Volume 102 Number 6 (941 - 1080)
Published 16 March 2010
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British Journal of Cancer publishes high quality original papers and reviews
that make a significant contribution to increasing understanding of the causes
of cancer and to improving the treatment and survival of patients.
Visit the journal online at http://links.ealert.nature.com/ctt?kn=2&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
to view the latest research and access selected articles FREE of charge.
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MINIREVIEW
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Lysophosphatidic acid production and action: critical new players in breast cancer initiation and progression
N Panupinthu, H Y Lee and G B Mills
Abstract: http://links.ealert.nature.com/ctt?kn=6&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=77&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
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CLINICAL STUDIES
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Are GPs under-investigating older patients presenting with symptoms of ovarian cancer[quest] Observational study using General Practice Research Database
A R Tate, A Nicholson and J A Cassell
Abstract: http://links.ealert.nature.com/ctt?kn=76&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=75&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
The prognostic value of plasma fibrinogen levels in patients with endometrial cancer: a multi-centre trial
V Seebacher, S Polterauer, C Grimm, H Husslein, H Leipold, K Hefler-Frischmuth, C Tempfer, A Reinthaller and L Hefler
Abstract: http://links.ealert.nature.com/ctt?kn=82&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=81&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
A comprehensive evaluation of the accuracy of cervical pre-cancer detection methods in a high-risk area in East Congo
S Hovland, M Arbyn, A K Lie, W Ryd, B Borge, E J Berle, H Skomedal, T M Kadima, L Kyembwa, E M Billay, D Mukwege, R B Chirimwami, T M Mvula, P J Snijders, C J L M Meijer and F Karlsen
Abstract: http://links.ealert.nature.com/ctt?kn=80&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=79&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
Prevalence, risk factors and clinical implications of malnutrition in French Comprehensive Cancer Centres
M Pressoir, S Desne, D Berchery, G Rossignol, B Poiree, M Meslier, S Traversier, M Vittot, M Simon, J P Gekiere, J Meuric, F Serot, M N Falewee, I Rodrigues, P Senesse, M P Vasson, F Chelle, B Maget, S Antoun and P Bachmann
Abstract: http://links.ealert.nature.com/ctt?kn=107&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=109&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
Preferences for colorectal cancer screening strategies: a discrete choice experiment
L Hol, E W de Bekker-Grob, L van Dam, B Donkers, E J Kuipers, J D F Habbema, E W Steyerberg, M E van Leerdam and M L Essink-Bot
Abstract: http://links.ealert.nature.com/ctt?kn=13&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=15&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
Efficacy and tolerability of bevacizumab plus capecitabine as first-line therapy in patients with advanced hepatocellular carcinoma
C-H Hsu, T-S Yang, C Hsu, H C Toh, R J Epstein, L-T Hsiao, P-J Chen, Z-Z Lin, T-Y Chao and A-L Cheng
Abstract: http://links.ealert.nature.com/ctt?kn=14&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=17&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
Oxaliplatin, irinotecan and capecitabine as first-line therapy in metastatic colorectal cancer (mCRC): a dose-finding study and pharmacogenomic analysis
R Zarate, J Rodriguez, E Bandres, A Patino-Garcia, M Ponz-Sarvise, A Viudez, N Ramirez, N Bitarte, A Chopitea and J Gacia-Foncillas
Abstract: http://links.ealert.nature.com/ctt?kn=16&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=19&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
Treatment of HER2-positive metastatic breast cancer with lapatinib and capecitabine in the lapatinib expanded access programme, including efficacy in brain metastases - the UK experience
S Sutherland, S Ashley, D Miles, S Chan, A Wardley, N Davidson, R Bhatti, M Shehata, H Nouras, T Camburn and S R D Johnston
Abstract: http://links.ealert.nature.com/ctt?kn=18&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=22&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
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TRANSLATIONAL THERAPEUTICS
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Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide
J Bray, J Sludden, M J Griffin, M Cole, M Verrill, D Jamieson and A V Boddy
Abstract: http://links.ealert.nature.com/ctt?kn=20&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=84&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
Combined effects of the bisphosphonate, zoledronic acid and the aromatase inhibitor letrozole on breast cancer cells in vitro: evidence of synergistic interaction
H L Neville-Webbe, R E Coleman and I Holen
Abstract: http://links.ealert.nature.com/ctt?kn=94&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=95&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
