Signaling Gateway - 23 October 2009
http://links.ealert.nature.com/ctt?kn=37&m=34306444&r=MTc2ODc4NDI0MAS2&b=2&j=NTk4NTY2NjYS1&mt=1&rt=0
*********************************************************************
Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
http://links.ealert.nature.com/ctt?kn=12&m=34306444&r=MTc2ODc4NDI0MAS2&b=2&j=NTk4NTY2NjYS1&mt=1&rt=0
*********************************************************************
Celebrate more color. Buy 4, get 2 more FREE.
Celebrate the release of BD Horizon(TM) V500 for the violet channel
with big savings on any fluorochrome or biotin-labeled antibodies from
our entire portfolio. Buy 4 and get 2 more FREE with no quantity limit.
More color. More choice. More flexibility. Welcome to a more
colorful world(SM).
http://links.ealert.nature.com/ctt?kn=27&m=34306444&r=MTc2ODc4NDI0MAS2&b=2&j=NTk4NTY2NjYS1&mt=1&rt=0
*********************************************************************
In Signaling Update this week:
------------------------
Featured Article
------------------------
PHOSPHOPROTEOMICS: NEW ERK TARGETS TURN NUP
A phosphoproteomics approach has revealed that ERK-mediated
phosphorylation of Nup50 inhibits the nuclear accumulation of
importin-beta.
Original research paper: Nature Structural & Molecular Biology 16,
1026-1035 (2009)
http://links.ealert.nature.com/ctt?kn=22&m=34306444&r=MTc2ODc4NDI0MAS2&b=2&j=NTk4NTY2NjYS1&mt=1&rt=0
------------------------
Molecule Pages
------------------------
OPIOID RECEPTOR DELTA
http://links.ealert.nature.com/ctt?kn=7&m=34306444&r=MTc2ODc4NDI0MAS2&b=2&j=NTk4NTY2NjYS1&mt=1&rt=0
Opioid receptor delta belongs to the rhodopsin subfamily of
G-protein-coupled receptors (GPCRs) and is widely distributed
throughout the central nervous system. Although its selective
endogenous ligands have not yet been conclusively identified,
endorphins and enkephalins have the highest affinity for the
receptor. Opioid receptor delta mediates the physiological response
to opioids by activating the Gi/o class of G proteins.
Also published this week:
Protein farnesyltransferase, alpha subunit
http://links.ealert.nature.com/ctt?kn=6&m=34306444&r=MTc2ODc4NDI0MAS2&b=2&j=NTk4NTY2NjYS1&mt=1&rt=0
search the molecule pages
http://links.ealert.nature.com/ctt?kn=10&m=34306444&r=MTc2ODc4NDI0MAS2&b=2&j=NTk4NTY2NjYS1&mt=1&rt=0
-------------------
Selected Updates
-------------------
CHONDROSARCOMA: P53 AND GLI COMBINE FORCES
The GLI2 transcription factor and a loss of p53 cooperate to induce
chondrosarcomas by decreasing expression of insulin-like growth
factor binding protein 3 (Igfbp3), which upregulates IGF signaling.
Original research paper: Cancer Cell 16, 126–136 (2009)
http://links.ealert.nature.com/ctt?kn=8&m=34306444&r=MTc2ODc4NDI0MAS2&b=2&j=NTk4NTY2NjYS1&mt=1&rt=0
NEURODEGENERATIVE DISEASE: PROVING THE LINK
Mutations in the prion protein (PrP) can produce an infectious form
of the protein, providing crucial evidence for the
'prion hypothesis'.
Original research paper: Neuron 63, 438–450 (2009)
http://links.ealert.nature.com/ctt?kn=2&m=34306444&r=MTc2ODc4NDI0MAS2&b=2&j=NTk4NTY2NjYS1&mt=1&rt=0
INNATE IMMUNITY: HELP FROM 'FRIENDLY' BACTERIA
Gut microbiota stimulate Toll-like receptors on dendritic cells
(DCs), which signal through MYD88 to mediate DC activation and induce
immunity to the parasite Toxoplasma gondii.
