November 2009 Volume 10 Number 11
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Nature Reviews Molecular Cell Biology
Article Series on Cytoskeletal Motors
From October 2009, Nature Reviews Molecular Cell Biology will be
publishing a Series of specially commissioned articles on cytoskeletal
motors. These articles will highlight the progress made in understanding
the mechanics and functions of different types of cytoskeletal motors,
discuss their important roles in cell division, cell motility,
intracellular trafficking and other cellular processes, and report
new approaches to study these molecules.
Follow the Series today: http://links.ealert.nature.com/ctt?kn=7&m=34306529&r=MTc2NzYzNjQ2NgS2&b=2&j=NTk4NTgyNzgS1&mt=1&rt=0
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This month's FEATURED article:
Traffic control: regulation of kinesin motors
Kristen J. Verhey and Jennetta W. Hammond
p765 | doi:10.1038/nrm2782
http://links.ealert.nature.com/ctt?kn=85&m=34306529&r=MTc2NzYzNjQ2NgS2&b=2&j=NTk4NTgyNzgS1&mt=1&rt=0
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From the editors
p733 | doi:10.1038/nrm2795
http://links.ealert.nature.com/ctt?kn=86&m=34306529&r=MTc2NzYzNjQ2NgS2&b=2&j=NTk4NTgyNzgS1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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Cell signalling: A new MAP for miRNAs
p734 | doi:10.1038/nrm2792
http://links.ealert.nature.com/ctt?kn=87&m=34306529&r=MTc2NzYzNjQ2NgS2&b=2&j=NTk4NTgyNzgS1&mt=1&rt=0
JOURNAL CLUB
35 years later, mRNA caps still matter
p735 | doi:10.1038/nrm2789
http://links.ealert.nature.com/ctt?kn=28&m=34306529&r=MTc2NzYzNjQ2NgS2&b=2&j=NTk4NTgyNzgS1&mt=1&rt=0
Autophagy: Autophagy takes an alternative route
p735 | doi:10.1038/nrm2790
http://links.ealert.nature.com/ctt?kn=89&m=34306529&r=MTc2NzYzNjQ2NgS2&b=2&j=NTk4NTgyNzgS1&mt=1&rt=0
mRNA decay: Removing the tail
p736 | doi:10.1038/nrm2781
http://links.ealert.nature.com/ctt?kn=25&m=34306529&r=MTc2NzYzNjQ2NgS2&b=2&j=NTk4NTgyNzgS1&mt=1&rt=0
Chromatin: JAK2 goes nuclear
p736 | doi:10.1038/nrm2783
http://links.ealert.nature.com/ctt?kn=24&m=34306529&r=MTc2NzYzNjQ2NgS2&b=2&j=NTk4NTgyNzgS1&mt=1&rt=0
IN THE NEWS
And the winner is...
p736 | doi:10.1038/nrm2785
http://links.ealert.nature.com/ctt?kn=23&m=34306529&r=MTc2NzYzNjQ2NgS2&b=2&j=NTk4NTgyNzgS1&mt=1&rt=0
IN BRIEF
Transcription | Molecular motors | Ion transporters
p737 | doi:10.1038/nrm2793
http://links.ealert.nature.com/ctt?kn=31&m=34306529&r=MTc2NzYzNjQ2NgS2&b=2&j=NTk4NTgyNzgS1&mt=1&rt=0
Chromosome biology: Small RNAs find the centre
p738 | doi:10.1038/nrm2791
http://links.ealert.nature.com/ctt?kn=30&m=34306529&r=MTc2NzYzNjQ2NgS2&b=2&j=NTk4NTgyNzgS1&mt=1&rt=0
Stem cells: iPS cells strike a cord
p738 | doi:10.1038/nrm2794
http://links.ealert.nature.com/ctt?kn=29&m=34306529&r=MTc2NzYzNjQ2NgS2&b=2&j=NTk4NTgyNzgS1&mt=1&rt=0
Apoptosis: Watching caspase 2 get active
p739 | doi:10.1038/nrm2788
http://links.ealert.nature.com/ctt?kn=27&m=34306529&r=MTc2NzYzNjQ2NgS2&b=2&j=NTk4NTgyNzgS1&mt=1&rt=0
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REVIEWS
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Mechanisms of alternative splicing regulation: insights from molecular
and genomics approaches
Mo Chen and James L. Manley
p741 | doi:10.1038/nrm2777
Alternative splicing is an important gene regulatory mechanism for
generating proteomic diversity, which markedly affects human development
and is misregulated in many human diseases. Alternative splicing can
be regulated at different stages of spliceosome assembly and by different
mechanisms.
