October 2009 Volume 6 Number 10
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RESEARCH HIGHLIGHTS
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Pain: Tailoring treatment of chronic pelvic pain
p517 | doi:10.1038/nrurol.2009.174
http://links.ealert.nature.com/ctt?kn=14&m=34135803&r=MTc2NDg0NjM5NAS2&b=2&j=NTkwODU5MTkS1&mt=1&rt=0
Prostate cancer: Further data on sipuleucel-T immunotherapy
p518 | doi:10.1038/nrurol.2009.171
http://links.ealert.nature.com/ctt?kn=28&m=34135803&r=MTc2NDg0NjM5NAS2&b=2&j=NTkwODU5MTkS1&mt=1&rt=0
Prostate cancer: Suspension stitch aids post-RALP continence recovery
p518 | doi:10.1038/nrurol.2009.172
http://links.ealert.nature.com/ctt?kn=31&m=34135803&r=MTc2NDg0NjM5NAS2&b=2&j=NTkwODU5MTkS1&mt=1&rt=0
Pain: Targeting anesthesia to the pelvic plexus for prostate biopsy
p519 | doi:10.1038/nrurol.2009.170
http://links.ealert.nature.com/ctt?kn=21&m=34135803&r=MTc2NDg0NjM5NAS2&b=2&j=NTkwODU5MTkS1&mt=1&rt=0
Web tool predicts repeat biopsy result
p519 | doi:10.1038/nrurol.2009.182
http://links.ealert.nature.com/ctt?kn=26&m=34135803&r=MTc2NDg0NjM5NAS2&b=2&j=NTkwODU5MTkS1&mt=1&rt=0
Prostate cancer: Survival with metastases improved by clodronate
p519 | doi:10.1038/nrurol.2009.185
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Stones: Tamsulosin does not increase the rate of expulsion
p520 | doi:10.1038/nrurol.2009.175
http://links.ealert.nature.com/ctt?kn=37&m=34135803&r=MTc2NDg0NjM5NAS2&b=2&j=NTkwODU5MTkS1&mt=1&rt=0
IN BRIEF
Sexual dysfunction | Testicular cancer
p520 | doi:10.1038/nrurol.2009.190
http://links.ealert.nature.com/ctt?kn=53&m=34135803&r=MTc2NDg0NjM5NAS2&b=2&j=NTkwODU5MTkS1&mt=1&rt=0
Bladder cancer: DNA changes can distinguish muscle-invasive from
papillary tumors
p521 | doi:10.1038/nrurol.2009.173
http://links.ealert.nature.com/ctt?kn=50&m=34135803&r=MTc2NDg0NjM5NAS2&b=2&j=NTkwODU5MTkS1&mt=1&rt=0
BPH: [beta]-Blockers mitigate exacerbation of heart failure by
[alpha]-antagonists
p521 | doi:10.1038/nrurol.2009.187
http://links.ealert.nature.com/ctt?kn=65&m=34135803&r=MTc2NDg0NjM5NAS2&b=2&j=NTkwODU5MTkS1&mt=1&rt=0
Urothelial carcinoma: Removing lymph nodes extends the life of patients
without metastases
p522 | doi:10.1038/nrurol.2009.183
http://links.ealert.nature.com/ctt?kn=63&m=34135803&r=MTc2NDg0NjM5NAS2&b=2&j=NTkwODU5MTkS1&mt=1&rt=0
Sexual dysfunction: Finasteride to treat recurrent priapism in sickle
cell anemia
p522 | doi:10.1038/nrurol.2009.186
http://links.ealert.nature.com/ctt?kn=69&m=34135803&r=MTc2NDg0NjM5NAS2&b=2&j=NTkwODU5MTkS1&mt=1&rt=0
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NEWS AND VIEWS
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Urinary incontinence: Relative efficacy of retropubic and transobturator
slings
Elizabeth R. Mueller
p523 | doi:10.1038/nrurol.2009.193
Insertion of midurethral synthetic slings is now the cornerstone
surgical approach to treatment of stress urinary incontinence. A group
from Poland randomized 537 women to synthetic sling placement using
either a retropubic or transobturator technique. The investigators
found both procedures to be equally effective in curing or improving
the condition.
http://links.ealert.nature.com/ctt?kn=67&m=34135803&r=MTc2NDg0NjM5NAS2&b=2&j=NTkwODU5MTkS1&mt=1&rt=0
Health policy: Do end-of-life discussions have a role in health care
reform?
