Signaling Gateway - 28 September 2009
http://links.ealert.nature.com/ctt?kn=32&m=34078434&r=MTc2ODc4NDI0MAS2&b=2&j=NTg1NjM5ODYS1&mt=1&rt=0
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
http://links.ealert.nature.com/ctt?kn=4&m=34078434&r=MTc2ODc4NDI0MAS2&b=2&j=NTg1NjM5ODYS1&mt=1&rt=0
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In Signaling Update this week:
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Featured Article
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INTEGRIN ADHESION SIGNALING: TUMORS DECLARE INDEPENDENCE
Integrin alphavbeta3 and c-Src interact to promote
anchorage-independent growth and tumor cell survival.
Original research paper: Nature Medicine advance online publication,
6 September 2009
http://links.ealert.nature.com/ctt?kn=21&m=34078434&r=MTc2ODc4NDI0MAS2&b=2&j=NTg1NjM5ODYS1&mt=1&rt=0
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Selected Updates
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VIRAL IMMUNITY: ARE MEN AND WOMEN DIFFERENT?
Plasmacytoid dendritic cells produce more interferon-alpha (IFNalpha)
in response to HIV-1 in women than in men, which leads to higher
levels of CD8<sup>+</sup> T-cell activation and might explain the
tendency for women to progress significantly faster to AIDS than men
with the same viral load.
Original research paper: Nature Med. 15, 955–959 (2009)
http://links.ealert.nature.com/ctt?kn=6&m=34078434&r=MTc2ODc4NDI0MAS2&b=2&j=NTg1NjM5ODYS1&mt=1&rt=0
TUMOUR SUPPRESSORS: DIFFERENT ROADS TO INACTIVATION
Inhibition of protein kinase C (PKC) might be a strategy to treat
glioblastomas that do not harbor mutations in the NF1 tumor
suppressor gene, whereas glioblastomas with genetic inactivation of
NF1 may respond to mTOR inhibition.
Original research paper: Cancer Cell 16, 44–54 (2009)
http://links.ealert.nature.com/ctt?kn=5&m=34078434&r=MTc2ODc4NDI0MAS2&b=2&j=NTg1NjM5ODYS1&mt=1&rt=0
MIGRATION: EXCHANGE TO MIGRATE
Activation of GABAA receptors in glial precursor NG2 cells regulates
cell migration in part by triggering a Ca2+ signaling pathway that
reverses the activity of the Na+-Ca2+ exchanger 1 (NCX1).
Original research paper: J. Cell Biol. 186, 113–128 (2009)
http://links.ealert.nature.com/ctt?kn=9&m=34078434&r=MTc2ODc4NDI0MAS2&b=2&j=NTg1NjM5ODYS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=7&m=34078434&r=MTc2ODc4NDI0MAS2&b=2&j=NTg1NjM5ODYS1&mt=1&rt=0
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Research Library
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http://links.ealert.nature.com/ctt?kn=2&m=34078434&r=MTc2ODc4NDI0MAS2&b=2&j=NTg1NjM5ODYS1&mt=1&rt=0
A DIMERIZATION-DEPENDENT MECHANISM DRIVES RAF CATALYTIC ACTIVATION
Nature 461, 542-545 (2009)
http://links.ealert.nature.com/ctt?kn=13&m=34078434&r=MTc2ODc4NDI0MAS2&b=2&j=NTg1NjM5ODYS1&mt=1&rt=0
P53 ISOFORMS [DELTA]133P53 AND P53[BETA] ARE ENDOGENOUS REGULATORS OF
REPLICATIVE CELLULAR SENESCENCE
Nature Cell Biology 11, 1135-1142 (2009)
http://links.ealert.nature.com/ctt?kn=25&m=34078434&r=MTc2ODc4NDI0MAS2&b=2&j=NTg1NjM5ODYS1&mt=1&rt=0
MODULAR SCANNING FCS QUANTIFIES RECEPTOR-LIGAND INTERACTIONS IN
LIVING MULTICELLULAR ORGANISMS
Nature Methods 6, 643-645 (2009)
http://links.ealert.nature.com/ctt?kn=26&m=34078434&r=MTc2ODc4NDI0MAS2&b=2&j=NTg1NjM5ODYS1&mt=1&rt=0
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Signaling News
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PROTEIN BURNS ITS EVOLUTIONARY BRIDGES
http://links.ealert.nature.com/ctt?kn=11&m=34078434&r=MTc2ODc4NDI0MAS2&b=2&j=NTg1NjM5ODYS1&mt=1&rt=0
The glucocorticoid receptor (GR) evolved more than 400 million years
ago from an ancestral receptor that was activated by a trio of
hormones (cortisol, aldosterone and deoxycorticosterone).
Researchers have now shown that mutations that impart selectivity to
cortisol cannot be reverted; suggesting that changes in protein
function or structure happening over the course of tens of millions
of years can prevent molecular turnarounds and render evolution
irreversible.
More news
http://links.ealert.nature.com/ctt?kn=1&m=34078434&r=MTc2ODc4NDI0MAS2&b=2&j=NTg1NjM5ODYS1&mt=1&rt=0
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Gateway Updates
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NCI-NATURE PATHWAY INTERACTION DATABASE - SEPTEMBER UPDATE
http://links.ealert.nature.com/ctt?kn=17&m=34078434&r=MTc2ODc4NDI0MAS2&b=2&j=NTg1NjM5ODYS1&mt=1&rt=0
The Pathway Interaction Database is a free, high-quality resource of
signaling pathways in human cells for biologists and
bioinformaticians to explore, visualize and mine signaling events.
This month's update features the p53 pathway and LKB1 signaling
events.
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Job of the Week
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Instructor
Employer: The University of Tennessee Health Science Center
Location: Memphis, Tennessee, USA
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An instructor faculty position is available at the Department of
Physiology in the University of Tennessee Health Science Center.
The successful applicant will examine the role of protein
phosphatase 2a in myocardial ischemia and reperfusion, and will be
responsible for supervising postdoctoral fellows, research associates
and graduate students.
More Jobs:
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To advertise a job in this spot, please contact Naturejobs.
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