March 2010 Volume 11 Number 3, pp 181 - 272
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Nature Reviews Immunology
Poster on Regulatory T cells
Regulatory T cells are vital for keeping the immune system in check,
and they have been the focus of extensive research over the past few years.
This Poster provides an updated overview of the development,
phenotype and functions of regulatory T cells, in particular
those subsets that express the transcription factor forkhead
box P3 (FOXP3).
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EDITORIAL
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Educating the public p181
doi:10.1038/ni0310-181
California has one of the most prestigious public university
systems. However, budget woes and lack of clear strategic
planning may undermine its continued success.
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COMMENTARY
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In vivo veritas: the surprising roles of Fc receptors in
immunity pp183 - 185
Jeffrey Ravetch
doi:10.1038/ni0310-183
Jeffrey Ravetch describes how he came to identify the in vivo
function of the once mysterious Fc receptors.
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NEWS AND VIEWS
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Vanilloid flavor for a good appetite? pp187 - 189
Shigeo Koyasu
doi:10.1038/ni0310-187
Members of the transient receptor potential vanilloid ion-channel
family are expressed in a wide variety of cells and function as
sensors of mechanical stress. The second such family member, TVRP2,
is now also linked to phagocytosis in macrophages.
http://links.ealert.nature.com/ctt?kn=23&m=34636023&r=MTc2NTA4MDAwNgS2&b=2&j=Njc1Mjc0NjES1&mt=1&rt=0
CD8+ thymocyte differentiation: T cell two-step pp189 - 190
Nicholas R J Gascoigne
doi:10.1038/ni0310-189
A new study demonstrates that commitment to the CD8 lineage in
the thymus requires sequential T cell antigen receptor (TCR) and
interleukin 7 (IL-7) signaling. The TCR signal first induces IL-7
responsiveness, then recognition of IL-7 induces the nuclear factor
Runx3, which specifies the CD8 lineage.
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Voltage control for B cell activation pp191 - 192
Michael Reth and Tobias P Dick
doi:10.1038/ni0310-191
Transient formation of reactive oxygen species (ROS) accompanies B
cell signaling and activation. Now the voltage-gated proton channel
HVCN1 has been linked to ROS formation and B cell activation.
http://links.ealert.nature.com/ctt?kn=77&m=34636023&r=MTc2NTA4MDAwNgS2&b=2&j=Njc1Mjc0NjES1&mt=1&rt=0
Controlling stem cell fate one substrate at a time pp193 - 194
Brian S Garrison and Derrick J Rossi
doi:10.1038/ni0310-193
Hematopoietic stem cell self-renewal is tightly regulated. Regulation
of the stability of c-Myc protein contributes to this control of
hematopoietic stem cell quiescence and repopulation.
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RESEARCH HIGHLIGHTS
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Research Highlights p195
doi:10.1038/ni0310-195
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REVIEW
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Raising the NKT cell family pp197 - 206
Dale I Godfrey, Sanda Stankovic and Alan G Baxter
doi:10.1038/ni.1841
Abstract: http://links.ealert.nature.com/ctt?kn=11&m=34636023&r=MTc2NTA4MDAwNgS2&b=2&j=Njc1Mjc0NjES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=56&m=34636023&r=MTc2NTA4MDAwNgS2&b=2&j=Njc1Mjc0NjES1&mt=1&rt=0
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ARTICLES
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Regulation of hematopoietic stem cell differentiation by a single
ubiquitin ligase-substrate complex pp207 - 215
Linsey Reavie et al.
doi:10.1038/ni.1839
Hematopoietic stem cells infrequently proliferate, but their
self-renewal is essential. Aifantis and colleagues show regulation
of c-Myc protein stability by the ubiquitin ligase Fbw7 controls the
self-renewal and differentiation potential of these cells.
Abstract: http://links.ealert.nature.com/ctt?kn=16&m=34636023&r=MTc2NTA4MDAwNgS2&b=2&j=Njc1Mjc0NjES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=59&m=34636023&r=MTc2NTA4MDAwNgS2&b=2&j=Njc1Mjc0NjES1&mt=1&rt=0
Temporal changes in dendritic cell subsets, cross-priming and
costimulation via CD70 control CD8+ T cell responses to influenza
pp216 - 224
Andre Ballesteros-Tato, Beatriz Leon, Frances E Lund and Troy D Randall
doi:10.1038/ni.1838
Efficient antiviral responses require cross-priming of cytolytic T
lymphocytes by dendritic cells. Randall and colleagues show that
CD103-CD11bhi dendritic cells directly cross-prime CD8+ T cells
after influenza infection.
