October 2009 Volume 11 Number 10, pp 1165 - 1272
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The University of Miami, Scripps Florida and Nature Publishing Group present
MIAMI 2010 WINTER SYMPOSIUM
Targeting Cancer Invasion and Metastasis
February 21-24, 2010
Miami Beach, FL, USA
This meeting will focus on recent advances in our knowledge of basic
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EDITORIAL
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Milestones in light microscopy p1165
doi:10.1038/ncb1009-1165
A supplement contextualizes key advances in light microscopy over
400 years, while the Tara expedition sets sail to explore oceanic
ecosystems at the microscopic level.
http://links.ealert.nature.com/ctt?kn=29&m=34091468&r=MTc2NDEyMTk0MQS2&b=2&j=NTg3MzcwNjYS1&mt=1&rt=0
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REVIEW
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Receptor-like kinases shape the plant pp1166 - 1173
Ive De Smet, Ute Vosz, Gerd Jurgens and Tom Beeckman
doi:10.1038/ncb1009-1166
Abstract: http://links.ealert.nature.com/ctt?kn=61&m=34091468&r=MTc2NDEyMTk0MQS2&b=2&j=NTg3MzcwNjYS1&mt=1&rt=0
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NEWS AND VIEWS
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A bacterial virulence factor that dissipates tension pp1174 - 1175
Stephane Romero and Guy Tran Van Nhieu
doi:10.1038/ncb1009-1174
Various microbes harness the actin polymerization machinery through
their surface proteins to allow intracellular motility within host cells,
but other virulence factors regulate dissemination. The cortical actin
tension of polarized cells may represent a physical barrier that hinders
the formation of microbial protrusions during cell-to-cell spreading.
http://links.ealert.nature.com/ctt?kn=25&m=34091468&r=MTc2NDEyMTk0MQS2&b=2&j=NTg3MzcwNjYS1&mt=1&rt=0
NURD keeps chromatin young pp1176 - 1177
Eran Meshorer and Yosef Gruenbaum
doi:10.1038/ncb1009-1176
Progerin, a mutated form of lamin A, causes the premature ageing disease
Hutchinson-Gilford progeria syndrome and is also involved in normal ageing.
Progerin accumulation leads to distinct chromatin-related defects and the
NURD complex appears to affect ageing-related chromatin defects.
http://links.ealert.nature.com/ctt?kn=20&m=34091468&r=MTc2NDEyMTk0MQS2&b=2&j=NTg3MzcwNjYS1&mt=1&rt=0
A motor driving PTEN pp1177 - 1179
Jing Zhou and Luis F. Parada
doi:10.1038/ncb1009-1177
To fulfil its lipid phosphatase function, PTEN must be in close proximity
to the plasma membrane where its substrates reside. PTEN translocation to
the plasma membrane is an active process that is mediated by the myosin-based
transport machinery. MyosinV controls PTEN membrane association and thus,
PTEN-mediated cell growth in neurons.
http://links.ealert.nature.com/ctt?kn=80&m=34091468&r=MTc2NDEyMTk0MQS2&b=2&j=NTg3MzcwNjYS1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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Research highlights p1180
Bernd Pulverer, Christina Karlsson Rosenthal, Alison Schuldt and
Sowmya Swaminathan
doi:10.1038/ncb1009-1180
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Nature Milestones in Light Microscopy
Milestones in Light Microscopy is a collaboration from Nature Cell Biology,
Nature Methods and Nature Reviews Molecular Cell Biology. The feature
contains a series of short articles, called Milestones, that represent
key developments in the field, written by editors of the Nature Publishing Group.
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ARTICLE
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C/EBPalpha and beta couple interfollicular keratinocyte proliferation
arrest to commitment and terminal differentiation pp1181 - 1190
Rodolphe G. Lopez et al.
doi:10.1038/ncb1960
The transcriptional regulators that couple keratinocyte proliferation
arrest with commitment to differentiation are yet to be identified.
