January 2010 Volume 11 Number 1, pp 1 - 71
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=========================== ADVERTISEMENT ===========================
The Middle & The End
This 2009 EMBO Journal review series focuses on different facets of centromere
and telomere biology. Nine review articles summarize our current understanding
of various aspects of chromosome biology, especiallyin the light of recent
advances, demonstrating parallels as well as differences in the function and
organization of centers and ends.
Focus on Telomeres and Centromeres in full
http://links.ealert.nature.com/ctt?kn=39&m=34511311&r=MTc2MDI0MTQ4MQS2&b=2&j=NjI5NDM1NjQS1&mt=1&rt=0
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UPFRONT
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EDITORIAL
Postdockin' in the free world
Does postdoctoral research experience properly train biological scientists? Howy Jacobs explores the shortcomings of the current system and suggests how we might improve the lot of those currently on the long road to scientific fame and fortune.
Howy Jacobs
doi:10.1038/embor.2009.259
http://links.ealert.nature.com/ctt?kn=81&m=34511311&r=MTc2MDI0MTQ4MQS2&b=2&j=NjI5NDM1NjQS1&mt=1&rt=0
HOT OFF THE PRESS
Opening a new DOR to autophagy
Our understanding of the autophagic pathway and the mechanisms that target specific components for degradation is still in its infancy. A new regulator, DOR, and a receptor that specifically targets mitochondria for degradation, Nix, provide new insights into this important process.
Jaeline Spowart and Julian J. Lum
doi:10.1038/embor.2009.265
http://links.ealert.nature.com/ctt?kn=82&m=34511311&r=MTc2MDI0MTQ4MQS2&b=2&j=NjI5NDM1NjQS1&mt=1&rt=0
MEETING POINT
Constructing ribosomes along the Danube
The EMBO Conference on Ribosome Synthesis explored the latest breakthroughs in ribosome assembly and how it impacts disease. Both of these topics have seen important advances that enlighten how translation is orchestrated and the consequences of its malfunction.
Jonathan R. Warner
doi:10.1038/embor.2009.252
Abstract: http://links.ealert.nature.com/ctt?kn=58&m=34511311&r=MTc2MDI0MTQ4MQS2&b=2&j=NjI5NDM1NjQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=63&m=34511311&r=MTc2MDI0MTQ4MQS2&b=2&j=NjI5NDM1NjQS1&mt=1&rt=0
OPINION
The 20 W sleep-walkers
We expend a lot of energy dreaming, both day and night. Ladislav Kovac explains why this is energy well spent and how our desires and dreams can drive us to ever-greater achievements.
Ladislav Kovac
doi:10.1038/embor.2009.266
http://links.ealert.nature.com/ctt?kn=62&m=34511311&r=MTc2MDI0MTQ4MQS2&b=2&j=NjI5NDM1NjQS1&mt=1&rt=0
Autophagy: where next?
How far are we in understanding autophagy and the processes it regulates? What challenges lie ahead? If we decipher how autophagy affects disease, we might obtain new leads to fight it.
David C. Rubinsztein
doi:10.1038/embor.2009.253
http://links.ealert.nature.com/ctt?kn=61&m=34511311&r=MTc2MDI0MTQ4MQS2&b=2&j=NjI5NDM1NjQS1&mt=1&rt=0
CORRESPONDENCE
Legislation, social licence and primate research
I. Anna S. Olsson and Augusto Vitale
doi:10.1038/embor.2009.268
http://links.ealert.nature.com/ctt?kn=60&m=34511311&r=MTc2MDI0MTQ4MQS2&b=2&j=NjI5NDM1NjQS1&mt=1&rt=0
Response by Howard Wolinsky
Howard Wolinsky
doi:10.1038/embor.2009.257
http://links.ealert.nature.com/ctt?kn=67&m=34511311&r=MTc2MDI0MTQ4MQS2&b=2&j=NjI5NDM1NjQS1&mt=1&rt=0
Helicobacter pylori induces NF-[kappa]B independent of CagA
Katrin Schweitzer, Olga Sokolova, Przemyslaw M. Bozko and Michael Naumann
doi:10.1038/embor.2009.263
http://links.ealert.nature.com/ctt?kn=66&m=34511311&r=MTc2MDI0MTQ4MQS2&b=2&j=NjI5NDM1NjQS1&mt=1&rt=0
Response: strain-specific activation of NF-[kappa]B by Helicobacter pylori CagA
Acacia Lamb et al.
doi:10.1038/embor.2009.269
http://links.ealert.nature.com/ctt?kn=65&m=34511311&r=MTc2MDI0MTQ4MQS2&b=2&j=NjI5NDM1NjQS1&mt=1&rt=0
The Bronze Age of science in Spain
Jose L. Neira and Rodrigo J. Carbajo
doi:10.1038/embor.2009.260
http://links.ealert.nature.com/ctt?kn=64&m=34511311&r=MTc2MDI0MTQ4MQS2&b=2&j=NjI5NDM1NjQS1&mt=1&rt=0
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SCIENCE & SOCIETY
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OUTLOOK
The candid approach
What is the most important reason for preserving the diversity of life on Earth? Valenti Rull dismisses current anthropocentric arguments and proposes a new, candid approach.
