Signaling Gateway - 11 September 2009
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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G-PROTEIN-COUPLED RECEPTORS: SIGNALING FROM THE INSIDE
Parathyroid hormone (PTH) elicits sustained cAMP production by
stimulating a prolonged association between the PTH receptor,
activated G protein and adenylyl cyclase in early endosomes.
Original research paper: Nature Chemical Biology advance online
publication, 23 August 2009 (DOI 10.1038/nchembio.206)
http://links.ealert.nature.com/ctt?kn=30&m=34030818&r=MTc2ODc4NDI0MAS2&b=2&j=NTc4MzY4MTIS1&mt=1&rt=0
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Molecule Pages
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PHOSPHODIESTERASE 1A
http://links.ealert.nature.com/ctt?kn=7&m=34030818&r=MTc2ODc4NDI0MAS2&b=2&j=NTc4MzY4MTIS1&mt=1&rt=0
Phosphodiesterase 1A (PDE1A) hydrolyzes the nucleotides cyclic
adenosine monophosphate (cAMP) and cyclic guanosine monophosphate
(cGMP) to AMP and GMP, respectively. The enzymatic activity of PDE1A
is stimulated by the binding of Ca2+/calmodulin. It was initially
suggested that PDE1 consisted of a single species, but it is now
clear that PDE1 activity can be ascribed to several different
isozymes, namely PDE1A, PDE1B, PDE1C and their various splice
variants. Many studies have indicated that the activity of PDE1 is
regulated by cross-talk between Ca2+ and cAMP signaling pathways.
Although an alteration in expression and activity of PDE1 has been
reported in pulmonary arterial hypertension, an understanding of the
functions of PDE1 in disease is far from complete.
Also published this week:
PHOSPHODIESTERASE 1B
http://links.ealert.nature.com/ctt?kn=6&m=34030818&r=MTc2ODc4NDI0MAS2&b=2&j=NTc4MzY4MTIS1&mt=1&rt=0
PHOSPHODIESTERASE 1C
http://links.ealert.nature.com/ctt?kn=11&m=34030818&r=MTc2ODc4NDI0MAS2&b=2&j=NTc4MzY4MTIS1&mt=1&rt=0
Search the molecule pages
http://links.ealert.nature.com/ctt?kn=9&m=34030818&r=MTc2ODc4NDI0MAS2&b=2&j=NTc4MzY4MTIS1&mt=1&rt=0
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Selected Updates
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STEM CELLS: THE GREAT iPS BARRIER
Research from five groups has revealed that the p16INK4A and ARF-p53
pathways function as a barrier against induced pluripotent stem (iPS)
cell generation in mouse and human cells.
Original research paper: Nature 460, 1132-1135 (2009)
http://links.ealert.nature.com/ctt?kn=2&m=34030818&r=MTc2ODc4NDI0MAS2&b=2&j=NTc4MzY4MTIS1&mt=1&rt=0
TUMOUR SUPPRESSION: FULL ON
In response to genotoxic stress, phosphorylation and subsequent
degradation of MDM4 permits an increase in p53 activity.
Original research paper: Cancer Cell 16, 33-43 (2009)
http://links.ealert.nature.com/ctt?kn=1&m=34030818&r=MTc2ODc4NDI0MAS2&b=2&j=NTc4MzY4MTIS1&mt=1&rt=0
AXON GUIDANCE: SORTING THEMSELVES OUT
Interactions between neuropilin 1 (NRP1) and its ligand semaphorin 3A
(SEMA3A) regulate the organization of olfactory sensory neuron axons
long before they reach the olfactory bulb.
