January 2010 Volume 10 Number 1
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MIAMI 2010 WINTER SYMPOSIUM
Targeting Cancer Invasion and Metastasis
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This month's FEATURED article:
Leukaemogenesis: more than mutant genes
Jianjun Chen, Olatoyosi Odenike and Janet D. Rowley
p23 | doi:10.1038/nrc2765
http://links.ealert.nature.com/ctt?kn=59&m=34511101&r=MTc2Njc4NzkyNgS2&b=2&j=NjI5MzUzMjkS1&mt=1&rt=0
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From the editors
p1 | doi:10.1038/nrc2788
The importance of understanding basic biology.
http://links.ealert.nature.com/ctt?kn=14&m=34511101&r=MTc2Njc4NzkyNgS2&b=2&j=NjI5MzUzMjkS1&mt=1&rt=0
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COMMENT
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Systemic inflammation as a confounding factor in cancer biomarker
discovery and validation
Magdalena Chechlinska, Magdalena Kowalewska and Radoslawa Nowak
p2 | doi:10.1038/nrc2782
Cancer and inflammation are inextricably linked and cancer patients have
local and systemic changes in inflammatory parameters. However, this crucial
aspect of tumour biology is often overlooked in biomarker studies and needs
to be urgently addressed.
http://links.ealert.nature.com/ctt?kn=16&m=34511101&r=MTc2Njc4NzkyNgS2&b=2&j=NjI5MzUzMjkS1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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Signalling: Different strokes
p4 | doi:10.1038/nrc2777
Signals from EphB receptors that trigger cell proliferation and migration
are mediated by two distinct downstream pathways.
http://links.ealert.nature.com/ctt?kn=18&m=34511101&r=MTc2Njc4NzkyNgS2&b=2&j=NjI5MzUzMjkS1&mt=1&rt=0
Immunology: Inflammatory transformation
p5 | doi:10.1038/nrc2776
http://links.ealert.nature.com/ctt?kn=20&m=34511101&r=MTc2Njc4NzkyNgS2&b=2&j=NjI5MzUzMjkS1&mt=1&rt=0
Tumorigenesis: Them's the breaks kid
p5 | doi:10.1038/nrc2784
Hyperactive AID can result in widespread genomic damage and lymphoma.
http://links.ealert.nature.com/ctt?kn=22&m=34511101&r=MTc2Njc4NzkyNgS2&b=2&j=NjI5MzUzMjkS1&mt=1&rt=0
Metastasis: Self-renewal migrates onwards
p6 | doi:10.1038/nrc2778
How does ZEB1 regulate self-renewal and migration?
http://links.ealert.nature.com/ctt?kn=2&m=34511101&r=MTc2Njc4NzkyNgS2&b=2&j=NjI5MzUzMjkS1&mt=1&rt=0
Signalling: All roads lead to YAP1
p6 | doi:10.1038/nrc2779
Several papers find that YAP1 has many important roles in tumorigenesis
and tumour progression.
http://links.ealert.nature.com/ctt?kn=4&m=34511101&r=MTc2Njc4NzkyNgS2&b=2&j=NjI5MzUzMjkS1&mt=1&rt=0
IN BRIEF
Therapy | Genetics | Therapy | Metabolism
p7 | doi:10.1038/nrc2786
http://links.ealert.nature.com/ctt?kn=55&m=34511101&r=MTc2Njc4NzkyNgS2&b=2&j=NjI5MzUzMjkS1&mt=1&rt=0
Senescence: A family trait
p8 | doi:10.1038/nrc2783
TAp63 induces senescence and suppresses tumour growth in vivo.
http://links.ealert.nature.com/ctt?kn=94&m=34511101&r=MTc2Njc4NzkyNgS2&b=2&j=NjI5MzUzMjkS1&mt=1&rt=0
Metabolism: An oncogenic change of function
p8 | doi:10.1038/nrc2785
Missense mutations of IDH1 confer oncogenic gain-of-function properties.
http://links.ealert.nature.com/ctt?kn=82&m=34511101&r=MTc2Njc4NzkyNgS2&b=2&j=NjI5MzUzMjkS1&mt=1&rt=0
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REVIEWS
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Integrins in cancer: biological implications and therapeutic opportunities
Jay S. Desgrosellier and David A. Cheresh
p9 | doi:10.1038/nrc2748
The integrins regulate a diverse array of cellular functions that are
crucial to the initiation, progression and metastasis of solid tumours.
