Signaling Gateway - 13 November 2009
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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CANCER BIOLOGY: THE BENEFIT OF BEING SINGLE
TGFbeta signaling drives single cell motility and stimulates
hematogenic metastasis in breast cancer cells.
Original research paper: Nature Cell Biology 11, 1287-1296 (2009)
http://links.ealert.nature.com/ctt?kn=23&m=34412718&r=MTc2ODc4NDI0MAS2&b=2&j=NjA4OTQwNTMS1&mt=1&rt=0
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Molecule Pages
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HIPK2
http://links.ealert.nature.com/ctt?kn=7&m=34412718&r=MTc2ODc4NDI0MAS2&b=2&j=NjA4OTQwNTMS1&mt=1&rt=0
Homeodomain-interacting protein kinase 2 (HIPK2) is a promiscuous,
predominantly nuclear-localized serine/threonine protein kinase.
HIPK2 activity has been implicated in transcriptional regulation,
differentiation and development, and DNA damage signaling and
apoptosis. This broad range of cellular responses is orchestrated
through its functional regulation of key signaling molecules in the
p53, Wnt, transforming growth factor beta (TGF-beta), bone morphogenetic
protein (BMP) and hypoxia pathways.
search the molecule pages
http://links.ealert.nature.com/ctt?kn=6&m=34412718&r=MTc2ODc4NDI0MAS2&b=2&j=NjA4OTQwNTMS1&mt=1&rt=0
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Selected Updates
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AUTOPHAGY: AUTOPHAGY TAKES AN ALTERNATIVE ROUTE
Mammalian autophagy can occur through a canonical ATG5- and
ATG7-dependent pathway, as well as through an alternative ATG5- and
ATG7-independent pathway.
Original research paper: Nature 461, 654-658 (2009)
http://links.ealert.nature.com/ctt?kn=10&m=34412718&r=MTc2ODc4NDI0MAS2&b=2&j=NjA4OTQwNTMS1&mt=1&rt=0
GENETICS: AN UNANTICIPATED ROLE
Polycomb group (PcG) proteins are thought to have an oncogenic role
in human cancer, but two studies in Drosophila melanogaster have
shown that PcG proteins can also function as tumor suppressors by
repressing key oncogenic signaling pathways.
Original research paper: Nature Genetics 41, 1150-1155 (2009)
http://links.ealert.nature.com/ctt?kn=8&m=34412718&r=MTc2ODc4NDI0MAS2&b=2&j=NjA4OTQwNTMS1&mt=1&rt=0
PSYCHIATRIC DISORDERS: DISC1 DRIVES DEVELOPMENT THROUGH GIRDIN
An interaction between disrupted in schizophrenia 1 (DISC1) and the
actin-binding protein girdin is important for DISC1-mediated
regulation of neuronal growth and migration in the postnatal and
adult hippocampus.
Original research paper: Neuron 63, 761-773 (2009)
http://links.ealert.nature.com/ctt?kn=2&m=34412718&r=MTc2ODc4NDI0MAS2&b=2&j=NjA4OTQwNTMS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=1&m=34412718&r=MTc2ODc4NDI0MAS2&b=2&j=NjA4OTQwNTMS1&mt=1&rt=0
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Research Library
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http://links.ealert.nature.com/ctt?kn=5&m=34412718&r=MTc2ODc4NDI0MAS2&b=2&j=NjA4OTQwNTMS1&mt=1&rt=0
DIRECT INHIBITION OF THE NOTCH TRANSCRIPTION FACTOR COMPLEX
Nature 462, 182-188 (2009)
http://links.ealert.nature.com/ctt?kn=31&m=34412718&r=MTc2ODc4NDI0MAS2&b=2&j=NjA4OTQwNTMS1&mt=1&rt=0
ACTIVATION OF PKC-DELTA AND SHP-1 BY HYPERGLYCEMIA CAUSES VASCULAR
CELL APOPTOSIS AND DIABETIC RETINOPATHY
Nature Medicine 15, 1298-1306 (2009)
http://links.ealert.nature.com/ctt?kn=30&m=34412718&r=MTc2ODc4NDI0MAS2&b=2&j=NjA4OTQwNTMS1&mt=1&rt=0
THE KINASE TNIK IS AN ESSENTIAL ACTIVATOR OF WNT TARGET GENES
The EMBO Journal 28, 3329-3340 (2009)
http://links.ealert.nature.com/ctt?kn=34&m=34412718&r=MTc2ODc4NDI0MAS2&b=2&j=NjA4OTQwNTMS1&mt=1&rt=0
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Signaling News
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BIOMEDICAL PATENTS: OVERTURNING PRECONCEPTIONS
http://links.ealert.nature.com/ctt?kn=39&m=34412718&r=MTc2ODc4NDI0MAS2&b=2&j=NjA4OTQwNTMS1&mt=1&rt=0
The November issue of Nature Medicine explores the changing landscape
of biomedical patent law. As regulators and lawmakers in Europe and
the US consider making changes to the current laws, these news stories
examine how the spate of upcoming patent expirations will threaten
pharmaceutical companies' profits, and ask whether alternative systems
to replace patents make more sense for medicine.
More news
http://links.ealert.nature.com/ctt?kn=14&m=34412718&r=MTc2ODc4NDI0MAS2&b=2&j=NjA4OTQwNTMS1&mt=1&rt=0
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Gateway Updates
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NCI-NATURE PATHWAY INTERACTION DATABASE - NOVEMBER UPDATE
http://links.ealert.nature.com/ctt?kn=19&m=34412718&r=MTc2ODc4NDI0MAS2&b=2&j=NjA4OTQwNTMS1&mt=1&rt=0
The Pathway Interaction Database is a free, high-quality resource of
more than 100 signaling pathways in human cells for biologists and
bioinformaticians to explore, visualize and mine signaling events.
This month's update features CXCR4-mediated signaling events, ErbB1
downstream signaling and the internalization of ErbB1.
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Job of the Week
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Research Associate
Employer: University of Cambridge
Location: Cambridge, UK
http://links.ealert.nature.com/ctt?kn=29&m=34412718&r=MTc2ODc4NDI0MAS2&b=2&j=NjA4OTQwNTMS1&mt=1&rt=0
A postdoctoral position is available in the laboratory of Professor
Chris Rudd in the Department of Pathology at the University of
Cambridge. The successful candidate will study signal transduction
in the immune system, with a special emphasis on the role of
co-receptors (such as CD28 and CTLA-4) and transmembrane adapter
proteins in T-cell signaling and function.
More Jobs:
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To advertise a job in this spot, please contact Naturejobs.
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