Abstract: http://links.ealert.nature.com/ctt?kn=22&m=34306529&r=MTc2NzYzNjQ2NgS2&b=2&j=NTk4NTgyNzgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=21&m=34306529&r=MTc2NzYzNjQ2NgS2&b=2&j=NTk4NTgyNzgS1&mt=1&rt=0
Building ubiquitin chains: E2 enzymes at work
Yihong Ye and Michael Rape
p755 | doi:10.1038/nrm2780
Ubiquitin-conjugating enzymes (E2s) are major regulators of ubiquitin
chain assembly. These enzymes control ubiquitin chain initiation or
elongation, the processivity of chain formation and the topology of
the assembled chains.
Abstract: http://links.ealert.nature.com/ctt?kn=20&m=34306529&r=MTc2NzYzNjQ2NgS2&b=2&j=NTk4NTgyNzgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=40&m=34306529&r=MTc2NzYzNjQ2NgS2&b=2&j=NTk4NTgyNzgS1&mt=1&rt=0
Traffic control: regulation of kinesin motors
Kristen J. Verhey and Jennetta W. Hammond
p765 | doi:10.1038/nrm2782
How kinesin motors are regulated in cells to ensure the temporal and
spatial fidelity of their microtubule-based activities is poorly understood.
Recent work has revealed molecular mechanisms that control kinesin
autoinhibition, activation, binding to cargos and microtubule tracks,
and localization.
Abstract: http://links.ealert.nature.com/ctt?kn=38&m=34306529&r=MTc2NzYzNjQ2NgS2&b=2&j=NTk4NTgyNzgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=42&m=34306529&r=MTc2NzYzNjQ2NgS2&b=2&j=NTk4NTgyNzgS1&mt=1&rt=0
Non-muscle myosin II takes centre stage in cell adhesion and migration
Miguel Vicente-Manzanares, Xuefei Ma, Robert S. Adelstein and
Alan Rick Horwitz
p778 | doi:10.1038/nrm2786
Non-muscle myosin II (NM II) is an actin-binding protein with actin
cross-linking and contractile properties. The three mammalian NM II
isoforms have both overlapping and distinct roles in cell adhesion
and cell migration and their mutation results in specific developmental
defects and disease phenotypes.
Abstract: http://links.ealert.nature.com/ctt?kn=41&m=34306529&r=MTc2NzYzNjQ2NgS2&b=2&j=NTk4NTgyNzgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=44&m=34306529&r=MTc2NzYzNjQ2NgS2&b=2&j=NTk4NTgyNzgS1&mt=1&rt=0
Evolution of biomolecular networks - lessons from metabolic and
protein interactions
Takuji Yamada and Peer Bork
p791 | doi:10.1038/nrm2787
The evolution of protein-protein interaction and metabolic networks is
mostly based on the duplication and loss of entire genes or on point
mutations, small insertions or deletions that affect gene regulation.
However, network evolution can be understood only when spatiotemporal
resolution is taken into account.
Abstract: http://links.ealert.nature.com/ctt?kn=43&m=34306529&r=MTc2NzYzNjQ2NgS2&b=2&j=NTk4NTgyNzgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=46&m=34306529&r=MTc2NzYzNjQ2NgS2&b=2&j=NTk4NTgyNzgS1&mt=1&rt=0
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PERSPECTIVES
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OPINION
Biased segregation of DNA and centrosomes - moving together or drifting
apart?
Shahragim Tajbakhsh and Cayetano Gonzalez
p804 | doi:10.1038/nrm2784
During cell division, the asymmetric localization of epigenetic marks
and kinetochore proteins might lead to the differential recognition of
sister chromatids and the biased segregation of DNA strands to daughter
cells. This might ultimately result in the acquisition of distinct
cell fates after mitosis.
Abstract: http://links.ealert.nature.com/ctt?kn=45&m=34306529&r=MTc2NzYzNjQ2NgS2&b=2&j=NTk4NTgyNzgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=35&m=34306529&r=MTc2NzYzNjQ2NgS2&b=2&j=NTk4NTgyNzgS1&mt=1&rt=0
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