C/EBPs are shown to couple mice basal keratinocyte cell-cycle exit
with commitment to differentiation through, respectively, E2F repression
and DNA binding.
Abstract: http://links.ealert.nature.com/ctt?kn=62&m=34091468&r=MTc2NDEyMTk0MQS2&b=2&j=NTg3MzcwNjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=70&m=34091468&r=MTc2NDEyMTk0MQS2&b=2&j=NTg3MzcwNjYS1&mt=1&rt=0
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LETTERS
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MyosinV controls PTEN function and neuronal cell size pp1191 - 1196
Michiel T. van Diepen et al.
doi:10.1038/ncb1961
Inactivation of the tumour suppressor PTEN leads to enlarged neuronal soma.
The actin-based motor myosin Va is shown to control soma size by transporting
PTEN in a manner dependent on PTEN phosphorylation by CK2 and/or GSK3.
Abstract: http://links.ealert.nature.com/ctt?kn=63&m=34091468&r=MTc2NDEyMTk0MQS2&b=2&j=NTg3MzcwNjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=88&m=34091468&r=MTc2NDEyMTk0MQS2&b=2&j=NTg3MzcwNjYS1&mt=1&rt=0
Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated
Sec23a pathway is essential for chondrogenesis pp1197 - 1204
Atsushi Saito et al.
doi:10.1038/ncb1962
BBF2H7, a transcription factor activated by ER stress, is shown to be
essential for chondrogenesis. Mice lacking BBF2H7 show severe chondrodysplasia
and null chondrocytes have defects in secreting cartilage matrix proteins.
BBF2H7 induces the expression of Sec23a, which is required for ER to Golgi
transport, and rescues the secretion of cartilage matrix proteins in null cells.
Abstract: http://links.ealert.nature.com/ctt?kn=64&m=34091468&r=MTc2NDEyMTk0MQS2&b=2&j=NTg3MzcwNjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=133&m=34091468&r=MTc2NDEyMTk0MQS2&b=2&j=NTg3MzcwNjYS1&mt=1&rt=0
Signalling mediated by the endoplasmic reticulum stress transducer OASIS
is involved in bone formation pp1205 - 1211
Tomohiko Murakami et al.
doi:10.1038/ncb1963
The transcription factor OASIS was previously implicated in the ER stress
response. BMP2 signalling, which is required for bone formation, induces
OASIS expression and activation. Mice lacking OASIS show severe defects
in bone formation and in response to BMP2 signalling. OASIS directly induces
expression of Col1a1, a component of type 1 collagen.
Abstract: http://links.ealert.nature.com/ctt?kn=56&m=34091468&r=MTc2NDEyMTk0MQS2&b=2&j=NTg3MzcwNjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=124&m=34091468&r=MTc2NDEyMTk0MQS2&b=2&j=NTg3MzcwNjYS1&mt=1&rt=0
The bacterial virulence factor InlC perturbs apical cell junctions and
promotes cell-to-cell spread of Listeria pp1212 - 1218
Tina Rajabian et al.
doi:10.1038/ncb1964
Listeria monocytogenes spreads by membrane protrusions produced by actin
'comet tails'. The secreted Listeria protein InclC binds the mammalian
adaptor protein Tuba to prevent activation of the actin regulator N-WASP2,
which causes disruption of apical junctions and protrusion formation.
Abstract: http://links.ealert.nature.com/ctt?kn=57&m=34091468&r=MTc2NDEyMTk0MQS2&b=2&j=NTg3MzcwNjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=23&m=34091468&r=MTc2NDEyMTk0MQS2&b=2&j=NTg3MzcwNjYS1&mt=1&rt=0
Intracellular fluid flow in rapidly moving cells pp1219 - 1224
Kinneret Keren et al.
doi:10.1038/ncb1965
Fluid flow towards the leading edge has been suggested to have a role in
cell motility, but the existence of fluid flow had not been demonstrated
directly. Insertion of quantum dots into the lamellipodia of fish
keratinocytes now reveals a forward-directed fluid flow that is dependent
on myosin II activity.
