs pp40-41
The observed growth of galaxies suggests that the black holes thought
to lurk at their centres may find each other and merge. A large survey
of galaxies has finally netted two black holes in a tight pairing.
Jon M. Miller
doi:10.1038/458040a
http://links.ealert.nature.com/ctt?kn=85&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Cancer: Blood vessels kept quiet pp41-42
Tumours must get their oxygen fix, otherwise invasive tumour growth
and spread can occur. One way of quelling oxygen-deprived tumours
might be through manipulating the oxygen sensor PHD2.
Andrew V. Benest and Hellmut G. Augustin
doi:10.1038/458041a
http://links.ealert.nature.com/ctt?kn=255&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Chemical physics: Melted in a flash pp42-43
The observation that atomic disorder emerges exceptionally fast
during laser-induced melting of crystalline bismuth prompts fresh
thinking about the nature of this phase transition.
A. Cavalleri
doi:10.1038/458042a
http://links.ealert.nature.com/ctt?kn=267&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Immunology: Cause of death matters pp44-45
The process of programmed cell death can either induce anti-inflammatory
immune responses or actively promote inflammation. Whether the dying
cell is infected seems to govern which response is triggered.
Brigitta Stockinger
doi:10.1038/458044a
http://links.ealert.nature.com/ctt?kn=136&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Planetary science: Volatility in Martian magmas p45
The geochemistry of the Martian surface has largely been determined
by the eruption of magmas to form basaltic rocks. A new line of
argument has chlorine as an influential agent in that process.
Harry Y. McSween
doi:10.1038/458045a
http://links.ealert.nature.com/ctt?kn=11&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
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ARTICLE
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Molecular basis of transport and regulation in the Na+/betaine
symporter BetP pp47-52
This paper presents the first X-ray structure of a member of the the
betaine/choline/carnitine transporter family. This Na+-coupled symporter
(BetP) has the same overall fold as other unrelated Na+-coupled transporters
and is captured in an intermediate conformation, whereby the substrate
(glycine betaine) is occluded from both sides of the membrane.
Susanne Ressl et al.
doi:10.1038/nature07819
Abstract: http://links.ealert.nature.com/ctt?kn=269&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
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LETTERS
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A candidate sub-parsec supermassive binary black hole system pp53-55
The role of mergers in producing galaxies, together with the finding
that most large galaxies harbour black holes in their nuclei, implies
that binary supermassive black hole systems should be common. This
study reports that the quasar SDSS J153636.22+044127.0 is a candidate
binary, and shows two broad-line emission systems, separated in
velocity by 3,500 km s-1.
Todd A. Boroson and Tod R. Lauer
doi:10.1038/nature07779
Abstract: http://links.ealert.nature.com/ctt?kn=290&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=204&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Electronic acceleration of atomic motions and disordering in bismuth pp56-59
Electron diffraction is used to show that the melting of crystalline
bismuth after laser excitation occurs exceptionally fast, within half
the period of a lattice vibration. The extraordinary fast melting is
attributed to profound laser-induced changes in the potential energy
surface of the bismuth lattice: in the changed potential, the atoms
experience strong driving forces that launch them from their initial
equilibrium positions and towards the disorder typical of liquids.
German Sciaini et al.
doi:10.1038/nature07788
Abstract: http://links.ealert.nature.com/ctt?kn=148&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=278&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Temperature-induced A-B intersite charge transfer in an A-site-ordered
LaCu3Fe4O12 perovskite pp60-63
This paper identifies an oxide system where changes in valence state
occur as a result of charge being shuffled between different cations
in the host structure, rather than via doping, this charge transfer
being sensitive to temperature. As a result, the material can be
reversibly transformed from one possessing iron in an unusually high
Fe3.75+ state to one possessing rare Cu3+ ions. These changes are
reflected in the magnetic and electronic properties of the material and,
intriguingly, are accompanied by negative thermal expansion.
Y. W. Long et al.
doi:10.1038/nature07816
Abstract: http://links.ealert.nature.com/ctt?kn=67&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=209&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Shallow fault-zone dilatancy recovery after the 2003 Bam earthquake
in Iran pp64-68
This study used interferometric analysis of synthetic aperture radar
images to measure postseismic surface deformation after the 2003 Bam,
Iran earthquake and shows reversal of coseismic dilatancy in the shallow
fault zone that causes subsidence of the surface. Such deformation
spread through a fault zone volume may explain the observed shallow slip
deficits for some strike-slip fault ruptures.