Leonard G. Gomella
p524 | doi:10.1038/nrurol.2009.192
Considerable costs are incurred when caring for patients with terminal
cancer in their last few days of life. With the debate over health care
reform in the US being at center stage, focusing primarily on cost
reduction, how can we best serve our cancer patients in their final
days?
http://links.ealert.nature.com/ctt?kn=71&m=34135803&r=MTc2NDg0NjM5NAS2&b=2&j=NTkwODU5MTkS1&mt=1&rt=0
Stones: Impact of dose reduction on CT detection of urolithiasis
M. Hammad Ather and Wasim A. Memon
p526 | doi:10.1038/nrurol.2009.196
Patients undergoing CT for the evaluation of stone disease are likely
to receive high levels of radiation over time. Although the results
from small studies using simulation software suggest that using a
reduced radiation dose has little effect on calculi detection, larger
prospective randomized studies are required to produce clinically
applicable results.
http://links.ealert.nature.com/ctt?kn=90&m=34135803&r=MTc2NDg0NjM5NAS2&b=2&j=NTkwODU5MTkS1&mt=1&rt=0
Prostate cancer: Optimizing the duration of androgen deprivation
therapy
Eric M. Horwitz
p527 | doi:10.1038/nrurol.2009.194
EORTC 22961 is the latest trial to investigate the optimum duration of
adjuvant androgen deprivation therapy for patients with locally
advanced prostate cancer. The results conclusively show superiority of
long-term over short-term treatment, and the former protocol should,
therefore, be considered standard of care in this setting.
http://links.ealert.nature.com/ctt?kn=78&m=34135803&r=MTc2NDg0NjM5NAS2&b=2&j=NTkwODU5MTkS1&mt=1&rt=0
Prostate cancer: How can we improve the health of men who receive ADT?
Philip J. Saylor and Matthew R. Smith
p529 | doi:10.1038/nrurol.2009.195
Clinical research in recent years has produced a deepening appreciation
of the metabolic consequences of androgen deprivation therapy. On the
basis of this knowledge, proactive management of risk factors for
diabetes and cardiovascular events is appropriate in men who receive
this treatment for prostate cancer.
http://links.ealert.nature.com/ctt?kn=81&m=34135803&r=MTc2NDg0NjM5NAS2&b=2&j=NTkwODU5MTkS1&mt=1&rt=0
Prostatitis: Clinical phenotyping of patients with pelvic pain
Richard B. Alexander
p531 | doi:10.1038/nrurol.2009.197
Despite a plethora of clinical trials, no treatment has shown consistent
success for symptomatic management in patients with chronic
prostatitis-chronic pelvic pain syndrome. Subdividing this heterogeneous
patient population according to phenotype, and selecting therapy
accordingly, represents an important step forward in the treatment of
this disorder.
http://links.ealert.nature.com/ctt?kn=83&m=34135803&r=MTc2NDg0NjM5NAS2&b=2&j=NTkwODU5MTkS1&mt=1&rt=0
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REVIEWS
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Management of distal anterior urethral strictures
Jeremy B. Tonkin and Gerald H. Jordan
Published online: 08 September 2009
p533 | doi:10.1038/nrurol.2009.181
In this Review, Tonkin and Jordan draw on their clinical experience to
discuss the etiology, diagnosis and management of distal anterior
urethral stricture disease. They highlight that curative open surgery,
such as graft or flap urethroplasty, should be preferred over repeated
minimally invasive procedures in order to optimize patient outcomes.
