October 2009 Volume 9 Number 10
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This month's FEATURED article:
Transcriptional control of the inflammatory response
Ruslan Medzhitov and Tiffany Horng
p692 | doi:10.1038/nri2634
http://links.ealert.nature.com/ctt?kn=8&m=34071442&r=MTc2NzU2Mjg3MwS2&b=2&j=NTg0NDMyOTUS1&mt=1&rt=0
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From the editors
p669 | doi:10.1038/nri2648
http://links.ealert.nature.com/ctt?kn=76&m=34071442&r=MTc2NzU2Mjg3MwS2&b=2&j=NTg0NDMyOTUS1&mt=1&rt=0
----------------------
RESEARCH HIGHLIGHTS
----------------------
[gamma][delta] T cells: Innate source of IL-17
p671 | doi:10.1038/nri2645
http://links.ealert.nature.com/ctt?kn=77&m=34071442&r=MTc2NzU2Mjg3MwS2&b=2&j=NTg0NDMyOTUS1&mt=1&rt=0
Innate immunity: A protective fungal spore coat
p672 | doi:10.1038/nri2641
http://links.ealert.nature.com/ctt?kn=79&m=34071442&r=MTc2NzU2Mjg3MwS2&b=2&j=NTg0NDMyOTUS1&mt=1&rt=0
Tumour immunology: Neutrophil plasticity
p672 | doi:10.1038/nri2649
http://links.ealert.nature.com/ctt?kn=82&m=34071442&r=MTc2NzU2Mjg3MwS2&b=2&j=NTg0NDMyOTUS1&mt=1&rt=0
IN THE NEWS
Common ills linked to memory loss
p672 | doi:10.1038/nri2650
http://links.ealert.nature.com/ctt?kn=86&m=34071442&r=MTc2NzU2Mjg3MwS2&b=2&j=NTg0NDMyOTUS1&mt=1&rt=0
IN BRIEF
Inflammation | Natural killer cells | Immune regulation
p673 | doi:10.1038/nri2652
http://links.ealert.nature.com/ctt?kn=44&m=34071442&r=MTc2NzU2Mjg3MwS2&b=2&j=NTg0NDMyOTUS1&mt=1&rt=0
Regulatory T cells: Eos: the sound of silence
p674 | doi:10.1038/nri2639
http://links.ealert.nature.com/ctt?kn=65&m=34071442&r=MTc2NzU2Mjg3MwS2&b=2&j=NTg0NDMyOTUS1&mt=1&rt=0
Natural killer cells: Peace not war
p674 | doi:10.1038/nri2643
http://links.ealert.nature.com/ctt?kn=63&m=34071442&r=MTc2NzU2Mjg3MwS2&b=2&j=NTg0NDMyOTUS1&mt=1&rt=0
Innate immunity: Help from 'friendly' bacteria
p675 | doi:10.1038/nri2642
http://links.ealert.nature.com/ctt?kn=61&m=34071442&r=MTc2NzU2Mjg3MwS2&b=2&j=NTg0NDMyOTUS1&mt=1&rt=0
Dendritic cells: One SIGN, different paths
p676 | doi:10.1038/nri2640
http://links.ealert.nature.com/ctt?kn=92&m=34071442&r=MTc2NzU2Mjg3MwS2&b=2&j=NTg0NDMyOTUS1&mt=1&rt=0
VACCINE WATCH
One jab protects from swine flu
p676 | doi:10.1038/nri2651
http://links.ealert.nature.com/ctt?kn=95&m=34071442&r=MTc2NzU2Mjg3MwS2&b=2&j=NTg0NDMyOTUS1&mt=1&rt=0
Immune responses: Seeing is believing
p677 | doi:10.1038/nri2646
http://links.ealert.nature.com/ctt?kn=88&m=34071442&r=MTc2NzU2Mjg3MwS2&b=2&j=NTg0NDMyOTUS1&mt=1&rt=0
Tolerance: SIRT1 keeps escapees quiet
p677 | doi:10.1038/nri2647
http://links.ealert.nature.com/ctt?kn=90&m=34071442&r=MTc2NzU2Mjg3MwS2&b=2&j=NTg0NDMyOTUS1&mt=1&rt=0
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REVIEWS
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Article series: Tissue-specific immune responses
http://links.ealert.nature.com/ctt?kn=73&m=34071442&r=MTc2NzU2Mjg3MwS2&b=2&j=NTg0NDMyOTUS1&mt=1&rt=0
Skin immune sentinels in health and disease
Frank O. Nestle, Paola Di Meglio, Jian-Zhong Qin and Brian
J. Nickoloff
p679 | doi:10.1038/nri2622
The skin and the immune cells that it contains provide essential
protection from injury and infection. This Review describes recent
studies that expand our understanding of the functional role of these
sentinel cells in sensing danger and mediating homeostasis and
disease in the skin.
