January 2010 Volume 10 Number 1
Visit Nature Reviews Immunology online to browse the journal.
Now available at http://links.ealert.nature.com/ctt?kn=24&m=34510972&r=MTc2NzU2Mjg3MwS2&b=2&j=NjI5MzIzMzMS1&mt=1&rt=0
Please note that you need to be a subscriber to enjoy full text
access to Nature Reviews Immunology online. To purchase a
subscription, please visit: http://links.ealert.nature.com/ctt?kn=51&m=34510972&r=MTc2NzU2Mjg3MwS2&b=2&j=NjI5MzIzMzMS1&mt=1&rt=0
Alternatively, to recommend a subscription to your library, please
visit http://links.ealert.nature.com/ctt?kn=18&m=34510972&r=MTc2NzU2Mjg3MwS2&b=2&j=NjI5MzIzMzMS1&mt=1&rt=0
*********************************************************************
Nature Reviews Immunology Impact Factor: 30.01*
(*2008 Journal Citation Report (Thomson Reuters, 2009))
*********************************************************************
=========================== ADVERTISEMENT ===========================
Find over 5,000 vacancies across scientific disciplines as well as
the latest job market news, career advice and more, only at...
naturejobs.com
http://links.ealert.nature.com/ctt?kn=9&m=34510972&r=MTc2NzU2Mjg3MwS2&b=2&j=NjI5MzIzMzMS1&mt=1&rt=0
ATTENTION EMPLOYERS! Stay up to date with Naturejobs advertising
deadlines and upcoming features:
http://links.ealert.nature.com/ctt?kn=95&m=34510972&r=MTc2NzU2Mjg3MwS2&b=2&j=NjI5MzIzMzMS1&mt=1&rt=0 or
telephone:
US: + 1 800 989 7718
EUR: +44 (0) 20 7843 4961
=====================================================================
=========================== ADVERTISEMENT ===========================
Nature Reprint Collection
Immuno-epigenetics
Epigenetic mechanisms are increasingly appreciated to have an
important role in immune cell functional diversity and adaptability,
and understanding these mechanisms holds considerable potential for
revealing new opportunities to therapeutically modulate the immune
response in a range of diseases.
This special collection brings together articles from Nature, Nature
Immunology, Nature Reviews Immunology and Nature Reviews Drug
Discovery that have contributed to advances and discussions in the
field of immune cell epigenetics.
Read the Collection online for FREE:
http://links.ealert.nature.com/ctt?kn=22&m=34510972&r=MTc2NzU2Mjg3MwS2&b=2&j=NjI5MzIzMzMS1&mt=1&rt=0
Produced with Support from:
GlaxoSmithKline
http://links.ealert.nature.com/ctt?kn=14&m=34510972&r=MTc2NzU2Mjg3MwS2&b=2&j=NjI5MzIzMzMS1&mt=1&rt=0
=====================================================================
This month's FEATURED article:
The immune response during acute HIV-1 infection: clues for vaccine
development
Andrew J. McMichael, Persephone Borrow, Georgia D. Tomaras, Nilu
Goonetilleke and Barton F. Haynes
p11 | doi:10.1038/nri2674
http://links.ealert.nature.com/ctt?kn=55&m=34510972&r=MTc2NzU2Mjg3MwS2&b=2&j=NjI5MzIzMzMS1&mt=1&rt=0
=====================================================================
From the editors
p1 | doi:10.1038/nri2706
http://links.ealert.nature.com/ctt?kn=82&m=34510972&r=MTc2NzU2Mjg3MwS2&b=2&j=NjI5MzIzMzMS1&mt=1&rt=0
----------------------
COMMENT
----------------------
How did our complex immune system evolve?
Max D. Cooper and Brantley R. Herrin
p2 | doi:10.1038/nri2686
Learning from the similarities and differences between phylogenetic
branches.
http://links.ealert.nature.com/ctt?kn=83&m=34510972&r=MTc2NzU2Mjg3MwS2&b=2&j=NjI5MzIzMzMS1&mt=1&rt=0
----------------------
RESEARCH HIGHLIGHTS
----------------------
Autoimmunity: Modelling autoimmune lung disease
p4 | doi:10.1038/nri2694
A potential mechanism for the pulmonary complications of autoimmune
diseases.
http://links.ealert.nature.com/ctt?kn=91&m=34510972&r=MTc2NzU2Mjg3MwS2&b=2&j=NjI5MzIzMzMS1&mt=1&rt=0
Chemokines: A class apart - uncovering a role for the C-chemokine
p5 | doi:10.1038/nri2697
XCL1 chemoattracts CD8+ DCs and promotes antigen cross-presentation.
