March 2010 Volume 6 Number 3
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=========================== ADVERTISEMENT ===========================
Nature Neuroscience
No. 1 monthly primary research journal in the Neurosciences*
Nature Neuroscience provides the international neuroscience community with
a highly visible forum in which the most exciting developments in all areas
of neuroscience can be communicated to a broad readership. A lively front
half, including News and Views, Reviews, Book Reviews and editorials, helps
place the primary research in context, providing readers with a broad
perspective on the entire field.
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*2008 Journal Citation Reports (Thomson Reuters, 2009)
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RESEARCH HIGHLIGHTS
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Multiple sclerosis: Fingolimod is an effective oral treatment for MS
p121 | doi:10.1038/nrneurol.2010.6
http://links.ealert.nature.com/ctt?kn=80&m=34684407&r=MTc2NDUyMzIwMwS2&b=2&j=Njg2MjcxNTYS1&mt=1&rt=0
IN BRIEF
Multiple sclerosis | Parkinson disease | Headache | Clinical trials
p122 | doi:10.1038/nrneurol.2010.11
http://links.ealert.nature.com/ctt?kn=34&m=34684407&r=MTc2NDUyMzIwMwS2&b=2&j=Njg2MjcxNTYS1&mt=1&rt=0
Movement disorders: Image-based analysis reveals cause of parkinsonism
p122 | doi:10.1038/nrneurol.2010.9
http://links.ealert.nature.com/ctt?kn=89&m=34684407&r=MTc2NDUyMzIwMwS2&b=2&j=Njg2MjcxNTYS1&mt=1&rt=0
Alzheimer disease: Amyloid-[beta] plaques and glucose metabolism in
early-onset AD
p123 | doi:10.1038/nrneurol.2010.10
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IN BRIEF
Migraine | Epilepsy | Aging | Headache
p123 | doi:10.1038/nrneurol.2010.12
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Alzheimer disease: Cancer link to Alzheimer disease, but not vascular
dementia
p124 | doi:10.1038/nrneurol.2010.7
http://links.ealert.nature.com/ctt?kn=68&m=34684407&r=MTc2NDUyMzIwMwS2&b=2&j=Njg2MjcxNTYS1&mt=1&rt=0
Stroke: Common pathogens increase stroke risk
p124 | doi:10.1038/nrneurol.2010.8
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NEWS AND VIEWS
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Multiple sclerosis: Can retinal imaging accurately detect optic neuritis?
Elliot M. Frohman, Laura J. Balcer and Peter A. Calabresi
p125 | doi:10.1038/nrneurol.2010.13
A new study has compared the utility of optical coherence tomography and
visual evoked potentials in the diagnosis of optic neuritis-an inflammatory
condition that is frequently the presenting symptom of multiple sclerosis.
The results indicate that the two techniques can provide complementary
information for the diagnosis of this condition.
http://links.ealert.nature.com/ctt?kn=51&m=34684407&r=MTc2NDUyMzIwMwS2&b=2&j=Njg2MjcxNTYS1&mt=1&rt=0
Parkinson disease: ADAGIO trial hints that rasagiline slows disease
progression
Cristina Sampaio and Joaquim J. Ferreira
p126 | doi:10.1038/nrneurol.2010.2
The results of the ADAGIO trial, combined with those of the TEMPO trial
and a large body of additional clinical and preclinical data, indicate
that the possibility of treatment with rasagiline should be discussed with
all patients with early Parkinson disease.
http://links.ealert.nature.com/ctt?kn=53&m=34684407&r=MTc2NDUyMzIwMwS2&b=2&j=Njg2MjcxNTYS1&mt=1&rt=0
Migraine: Migraine with aura increases the risk of stroke
Ann I. Scher and Lenore J. Launer
p128 | doi:10.1038/nrneurol.2010.14
Migraine-in particular, migraine with aura-seems to confer an increased
risk of ischemic stroke and might also be linked with other cardiovascular
events. Findings from a new meta-analysis support the former association;
however, insufficient data exist to conclude whether this type of headache
increases the risk of nonstroke cardiovascular disease.
http://links.ealert.nature.com/ctt?kn=42&m=34684407&r=MTc2NDUyMzIwMwS2&b=2&j=Njg2MjcxNTYS1&mt=1&rt=0
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REVIEWS
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Cerebrospinal fluid and plasma biomarkers in Alzheimer disease
Kaj Blennow, Harald Hampel, Michael Weiner and Henrik Zetterberg
Published online: 16 February 2010
p131 | doi:10.1038/nrneurol.2010.4
The early detection of Alzheimer disease might be critical to the
effectiveness of disease-modifying drugs, when such therapies become
available. In this Review, Blennow et al. examine the use of cerebrospinal
fluid and plasma biomarkers in the early diagnosis of this neurodegenerative
disorder. The authors also explore roles for cerebrospinal fluid biomarkers
in Alzheimer disease clinical trials.