Abstract: http://links.ealert.nature.com/ctt?kn=15&m=34636023&r=MTc2NTA4MDAwNgS2&b=2&j=Njc1Mjc0NjES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=44&m=34636023&r=MTc2NTA4MDAwNgS2&b=2&j=Njc1Mjc0NjES1&mt=1&rt=0
Chromogranin A is an autoantigen in type 1 diabetes pp225 - 231
Brian D Stadinski et al.
doi:10.1038/ni.1844
The identity of self antigens targeted in various autoimmune diseases
is often unknown. Haskins and colleagues identify a chromagranin A
epitope whose presentation by I-Ag7 involves an unusual peptide-binding
mode.
Abstract: http://links.ealert.nature.com/ctt?kn=14&m=34636023&r=MTc2NTA4MDAwNgS2&b=2&j=Njc1Mjc0NjES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=47&m=34636023&r=MTc2NTA4MDAwNgS2&b=2&j=Njc1Mjc0NjES1&mt=1&rt=0
TRPV2 has a pivotal role in macrophage particle binding and
phagocytosis pp232 - 239
Tiffany M Link et al.
doi:10.1038/ni.1842
Phagocytosis involves ionic flux, but the identity of the ion
channels involved remains ill defined. Caterina and co-workers
show that the cation channel TRPV2 is involved in particle binding
and phagocytosis in macrophages.
Abstract: http://links.ealert.nature.com/ctt?kn=13&m=34636023&r=MTc2NTA4MDAwNgS2&b=2&j=Njc1Mjc0NjES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=26&m=34636023&r=MTc2NTA4MDAwNgS2&b=2&j=Njc1Mjc0NjES1&mt=1&rt=0
An essential role for the transcription factor HEB in thymocyte survival,
Tcra rearrangement and the development of natural killer T cells
pp240 - 249
Louise M D'Cruz, Jamie Knell, Jessica K Fujimoto and Ananda W Goldrath
doi:10.1038/ni.1845
Lymphocyte development requires transcription factors of the E2A family.
Goldrath and colleagues identify a unique role for the E2 protein HEB in
the generation and survival of invariant natural killer T cells.
Abstract: http://links.ealert.nature.com/ctt?kn=6&m=34636023&r=MTc2NTA4MDAwNgS2&b=2&j=Njc1Mjc0NjES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=34&m=34636023&r=MTc2NTA4MDAwNgS2&b=2&j=Njc1Mjc0NjES1&mt=1&rt=0
Regulation of IL-9 expression by IL-25 signaling pp250 - 256
Pornpimon Angkasekwinai et al.
doi:10.1038/ni.1846
How IL-9 expression is regulated remains unclear. Dong and co-workers
show that the IL-25-IL-17RB pathway is central to the physiological
regulation of this cytokine in vivo.
Abstract: http://links.ealert.nature.com/ctt?kn=7&m=34636023&r=MTc2NTA4MDAwNgS2&b=2&j=Njc1Mjc0NjES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=29&m=34636023&r=MTc2NTA4MDAwNgS2&b=2&j=Njc1Mjc0NjES1&mt=1&rt=0
Signaling by intrathymic cytokines, not T cell antigen receptors,
specifies CD8 lineage choice and promotes the differentiation of
cytotoxic-lineage T cells pp257 - 264
Jung-Hyun Park et al.
doi:10.1038/ni.1840
Whether CD8-lineage specification and CD8+ T cell differentiation
is dependent on intrathymic cytokines signaling is unclear. Singer
and co-workers show that interleukin 7 specifies CD8-lineage choice
and promotes the differentiation of cytotoxic-lineage T cells.
Abstract: http://links.ealert.nature.com/ctt?kn=8&m=34636023&r=MTc2NTA4MDAwNgS2&b=2&j=Njc1Mjc0NjES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=28&m=34636023&r=MTc2NTA4MDAwNgS2&b=2&j=Njc1Mjc0NjES1&mt=1&rt=0
HVCN1 modulates BCR signal strength via regulation of BCR-dependent
generation of reactive oxygen species pp265 - 272
Melania Capasso et al.
doi:10.1038/ni.1843
Reactive oxygen species can enhance B cell antigen receptor (BCR)
signaling strength. Dyer and colleagues show that the voltage-gated
proton channel HVCN1 associates with BCRs and contributes to BCR
signaling via the generation of reactive oxygen species.
Abstract: http://links.ealert.nature.com/ctt?kn=9&m=34636023&r=MTc2NTA4MDAwNgS2&b=2&j=Njc1Mjc0NjES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=74&m=34636023&r=MTc2NTA4MDAwNgS2&b=2&j=Njc1Mjc0NjES1&mt=1&rt=0
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