Abstract: http://links.ealert.nature.com/ctt?kn=59&m=34091468&r=MTc2NDEyMTk0MQS2&b=2&j=NTg3MzcwNjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=107&m=34091468&r=MTc2NDEyMTk0MQS2&b=2&j=NTg3MzcwNjYS1&mt=1&rt=0
The planar cell polarity effector Fuz is essential for targeted membrane
trafficking, ciliogenesis and mouse embryonic development pp1225 - 1232
Ryan S. Gray et al.
doi:10.1038/ncb1966
The planar cell polarity (PCP) effector Fuz had not been studied in mice.
Due to disrupted ciliogenesis, Fuz mutant mice show neural tube and skeletal
defects. Fuz regulates trafficking of membrane cargoes to cilia through
its interaction with a GTPase of the Rab family.
Abstract: http://links.ealert.nature.com/ctt?kn=60&m=34091468&r=MTc2NDEyMTk0MQS2&b=2&j=NTg3MzcwNjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=114&m=34091468&r=MTc2NDEyMTk0MQS2&b=2&j=NTg3MzcwNjYS1&mt=1&rt=0
Listeria monocytogenes ActA-mediated escape from autophagic recognition
pp1233 - 1240
Yuko Yoshikawa et al.
doi:10.1038/ncb1967
Autophagy degrades invading bacteria in the cytoplasm, however,
Listeria monocytogenes can efficiently escape autophagy. The Listeria
protein ActA recruits the actin-regulators Arp2/3 and Ena/VASP to disguise
it from autophagic recognition. Tagging PolyQ-containing, aggregate-prone
proteins or a Golgi-membrane protein with ActA also prevents their
autophagy-mediated degradation.
Abstract: http://links.ealert.nature.com/ctt?kn=52&m=34091468&r=MTc2NDEyMTk0MQS2&b=2&j=NTg3MzcwNjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=111&m=34091468&r=MTc2NDEyMTk0MQS2&b=2&j=NTg3MzcwNjYS1&mt=1&rt=0
Oxidant-induced apoptosis is mediated by oxidation of the actin-regulatory
protein cofilin pp1241 - 1246
Fabio Klamt et al.
doi:10.1038/ncb1968
The function of oxidation of specific proteins during apoptosis has been
unclear. Oxidation of the actin-binding protein cofilin induces its
translocation to the mitochondria, where it triggers the opening of
the permeability transition pore independently of the BH3-only apoptotic
factor Bax, and is required for oxidant-induced apoptosis.
Abstract: http://links.ealert.nature.com/ctt?kn=54&m=34091468&r=MTc2NDEyMTk0MQS2&b=2&j=NTg3MzcwNjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=106&m=34091468&r=MTc2NDEyMTk0MQS2&b=2&j=NTg3MzcwNjYS1&mt=1&rt=0
NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint
pp1247 - 1253
Marina Melixetian, Ditte Kjaersgaard Klein, Claus Storgaard Sorensen
and Kristian Helin
doi:10.1038/ncb1969
Inhibition of the CDC25A phosphatase is critical for activation of the
DNA damage-induced G2/M checkpoint. The DNA damage-activated kinase
CHK1 phosphorylates the NIMA-related kinase NEK11, which in turn phosphorylates
CDC25A to induce its degradation.