Original research paper: Cell Host Microbe 6, 187–196 (2009)
http://links.ealert.nature.com/ctt?kn=1&m=34306444&r=MTc2ODc4NDI0MAS2&b=2&j=NTk4NTY2NjYS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=4&m=34306444&r=MTc2ODc4NDI0MAS2&b=2&j=NTk4NTY2NjYS1&mt=1&rt=0
------------------------
Research Library
------------------------
http://links.ealert.nature.com/ctt?kn=15&m=34306444&r=MTc2ODc4NDI0MAS2&b=2&j=NTk4NTY2NjYS1&mt=1&rt=0
PTEN IN STROMAL FIBROBLASTS SUPPRESSES MAMMARY EPITHELIAL TUMOURS
Nature 461, 1084-1091 (2009)
http://links.ealert.nature.com/ctt?kn=17&m=34306444&r=MTc2ODc4NDI0MAS2&b=2&j=NTk4NTY2NjYS1&mt=1&rt=0
TISSUE REGENERATIVE DELAYS AND SYNTHETIC LETHALITY IN ADULT MICE
AFTER COMBINED DELETION OF ATR AND TRP53
Nature Genetics 41, 1144-1149 (2009)
http://links.ealert.nature.com/ctt?kn=29&m=34306444&r=MTc2ODc4NDI0MAS2&b=2&j=NTk4NTY2NjYS1&mt=1&rt=0
SENSITIVE MULTIPLEXED ANALYSIS OF KINASE ACTIVITIES AND
ACTIVITY-BASED KINASE IDENTIFICATION
Nature Biotechnology 27, 933-940 (2009)
http://links.ealert.nature.com/ctt?kn=39&m=34306444&r=MTc2ODc4NDI0MAS2&b=2&j=NTk4NTY2NjYS1&mt=1&rt=0
------------------------
Signaling News
------------------------
NATURE MEDICINE FOCUS ISSUE: THE 2009 LASKER MEDICAL RESEARCH AWARDS
http://links.ealert.nature.com/ctt?kn=40&m=34306444&r=MTc2ODc4NDI0MAS2&b=2&j=NTk4NTY2NjYS1&mt=1&rt=0
The 2009 Albert Lasker Medical Research Awards were given to
John Gurdon and Shinya Yamanaka for their insights into nuclear
reprogramming, and to Brian Druker, Nicholas Lydon and
Charles Sawyers for their development of imatinib — a small-molecule
inhibitor of BCR-ABL for the treatment of chronic myeloid leukemia
(CML). This Nature Medicine Focus Issue features commentaries from
this year's awardees.
More news
http://links.ealert.nature.com/ctt?kn=14&m=34306444&r=MTc2ODc4NDI0MAS2&b=2&j=NTk4NTY2NjYS1&mt=1&rt=0
-------------------------
Gateway Updates
-------------------------
THE FUNCTIONAL GLYCOMICS GATEWAY - OCTOBER UPDATE
http://links.ealert.nature.com/ctt?kn=24&m=34306444&r=MTc2ODc4NDI0MAS2&b=2&j=NTk4NTY2NjYS1&mt=1&rt=0
The Functional Glycomics Gateway is a comprehensive FREE online
resource to keep you abreast of the latest findings in the field.
This month's update includes "Stopping HIV: Glycopeptide opens the
envelope" and "Wound healing: Integrin glycans galectin going".
Sign up to receive the monthly table of contents e-alert for the
Functional Glycomics Update.
http://links.ealert.nature.com/ctt?kn=36&m=34306444&r=MTc2ODc4NDI0MAS2&b=2&j=NTk4NTY2NjYS1&mt=1&rt=0
-----------------------------
Job of the Week
-----------------------------
Postdoctoral position
Employer: University of Pittsburgh
Location: Pittsburgh, Pennsylvania, USA
http://links.ealert.nature.com/ctt?kn=31&m=34306444&r=MTc2ODc4NDI0MAS2&b=2&j=NTk4NTY2NjYS1&mt=1&rt=0
A post-doctoral fellowship position is available at the Department of
Pharmacology and Chemical Biology at the University of Pittsburgh.
The successful applicant will elucidate the molecular mechanisms of
signal transduction mediated by G-protein-coupled receptors.
Fluorescence, biochemical, pharmacological, cellular and molecular
biology techniques will be used to study transmembrane signaling and
intracellular trafficking mechanisms.
More Jobs:
http://links.ealert.nature.com/ctt?kn=20&m=34306444&r=MTc2ODc4NDI0MAS2&b=2&j=NTk4NTY2NjYS1&mt=1&rt=0
To advertise a job in this spot, please contact Naturejobs.
http://links.ealert.nature.com/ctt?kn=21&m=34306444&r=MTc2ODc4NDI0MAS2&b=2&j=NTk4NTY2NjYS1&mt=1&rt=0
======================================================================
Genentech is proud to be a corporate sponsor of the UCSD-Nature Signaling Gateway.
Genentech is a leading biotechnology company that discovers,
develops, manufactures and commercializes biotherapeutics
for significant unmet medical needs. Fifteen of the currently
approved biotechnology products stem from or are based on
Genentech science. Genentech manufactures and commercializes
ten biotechnology products directly in the United States.
The company has headquarters in South San Francisco, California,
and is traded on the New York Stock Exchange under the symbol DNA.
http://links.ealert.nature.com/ctt?kn=11&m=34306444&r=MTc2ODc4NDI0MAS2&b=2&j=NTk4NTY2NjYS1&mt=1&rt=0
=====================================================================
As a registered user of the Nature Publishing Group web sites, you
were selected to receive this message in the genuine belief that it
would be of interest to you.
If you no longer wish to receive news and announcements from Nature
Publishing Group or wish to unsubscribe from the Signaling Update
email alert please update your online Nature.com account details here:
http://links.ealert.nature.com/ctt?kn=35&m=34306444&r=MTc2ODc4NDI0MAS2&b=2&j=NTk4NTY2NjYS1&mt=1&rt=0
For further technical assistance or any other enquiries, please click here:
http://links.ealert.nature.com/ctt?kn=13&m=34306444&r=MTc2ODc4NDI0MAS2&b=2&j=NTk4NTY2NjYS1&mt=1&rt=0
Nature's world-wide offices:
London . Paris . Munich . New Delhi . Tokyo . Melbourne . San Diego .
San Francisco . Washington . New York . Boston
(c) 2009 Nature Publishing Group
---------------------------------------------------------------------