Abstract: http://links.ealert.nature.com/ctt?kn=54&m=34135803&r=MTc2NDg0NjM5NAS2&b=2&j=NTkwODU5MTkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=84&m=34135803&r=MTc2NDg0NjM5NAS2&b=2&j=NTkwODU5MTkS1&mt=1&rt=0
Enhancing the efficacy of cancer vaccines in urologic oncology: new
directions
Sergei Kusmartsev and Johannes Vieweg
Published online: 08 September 2009
p540 | doi:10.1038/nrurol.2009.177
Cancer vaccines, which stimulate the host immune response to malignant
disease, have generally failed to induce durable clinical responses in
patients, partly owing to tumor-mediated suppression of the host immune
system. Here, Kusmartsev and Vieweg explore ways of targeting these
tumor-mediated changes to enhance the efficacy of vaccine therapy for
urologic cancers.
Abstract: http://links.ealert.nature.com/ctt?kn=44&m=34135803&r=MTc2NDg0NjM5NAS2&b=2&j=NTkwODU5MTkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=94&m=34135803&r=MTc2NDg0NjM5NAS2&b=2&j=NTkwODU5MTkS1&mt=1&rt=0
Male infertility: a risk factor for testicular cancer
James M. Hotaling and Thomas J. Walsh
Published online: 01 September 2009
p550 | doi:10.1038/nrurol.2009.179
A growing body of evidence supports an epidemiologic association between
male infertility and testicular germ cell tumor; however, few
population-based studies have investigated this relationship. In this
Review, Hotaling and Walsh explore the epidemiologic data linking the
two disorders, and discuss the potential mechanisms that underlie this
association.
Abstract: http://links.ealert.nature.com/ctt?kn=45&m=34135803&r=MTc2NDg0NjM5NAS2&b=2&j=NTkwODU5MTkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=15&m=34135803&r=MTc2NDg0NjM5NAS2&b=2&j=NTkwODU5MTkS1&mt=1&rt=0
Differential diagnosis of chronic pelvic pain in women: the urologist's
approach
Sophie G. Fletcher and Philippe E. Zimmern
Published online: 01 September 2009
p557 | doi:10.1038/nrurol.2009.178
Chronic pelvic pain in women is a challenging clinical entity that is
frequently encountered by urologists. The diagnostic process can be
laborious, and often requires multidisciplinary collaboration. In this
Review, the authors discuss the key issues in the diagnosis of this
disorder, highlighting the importance of a thorough patient history to
direct subsequent investigations.
Abstract: http://links.ealert.nature.com/ctt?kn=47&m=34135803&r=MTc2NDg0NjM5NAS2&b=2&j=NTkwODU5MTkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=13&m=34135803&r=MTc2NDg0NjM5NAS2&b=2&j=NTkwODU5MTkS1&mt=1&rt=0
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CASE STUDIES
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Bilateral renal hemorrhage due to polyarteritis nodosa wrongly attributed
to blunt trauma
Ihab El Madhoun, Niall G. Warnock, Anu Roy and Colin H. Jones
p563 | doi:10.1038/nrurol.2009.180
In this Case Study, El Madhoun and colleagues describe the diagnosis
and management of a patient with bilateral renal hemorrhage caused by
polyarteritis nodosa. The perirenal bleeding was at first attributed
to trauma experienced 1 week before the initial presentation, but
review of the case at a subsequent hospital admission identified the
true cause of the bilateral hemorrhage.
Abstract: http://links.ealert.nature.com/ctt?kn=57&m=34135803&r=MTc2NDg0NjM5NAS2&b=2&j=NTkwODU5MTkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=25&m=34135803&r=MTc2NDg0NjM5NAS2&b=2&j=NTkwODU5MTkS1&mt=1&rt=0
A rare case of renal infarction caused by infective endocarditis
Rasheed Zakaria, Vhari Forsyth and Tomas Rosenbaum
p568 | doi:10.1038/nrurol.2009.176
Zakaria and colleagues describe the case of a previously healthy
29-year-old man with renal infarction. The nonspecific nature of his
presenting symptoms caused a delay in diagnosis. The authors provide
a comprehensive account of the presenting features, and of diagnostic
tests that can distinguish renal infarction from more common conditions.
Abstract: http://links.ealert.nature.com/ctt?kn=56&m=34135803&r=MTc2NDg0NjM5NAS2&b=2&j=NTkwODU5MTkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=49&m=34135803&r=MTc2NDg0NjM5NAS2&b=2&j=NTkwODU5MTkS1&mt=1&rt=0
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