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MOLECULAR DIAGNOSTICS
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8-Hydroxydeoxyguanosine: a new potential independent prognostic factor in breast cancer
H Sova, A Jukkola-Vuorinen, U Puistola, S Kauppila and P Karihtala
Abstract: http://links.ealert.nature.com/ctt?kn=92&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=93&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
High expression of gabarapl1 is associated with a better outcome for patients with lymph node-positive breast cancer
A Berthier, S Seguin, A J Sasco, J Y Bobin, G De Laroche, J Datchary, S Saez, C Rodriguez-Lafrasse, F Tolle, A Fraichard, M Boyer-Guittaut, M Jouvenot, R Delage-Mourroux and F Descotes
Abstract: http://links.ealert.nature.com/ctt?kn=90&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=91&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
High frequency of [beta]-catenin heterozygous mutations in extra-abdominal fibromatosis: a potential molecular tool for disease management
J Domont, S Salas, L Lacroix, V Brouste, P Saulnier, P Terrier, D Ranchere, A Neuville, A Leroux, L Guillou, R Sciot, F Collin, A Dufresne, J-Y Blay, A Le Cesne, J-M Coindre, S Bonvalot and J Benard
Abstract: http://links.ealert.nature.com/ctt?kn=88&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=89&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
/`Desperate house genes/': the dramatic example of hypoxia
J Caradec, N Sirab, C Keumeugni, S Moutereau, M Chimingqi, C Matar, D Revaud, M Bah, P Manivet, M Conti and S Loric
Abstract: http://links.ealert.nature.com/ctt?kn=85&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=87&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
High-resolution genomic profiling of human papillomavirus-associated vulval neoplasia
K J Purdie, C A Harwood, K Gibbon, T Chaplin, B D Young, J B Cazier, N Singh, I M Leigh and C M Proby
Abstract: http://links.ealert.nature.com/ctt?kn=110&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=111&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
The G-protein-coupled formylpeptide receptor FPR confers a more invasive phenotype on human glioblastoma cells
J Huang, K Chen, J Chen, W Gong, N M Dunlop, O M Z Howard, Y Gao, X-w Bian and J M Wang
Abstract: http://links.ealert.nature.com/ctt?kn=112&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=102&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
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GENETICS AND GENOMICS
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Identification of DBC1 as a transcriptional repressor for BRCA1
H Hiraike, O Wada-Hiraike, S Nakagawa, S Koyama, Y Miyamoto, K Sone, M Tanikawa, T Tsuruga, K Nagasaka, Y Matsumoto, K Oda, K Shoji, H Fukuhara, S Saji, K Nakagawa, S Kato, T Yano and Y Taketani
Abstract: http://links.ealert.nature.com/ctt?kn=103&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=105&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
MutS[beta] exceeds MutS[alpha] in dinucleotide loop repair
J Kantelinen, M Kansikas, M K Korhonen, S Ollila, K Heinimann, R Kariola and M Nystrom
Abstract: http://links.ealert.nature.com/ctt?kn=106&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=98&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
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LETTERS TO THE EDITOR
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KRAS status analysis and anti-EGFR therapies: is comprehensiveness a biologist's fancy or a clinical necessity[quest]
E Lopez-Crapez, L Mineur, H Emptas and P-J Lamy
http://links.ealert.nature.com/ctt?kn=101&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
Reply: KRAS status analysis and anti-EGFR therapies: is comprehensiveness a biologist's fancy or a clinical necessity[quest]
C Cremolini, A Ruzzo, F Graziano, A Falcone and F Loupakis
http://links.ealert.nature.com/ctt?kn=57&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
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CORRIGENDA
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Letter to the Editor: SUN vs BEV[thorn]IFN in first-line mRCC therapy: no evidence for a statistically significant difference in progression-free survival
M Nuijten and G Mickisch
http://links.ealert.nature.com/ctt?kn=54&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
Prospective study of predictors of vitamin D status and survival in patients with colorectal cancer
K Ng, B M Wolpin, J A Meyerhardt, K Wu, A T Chan, B W Hollis, E L Giovannucci, M J Stampfer, W C Willett and C S Fuchs
http://links.ealert.nature.com/ctt?kn=51&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
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ERRATUM
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MLH1 mediates PARP-dependent cell death in response to the methylating agent N-methyl-N-nitrosourea
J R McDaid, J Loughery, P Dunne, J C Boyer, C S Downes, R A Farber and C P Walsh
http://links.ealert.nature.com/ctt?kn=49&m=34707799&r=MTc2MDAwMTgxNgS2&b=2&j=NjkwOTc4MjYS1&mt=1&rt=0
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