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| 1. | Editors' Notes Page xi |
| Previews |
| 2. | A New Member of the Spindle Orientation Club: Mammalian Intestinal Stem Cells Pages 91-92 Yukiko M. Yamashita |
| 3. | Age-Related Changes in Niche Cells Influence Hematopoietic Stem Cell Function Pages 93-94 Erin J. Oakley, Gary Van Zant |
| 4. | A Dominant Role of the Hair Follicle Stem Cell Niche in Regulating Melanocyte Stemness Pages 95-96 Cédric Blanpain, Panagiota A. Sotiropoulou |
| 5. | NO Signals from the Cancer Stem Cell Niche Pages 97-98 Joan Seoane |
| Forum |
| 6. | A Legal Defense for Compensating Research Egg Donors Pages 99-102 Susan L. Crockin |
| Review |
| 7. | Stem Cells and the Niche: A Dynamic Duo Pages 103-115 Justin Voog, D. Leanne Jones |
| Articles |
| 8. | Sprouty1 Regulates Reversible Quiescence of a Self-Renewing Adult Muscle Stem Cell Pool during Regeneration Pages 117-129 Kelly L. Shea, Wanyi Xiang, Vincent S. LaPorta, Jonathan D. Licht, Charles Keller, M. Albert Basson, Andrew S. Brack Graphical Abstract► Pax7+ skeletal satellite cells regenerate muscle in their endogenous environment ► Quiescent satellite cells express the RTK inhibitor Spry1 ► Spry1 is needed for satellite cells to return to quiescence after muscle injury ► Deletion of Spry1 in satellite cells depletes the muscle stem cell pool |
| 9. | Key Roles for Transforming Growth Factor β in Melanocyte Stem Cell Maintenance Pages 130-140 Emi K. Nishimura, Misa Suzuki, Vivien Igras, Jinyan Du, Scott Lonning, Yoshiki Miyachi, Jürgen Roes, Friedrich Beermann, David E. Fisher Graphical Abstract► TGF-β signaling active as melanocyte stem cells enter quiescence ► TGF-β from niche induces cell cycle arrest and suppresses melanogenic genes ► Deletion of TGF-β receptor depletes melanocyte stem cells ► Hair grays prematurely in mice lacking melanocyte TFG-β receptor |
| 10. | Perivascular Nitric Oxide Activates Notch Signaling and Promotes Stem-like Character in PDGF-Induced Glioma Cells Pages 141-152 Nikki Charles, Tatsuya Ozawa, Massimo Squatrito, Anne-Marie Bleau, Cameron W. Brennan, Dolores Hambardzumyan, Eric C. Holland Graphical Abstract► Perivascular niche nitric oxide activates Notch in PDGF-induced gliomas ► Notch signaling drives tumor stem-like characteristics and reduces survival ► Loss of eNOS activity decreases tumor stem-like characteristics ► Suppressing eNOS activity prolongs survival in glioma-bearing mice |
| 11. | Polycomb-like 2 Associates with PRC2 and Regulates Transcriptional Networks during Mouse Embryonic Stem Cell Self-Renewal and Differentiation Pages 153-166 Emily Walker, Wing Y. Chang, Julie Hunkapiller, Gerard Cagney, Kamal Garcha, Joseph Torchia, Nevan J. Krogan, Jeremy F. Reiter, William L. Stanford Graphical Abstract► PCL2 associates with the PRC2 complex in mouse ESCs ► PCL2 knockdown increases self-renewal and disrupts differentiation ► Reducing PLC2 decreases H3K27me3 at specific targets ► PCL2 represses transcription of self-renewal genes in ESCs |
| Short Articles |
| 12. | The Nuclear Receptor Nr5a2 Can Replace Oct4 in the Reprogramming of Murine Somatic Cells to Pluripotent Cells Pages 167-174 Jian-Chien Dominic Heng, Bo Feng, Jianyong Han, Jianming Jiang, Petra Kraus, Jia-Hui Ng, Yuriy L. Orlov, Mikael Huss, Lin Yang, Thomas Lufkin, Bing Lim, Huck-Hui Ng Graphical Abstract► Nuclear receptor Nr5a2 enhances reprogramming of mouse fibroblasts ► Nr5a2 can replace Oct4 in the reprogramming cocktail ► Nr5a2 with enhanced transcriptional activity more effective in reprogramming ► DNA binding links Nr5a2 to the core pluripotency network |
| 13. | Spindle Orientation Bias in Gut Epithelial Stem Cell Compartments Is Lost in Precancerous Tissue Pages 175-181 Aaron J. Quyn, Paul L. Appleton, Francis A. Carey, Robert J.C. Steele, Nick Barker, Hans Clevers, Rachel A. Ridgway, Owen J. Sansom, Inke S. Näthke Graphical Abstract► Mitotic spindles in intestinal stem cells align perpendicularly ► In precancerous tissue, this spindle orientation bias is lost ► Spindle alignment correlates with segregation of unreplicated DNA ► Loss of unreplicated DNA occurs more quickly in precancerous tissue |
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