November 2009 Volume 9 Number 11
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Nature Reviews Immunology Impact Factor: 30.01*
(*2008 Journal Citation Report (Thomson Reuters, 2009))
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Nature Reviews Rheumatology (previously Nature Clinical Practice
Rheumatology)
The number one review journal in the field of rheumatology
2008 Impact Factor 5.677*
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* 2008 Journal Citation Reports (Thomson Reuters, 2009)
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This month's FEATURED article:
Regulation of tissue homeostasis by NF-[kappa]B signalling:
implications for inflammatory diseases
Manolis Pasparakis
p778 | doi:10.1038/nri2655
http://links.ealert.nature.com/ctt?kn=45&m=34307417&r=MTc2NzU2Mjg3MwS2&b=2&j=NTk4NjkzNTkS1&mt=1&rt=0
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From the editors
p749 | doi:10.1038/nri2664
http://links.ealert.nature.com/ctt?kn=68&m=34307417&r=MTc2NzU2Mjg3MwS2&b=2&j=NTk4NjkzNTkS1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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T cell development: Seeing self in a positive light
p751 | doi:10.1038/nri2661
http://links.ealert.nature.com/ctt?kn=69&m=34307417&r=MTc2NzU2Mjg3MwS2&b=2&j=NTk4NjkzNTkS1&mt=1&rt=0
Mast cells: Delivery of cytokine packages to the lymph nodes
p752 | doi:10.1038/nri2658
http://links.ealert.nature.com/ctt?kn=72&m=34307417&r=MTc2NzU2Mjg3MwS2&b=2&j=NTk4NjkzNTkS1&mt=1&rt=0
T cells: Crawling into the brain
p752 | doi:10.1038/nri2663
http://links.ealert.nature.com/ctt?kn=75&m=34307417&r=MTc2NzU2Mjg3MwS2&b=2&j=NTk4NjkzNTkS1&mt=1&rt=0
IN BRIEF
Innate immunity | Lymphoid organogenesis | T cell responses
p752 | doi:10.1038/nri2666
http://links.ealert.nature.com/ctt?kn=39&m=34307417&r=MTc2NzU2Mjg3MwS2&b=2&j=NTk4NjkzNTkS1&mt=1&rt=0
Immunotherapy: CpG-siRNA deals double blow to tumours
p753 | doi:10.1038/nri2665
http://links.ealert.nature.com/ctt?kn=56&m=34307417&r=MTc2NzU2Mjg3MwS2&b=2&j=NTk4NjkzNTkS1&mt=1&rt=0
Immune regulation: TReg cells offer a bespoke service
p754 | doi:10.1038/nri2659
http://links.ealert.nature.com/ctt?kn=53&m=34307417&r=MTc2NzU2Mjg3MwS2&b=2&j=NTk4NjkzNTkS1&mt=1&rt=0
IN BRIEF
Immune tolerance | Apoptosis | Tumour immunology
p754 | doi:10.1038/nri2667
http://links.ealert.nature.com/ctt?kn=38&m=34307417&r=MTc2NzU2Mjg3MwS2&b=2&j=NTk4NjkzNTkS1&mt=1&rt=0
Dendritic cells: Division of DC labour in the gut
p755 | doi:10.1038/nri2662
http://links.ealert.nature.com/ctt?kn=85&m=34307417&r=MTc2NzU2Mjg3MwS2&b=2&j=NTk4NjkzNTkS1&mt=1&rt=0
IN THE NEWS
HIV vaccine results controversy
p755 | doi:10.1038/nri2668
http://links.ealert.nature.com/ctt?kn=88&m=34307417&r=MTc2NzU2Mjg3MwS2&b=2&j=NTk4NjkzNTkS1&mt=1&rt=0
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REVIEWS
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New insights into the differentiation and function of T follicular
helper cells
Cecile King
p757 | doi:10.1038/nri2644
T follicular helper cells are strategically positioned in germinal
centres and equipped to provide the signals necessary for antibody
production by B cells. This Review describes the latest studies that
explore their development and function and their relationship with
other T helper cell subsets.
