November 2009 Volume 9 Number 11
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Autoimmune disease: Treating MS with hypertension drugs
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This month's Featured article:
STATs in cancer inflammation and immunity: a leading role for STAT3
Hua Yu, Drew Pardoll and Richard Jove
p798 | doi:10.1038/nrc2734
http://links.ealert.nature.com/ctt?kn=61&m=34308779&r=MTc2Njc4NzkyNgS2&b=2&j=NTk4OTU4NjMS1&mt=1&rt=0
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From the editors
p763 | doi:10.1038/nrc2762
http://links.ealert.nature.com/ctt?kn=20&m=34308779&r=MTc2Njc4NzkyNgS2&b=2&j=NTk4OTU4NjMS1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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Genetics: An unanticipated role
p765 | doi:10.1038/nrc2749
http://links.ealert.nature.com/ctt?kn=22&m=34308779&r=MTc2Njc4NzkyNgS2&b=2&j=NTk4OTU4NjMS1&mt=1&rt=0
Genetics: Becoming mobile
p766 | doi:10.1038/nrc2750
http://links.ealert.nature.com/ctt?kn=24&m=34308779&r=MTc2Njc4NzkyNgS2&b=2&j=NTk4OTU4NjMS1&mt=1&rt=0
MicroRNA: Stage-specific signatures
p766 | doi:10.1038/nrc2752
http://links.ealert.nature.com/ctt?kn=26&m=34308779&r=MTc2Njc4NzkyNgS2&b=2&j=NTk4OTU4NjMS1&mt=1&rt=0
IN BRIEF
Therapy | Senescence | Genetics
p766 | doi:10.1038/nrc2758
http://links.ealert.nature.com/ctt?kn=52&m=34308779&r=MTc2Njc4NzkyNgS2&b=2&j=NTk4OTU4NjMS1&mt=1&rt=0
TRIAL WATCH
A double hit | Ligands could be key
p767 | doi:10.1038/nrc2759
http://links.ealert.nature.com/ctt?kn=54&m=34308779&r=MTc2Njc4NzkyNgS2&b=2&j=NTk4OTU4NjMS1&mt=1&rt=0
Therapeutic resistance: Smoothing the way
p768 | doi:10.1038/nrc2751
http://links.ealert.nature.com/ctt?kn=118&m=34308779&r=MTc2Njc4NzkyNgS2&b=2&j=NTk4OTU4NjMS1&mt=1&rt=0
Cancer stem cells: Symmetry is key
p768 | doi:10.1038/nrc2757
http://links.ealert.nature.com/ctt?kn=115&m=34308779&r=MTc2Njc4NzkyNgS2&b=2&j=NTk4OTU4NjMS1&mt=1&rt=0
Hypoxia: HIF1 in opposition
p769 | doi:10.1038/nrc2755
http://links.ealert.nature.com/ctt?kn=107&m=34308779&r=MTc2Njc4NzkyNgS2&b=2&j=NTk4OTU4NjMS1&mt=1&rt=0
Therapy: Swings and roundabouts
p770 | doi:10.1038/nrc2754
http://links.ealert.nature.com/ctt?kn=113&m=34308779&r=MTc2Njc4NzkyNgS2&b=2&j=NTk4OTU4NjMS1&mt=1&rt=0
Genomics: We are individuals
p770 | doi:10.1038/nrc2756
http://links.ealert.nature.com/ctt?kn=111&m=34308779&r=MTc2Njc4NzkyNgS2&b=2&j=NTk4OTU4NjMS1&mt=1&rt=0
IN THE NEWS
Emotionally stressed
p770 | doi:10.1038/nrc2760
http://links.ealert.nature.com/ctt?kn=102&m=34308779&r=MTc2Njc4NzkyNgS2&b=2&j=NTk4OTU4NjMS1&mt=1&rt=0
Nanotechnology: Take a deep breath
p771 | doi:10.1038/nrc2753
http://links.ealert.nature.com/ctt?kn=104&m=34308779&r=MTc2Njc4NzkyNgS2&b=2&j=NTk4OTU4NjMS1&mt=1&rt=0
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Focus on: p53 - 30 years on
http://links.ealert.nature.com/ctt?kn=72&m=34308779&r=MTc2Njc4NzkyNgS2&b=2&j=NTk4OTU4NjMS1&mt=1&rt=0
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REVIEW
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p53 - a Jack of all trades but master of none
Melissa R. Junttila and Gerard I. Evan
p821 | doi:10.1038/nrc2728
p53 is an evolutionarily ancient coordinator of metazoan stress responses
and its role in tumour suppression is likely to be a relatively recent
adaptation. This Review discusses how such evolutionary retooling of
this venerable transcription factor entails compromises that restrict
its efficacy as a tumour suppressor.
Abstract: http://links.ealert.nature.com/ctt?kn=55&m=34308779&r=MTc2Njc4NzkyNgS2&b=2&j=NTk4OTU4NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=94&m=34308779&r=MTc2Njc4NzkyNgS2&b=2&j=NTk4OTU4NjMS1&mt=1&rt=0
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PERSPECTIVES
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TIMELINE
20 years studying p53 functions in genetically engineered mice
Lawrence A. Donehower and Guillermina Lozano
p831 | doi:10.1038/nrc2731
Understanding the activities of p53 in tumour suppression and in other
processes has been substantially aided by the use of mouse models. How
have these models evolved and what have they taught us about p53 and
tumour suppression?