http://links.ealert.nature.com/ctt?kn=93&m=34510972&r=MTc2NzU2Mjg3MwS2&b=2&j=NjI5MzIzMzMS1&mt=1&rt=0
IN BRIEF
Macrophages | Dendritic cells | Tumour immunology
p5 | doi:10.1038/nri2700
http://links.ealert.nature.com/ctt?kn=50&m=34510972&r=MTc2NzU2Mjg3MwS2&b=2&j=NjI5MzIzMzMS1&mt=1&rt=0
Antiviral immunity: Ageing immune systems work too hard
p6 | doi:10.1038/nri2699
High virus-induced mortality among the elderly blamed on exaggerated
IL-17 responses.
http://links.ealert.nature.com/ctt?kn=73&m=34510972&r=MTc2NzU2Mjg3MwS2&b=2&j=NjI5MzIzMzMS1&mt=1&rt=0
IN BRIEF
T cells | Innate immunity | Regulatory T cells
p6 | doi:10.1038/nri2701
http://links.ealert.nature.com/ctt?kn=15&m=34510972&r=MTc2NzU2Mjg3MwS2&b=2&j=NjI5MzIzMzMS1&mt=1&rt=0
T cell memory: Subsetting memory
p6 | doi:10.1038/nri2704
Memory TH1 and TH17 cells arise from different infection routes and
differ in longevity.
http://links.ealert.nature.com/ctt?kn=100&m=34510972&r=MTc2NzU2Mjg3MwS2&b=2&j=NjI5MzIzMzMS1&mt=1&rt=0
T cell signalling: CD3 conformation is crucial for signalling
p7 | doi:10.1038/nri2703
More than simple molecule clustering needed for signal transduction.
http://links.ealert.nature.com/ctt?kn=103&m=34510972&r=MTc2NzU2Mjg3MwS2&b=2&j=NjI5MzIzMzMS1&mt=1&rt=0
Innate immunity: MicroRNAs limit LPS lethality
p8 | doi:10.1038/nri2696
Pro-inflammatory protein PDCD4 targeted by microRNA tempers LPS
toxicity.
http://links.ealert.nature.com/ctt?kn=96&m=34510972&r=MTc2NzU2Mjg3MwS2&b=2&j=NjI5MzIzMzMS1&mt=1&rt=0
Asthma and allergy: Prenatal protection through TLRs
p8 | doi:10.1038/nri2698
Maternal exposure to farm-associated bacteria may protect offspring
from asthma
http://links.ealert.nature.com/ctt?kn=98&m=34510972&r=MTc2NzU2Mjg3MwS2&b=2&j=NjI5MzIzMzMS1&mt=1&rt=0
Innate immunity: An unexpected guest at the regulatory table
p9 | doi:10.1038/nri2695
Neutrophils are found to produce interleukin-10 in response to
bacterial stimuli.
http://links.ealert.nature.com/ctt?kn=90&m=34510972&r=MTc2NzU2Mjg3MwS2&b=2&j=NjI5MzIzMzMS1&mt=1&rt=0
Innate immunity: Bacteria ensure injury is only skin deep
p10 | doi:10.1038/nri2693
Commensal staphylococci on the skin help limit potentially harmful
inflammation.
http://links.ealert.nature.com/ctt?kn=79&m=34510972&r=MTc2NzU2Mjg3MwS2&b=2&j=NjI5MzIzMzMS1&mt=1&rt=0
IN THE NEWS
Eli Sercarz's legacy
p10 | doi:10.1038/nri2702
http://links.ealert.nature.com/ctt?kn=39&m=34510972&r=MTc2NzU2Mjg3MwS2&b=2&j=NjI5MzIzMzMS1&mt=1&rt=0
----------------------
REVIEWS
----------------------
The immune response during acute HIV-1 infection: clues for vaccine
development
Andrew J. McMichael, Persephone Borrow, Georgia D. Tomaras, Nilu
Goonetilleke and Barton F. Haynes
p11 | doi:10.1038/nri2674
Unprecedented insight into the early stages of HIV-1 infection has
provided important clues for vaccine design. Here, the authors
discuss how early virological and immunological events, including
transmission by a single founder virus and marked CD4+ T cell loss,
might influence the course of disease.
Abstract: http://links.ealert.nature.com/ctt?kn=55&m=34510972&r=MTc2NzU2Mjg3MwS2&b=2&j=NjI5MzIzMzMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=46&m=34510972&r=MTc2NzU2Mjg3MwS2&b=2&j=NjI5MzIzMzMS1&mt=1&rt=0
Post-transcriptional regulons coordinate the initiation and
resolution of inflammation
Paul Anderson
p24 | doi:10.1038/nri2685
This Review article describes the variety of mechanisms that regulate
the production of protein and lipid mediators of inflammation through
effects on translation initiation and mRNA decay, with an emphasis on
mechanisms that link the initiation and resolution phases of
inflammation.