Valenti Rull
doi:10.1038/embor.2009.261
http://links.ealert.nature.com/ctt?kn=68&m=34511311&r=MTc2MDI0MTQ4MQS2&b=2&j=NjI5NDM1NjQS1&mt=1&rt=0
The mousepox experience
Can dual-use research be conducted safely, or are some things simply too dangerous to ever be appropriate research topics? Ronald Jackson and Ian Ramshaw offer their own perspectives in interviews about their groundbreaking work with mousepox virus.
doi:10.1038/embor.2009.270
http://links.ealert.nature.com/ctt?kn=104&m=34511311&r=MTc2MDI0MTQ4MQS2&b=2&j=NjI5NDM1NjQS1&mt=1&rt=0
FEATURES
The science of online dating
Would Romeo and Juliet have had a happier ending if they had been assessed for genetic compatibility? Giovanni Frazzetto explores some of the reasons why science may yet play an important role in the pursuit of love.
Giovanni Frazzetto
doi:10.1038/embor.2009.264
http://links.ealert.nature.com/ctt?kn=103&m=34511311&r=MTc2MDI0MTQ4MQS2&b=2&j=NjI5NDM1NjQS1&mt=1&rt=0
The missing link
Viruses exceed the potential of all other organisms to adapt and evolve rapidly. Philip Hunter explores the evidence that these oft-maligned pathogens might have also contributed some of their adaptability to human evolution.
Philip Hunter
doi:10.1038/embor.2009.267
http://links.ealert.nature.com/ctt?kn=111&m=34511311&r=MTc2MDI0MTQ4MQS2&b=2&j=NjI5NDM1NjQS1&mt=1&rt=0
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REVIEWS
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CONCEPT
Intrauterine programming of ageing
Recent results suggest that the accumulation of DNA damage during development could be a direct cause of premature ageing. Here, the author discusses results that associate fetal distress with adult diseases and puts forward his thought-provoking ideas on how early stresses could determine postnatal phenotypes, including ageing. The potential implications of this phenomenon for anti-cancer and anti-ageing treatments are also considered.
Oscar Fernandez-Capetillo
doi:10.1038/embor.2009.262
Abstract: http://links.ealert.nature.com/ctt?kn=110&m=34511311&r=MTc2MDI0MTQ4MQS2&b=2&j=NjI5NDM1NjQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=113&m=34511311&r=MTc2MDI0MTQ4MQS2&b=2&j=NjI5NDM1NjQS1&mt=1&rt=0
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SCIENTIFIC REPORTS
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The nuclear cofactor DOR regulates autophagy in mammalian and Drosophila cells
Caroline Mauvezin et al.
doi:10.1038/embor.2009.242
Abstract: http://links.ealert.nature.com/ctt?kn=112&m=34511311&r=MTc2MDI0MTQ4MQS2&b=2&j=NjI5NDM1NjQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=106&m=34511311&r=MTc2MDI0MTQ4MQS2&b=2&j=NjI5NDM1NjQS1&mt=1&rt=0
Nix is a selective autophagy receptor for mitochondrial clearance
Ivana Novak et al.
doi:10.1038/embor.2009.256
Abstract: http://links.ealert.nature.com/ctt?kn=105&m=34511311&r=MTc2MDI0MTQ4MQS2&b=2&j=NjI5NDM1NjQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=108&m=34511311&r=MTc2MDI0MTQ4MQS2&b=2&j=NjI5NDM1NjQS1&mt=1&rt=0
Intergenic transcripts originating from a subclass of ribosomal DNA repeats silence ribosomal RNA genes in trans
Raffaella Santoro, Kerstin-Maike Schmitz, Juan Sandoval and Ingrid Grummt
doi:10.1038/embor.2009.254
Abstract: http://links.ealert.nature.com/ctt?kn=107&m=34511311&r=MTc2MDI0MTQ4MQS2&b=2&j=NjI5NDM1NjQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=90&m=34511311&r=MTc2MDI0MTQ4MQS2&b=2&j=NjI5NDM1NjQS1&mt=1&rt=0
Coordination of genomic structure and transcription by the main bacterial nucleoid-associated protein HU
Michael Berger et al.
doi:10.1038/embor.2009.232
Abstract: http://links.ealert.nature.com/ctt?kn=89&m=34511311&r=MTc2MDI0MTQ4MQS2&b=2&j=NjI5NDM1NjQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=88&m=34511311&r=MTc2MDI0MTQ4MQS2&b=2&j=NjI5NDM1NjQS1&mt=1&rt=0
RNA-directed DNA methylation and plant development require an IWR1-type transcription factor
Tatsuo Kanno et al.
doi:10.1038/embor.2009.246
Abstract: http://links.ealert.nature.com/ctt?kn=92&m=34511311&r=MTc2MDI0MTQ4MQS2&b=2&j=NjI5NDM1NjQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=91&m=34511311&r=MTc2MDI0MTQ4MQS2&b=2&j=NjI5NDM1NjQS1&mt=1&rt=0
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