Abstract: http://links.ealert.nature.com/ctt?kn=31&m=34684407&r=MTc2NDUyMzIwMwS2&b=2&j=Njg2MjcxNTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=49&m=34684407&r=MTc2NDUyMzIwMwS2&b=2&j=Njg2MjcxNTYS1&mt=1&rt=0
Hyperglycemia in acute ischemic stroke: pathophysiology and clinical
management
Nyika D. Kruyt, Geert Jan Biessels, J. Hans DeVries and Yvo B. Roos
Published online: 16 February 2010
p145 | doi:10.1038/nrneurol.2009.231
Individuals with acute ischemic stroke are frequently shown to have
hyperglycemia when admitted to hospital and elevated levels of blood
glucose are associated with a poor prognosis. Tight glycemic control (TGC)
might be an effective treatment for hyperglycemia in patients with acute
ischemic stroke; however, successful and safe provision of TGC is a
challenging task. This Review examines the evidence linking hyperglycemia
to unfavorable prognoses in patients with acute stroke, provides a systematic
review of the literature concerning TGC treatment after stroke and proposes
directions on how to treat hyperglycemia in patients with stroke.
Abstract: http://links.ealert.nature.com/ctt?kn=30&m=34684407&r=MTc2NDUyMzIwMwS2&b=2&j=Njg2MjcxNTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=17&m=34684407&r=MTc2NDUyMzIwMwS2&b=2&j=Njg2MjcxNTYS1&mt=1&rt=0
Environmental factors and their timing in adult-onset multiple sclerosis
Adam E. Handel, Gavin Giovannoni, George C. Ebers and Sreeram V. Ramagopalan
Published online: 16 February 2010
p156 | doi:10.1038/nrneurol.2010.1
Epidemiological data indicate that genetic and environmental factors
interact to determine an individual's risk of developing multiple sclerosis
(MS). Handel et al. examine the key periods of life during which the
environment might contribute to MS susceptibility, focusing on three
putative MS risk factors: sun exposure (and its relationship with vitamin
D levels), Epstein-Barr virus infection, and smoking.
Abstract: http://links.ealert.nature.com/ctt?kn=24&m=34684407&r=MTc2NDUyMzIwMwS2&b=2&j=Njg2MjcxNTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=16&m=34684407&r=MTc2NDUyMzIwMwS2&b=2&j=Njg2MjcxNTYS1&mt=1&rt=0
Behavior of spinal neurons deprived of supraspinal input
Volker Dietz
Published online: 26 January 2010
p167 | doi:10.1038/nrneurol.2009.227
Severe spinal cord injury (SCI) leads to dysfunction of the spinal neuronal
circuits that underlie locomotion and associated reflexes. In this article,
Volker Dietz discusses the time course of changes in the spinal circuitry
after SCI, and considers how an understanding of these changes might guide
the development of countermeasures to prevent neuronal dysfunction in the
chronic stage of SCI.
Abstract: http://links.ealert.nature.com/ctt?kn=29&m=34684407&r=MTc2NDUyMzIwMwS2&b=2&j=Njg2MjcxNTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=8&m=34684407&r=MTc2NDUyMzIwMwS2&b=2&j=Njg2MjcxNTYS1&mt=1&rt=0
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CASE STUDY
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The case of a 48 year-old woman with bizarre and complex delusions
Clement T. Loy, Jillian J. Kril, Julian N. Trollor, Matthew C. Kiernan,
John B. J. Kwok, Steve Vucic, Glenda M. Halliday and John R. Hodges
p175 | doi:10.1038/nrneurol.2010.3
In this article, Loy and colleagues examine the case of a woman with
frontotemporal dementia who presented in the clinic with complex delusions.
Psychosis is considered an unusual early feature of this form of dementia
but, when present, can wrongly suggest a diagnosis of schizophrenia. In
discussing the case, Loy et al. highlight the clinical features that might
assist in the differentiation between these two conditions.
Abstract: http://links.ealert.nature.com/ctt?kn=38&m=34684407&r=MTc2NDUyMzIwMwS2&b=2&j=Njg2MjcxNTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=1&m=34684407&r=MTc2NDUyMzIwMwS2&b=2&j=Njg2MjcxNTYS1&mt=1&rt=0
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CORRESPONDENCE
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Correspondence: Temporal lobe epilepsy is a progressive disorder
Neda Bernasconi and Boris C. Bernhardt
doi:10.1038/nrneurol.2009.82-c1
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=========================== ADVERTISEMENT ===========================
Nature Reviews Neuroscience
No. 1 monthly review journal in the Neurosciences*
The leading monthly review journal in the neurosciences, the journal
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Subjects covered:
* Cellular and molecular neuroscience
* Development of the nervous system
* Sensory, motor systems and behaviour
* Regulatory systems
* Higher cognition and language
* Computational neuroscience
* Disorders of the brain
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