Eric J. Fielding, Paul R. Lundgren, Roland Burgmann and Gareth J. Funning
doi:10.1038/nature07817
Abstract: http://links.ealert.nature.com/ctt?kn=286&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=76&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Phytoplankton in the ocean use non-phosphorus lipids in response to
phosphorus scarcity pp69-72
Phytoplankton respond to phosphorous limitation with a decrease in
cellular phosphorous content. Using the populations in the oligotrophic
Saragossa Sea as an example, it is now shown that phytoplankton, but
not heterotrophic bacteria, substitute their membrane phospholipids
with lipid classes containing sulphur and nitrogen, which may provide
them with a competitive advantage in these environments.
Benjamin A. S. Van Mooy et al.
doi:10.1038/nature07659
Abstract: http://links.ealert.nature.com/ctt?kn=142&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=240&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Sleep and sensorimotor integration during early vocal learning in
a songbird pp73-77
In sleeping adult zebra finches, forebrain premotor neuron activity
is proposed to reflect daytime singing episodes. This study shows
that in juvenile songbirds yet to master their song, auditory exposure
to an adult 'tutor' song produced profound changes in the premotor
neuronal activity during the subsequent sleep session. These changes
in night time activity preceded and reflected tutor-song induced
changes in singing the next day.
Sylvan S. Shank and Daniel Margoliash
doi:10.1038/nature07615
Abstract: http://links.ealert.nature.com/ctt?kn=37&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=116&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Innate immune recognition of infected apoptotic cells directs TH17
cell differentiation pp78-82
Apoptotic cell engulfment of infected cells is shown to be a prominent
signal for the induction of TH17 cell development.
Miriam Beer Torchinsky, Johan Garaude, Andrea P. Martin and
J. Magarian Blander
doi:10.1038/nature07781
Abstract: http://links.ealert.nature.com/ctt?kn=86&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=66&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Type II fatty acid synthesis is not a suitable antibiotic target for
Gram-positive pathogens pp83-86
The type II fatty acid biosynthesis pathway has been suggested to be
a promising antimicrobial target. It is shown that major Gram-positive
pathogen groups may circumvent the action of these antimicrobials by
using host derived fatty acids instead, leaving these antibiotics
ineffective.
Sophie Brinster et al.
doi:10.1038/nature07772
Abstract: http://links.ealert.nature.com/ctt?kn=92&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=232&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
The rate of N-WASP exchange limits the extent of ARP2/3-complex-dependent
actin-based motility pp87-91
Use of live cell imaging of vaccinia virus-infected cells with
fluorescence bleaching shows that the turnover rate of N-WASP
(an activator of the ARP2/3 complex) is inversely proportional to the
rate of actin-based motility of the virus. Actin polymerization is also
required to promote N-WASP turnover on the virus. These observations
are consistent with a model in which the stability of N-WASP association
beneath the virus controls the overall rate of Arp2/3 complex-dependent
actin-based motility.
Ina Weisswange, Timothy P. Newsome, Sibylle Schleich and Michael Way
doi:10.1038/nature07773
Abstract: http://links.ealert.nature.com/ctt?kn=97&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=215&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Casein kinase 1[agr] governs antigen-receptor-induced NF-[kgr]B
activation and human lymphoma cell survival pp92-96
The CBM complex has a key role in transducing signals from the antigen
receptors in T and B cells to the transcription factor NF-[kappa]B during
lymphocyte activation. Casein kinase 1[alpha] (CK1[alpha]) is shown to
regulate the CBM complex in two opposing ways, first promoting and then
subsequently terminating receptor-induced NF-[kappa]B activity and
lymphocyte activation.
Nicolas Bidere et al.
doi:10.1038/nature07613
Abstract: http://links.ealert.nature.com/ctt?kn=229&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=230&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Transcriptome sequencing to detect gene fusions in cancer pp97-101
Using a combination of new generation long- and short-read sequencing
technologies, this study analyses cancer samples for gene fusion
transcripts. The approach uncovers transcripts arising from known gene
fusions in leukaemia and prostate cancer, as well as newly discovered
ones in prostate cancer.
Christopher A. Maher et al.
doi:10.1038/nature07638
Abstract: http://links.ealert.nature.com/ctt?kn=200&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=42&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Protein structure determination in living cells by in-cell NMR
spectroscopy pp102-105
This paper determines the first 3D protein structure calculated
exclusively on the basis of information obtained in living cells.
The model protein used in this 'proof of principle' study is the
putative heavy metal-binding protein TTHA1718 from Thermus thermophilus,
and it is proposed that the approach could be used to generate accurate
high-resolution structures of many other proteins in living environments.