This Review discusses the exciting developments in targeting integrins,
including the recent initiation of a Phase III trial for an integrin
antagonist in patients with glioblastoma.
Abstract: http://links.ealert.nature.com/ctt?kn=57&m=34511101&r=MTc2Njc4NzkyNgS2&b=2&j=NjI5MzUzMjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=85&m=34511101&r=MTc2Njc4NzkyNgS2&b=2&j=NjI5MzUzMjkS1&mt=1&rt=0
Leukaemogenesis: more than mutant genes
Jianjun Chen, Olatoyosi Odenike and Janet D. Rowley
p23 | doi:10.1038/nrc2765
Epigenetic modifications, including DNA methylation and histone modifications,
as well as microRNAs, contribute to the development of acute leukaemias.
This Review describes the current understanding of epigenetic changes
(including microRNA regulation) in acute leukaemias, with a particular focus
on those characterized by balanced chromosomal aberrations.
Abstract: http://links.ealert.nature.com/ctt?kn=50&m=34511101&r=MTc2Njc4NzkyNgS2&b=2&j=NjI5MzUzMjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=67&m=34511101&r=MTc2Njc4NzkyNgS2&b=2&j=NjI5MzUzMjkS1&mt=1&rt=0
From pathogenesis to treatment of chronic lymphocytic leukaemia
Thorsten Zenz, Daniel Mertens, Ralf Kuppers, Hartmut Dohner and
Stephan Stilgenbauer
p37 | doi:10.1038/nrc2764
Many factors, including genetic and epigenetic alterations, antigenic
drive and the microenvironment, are crucial in the initiation and progression
of chronic lymphocytic leukaemia (CLL). How will our growing understanding
of CLL biology lead to the translation of therapeutic targets and prognostic
markers into clinical practice?
Abstract: http://links.ealert.nature.com/ctt?kn=52&m=34511101&r=MTc2Njc4NzkyNgS2&b=2&j=NjI5MzUzMjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=68&m=34511101&r=MTc2Njc4NzkyNgS2&b=2&j=NjI5MzUzMjkS1&mt=1&rt=0
Senescence in tumours: evidence from mice and humans
Manuel Collado and Manuel Serrano
p51 | doi:10.1038/nrc2772
Oncogene-induced senescence was first seen in cultured cells. However,
since the initial in vitro observation of this phenomenon, it has been shown
to occur in both mouse and human tumours. What do we know about tumour cell
senescence in vivo, and how might this be exploited therapeutically?
Abstract: http://links.ealert.nature.com/ctt?kn=44&m=34511101&r=MTc2Njc4NzkyNgS2&b=2&j=NjI5MzUzMjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=71&m=34511101&r=MTc2Njc4NzkyNgS2&b=2&j=NjI5MzUzMjkS1&mt=1&rt=0
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ANALYSIS
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A census of amplified and overexpressed human cancer genes
Thomas Santarius, Janet Shipley, Daniel Brewer, Michael R. Stratton and
Colin S. Cooper
p59 | doi:10.1038/nrc2771
This article proposes a weight-of-evidence based classification system for
identifying individual genes in an amplified region of the genome that
contribute to cancer development. The 77 genes identified using this approach
have been further subdivided into different gene classes.
Abstract: http://links.ealert.nature.com/ctt?kn=42&m=34511101&r=MTc2Njc4NzkyNgS2&b=2&j=NjI5MzUzMjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=74&m=34511101&r=MTc2Njc4NzkyNgS2&b=2&j=NjI5MzUzMjkS1&mt=1&rt=0
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PERSPECTIVES
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OPINION
Emerging roles of ATF2 and the dynamic AP1 network in cancer
Pablo Lopez-Bergami, Eric Lau and Ze'ev Ronai
p65 | doi:10.1038/nrc2681
Cooperation among transcription factors is central for their ability to
execute specific transcriptional programmes. This Perspective summarizes
the emerging role of the transcription factor ATF2 as part of the AP1
complex in tumorigenesis.
Abstract: http://links.ealert.nature.com/ctt?kn=39&m=34511101&r=MTc2Njc4NzkyNgS2&b=2&j=NjI5MzUzMjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=60&m=34511101&r=MTc2Njc4NzkyNgS2&b=2&j=NjI5MzUzMjkS1&mt=1&rt=0
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British Journal of Cancer presents:
Breast cancer: Improved care through effective management of febrile
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An examination of the increasing use of intensive adjuvant regimens for
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with these regimens.
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