Abstract: http://links.ealert.nature.com/ctt?kn=56&m=34308779&r=MTc2Njc4NzkyNgS2&b=2&j=NTk4OTU4NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=98&m=34308779&r=MTc2Njc4NzkyNgS2&b=2&j=NTk4OTU4NjMS1&mt=1&rt=0
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REVIEWS
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Artilce series: Epigenetics and genetics
http://links.ealert.nature.com/ctt?kn=30&m=34308779&r=MTc2Njc4NzkyNgS2&b=2&j=NTk4OTU4NjMS1&mt=1&rt=0
Polycomb group proteins: navigators of lineage pathways led astray in cancer
Adrian P. Bracken and Kristian Helin
p773 | doi:10.1038/nrc2736
The Polycomb group (PcG) proteins are transcriptional repressors that
regulate lineage choices during development and differentiation and are
often deregulated in cancer. How might they become deregulated and how
does this contribute to tumorigenesis?
Abstract: http://links.ealert.nature.com/ctt?kn=5&m=34308779&r=MTc2Njc4NzkyNgS2&b=2&j=NTk4OTU4NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=88&m=34308779&r=MTc2Njc4NzkyNgS2&b=2&j=NTk4OTU4NjMS1&mt=1&rt=0
Artilce series: RB and E2F
http://links.ealert.nature.com/ctt?kn=19&m=34308779&r=MTc2Njc4NzkyNgS2&b=2&j=NTk4OTU4NjMS1&mt=1&rt=0
Emerging roles of E2Fs in cancer: an exit from cell cycle control
Hui-Zi Chen, Shih-Yin Tsai and Gustavo Leone
p785 | doi:10.1038/nrc2696
The E2F transcription factors function in cell cycle control and are
intimately regulated by RB. However, some tumours have concurrent RB1
inactivation and E2F overexpression. Are there alternative tumour-promoting
activities for the E2F family that are independent of cell cycle regulation?
Abstract: http://links.ealert.nature.com/ctt?kn=11&m=34308779&r=MTc2Njc4NzkyNgS2&b=2&j=NTk4OTU4NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=83&m=34308779&r=MTc2Njc4NzkyNgS2&b=2&j=NTk4OTU4NjMS1&mt=1&rt=0
STATs in cancer inflammation and immunity: a leading role for STAT3
Hua Yu, Drew Pardoll and Richard Jove
p798 | doi:10.1038/nrc2734
Signal transducer and activator of transcription (STAT) proteins help
determine whether immune responses promote or inhibit tumours. Specifically,
STAT3 increases tumour cell proliferation, survival and invasion and
activates tumour-promoting inflammation, but also suppresses anti-tumour
immune responses. STAT3 is therefore a promising target for cancer therapy.
Abstract: http://links.ealert.nature.com/ctt?kn=9&m=34308779&r=MTc2Njc4NzkyNgS2&b=2&j=NTk4OTU4NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=60&m=34308779&r=MTc2Njc4NzkyNgS2&b=2&j=NTk4OTU4NjMS1&mt=1&rt=0
NFAT proteins: emerging roles in cancer progression
Maria Mancini and Alex Toker
p810 | doi:10.1038/nrc2735
Although the nuclear factor of activated T cells (NFAT) transcription factors
have been studied predominantly in the immune system, they are expressed in
all tissues. This Review discusses the emerging roles of NFATs in cells that
comprise the tumour and tumour microenvironment, and how this pathway might
be targeted therapeutically.
Abstract: http://links.ealert.nature.com/ctt?kn=16&m=34308779&r=MTc2Njc4NzkyNgS2&b=2&j=NTk4OTU4NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=73&m=34308779&r=MTc2Njc4NzkyNgS2&b=2&j=NTk4OTU4NjMS1&mt=1&rt=0
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CORRESPONDENCE
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Correspondence: Increase of wildlife cancer: an echo of plastic pollution?
Thomas Erren, Dominique Zeusz, Frank Steffany and Benno Meyer-Rochow
p842 | doi:10.1038/nrc2665-c1
http://links.ealert.nature.com/ctt?kn=64&m=34308779&r=MTc2Njc4NzkyNgS2&b=2&j=NTk4OTU4NjMS1&mt=1&rt=0
Correspondence: Wildlife cancer and plastic pollution
Denise McAloose and Alisa L. Newton
p842 | doi:10.1038/nrc2665-c2
http://links.ealert.nature.com/ctt?kn=50&m=34308779&r=MTc2Njc4NzkyNgS2&b=2&j=NTk4OTU4NjMS1&mt=1&rt=0
Correspondence: Genetic matters of CYP2D6 in breast cancer: copy number
variations and nucleotide polymorphisms
Ke-Da Yu and Zhi-Ming Shao
p842 | doi:10.1038/nrc2683-c1
http://links.ealert.nature.com/ctt?kn=58&m=34308779&r=MTc2Njc4NzkyNgS2&b=2&j=NTk4OTU4NjMS1&mt=1&rt=0
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