Daisuke Sakakibara et al.
doi:10.1038/nature07814
Abstract: http://links.ealert.nature.com/ctt?kn=227&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=206&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
High-resolution multi-dimensional NMR spectroscopy of proteins in
human cells pp106-109
In-cell NMR is a relatively new technique that can be used to
examine the conformations of proteins in living cells at the atomic
level. This method has been successfully used in bacteria and Xenopus
laevis oocytes, but wider application of the technique to living
eukaryote cells has been limited by the inefficient delivery of
isotope-labeled proteins into eukaryote somatic cells. This study
shows that it is possible to deliver suitably labelled proteins into
the cytosol of human cells through the pyrenebutyrate-mediated action
of cell-penetrating peptides that have been linked covalently to the
proteins of interest.
Kohsuke Inomata et al.
doi:10.1038/nature07839
Abstract: http://links.ealert.nature.com/ctt?kn=161&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=16&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
----------------------
ADDENDUM
----------------------
Reconciling complexity with stability in naturally assembling food webs p110
Anje-Margriet Neutel et al.
doi:10.1038/nature07825
http://links.ealert.nature.com/ctt?kn=173&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
----------------------
NATUREJOBS
----------------------
Prospects
Levelling the playing field p111
There are concrete ways to address the obstacles that face women and
people from minority groups in science.
Karen Kaplan
doi:10.1038/nj7234-111a
http://links.ealert.nature.com/ctt?kn=242&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Career View
Mary Pearl, dean and administrative vice-president, Stony Brook
University, Southampton, New York p112
Conservation scientist brings zeal to innovative new curriculum.
Karen Kaplan
doi:10.1038/nj7234-112a
http://links.ealert.nature.com/ctt?kn=48&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Precourt takes up energy challenge p112
New energy institute at Stanford aims to help meet future energy
demands.
Virginia Gewin
doi:10.1038/nj7234-112b
http://links.ealert.nature.com/ctt?kn=98&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Cyclical science p112
Not your father's recession
Bryan Venters
doi:10.1038/nj7234-112c
http://links.ealert.nature.com/ctt?kn=194&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
----------------------
FUTURES
----------------------
A smooth hero p114
Dancing machine.
Julian Tang
doi:10.1038/458114a
http://links.ealert.nature.com/ctt?kn=5&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
----------------------
Advance Online Publication
----------------------
04 March 2009
Germline-encoded amino acids in the [agr][bgr] T-cell receptor
control thymic selection
James P. Scott-Browne et al.
doi:10.1038/nature07812
Abstract: http://links.ealert.nature.com/ctt?kn=275&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=53&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
AMPK regulates energy expenditure by modulating NAD+ metabolism
and SIRT1 activity
Carles Canto et al.
doi:10.1038/nature07813
Abstract: http://links.ealert.nature.com/ctt?kn=174&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=145&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Natural variation in a neural globin tunes oxygen sensing in
wild Caenorhabditis elegans
Annelie Persson et al.
doi:10.1038/nature07820
Abstract: http://links.ealert.nature.com/ctt?kn=109&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=178&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Glycerol monolaurate prevents mucosal SIV transmission
Qingsheng Li et al.
doi:10.1038/nature07831
Abstract: http://links.ealert.nature.com/ctt?kn=27&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=56&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
01 March 2009
Nicotine binding to brain receptors requires a strong
cation-[pgr] interaction
Xinan Xiu et al.
doi:10.1038/nature07768
Abstract: http://links.ealert.nature.com/ctt?kn=198&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=199&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Toxin B is essential for virulence of Clostridium difficile
Dena Lyras et al.
doi:10.1038/nature07822
Abstract: http://links.ealert.nature.com/ctt?kn=277&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=28&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
The structural basis of lipopolysaccharide recognition by the
TLR4-MD-2 complex
Beom Seok Park et al.
doi:10.1038/nature07830
Abstract: http://links.ealert.nature.com/ctt?kn=113&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=265&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
A mutation in Ihh that causes digit abnormalities alters its
signalling capacity and range
Bo Gao et al.
doi:10.1038/nature07862
Abstract: http://links.ealert.nature.com/ctt?kn=233&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=104&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
piggyBac transposition reprograms fibroblasts to induced pluripotent
stem cells
Knut Woltjen et al.
doi:10.1038/nature07863
Abstract: http://links.ealert.nature.com/ctt?kn=144&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=87&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Virus-free induction of pluripotency and subsequent excision of
reprogramming factors
Keisuke Kaji et al.
doi:10.1038/nature07864
Abstract: http://links.ealert.nature.com/ctt?kn=110&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=126&m=31809207&r=MTc2MTc4Mzk0MQS2&b=2&j=NDYyNzMxMDkS1&mt=1&rt=0
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