ScienceDirect Alert: Cell Stem Cell, Vol. 6, Iss. 2, 2010

New Volume/Issue is now available on ScienceDirect

Cell Stem Cell Volume 6, Issue 2,  Pages 91-182 (5 February 2010)

1.

Editors' Notes Page xi

Previews

2.

A New Member of the Spindle Orientation Club: Mammalian Intestinal Stem Cells Pages 91-92 Yukiko M. Yamashita

3.

Age-Related Changes in Niche Cells Influence Hematopoietic Stem Cell Function Pages 93-94 Erin J. Oakley, Gary Van Zant

4.

A Dominant Role of the Hair Follicle Stem Cell Niche in Regulating Melanocyte Stemness Pages 95-96 Cédric Blanpain, Panagiota A. Sotiropoulou

5.

NO Signals from the Cancer Stem Cell Niche Pages 97-98 Joan Seoane

Forum

6.

A Legal Defense for Compensating Research Egg Donors Pages 99-102 Susan L. Crockin

Review

7.

Stem Cells and the Niche: A Dynamic Duo Pages 103-115 Justin Voog, D. Leanne Jones

Articles

8.

Sprouty1 Regulates Reversible Quiescence of a Self-Renewing Adult Muscle Stem Cell Pool during Regeneration Pages 117-129 Kelly L. Shea, Wanyi Xiang, Vincent S. LaPorta, Jonathan D. Licht, Charles Keller, M. Albert Basson, Andrew S. Brack Graphical Abstract ► Pax7+ skeletal satellite cells regenerate muscle in their endogenous environment ► Quiescent satellite cells express the RTK inhibitor Spry1 ► Spry1 is needed for satellite cells to return to quiescence after muscle injury ► Deletion of Spry1 in satellite cells depletes the muscle stem cell pool

9.

Key Roles for Transforming Growth Factor β in Melanocyte Stem Cell Maintenance Pages 130-140 Emi K. Nishimura, Misa Suzuki, Vivien Igras, Jinyan Du, Scott Lonning, Yoshiki Miyachi, Jürgen Roes, Friedrich Beermann, David E. Fisher Graphical Abstract ► TGF-β signaling active as melanocyte stem cells enter quiescence ► TGF-β from niche induces cell cycle arrest and suppresses melanogenic genes ► Deletion of TGF-β receptor depletes melanocyte stem cells ► Hair grays prematurely in mice lacking melanocyte TFG-β receptor

10.

Perivascular Nitric Oxide Activates Notch Signaling and Promotes Stem-like Character in PDGF-Induced Glioma Cells Pages 141-152 Nikki Charles, Tatsuya Ozawa, Massimo Squatrito, Anne-Marie Bleau, Cameron W. Brennan, Dolores Hambardzumyan, Eric C. Holland Graphical Abstract ► Perivascular niche nitric oxide activates Notch in PDGF-induced gliomas ► Notch signaling drives tumor stem-like characteristics and reduces survival ► Loss of eNOS activity decreases tumor stem-like characteristics ► Suppressing eNOS activity prolongs survival in glioma-bearing mice

11.

Polycomb-like 2 Associates with PRC2 and Regulates Transcriptional Networks during Mouse Embryonic Stem Cell Self-Renewal and Differentiation Pages 153-166 Emily Walker, Wing Y. Chang, Julie Hunkapiller, Gerard Cagney, Kamal Garcha, Joseph Torchia, Nevan J. Krogan, Jeremy F. Reiter, William L. Stanford Graphical Abstract ► PCL2 associates with the PRC2 complex in mouse ESCs ► PCL2 knockdown increases self-renewal and disrupts differentiation ► Reducing PLC2 decreases H3K27me3 at specific targets ► PCL2 represses transcription of self-renewal genes in ESCs

Short Articles

12.

The Nuclear Receptor Nr5a2 Can Replace Oct4 in the Reprogramming of Murine Somatic Cells to Pluripotent Cells Pages 167-174 Jian-Chien Dominic Heng, Bo Feng, Jianyong Han, Jianming Jiang, Petra Kraus, Jia-Hui Ng, Yuriy L. Orlov, Mikael Huss, Lin Yang, Thomas Lufkin, Bing Lim, Huck-Hui Ng Graphical Abstract ► Nuclear receptor Nr5a2 enhances reprogramming of mouse fibroblasts ► Nr5a2 can replace Oct4 in the reprogramming cocktail ► Nr5a2 with enhanced transcriptional activity more effective in reprogramming ► DNA binding links Nr5a2 to the core pluripotency network

13.

Spindle Orientation Bias in Gut Epithelial Stem Cell Compartments Is Lost in Precancerous Tissue Pages 175-181 Aaron J. Quyn, Paul L. Appleton, Francis A. Carey, Robert J.C. Steele, Nick Barker, Hans Clevers, Rachel A. Ridgway, Owen J. Sansom, Inke S. Näthke Graphical Abstract ► Mitotic spindles in intestinal stem cells align perpendicularly ► In precancerous tissue, this spindle orientation bias is lost ► Spindle alignment correlates with segregation of unreplicated DNA ► Loss of unreplicated DNA occurs more quickly in precancerous tissue

Send my e-mail in plain text format

Modify or Remove My Alerts

Access the ScienceDirect Info site if you have questions about this message or other features of this service.

This email has been sent to you by ScienceDirect, a division of Elsevier B.V., Radarweg 29, 1043 NX Amsterdam, The Netherlands, Tel.+31 20 485 3911. ScienceDirect respects your privacy and does not disclose, rent or sell your personal information to any non-affiliated third parties without your consent, except as may be stated in the ScienceDirect online privacy policy. By using email or alert services, you agree to comply with the ScienceDirect Terms and Conditions. To unsubscribe to alert services, please go to the Alerts page. Copyright © 2010 ScienceDirect. All rights reserved. Any unauthorized use, reproduction, or transfer of this message or its contents, in any medium, is strictly prohibited. ScienceDirect® is a registered trademark of Elsevier B.V. Delivery Job ID: 11207:262158941:11205:222320604