Abstract: http://links.ealert.nature.com/ctt?kn=45&m=34071442&r=MTc2NzU2Mjg3MwS2&b=2&j=NTg0NDMyOTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=72&m=34071442&r=MTc2NzU2Mjg3MwS2&b=2&j=NTg0NDMyOTUS1&mt=1&rt=0
Transcriptional control of the inflammatory response
Ruslan Medzhitov and Tiffany Horng
p692 | doi:10.1038/nri2634
The regulation of gene expression at the level of transcription is
important for controlling inflammatory responses. Here, the authors
describe the key factors and molecular mechanisms involved in this
regulation in macrophages and explain how these factors and
mechanisms mediate the distinct but coordinated regulation of the
different components of the inflammatory response.
Abstract: http://links.ealert.nature.com/ctt?kn=8&m=34071442&r=MTc2NzU2Mjg3MwS2&b=2&j=NTg0NDMyOTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=33&m=34071442&r=MTc2NzU2Mjg3MwS2&b=2&j=NTg0NDMyOTUS1&mt=1&rt=0
Engineering lymphocyte subsets: tools, trials and tribulations
Carl H. June, Bruce R. Blazar and James L. Riley
p704 | doi:10.1038/nri2635
Recent advances in the techniques for genetically engineering various
lymphocyte subsets hold great promise for cell-based therapies to
improve or correct aberrant immune responses. With several new
approaches now entering clinical trials, continued efforts will focus
on improving their safety and efficacy.
Abstract: http://links.ealert.nature.com/ctt?kn=46&m=34071442&r=MTc2NzU2Mjg3MwS2&b=2&j=NTg0NDMyOTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=41&m=34071442&r=MTc2NzU2Mjg3MwS2&b=2&j=NTg0NDMyOTUS1&mt=1&rt=0
Monkeying around with HIV vaccines: using rhesus macaques to define
'gatekeepers' for clinical trials
Devon J. Shedlock, Guido Silvestri and David B. Weiner
p717 | doi:10.1038/nri2636
Studies in rhesus macaques have been instrumental in driving the
progression of potential HIV vaccines to clinical testing. But after
two failed clinical trials, David Weiner and colleagues re-evaluate
the predictive value of data from this animal model and explain how
it might be better used for HIV vaccine development.
Abstract: http://links.ealert.nature.com/ctt?kn=12&m=34071442&r=MTc2NzU2Mjg3MwS2&b=2&j=NTg0NDMyOTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=24&m=34071442&r=MTc2NzU2Mjg3MwS2&b=2&j=NTg0NDMyOTUS1&mt=1&rt=0
Complement regulators and inhibitory proteins
Peter F. Zipfel and Christine Skerka
p729 | doi:10.1038/nri2620
Complement is one of the first lines of innate immune defence in the
body. As reviewed here, complement regulators have a key role in
keeping the complement system in check, and dysregulation of
complement activation can result in pathology.
Abstract: http://links.ealert.nature.com/ctt?kn=13&m=34071442&r=MTc2NzU2Mjg3MwS2&b=2&j=NTg0NDMyOTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=51&m=34071442&r=MTc2NzU2Mjg3MwS2&b=2&j=NTg0NDMyOTUS1&mt=1&rt=0
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PERSPECTIVES
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TIMELINE
Learning immunology from the yellow fever vaccine: innate immunity to
systems vaccinology
Bali Pulendran
p741 | doi:10.1038/nri2629
Bali Pulendran provides a historical overview of the development of
the successful yellow fever vaccine. He describes recent advancements
in our understanding of its mechanisms of action resulting from the
use of systems biological approaches and how this knowledge might be
applicable to vaccine development in general.
Abstract: http://links.ealert.nature.com/ctt?kn=11&m=34071442&r=MTc2NzU2Mjg3MwS2&b=2&j=NTg0NDMyOTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=57&m=34071442&r=MTc2NzU2Mjg3MwS2&b=2&j=NTg0NDMyOTUS1&mt=1&rt=0
Corrigendum: Structure and signalling in the IL-17 receptor family
Sarah L. Gaffen
p747 | doi:10.1038/nri2625
http://links.ealert.nature.com/ctt?kn=59&m=34071442&r=MTc2NzU2Mjg3MwS2&b=2&j=NTg0NDMyOTUS1&mt=1&rt=0
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