Original research paper: Science 325, 585-590 (2009)
http://links.ealert.nature.com/ctt?kn=4&m=34030818&r=MTc2ODc4NDI0MAS2&b=2&j=NTc4MzY4MTIS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=18&m=34030818&r=MTc2ODc4NDI0MAS2&b=2&j=NTc4MzY4MTIS1&mt=1&rt=0
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Research Library
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http://links.ealert.nature.com/ctt?kn=17&m=34030818&r=MTc2ODc4NDI0MAS2&b=2&j=NTc4MzY4MTIS1&mt=1&rt=0
ERBB2 RESEMBLES AN AUTOINHIBITED INVERTEBRATE EPIDERMAL GROWTH FACTOR
RECEPTOR
Nature 461, 287-291 (2009)
http://links.ealert.nature.com/ctt?kn=20&m=34030818&r=MTc2ODc4NDI0MAS2&b=2&j=NTc4MzY4MTIS1&mt=1&rt=0
PRIMARY CILIA CAN BOTH MEDIATE AND SUPPRESS HEDGEHOG
PATHWAY-DEPENDENT TUMORIGENESIS
Nature Medicine 15, 1055-1061 (2009)
http://links.ealert.nature.com/ctt?kn=34&m=34030818&r=MTc2ODc4NDI0MAS2&b=2&j=NTc4MzY4MTIS1&mt=1&rt=0
CANNABINOID MODULATION OF HIPPOCAMPAL LONG-TERM MEMORY IS MEDIATED
BY mTOR SIGNALING
Nature Neuroscience 12, 1152-1158 (2009)
http://links.ealert.nature.com/ctt?kn=37&m=34030818&r=MTc2ODc4NDI0MAS2&b=2&j=NTc4MzY4MTIS1&mt=1&rt=0
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Signaling News
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NATURE REVIEWS MOLECULAR CELL BIOLOGY: FOCUS ON ENDOCYTOSIS
http://links.ealert.nature.com/ctt?kn=13&m=34030818&r=MTc2ODc4NDI0MAS2&b=2&j=NTc4MzY4MTIS1&mt=1&rt=0
Endocytic membrane trafficking is required for a vast number of
cellular functions and involves the cellular internalization and
sorting of extracellular molecules, plasma membrane proteins and
lipids. This special Focus on endocytosis from Nature Reviews
Molecular Cell Biology contains review articles that reflect the
diversity and complexity of endocytic trafficking processes and their
associated machineries.
More news
http://links.ealert.nature.com/ctt?kn=15&m=34030818&r=MTc2ODc4NDI0MAS2&b=2&j=NTc4MzY4MTIS1&mt=1&rt=0
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Gateway Updates
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NATURE PRECEDINGS: PRE-PUBLICATION RESEARCH AND PRELIMINARY FINDINGS
http://links.ealert.nature.com/ctt?kn=29&m=34030818&r=MTc2ODc4NDI0MAS2&b=2&j=NTc4MzY4MTIS1&mt=1&rt=0
Nature Precedings is a place for researchers to share pre-publication
research and other scientific documents.
http://links.ealert.nature.com/ctt?kn=29&m=34030818&r=MTc2ODc4NDI0MAS2&b=2&j=NTc4MzY4MTIS1&mt=1&rt=0
Recent pre-print manuscripts posted to Nature Precedings include
"Mammalian cells in culture actively export specific microRNAs",
"Systems Biology Graphical Notation: Entity relationship language
Level 1" and "The Sonic Hedgehog pathway stimulates prostate tumor
growth by paracrine signaling and recaptures embryonic gene
expression in tumor myofibroblasts".
Search for documents or browse recently posted manuscripts to stay
informed of the latest research in your field.
http://links.ealert.nature.com/ctt?kn=19&m=34030818&r=MTc2ODc4NDI0MAS2&b=2&j=NTc4MzY4MTIS1&mt=1&rt=0
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Job of the Week
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University Teacher in Anatomy
Employer: The University of Nottingham
Location: Nottingham, UK
http://links.ealert.nature.com/ctt?kn=36&m=34030818&r=MTc2ODc4NDI0MAS2&b=2&j=NTc4MzY4MTIS1&mt=1&rt=0
An anatomy teacher position is available at the University of
Nottingham. Candidates should have prior postdoctoral and teaching
experience, as the position will entail significant preparation of
teaching material and delivery of lectures. In addition, the
successful applicant may be invited to carry out collaborative
research in molecular pharmacology, cell signaling, and
cardiovascular or respiratory pharmacology.
More Jobs:
http://links.ealert.nature.com/ctt?kn=26&m=34030818&r=MTc2ODc4NDI0MAS2&b=2&j=NTc4MzY4MTIS1&mt=1&rt=0
To advertise a job in this spot, please contact Naturejobs.
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