Abstract: http://links.ealert.nature.com/ctt?kn=49&m=34091468&r=MTc2NDEyMTk0MQS2&b=2&j=NTg3MzcwNjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=30&m=34091468&r=MTc2NDEyMTk0MQS2&b=2&j=NTg3MzcwNjYS1&mt=1&rt=0
Brassinosteroid signal transduction from cell-surface receptor kinases
to nuclear transcription factors pp1254 - 1260
Tae-Wuk Kim et al.
doi:10.1038/ncb1970
The brassinosteroid (BR) signalling pathway results in the activation
of BZR transcription factors to control plant development. The complete
pathway is established here, by showing that BR induces the BSU1
phosphatase-dependent inactivation of the GSK3-like kinase BIN2,
thereby leading to accumulation of unphosphorylated BZR factors in the nucleus.
Abstract: http://links.ealert.nature.com/ctt?kn=46&m=34091468&r=MTc2NDEyMTk0MQS2&b=2&j=NTg3MzcwNjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=33&m=34091468&r=MTc2NDEyMTk0MQS2&b=2&j=NTg3MzcwNjYS1&mt=1&rt=0
Ageing-related chromatin defects through loss of the NURD complex
pp1261 - 1267
Gianluca Pegoraro et al.
doi:10.1038/ncb1971
Cells undergoing normal or premature ageing show several global defects
in chromatin. Components of the NURD chromatin remodelling complex,
such as histone chaperones, are now shown to be lost in cells from
patients with a premature aging disorder and in normally aged cells.
Conversely, depleting NURD subunits and Hdac1 recapitulates the
chromatin defects seen in aged cells.
Abstract: http://links.ealert.nature.com/ctt?kn=47&m=34091468&r=MTc2NDEyMTk0MQS2&b=2&j=NTg3MzcwNjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=82&m=34091468&r=MTc2NDEyMTk0MQS2&b=2&j=NTg3MzcwNjYS1&mt=1&rt=0
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BRIEF COMMUNICATION
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The non-coding RNA of the multidrug resistance-linked vault particle
encodes multiple regulatory small RNAs pp1268 - 1271
Helena Persson et al.
doi:10.1038/ncb1972
Vault particles, containing three proteins and non-coding vault RNAs
(vRNAs), regulate multidrug resistance. Human vRNAs are found to be
processed into several small RNAs (svRNAs), one of which associates
with Argonaute proteins to downregulate the expression of CYP3A4,
an enzyme involved in drug metabolism.
Abstract: http://links.ealert.nature.com/ctt?kn=44&m=34091468&r=MTc2NDEyMTk0MQS2&b=2&j=NTg3MzcwNjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=18&m=34091468&r=MTc2NDEyMTk0MQS2&b=2&j=NTg3MzcwNjYS1&mt=1&rt=0
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ERRATA
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Persistent DNA damage signalling triggers senescence-associated
inflammatory cytokine secretion p1272
Francis Rodier et al.
doi:10.1038/ncb1009-1272a
http://links.ealert.nature.com/ctt?kn=17&m=34091468&r=MTc2NDEyMTk0MQS2&b=2&j=NTg3MzcwNjYS1&mt=1&rt=0
Multivesicular bodies associate with components of miRNA effector
complexes and modulate miRNA activity p1272
Derrick J. Gibbings, Constance Ciaudo, Mathieu Erhardt and Olivier Voinnet
doi:10.1038/ncb1009-1272b
http://links.ealert.nature.com/ctt?kn=9&m=34091468&r=MTc2NDEyMTk0MQS2&b=2&j=NTg3MzcwNjYS1&mt=1&rt=0
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CORRIGENDA
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Axin determines cell fate by controlling the p53 activation threshold
after DNA damage p1272
Qinxi Li et al.
doi:10.1038/ncb1009-1272c
http://links.ealert.nature.com/ctt?kn=6&m=34091468&r=MTc2NDEyMTk0MQS2&b=2&j=NTg3MzcwNjYS1&mt=1&rt=0
mRNA decay turns on apoptosis p1272
doi:10.1038/ncb1009-1272d
http://links.ealert.nature.com/ctt?kn=12&m=34091468&r=MTc2NDEyMTk0MQS2&b=2&j=NTg3MzcwNjYS1&mt=1&rt=0
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