Abstract: http://links.ealert.nature.com/ctt?kn=16&m=34510972&r=MTc2NzU2Mjg3MwS2&b=2&j=NjI5MzIzMzMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=42&m=34510972&r=MTc2NzU2Mjg3MwS2&b=2&j=NjI5MzIzMzMS1&mt=1&rt=0
Macrophage death and defective inflammation resolution in
atherosclerosis
Ira Tabas
p36 | doi:10.1038/nri2675
An important aspect of atherosclerosis is the defective resolution of
the inflammatory response to subendothelial lipoproteins. But what
are the pathways involved in inflammation resolution, why are they
defective in atherosclerotic lesions and how can they be
therapeutically targeted?
Abstract: http://links.ealert.nature.com/ctt?kn=12&m=34510972&r=MTc2NzU2Mjg3MwS2&b=2&j=NjI5MzIzMzMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=30&m=34510972&r=MTc2NzU2Mjg3MwS2&b=2&j=NjI5MzIzMzMS1&mt=1&rt=0
Evolution of host innate defence: insights from Caenorhabditis
elegans and primitive invertebrates
Javier E. Irazoqui, Jonathan M. Urbach and Frederick M. Ausubel
p47 | doi:10.1038/nri2689
The soil nematode Caenorhabditis elegans is easy to manipulate
genetically and is therefore a useful model organism. But C. elegans
does not use its Toll-like receptor homologue for immune defence. So
what can it tell us about the origins and functions of other immune
defence pathways in higher organisms?
Abstract: http://links.ealert.nature.com/ctt?kn=13&m=34510972&r=MTc2NzU2Mjg3MwS2&b=2&j=NjI5MzIzMzMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=59&m=34510972&r=MTc2NzU2Mjg3MwS2&b=2&j=NjI5MzIzMzMS1&mt=1&rt=0
Pairing computation with experimentation: a powerful coupling for
understanding T cell signalling
Arup K. Chakraborty and Jayajit Das
p59 | doi:10.1038/nri2688
In this Review, the authors illustrate how computational modelling
can complement experimental research to understand highly complex
signalling networks in T cells. They explain how computational
approaches can help to eliminate incorrect hypotheses, generate new
hypotheses, reveal gaps in our knowledge and design better
experiments.
Abstract: http://links.ealert.nature.com/ctt?kn=10&m=34510972&r=MTc2NzU2Mjg3MwS2&b=2&j=NjI5MzIzMzMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=61&m=34510972&r=MTc2NzU2Mjg3MwS2&b=2&j=NjI5MzIzMzMS1&mt=1&rt=0
----------------------
PERSPECTIVES
----------------------
OPINION
Proteasomes in immune cells: more than peptide producers?
Marcus Groettrup, Christopher J. Kirk and Michael Basler
p73 | doi:10.1038/nri2687
In this Opinion article, the authors discuss our current
understanding of the roles of immunoproteasomes and thymoproteasomes
in T cell receptor repertoire formation and propose that
immunoproteasomes have additional roles in cytokine production and T
helper cell differentiation.
Abstract: http://links.ealert.nature.com/ctt?kn=11&m=34510972&r=MTc2NzU2Mjg3MwS2&b=2&j=NjI5MzIzMzMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=48&m=34510972&r=MTc2NzU2Mjg3MwS2&b=2&j=NjI5MzIzMzMS1&mt=1&rt=0
=========================== ADVERTISEMENT ===========================
NATURE IMMUNOLOGY
FOCUS ON TOLERANCE BREAKDOWN
In January 2010, Nature Immunology presents a focus on the cellular
and molecular mechanisms required to maintain self tolerance, as well
as events that can precipitate tolerance breakdown and lead to
autoimmunity. The focus contains a specially commissioned overview,
four review articles and two perspectives. Also included are
highlights of recent research findings.
For more information, visit
http://links.ealert.nature.com/ctt?kn=19&m=34510972&r=MTc2NzU2Mjg3MwS2&b=2&j=NjI5MzIzMzMS1&mt=1&rt=0
=====================================================================
You have been sent this Table of Contents Alert because you have
opted in to receive it. You can change or discontinue your e-mail
alerts at any time, by modifying your preferences on your nature.com
account at: http://links.ealert.nature.com/ctt?kn=17&m=34510972&r=MTc2NzU2Mjg3MwS2&b=2&j=NjI5MzIzMzMS1&mt=1&rt=0
(You will need to log in to be recognised as a nature.com registrant).
For further technical assistance, please contact our registration
department: registration@nature.com
For print subscription enquiries, please contact our subscription
department: subscriptions@nature.com
For other enquiries, please contact our customer feedback department:
feedback@nature.com
Nature Publishing Group | 75 Varick Street, 9th Floor | New York |
NY 10013-1917 | USA
Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne -
San Diego - San Francisco - Washington - New York - Boston
(c) Copyright 2010 Nature Publishing Group
=====================================================================
