Signaling Gateway - 12 February 2010
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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CELL SIGNALING: NLK TURNS IT DOWN A NOTCH
Nemo-like kinase suppresses Notch signaling by hampering formation of
the ternary transcription complex.
Original research paper: Nature Cell Biology Advance online
publication (31 January 2010)
http://links.ealert.nature.com/ctt?kn=24&m=34625116&r=MTc2ODc4NDI0MAS2&b=2&j=NjcyNjQzMTUS1&mt=1&rt=0
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Molecule Pages
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THROMBOSPONDIN 1
http://links.ealert.nature.com/ctt?kn=7&m=34625116&r=MTc2ODc4NDI0MAS2&b=2&j=NjcyNjQzMTUS1&mt=1&rt=0
The thrombospondins are a family of extracellular matrix molecules
that mediate the cell-to-cell and cell-to-matrix interactions that
are involved in development, wound healing and neoplasia.
In Drosophila, the single thrombospondin gene mediates the attachment
of muscles to tendon. These effects are mediated through interactions
with cell surface receptors, such as integrins, proteoglycans,
calreticulin, CD36 and CD47. Thrombospondin-1 (TSP-1) is unique among
the members of the thrombospondin gene family in its ability to bind
and activate latent transforming growth factor-beta. TSP-1 also
regulates proliferative, adhesive, migratory and invasive properties
of various cell types. In the tumor microenvironment, TSP-1 promotes
the migration of tumor cells and cancer-associated fibroblasts but
inhibits the migration of endothelial cells. These activities have
prompted the development of TSP-1 mimetics for the inhibition of
tumor growth.
search the molecule pages
http://links.ealert.nature.com/ctt?kn=6&m=34625116&r=MTc2ODc4NDI0MAS2&b=2&j=NjcyNjQzMTUS1&mt=1&rt=0
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Selected Updates
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LIPID TRAFFICKING: EXCHANGE BY ORDER
ORPs bind two membranes simultaneously and regulate sterol transfer
between them.
Original research paper: J. Cell Biol. 187, 889–903 (2009)
http://links.ealert.nature.com/ctt?kn=10&m=34625116&r=MTc2ODc4NDI0MAS2&b=2&j=NjcyNjQzMTUS1&mt=1&rt=0
T CELL RESPONSES: mTOR MIXES UP A RECIPE FOR SUCCESS
How does mTOR integrate signals from antigen, costimulatory and
cytokine receptors in CD8+ T cells?
Original research paper: Immunity 7 Jan (2010)
doi:10.1016/j.immuni.2009.10.010
http://links.ealert.nature.com/ctt?kn=8&m=34625116&r=MTc2ODc4NDI0MAS2&b=2&j=NjcyNjQzMTUS1&mt=1&rt=0
METASTASIS: MOTION CAPTURE
Mutant p53 promotes cell migration and invasion through integrin
recycling.
Original research paper: Cell 139, 1327–1341 (2009)
http://links.ealert.nature.com/ctt?kn=2&m=34625116&r=MTc2ODc4NDI0MAS2&b=2&j=NjcyNjQzMTUS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=1&m=34625116&r=MTc2ODc4NDI0MAS2&b=2&j=NjcyNjQzMTUS1&mt=1&rt=0
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Research Library
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http://links.ealert.nature.com/ctt?kn=4&m=34625116&r=MTc2ODc4NDI0MAS2&b=2&j=NjcyNjQzMTUS1&mt=1&rt=0
OPPPOSING MICRO RNA FAMILIES REGULATE SELF-RENEWAL IN MOUSE EMBRYONIC
STEM CELLS
Nature 463, 621–626 (2010)
http://links.ealert.nature.com/ctt?kn=33&m=34625116&r=MTc2ODc4NDI0MAS2&b=2&j=NjcyNjQzMTUS1&mt=1&rt=0
TGF-BETA-FOXO SIGNALLING MAINTAINS LEUKAEMIA-INITIATING CELLS IN
CHRONIC MYELOID LEUKAEMIA
Nature 463, 676–680 (2010)
http://links.ealert.nature.com/ctt?kn=30&m=34625116&r=MTc2ODc4NDI0MAS2&b=2&j=NjcyNjQzMTUS1&mt=1&rt=0
MESENCHYMAL PROGENITORS DISTINCT FROM SATELLITE CELLS CONTRIBUTE TO
ECTOPIC FAT CELL FORMATION IN SKELETAL MUSCLE
Nature Cell Biology 12, 143-152 (2010)
http://links.ealert.nature.com/ctt?kn=37&m=34625116&r=MTc2ODc4NDI0MAS2&b=2&j=NjcyNjQzMTUS1&mt=1&rt=0
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Signaling News
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NATURE IMMUNOLOGY FOCUS: TOLERANCE BREAKDOWN
http://links.ealert.nature.com/ctt?kn=35&m=34625116&r=MTc2ODc4NDI0MAS2&b=2&j=NjcyNjQzMTUS1&mt=1&rt=0
Although recent progress has aided our understanding of the processes
that prevent immune tolerance breakdown, much still remains unknown
about susceptibility to and pathogenesis of autoimmune diseases.
This web focus from Nature Immunology presents an overview, four
review articles and two perspective articles that cover the cellular
and molecular mechanisms required to maintain self tolerance, as well
as events that can precipitate tolerance breakdown and lead to
autoimmunity.
More news
http://links.ealert.nature.com/ctt?kn=17&m=34625116&r=MTc2ODc4NDI0MAS2&b=2&j=NjcyNjQzMTUS1&mt=1&rt=0
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Gateway Updates
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THE CELL MIGRATION GATEWAY - FEBRUARY UPDATE
http://links.ealert.nature.com/ctt?kn=11&m=34625116&r=MTc2ODc4NDI0MAS2&b=2&j=NjcyNjQzMTUS1&mt=1&rt=0
The Cell Migration Gateway is a comprehensive FREE online resource
for news, highlights and research on cell migration.
This month's update features "Wound healing: Occludin polarizes the
leading edge" and "Cell migration: Signaling for persistence".
The Cell Migration Gateway now has a Twitter feed and a Facebook page
that will have the monthly update content and provide a venue for
interaction among interested researchers.
Sign up to receive the table of contents e-alert for the
Cell Migration Gateway Update.
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