Abstract: http://links.ealert.nature.com/ctt?kn=42&m=34307417&r=MTc2NzU2Mjg3MwS2&b=2&j=NTk4NjkzNTkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=84&m=34307417&r=MTc2NzU2Mjg3MwS2&b=2&j=NTk4NjkzNTkS1&mt=1&rt=0
The follicular versus marginal zone B lymphocyte cell fate decision
Shiv Pillai and Annaiah Cariappa
p767 | doi:10.1038/nri2656
This Review proposes an integrated model for the development of
follicular versus marginal zone B cells based on the coordination of
B cell receptor signal strength with signals through Notch2 and the
receptor for B cell-activating factor and signals that are involved
in the migration to and retention of B cells in the marginal zone of
the spleen.
Abstract: http://links.ealert.nature.com/ctt?kn=40&m=34307417&r=MTc2NzU2Mjg3MwS2&b=2&j=NTk4NjkzNTkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=74&m=34307417&r=MTc2NzU2Mjg3MwS2&b=2&j=NTk4NjkzNTkS1&mt=1&rt=0
Article series: Tissue-specific immune responses
http://links.ealert.nature.com/ctt?kn=63&m=34307417&r=MTc2NzU2Mjg3MwS2&b=2&j=NTk4NjkzNTkS1&mt=1&rt=0
Regulation of tissue homeostasis by NF-[kappa]B signalling:
implications for inflammatory diseases
Manolis Pasparakis
p778 | doi:10.1038/nri2655
This Review focuses on the recent studies showing that inhibition of
the nuclear factor-[kappa]B (NF-[kappa]B) pathway in epithelial cells
unexpectedly results in the spontaneous development of inflammatory
conditions. These results imply a role for NF-[kappa]B in these cells
in controlling tissue homeostasis rather than promoting inflammation.
Abstract: http://links.ealert.nature.com/ctt?kn=45&m=34307417&r=MTc2NzU2Mjg3MwS2&b=2&j=NTk4NjkzNTkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=19&m=34307417&r=MTc2NzU2Mjg3MwS2&b=2&j=NTk4NjkzNTkS1&mt=1&rt=0
Analysing immune cell migration
Joost B. Beltman, Athanasius F. M. Maree and Rob J. de Boer
Published online: 16 October 2009
p789 | doi:10.1038/nri2638
Time-lapse video microscopy is an important experimental tool for
examining the dynamic behaviour of immune cells in situ and involves
quantitative analysis of cell migration and cell-cell interactions.
Here, several commonly measured parameters and imaging artefacts are
described and potential solutions to detect and correct these
artefacts are proposed.
Abstract: http://links.ealert.nature.com/ctt?kn=44&m=34307417&r=MTc2NzU2Mjg3MwS2&b=2&j=NTk4NjkzNTkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=27&m=34307417&r=MTc2NzU2Mjg3MwS2&b=2&j=NTk4NjkzNTkS1&mt=1&rt=0
Intestinal mucosal barrier function in health and disease
Jerrold R. Turner
p799 | doi:10.1038/nri2653
Mucosal surfaces are lined by epithelial cells that establish a
barrier between external environments and the internal milieu. Recent
advances have uncovered mechanisms of barrier regulation by immune
stimuli and, conversely, how mucosal immunity is regulated by barrier
function.
Abstract: http://links.ealert.nature.com/ctt?kn=43&m=34307417&r=MTc2NzU2Mjg3MwS2&b=2&j=NTk4NjkzNTkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=10&m=34307417&r=MTc2NzU2Mjg3MwS2&b=2&j=NTk4NjkzNTkS1&mt=1&rt=0
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PERSPECTIVES
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VIEWPOINT
The functional plasticity of T cell subsets
Jeffrey A. Bluestone, Charles R. Mackay, John J. O'Shea and Brigitta
Stockinger
Published online: 07 October 2009
p811 | doi:10.1038/nri2654
The recent re-evaluation of the concept that CD4+ T helper cell
subsets are irreversibly differentiated lineages has become one of
the most hotly debated issues in immunology. Here, four leaders in
the field provide their thoughts on the complexities and
controversies surrounding the functional plasticity of T cell
subsets.
Abstract: http://links.ealert.nature.com/ctt?kn=29&m=34307417&r=MTc2NzU2Mjg3MwS2&b=2&j=NTk4NjkzNTkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=37&m=34307417&r=MTc2NzU2Mjg3MwS2&b=2&j=NTk4NjkzNTkS1&mt=1&rt=0
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