Signaling Gateway - 5 March 2010
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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THERAPEUTICS: SELECTIVE INHIBITORS GAIN TRACTION
A selective TORC1 and TORC2 active site inhibitor has high efficacy
and tolerability in models of acute leukaemia.
Original research paper: Nature Medicine 16, 205-213 (2010)
http://links.ealert.nature.com/ctt?kn=24&m=34679018&r=MTc2ODc4NDI0MAS2&b=2&j=NjgzODUyNTYS1&mt=1&rt=0
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Molecule Pages
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ARAP3
http://links.ealert.nature.com/ctt?kn=7&m=34679018&r=MTc2ODc4NDI0MAS2&b=2&j=NjgzODUyNTYS1&mt=1&rt=0
ARAP proteins are a unique subfamily of Arf GTPase activating
proteins (GAPs) that can act as GAPs for both Arf and Rho family
small GTPases. ARAP3 is a phosphatidylinositol(3,4,5)-triphosphate
(PtdIns(3,4,5)P3) binding protein. It is mostly localized in the
cytosol of unstimulated cells. Binding to PtdIns(3,4,5)P3 through its
pleckstrin homology (PH) domains results in ARAP3 translocation to
the plasma membrane, where it has been shown to regulate the actin
cytoskeleton, the formation of lamellipodia and cell spreading.
ARAP3 is tyrosine phosphorylated by Src, which negatively regulates
its cellular functions. ARAP3 interacts with CIN85/CMS through its
proline-arginine motif and with SH2-containing inositol phosphatase 2
(SHIP2) using the sterile alpha motif (SAM) domain. It also binds to
Rap1 through the Ras association (RA) domain. ARAP3 knockdown with
RNA interference alters cell shape and reduces platelet-derived
growth factor (PDGF)-induced lamellipodia formation.
search the molecule pages
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Selected Updates
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CELL SIGNALING: TEMPAI KEEPS TGFBETA UNDER CONTROL
The TGFbeta-induced protein TMEPAI negatively regulates TGFbeta
signaling.
Original research paper: Mol. Cell 37, 123–134 (2010)
http://links.ealert.nature.com/ctt?kn=10&m=34679018&r=MTc2ODc4NDI0MAS2&b=2&j=NjgzODUyNTYS1&mt=1&rt=0
B CELLS: DIRECT HIT BY IL-21
IL-21 receptor signaling by B cells prolongs germinal centre
response.
Original research paper: J. Exp. Med. 207, 353-363 (2010)
http://links.ealert.nature.com/ctt?kn=8&m=34679018&r=MTc2ODc4NDI0MAS2&b=2&j=NjgzODUyNTYS1&mt=1&rt=0
LIPIDOMICS: GROWING ON A FREE-FAT DIET
Monoglyceride lipase levels are increased in aggressive tumours,
provide the principal source of free fatty acids and increase the
production of biologically active lipids.
Original research paper: Cell 140, 49-61 (2010)
http://links.ealert.nature.com/ctt?kn=2&m=34679018&r=MTc2ODc4NDI0MAS2&b=2&j=NjgzODUyNTYS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=1&m=34679018&r=MTc2ODc4NDI0MAS2&b=2&j=NjgzODUyNTYS1&mt=1&rt=0
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Research Library
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http://links.ealert.nature.com/ctt?kn=4&m=34679018&r=MTc2ODc4NDI0MAS2&b=2&j=NjgzODUyNTYS1&mt=1&rt=0
ORM FAMILY PROTEINS MEDIATE SPHINGOLIPID HOMEOSTASIS
Nature 463, 1048-1053 (2010)
http://links.ealert.nature.com/ctt?kn=35&m=34679018&r=MTc2ODc4NDI0MAS2&b=2&j=NjgzODUyNTYS1&mt=1&rt=0
THE SELECTIVE AUTOPHAGY SUBSTRATE P62 ACTIVATES THE STRESS RESPONSIVE
TRANSCRIPTION FACTOR NRF2 THROUGH INACTIVATION OF KEAP1
Nature Cell Biology 12, 213-223 (2010)
http://links.ealert.nature.com/ctt?kn=40&m=34679018&r=MTc2ODc4NDI0MAS2&b=2&j=NjgzODUyNTYS1&mt=1&rt=0
REGULATION OF HEMATOPOIETIC STEM CELL DIFFERENTIATION BY A SINGLE
UBIQUITIN LIGASE-SUBSTRATE COMPLEX
Nature Immunology 11, 207-215 (2010)
http://links.ealert.nature.com/ctt?kn=33&m=34679018&r=MTc2ODc4NDI0MAS2&b=2&j=NjgzODUyNTYS1&mt=1&rt=0
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Signaling News
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NATURE REVIEWS MOLECULAR CELL BIOLOGY - MARCH ISSUE
http://links.ealert.nature.com/ctt?kn=11&m=34679018&r=MTc2ODc4NDI0MAS2&b=2&j=NjgzODUyNTYS1&mt=1&rt=0
Accompanying the March issue of Nature Reviews Molecular Cell Biology
is a Poster on Cellular regulation by deubiquitinating enzymes by
Eric J. Bennett, Mathew E. Sowa and J. Wade Harper, which provides a
schematic overview of the different deubiquitinating enzymes (DUB)
families, and highlights the cellular pathways in which some
DUB-associated complexes act. In this issue is also a web focus on
Genome Instability, which highlights some of the key mechanisms
devised to maintain genome integrity and discusses the potential
outcomes of genome instability.
SIGNALING GATEWAY IS NOW ON TWITTER!
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The Signaling Gateway now has Twitter feeds featuring recently
published Molecule Pages and highlights from the signaling world.
We aim to provide a place for interested researchers to interact.
Please give us your feedback and suggestions.
More news
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Gateway Updates
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PSI-NATURE STRUCTURAL GENOMICS KNOWLEDGEBASE - MARCH UPDATE
http://links.ealert.nature.com/ctt?kn=36&m=34679018&r=MTc2ODc4NDI0MAS2&b=2&j=NjgzODUyNTYS1&mt=1&rt=0
The Structural Genomics Knowledgebase provides news, techniques,
features and data on all the latest protein structures. Visit the
website to stay up to date with the latest developments in protein
cloning, expression, purification and structure solution.
This month's update features articles on the safer Alzheimer's drugs,
how to spot protein-protein interactions fast, and antibiotics and
ribosome function.
Sign up to receive monthly updates from the
PSI-Nature Structural Genomics Knowledgebase.
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